PubMed:23678002
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1075-1084 | Glycan_Motif | denotes | T antigen | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T1 | 1075-1084 | GlycoEpitope | denotes | T antigen | http://www.glycoepitope.jp/epitopes/EP0020 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-103 | Sentence | denotes | Differential regulation of c-Jun protein plays an instrumental role in chemoresistance of cancer cells. |
| T2 | 104-231 | Sentence | denotes | The chemotherapeutic drug cisplatin (cis-diamminedichloroplatinum(II) (CDDP)) is widely used in the treatment of human cancers. |
| T3 | 232-317 | Sentence | denotes | However, the mechanism underlying intrinsic tumor resistance to CDDP remains elusive. |
| T4 | 318-554 | Sentence | denotes | Here, we demonstrate that treatment with CDDP resulted in down-regulation of c-Jun expression via caspase-9-dependent cleavage of c-Jun at Asp-65 and MEKK1-mediated ubiquitylation and degradation of c-Jun in CDDP-sensitive cancer cells. |
| T5 | 555-682 | Sentence | denotes | In contrast, activation of JNK2 (but not JNK1) phosphorylated and up-regulated the expression of c-Jun in CDDP-resistant cells. |
| T6 | 683-782 | Sentence | denotes | Activated c-Jun bound to the promoter regions of the MDR1 gene and promoted the expression of MDR1. |
| T7 | 783-1009 | Sentence | denotes | Expression of a cleavage-resistant c-Jun mutant (D65A) suppressed CDDP-induced apoptosis of CDDP-sensitive cells, whereas depletion of JNK2, c-Jun, or MDR1 in CDDP-resistant cancer cells promoted apoptosis upon CDDP treatment. |
| T8 | 1010-1169 | Sentence | denotes | In addition, mammary gland tumors induced by polyomavirus middle T antigen in JNK2(-/-) mice were more sensitive to CDDP compared with those in JNK2(+/+) mice. |
| T9 | 1170-1352 | Sentence | denotes | These findings highlight the instrumental role of c-Jun in the resistance of tumors to treatment with CDDP and indicate that c-Jun is a molecular target for improving cancer therapy. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1075-1084 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | T antigen |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1023-1036 | http://purl.obolibrary.org/obo/MAT_0000073 | denotes | mammary gland |
| T2 | 1031-1036 | http://purl.obolibrary.org/obo/MAT_0000021 | denotes | gland |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 27-32 | gene:3725 | denotes | c-Jun |
| T1 | 90-96 | disease:C0006826 | denotes | cancer |
| T2 | 27-32 | gene:3725 | denotes | c-Jun |
| T3 | 90-96 | disease:C1306459 | denotes | cancer |
| R1 | T0 | T1 | associated_with | c-Jun,cancer |
| R2 | T2 | T3 | associated_with | c-Jun,cancer |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_23678002_1_0 | 141-173 | expanded | denotes | cis-diamminedichloroplatinum(II) |
| SS2_23678002_1_0 | 175-179 | abbr | denotes | CDDP |
| AE1_23678002_1_0 | SS1_23678002_1_0 | SS2_23678002_1_0 | abbreviatedTo | cis-diamminedichloroplatinum(II),CDDP |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 223-230 | HP_0002664 | denotes | cancers |
| T2 | 276-281 | HP_0002664 | denotes | tumor |
| T3 | 541-547 | HP_0002664 | denotes | cancer |
| T4 | 957-963 | HP_0002664 | denotes | cancer |
| T5 | 1037-1043 | HP_0002664 | denotes | tumors |
| T6 | 1247-1253 | HP_0002664 | denotes | tumors |
| T7 | 1337-1343 | HP_0002664 | denotes | cancer |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 23678002-6#151#155#gene5243 | 934-938 | gene5243 | denotes | MDR1 |
| 23678002-6#151#155#gene23158 | 934-938 | gene23158 | denotes | MDR1 |
| 23678002-6#164#180#diseaseC0677936 | 947-963 | diseaseC0677936 | denotes | resistant cancer |
| 151#155#gene5243164#180#diseaseC0677936 | 23678002-6#151#155#gene5243 | 23678002-6#164#180#diseaseC0677936 | associated_with | MDR1,resistant cancer |
| 151#155#gene23158164#180#diseaseC0677936 | 23678002-6#151#155#gene23158 | 23678002-6#164#180#diseaseC0677936 | associated_with | MDR1,resistant cancer |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1075-1084 | Glycan | denotes | T antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 90-96 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T2 | 276-281 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T3 | 541-547 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T4 | 947-963 | Disease | denotes | resistant cancer | http://purl.obolibrary.org/obo/MONDO_0036501 |
| T5 | 1037-1043 | Disease | denotes | tumors | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T6 | 1247-1253 | Disease | denotes | tumors | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T7 | 1337-1343 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 90-96 | Phenotype | denotes | cancer | HP:0002664 |
| T2 | 276-281 | Phenotype | denotes | tumor | HP:0002664 |
