PubMed:23676961 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/23676961","sourcedb":"PubMed","sourceid":"23676961","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/23676961","text":"Result of a randomized clinical trial comparing different types of anesthesia on the immune function of patients with osteosarcoma undergoing radical resection.\nAIM: The purpose of this article was to explore the effects of different anesthesia drugs and techniques on the immune function of patients with osteosarcoma around the knee undergoing radical resection.\nMETHODS: Forty-five ASA (American Society of Anesthesiologists) I-II patients were randomized and divided into three groups: the epidural anesthesia group (Group A), the general anesthesia group (Group B), and the combination of epidural anesthesia and general anesthesia group (Group C). The populations of T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+/CD8+) and a possible association between these variables were investigated 2 h before anesthesia, before and after skin incision, and on the 1st, 3rd and 5th days after operation.\nRESULTS: The serum sIL-2 levels and T lymphocyte subset populations did not show significant differences among the three groups before anesthesia and skin incision. Serum sIL-2R increased 2 h after skin incision and on the 1st and 3rd day after operation in groups A and B (P \u003c 0.01), and was higher than that of group C 2 h after skin incision and on the 1st day after operation (P \u003c 0.01). Serum sIL-2R increased on the 1st postoperative day in group C. The CD3+, CD4+ and CD4+/CD8+ populations decreased significantly in all groups 2 h after skin incision, and on the 1st and 3rd days after operation (P \u003c 0.05). However, in group C, CD4+/CD8+ levels had almost returned to baseline values on the 3rd day after operation (P \u003e 0.05), and were significantly higher than those of groups A and B (P \u003c 0.05). On the 5th day after operation, CD3+, CD4+ and CD4+/CD8+ levels had returned to baseline values before anesthesia in group C (P \u003e 0.05), and were significantly higher than those of groups A and B (P \u003c 0.05).\nCONCLUSION: Epidural anesthesia combined with general anesthesia might reduce the stress reaction and the effect of anesthetic drugs on sIL-2 levels and T lymphocyte subsets, contributing to the restoration of immune function in cancer patients.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":306,"end":318},"obj":"HP_0002669"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"}]},{"project":"Allie","denotations":[{"id":"SS1_23676961_4_0","span":{"begin":390,"end":427},"obj":"expanded"},{"id":"SS2_23676961_4_0","span":{"begin":385,"end":388},"obj":"abbr"}],"relations":[{"id":"AE1_23676961_4_0","pred":"abbreviatedTo","subj":"SS1_23676961_4_0","obj":"SS2_23676961_4_0"}],"attributes":[{"subj":"SS1_23676961_4_0","pred":"source","obj":"Allie"},{"subj":"SS2_23676961_4_0","pred":"source","obj":"Allie"}]},{"project":"yangbin123xm_800_3","denotations":[{"id":"T1","span":{"begin":118,"end":130},"obj":"DP"},{"id":"T2","span":{"begin":306,"end":318},"obj":"DP"}],"attributes":[{"subj":"T1","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T2","pred":"source","obj":"yangbin123xm_800_3"}]},{"project":"chenxin_473849_800_3","denotations":[{"id":"T1","span":{"begin":118,"end":130},"obj":"DP"},{"id":"T2","span":{"begin":306,"end":318},"obj":"DP"}],"attributes":[{"subj":"T1","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T2","pred":"source","obj":"chenxin_473849_800_3"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubmedHPO","color":"#93aaec","default":true},{"id":"Allie","color":"#c4ec93"},{"id":"yangbin123xm_800_3","color":"#ec93de"},{"id":"chenxin_473849_800_3","color":"#93ecdf"}]}]}}