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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-146 Sentence denotes Milk-derived peptides, Val-Pro-Pro and Ile-Pro-Pro, attenuate atherosclerosis development in apolipoprotein e-deficient mice: a preliminary study.
T2 147-306 Sentence denotes Milk-derived peptides, Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP), have angiotensin I-converting enzyme inhibitory activities and blood pressure-lowering effects.
T3 307-434 Sentence denotes We examined the effects of these peptides on the development of atherosclerosis in apolipoprotein E-deficient [apoE(-/-)] mice.
T4 435-704 Sentence denotes For 31 weeks, six-week-old male apoE(-/-) mice received a diet that included one of the following: fermented milk containing both VPP and IPP; casein hydrolysate containing both of these peptides; synthesized VPP; synthesized IPP; enalapril; captopril; or control diet.
T5 705-832 Sentence denotes At the end of feeding, blood biochemistry, aortic atherogenesis, and gene expression by DNA microarray analysis were evaluated.
T6 833-942 Sentence denotes There were no significant changes in the plasma lipid levels and 8-isoprostane, a marker of oxidative stress.
T7 943-1138 Sentence denotes The area ratio of intima to media in the aortic arch was significantly lower in the fermented milk, casein hydrolysate, synthesized VPP, enalapril, and captopril groups than in the control group.
T8 1139-1369 Sentence denotes As is common with diets containing VPP and/or IPP, we observed reductions in mRNA expression of inflammatory cytokines, such as interleukin (IL)-6 and IL-1β, oxidized low-density lipoprotein receptor, and transcription regulators.
T9 1370-1514 Sentence denotes These results suggest that a continuous intake of VPP and IPP might be beneficial for preventing atherosclerosis caused by hypercholesterolemia.
T1 0-146 Sentence denotes Milk-derived peptides, Val-Pro-Pro and Ile-Pro-Pro, attenuate atherosclerosis development in apolipoprotein e-deficient mice: a preliminary study.
T2 147-306 Sentence denotes Milk-derived peptides, Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP), have angiotensin I-converting enzyme inhibitory activities and blood pressure-lowering effects.
T3 307-434 Sentence denotes We examined the effects of these peptides on the development of atherosclerosis in apolipoprotein E-deficient [apoE(-/-)] mice.
T4 435-704 Sentence denotes For 31 weeks, six-week-old male apoE(-/-) mice received a diet that included one of the following: fermented milk containing both VPP and IPP; casein hydrolysate containing both of these peptides; synthesized VPP; synthesized IPP; enalapril; captopril; or control diet.
T5 705-832 Sentence denotes At the end of feeding, blood biochemistry, aortic atherogenesis, and gene expression by DNA microarray analysis were evaluated.
T6 833-942 Sentence denotes There were no significant changes in the plasma lipid levels and 8-isoprostane, a marker of oxidative stress.
T7 943-1138 Sentence denotes The area ratio of intima to media in the aortic arch was significantly lower in the fermented milk, casein hydrolysate, synthesized VPP, enalapril, and captopril groups than in the control group.
T8 1139-1369 Sentence denotes As is common with diets containing VPP and/or IPP, we observed reductions in mRNA expression of inflammatory cytokines, such as interleukin (IL)-6 and IL-1β, oxidized low-density lipoprotein receptor, and transcription regulators.
T9 1370-1514 Sentence denotes These results suggest that a continuous intake of VPP and IPP might be beneficial for preventing atherosclerosis caused by hypercholesterolemia.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23631494-0#93#109#gene348 93-109 gene348 denotes apolipoprotein e
23631494-0#62#77#diseaseC0003850 62-77 diseaseC0003850 denotes atherosclerosis
23631494-0#62#77#diseaseC0004153 62-77 diseaseC0004153 denotes atherosclerosis
93#109#gene34862#77#diseaseC0003850 23631494-0#93#109#gene348 23631494-0#62#77#diseaseC0003850 associated_with apolipoprotein e,atherosclerosis
93#109#gene34862#77#diseaseC0004153 23631494-0#93#109#gene348 23631494-0#62#77#diseaseC0004153 associated_with apolipoprotein e,atherosclerosis

DisGeNET

Id Subject Object Predicate Lexical cue
T0 93-109 gene:348 denotes apolipoprotein e
T1 62-77 disease:C0003850 denotes atherosclerosis
T2 93-109 gene:348 denotes apolipoprotein e
T3 62-77 disease:C0004153 denotes atherosclerosis
T4 390-406 gene:348 denotes apolipoprotein E
T5 371-386 disease:C0003850 denotes atherosclerosis
T6 390-406 gene:348 denotes apolipoprotein E
T7 371-386 disease:C0004153 denotes atherosclerosis
R1 T0 T1 associated_with apolipoprotein e,atherosclerosis
R2 T2 T3 associated_with apolipoprotein e,atherosclerosis
R3 T4 T5 associated_with apolipoprotein E,atherosclerosis
R4 T6 T7 associated_with apolipoprotein E,atherosclerosis

Allie

Id Subject Object Predicate Lexical cue
SS1_23631494_1_0 170-181 expanded denotes Val-Pro-Pro
SS2_23631494_1_0 183-186 abbr denotes VPP
SS1_23631494_1_1 192-203 expanded denotes Ile-Pro-Pro
SS2_23631494_1_1 205-208 abbr denotes IPP
SS1_23631494_7_0 1267-1278 expanded denotes interleukin
SS2_23631494_7_0 1280-1282 abbr denotes IL
AE1_23631494_1_0 SS1_23631494_1_0 SS2_23631494_1_0 abbreviatedTo Val-Pro-Pro,VPP
AE1_23631494_1_1 SS1_23631494_1_1 SS2_23631494_1_1 abbreviatedTo Ile-Pro-Pro,IPP
AE1_23631494_7_0 SS1_23631494_7_0 SS2_23631494_7_0 abbreviatedTo interleukin,IL

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 371-386 HP_0002621 denotes atherosclerosis
T2 1467-1482 HP_0002621 denotes atherosclerosis
T3 1493-1513 HP_0003124 denotes hypercholesterolemia