| T3 | 541-547 | Phenotype | denotes | cancer | HP:0002664 |
| T4 | 957-963 | Phenotype | denotes | cancer | HP:0002664 |
| T5 | 1337-1343 | Phenotype | denotes | cancer | HP:0002664 |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 1075-1084 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | T antigen | http://www.glycoepitope.jp/epitopes/EP0020 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 90-96 | Phenotype | denotes | cancer | HP:0002664 |
| T2 | 276-281 | Phenotype | denotes | tumor | HP:0002664 |
| T3 | 541-547 | Phenotype | denotes | cancer | HP:0002664 |
| T4 | 957-963 | Phenotype | denotes | cancer | HP:0002664 |
| T5 | 1337-1343 | Phenotype | denotes | cancer | HP:0002664 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 90-102 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
| T2 | 541-553 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
| T3 | 957-969 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 1023-1036 | Body_part | denotes | mammary gland | http://purl.obolibrary.org/obo/UBERON_0001911|http://purl.obolibrary.org/obo/UBERON_0005200 |
GlyCosmos15-Taxon
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 217-222 | Organism | denotes | human | 9606 |
| T2 | 1098-1102 | Organism | denotes | mice | 10088 |
| T3 | 1164-1168 | Organism | denotes | mice | 10088 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-103 | Sentence | denotes | Differential regulation of c-Jun protein plays an instrumental role in chemoresistance of cancer cells. |
| T2 | 104-231 | Sentence | denotes | The chemotherapeutic drug cisplatin (cis-diamminedichloroplatinum(II) (CDDP)) is widely used in the treatment of human cancers. |
| T3 | 232-317 | Sentence | denotes | However, the mechanism underlying intrinsic tumor resistance to CDDP remains elusive. |
| T4 | 318-554 | Sentence | denotes | Here, we demonstrate that treatment with CDDP resulted in down-regulation of c-Jun expression via caspase-9-dependent cleavage of c-Jun at Asp-65 and MEKK1-mediated ubiquitylation and degradation of c-Jun in CDDP-sensitive cancer cells. |
| T5 | 555-682 | Sentence | denotes | In contrast, activation of JNK2 (but not JNK1) phosphorylated and up-regulated the expression of c-Jun in CDDP-resistant cells. |
| T6 | 683-782 | Sentence | denotes | Activated c-Jun bound to the promoter regions of the MDR1 gene and promoted the expression of MDR1. |
| T7 | 783-1009 | Sentence | denotes | Expression of a cleavage-resistant c-Jun mutant (D65A) suppressed CDDP-induced apoptosis of CDDP-sensitive cells, whereas depletion of JNK2, c-Jun, or MDR1 in CDDP-resistant cancer cells promoted apoptosis upon CDDP treatment. |
| T8 | 1010-1169 | Sentence | denotes | In addition, mammary gland tumors induced by polyomavirus middle T antigen in JNK2(-/-) mice were more sensitive to CDDP compared with those in JNK2(+/+) mice. |
| T9 | 1170-1352 | Sentence | denotes | These findings highlight the instrumental role of c-Jun in the resistance of tumors to treatment with CDDP and indicate that c-Jun is a molecular target for improving cancer therapy. |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1075-1084 | Glycan | denotes | T antigen | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 1075-1084 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | T antigen | http://www.glycoepitope.jp/epitopes/EP0020 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 90-96 | Disease | denotes | cancer | MONDO:0004992 |
| T2 | 276-281 | Disease | denotes | tumor | MONDO:0005070 |
| T3 | 541-547 | Disease | denotes | cancer | MONDO:0004992 |
| T4 | 947-963 | Disease | denotes | resistant cancer | MONDO:0036501 |
| T5 | 1337-1343 | Disease | denotes | cancer | MONDO:0004992 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 1023-1036 | Body_part | denotes | mammary gland | FMA:286452 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1023-1036 | Body_part | denotes | mammary gland | http://purl.obolibrary.org/obo/MAT_0000073 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 217-222 | OrganismTaxon | denotes | human | 9606 |
| T2 | 1098-1102 | OrganismTaxon | denotes | mice | 10088 |
| T3 | 1164-1168 | OrganismTaxon | denotes | mice | 10088 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1023-1036 | Body_part | denotes | mammary gland | http://purl.obolibrary.org/obo/MAT_0000073 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 1023-1036 | Body_part | denotes | mammary gland | http://purl.obolibrary.org/obo/UBERON_0001911|http://purl.obolibrary.org/obo/UBERON_0005200 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 90-102 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
| T2 | 541-553 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
| T3 | 957-969 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |