PubMed:23630944 / 1387-1890 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/23630944","sourcedb":"PubMed","sourceid":"23630944","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/23630944","text":"subunit, specifically bβ2, and of Anp32a occur at the transcriptional level. The Pp2a pathway alterations were confirmed by identified phosphorylation changes of the known Pp2a-substrates, Erk2 and Gsk3β. Similarly, mutant ataxin-1-expressing SH-SY5Y cells exhibit abnormal neuritic morphology, decreased levels of both PP2A-Bβ and ANP32A, and PP2A pathway alterations, all of which are ameliorated by overexpressing ANP32A. Our results point to dysregulation of this newly assigned function of ataxin-1","tracks":[{"project":"DisGeNET5_gene_disease","denotations":[{"id":"23630944-0#87#116#diseaseC0752120","span":{"begin":0,"end":503},"obj":"diseaseC0752120"}],"attributes":[{"subj":"23630944-0#87#116#diseaseC0752120","pred":"source","obj":"DisGeNET5_gene_disease"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"DisGeNET5_gene_disease","color":"#93ece0","default":true}]}]}}