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PubMed:23625921 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 76-82 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109
T2 83-90 Cell denotes neurons http://purl.obolibrary.org/obo/CL:0000540
T3 102-122 Cell denotes embryonic stem cells http://purl.obolibrary.org/obo/CL:0002322
T4 128-134 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109
T5 270-276 Cell denotes Orexin http://purl.obolibrary.org/obo/CL:0011109
T6 283-289 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109
T7 331-337 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109
T8 420-427 Cell denotes neurons http://purl.obolibrary.org/obo/CL:0000540
T9 445-451 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109
T10 452-459 Cell denotes neurons http://purl.obolibrary.org/obo/CL:0000540
T11 465-487 Cell denotes pluripotent stem cells http://purl.obolibrary.org/obo/CL:0002248
T12 535-541 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109
T13 660-666 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109
T14 667-674 Cell denotes neurons http://purl.obolibrary.org/obo/CL:0000540
T15 863-869 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109
T16 1053-1059 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109
T17 1060-1067 Cell denotes neurons http://purl.obolibrary.org/obo/CL:0000540
T18 1349-1355 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109
T19 1356-1363 Cell denotes neurons http://purl.obolibrary.org/obo/CL:0000540
T20 1372-1378 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 1429-1437 Glycan_Motif denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO
T3 1491-1499 Glycan_Motif denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO
T5 1584-1591 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 1429-1437 https://glytoucan.org/Structures/Glycans/G49108TO denotes O-GlcNAc
T2 1429-1437 https://glytoucan.org/Structures/Glycans/G89565QL denotes O-GlcNAc
T3 1491-1499 https://glytoucan.org/Structures/Glycans/G49108TO denotes O-GlcNAc
T4 1491-1499 https://glytoucan.org/Structures/Glycans/G89565QL denotes O-GlcNAc
T5 1584-1591 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 1429-1437 GlycoEpitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T2 1491-1499 GlycoEpitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004

sentences

Id Subject Object Predicate Lexical cue
T1 0-123 Sentence denotes Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells.
T2 124-269 Sentence denotes The orexin system plays a central role in the integration of sleep/wake and feeding behaviors in a broad spectrum of neural-metabolic physiology.
T3 270-373 Sentence denotes Orexin-A and orexin-B are produced by the cleavage of prepro-orexin, which is encoded on the Hcrt gene.
T4 374-488 Sentence denotes To date, methods for generating other peptide neurons could not induce orexin neurons from pluripotent stem cells.
T5 489-695 Sentence denotes Considering that the metabolic status affects orexin expression, we supplemented the culture medium with a nutrient factor, ManNAc, and succeeded in generating functional orexin neurons from mouse ES cells.
T6 696-883 Sentence denotes Because DNA methylation inhibitors and histone deacetylase inhibitors could induce Hcrt expression in mouse ES cells, the epigenetic mechanism may be involved in this orexin neurogenesis.
T7 884-1045 Sentence denotes DNA methylation analysis showed the presence of a tissue-dependent differentially methylated region (T-DMR) around the transcription start site of the Hcrt gene.
T8 1046-1197 Sentence denotes In the orexin neurons induced by supplementation of ManNAc, the T-DMR of the Hcrt gene was hypomethylated in association with higher H3/H4 acetylation.
T9 1198-1364 Sentence denotes Concomitantly, the histone acetyltransferases p300, CREB-binding protein (CBP), and Mgea5 (also called O-GlcNAcase) were localized to the T-DMR in the orexin neurons.
T10 1365-1522 Sentence denotes In non-orexin-expressing cells, H3/H4 hypoacetylation and hyper-O-GlcNAc modification were observed at the T-DMRs occupied by O-GlcNAc transferase and Sirt1.
T11 1523-1734 Sentence denotes Therefore, the results of the present study suggest that the glucose metabolite, ManNAc, induces switching from the inactive state by Ogt-Sirt1 to the active state by Mgea5, p300, and CBP at the Hcrt gene locus.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 112-122 http://purl.obolibrary.org/obo/MAT_0000185 denotes stem cells
T2 112-116 http://purl.obolibrary.org/obo/MAT_0000239 denotes stem
T3 477-487 http://purl.obolibrary.org/obo/MAT_0000185 denotes stem cells
T4 477-481 http://purl.obolibrary.org/obo/MAT_0000239 denotes stem

Allie

Id Subject Object Predicate Lexical cue
SS1_23625921_6_0 934-983 expanded denotes tissue-dependent differentially methylated region
SS2_23625921_6_0 985-990 abbr denotes T-DMR
SS1_23625921_8_0 1250-1270 expanded denotes CREB-binding protein
SS2_23625921_8_0 1272-1275 abbr denotes CBP
AE1_23625921_6_0 SS1_23625921_6_0 SS2_23625921_6_0 abbreviatedTo tissue-dependent differentially methylated region,T-DMR
AE1_23625921_8_0 SS1_23625921_8_0 SS2_23625921_8_0 abbreviatedTo CREB-binding protein,CBP

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
PD-NGLY1-deficiency-B_T1 1431-1437 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T2 1493-1499 chem:24139 denotes GlcNAc

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 112-122 Body_part denotes stem cells http://purl.obolibrary.org/obo/MAT_0000185
T2 477-487 Body_part denotes stem cells http://purl.obolibrary.org/obo/MAT_0000185

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 1429-1437 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T2 1491-1499 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1272-1275 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T2 1707-1710 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1429-1437 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T2 1491-1499 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 1272-1275 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T2 1707-1710 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 96-101 OrganismTaxon denotes mouse 10088|10090
T3 680-685 OrganismTaxon denotes mouse 10088|10090
T5 798-803 OrganismTaxon denotes mouse 10088|10090

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 76-82 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109
T2 83-90 Cell denotes neurons http://purl.obolibrary.org/obo/CL:0000540
T3 102-122 Cell denotes embryonic stem cells http://purl.obolibrary.org/obo/CL:0002322
T4 128-134 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109
T5 270-276 Cell denotes Orexin http://purl.obolibrary.org/obo/CL:0011109
T6 283-289 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109
T7 331-337 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109
T8 420-427 Cell denotes neurons http://purl.obolibrary.org/obo/CL:0000540
T9 445-451 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109
T10 452-459 Cell denotes neurons http://purl.obolibrary.org/obo/CL:0000540
T11 465-487 Cell denotes pluripotent stem cells http://purl.obolibrary.org/obo/CL:0002248
T12 535-541 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109
T13 660-666 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109
T14 667-674 Cell denotes neurons http://purl.obolibrary.org/obo/CL:0000540
T15 863-869 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109
T16 1053-1059 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109
T17 1060-1067 Cell denotes neurons http://purl.obolibrary.org/obo/CL:0000540
T18 1349-1355 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109
T19 1356-1363 Cell denotes neurons http://purl.obolibrary.org/obo/CL:0000540
T20 1372-1378 Cell denotes orexin http://purl.obolibrary.org/obo/CL:0011109

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 112-122 Body_part denotes stem cells http://purl.obolibrary.org/obo/CL_0000034
T2 465-487 Body_part denotes pluripotent stem cells http://purl.obolibrary.org/obo/CL_0002248
T3 934-940 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 112-122 Body_part denotes stem cells http://purl.obolibrary.org/obo/MAT_0000185
T2 477-487 Body_part denotes stem cells http://purl.obolibrary.org/obo/MAT_0000185

sentences

Id Subject Object Predicate Lexical cue
T1 0-123 Sentence denotes Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells.
T2 124-269 Sentence denotes The orexin system plays a central role in the integration of sleep/wake and feeding behaviors in a broad spectrum of neural-metabolic physiology.
T3 270-373 Sentence denotes Orexin-A and orexin-B are produced by the cleavage of prepro-orexin, which is encoded on the Hcrt gene.
T4 374-488 Sentence denotes To date, methods for generating other peptide neurons could not induce orexin neurons from pluripotent stem cells.
T5 489-695 Sentence denotes Considering that the metabolic status affects orexin expression, we supplemented the culture medium with a nutrient factor, ManNAc, and succeeded in generating functional orexin neurons from mouse ES cells.
T6 696-883 Sentence denotes Because DNA methylation inhibitors and histone deacetylase inhibitors could induce Hcrt expression in mouse ES cells, the epigenetic mechanism may be involved in this orexin neurogenesis.
T7 884-1045 Sentence denotes DNA methylation analysis showed the presence of a tissue-dependent differentially methylated region (T-DMR) around the transcription start site of the Hcrt gene.
T8 1046-1197 Sentence denotes In the orexin neurons induced by supplementation of ManNAc, the T-DMR of the Hcrt gene was hypomethylated in association with higher H3/H4 acetylation.
T9 1198-1364 Sentence denotes Concomitantly, the histone acetyltransferases p300, CREB-binding protein (CBP), and Mgea5 (also called O-GlcNAcase) were localized to the T-DMR in the orexin neurons.
T10 1365-1522 Sentence denotes In non-orexin-expressing cells, H3/H4 hypoacetylation and hyper-O-GlcNAc modification were observed at the T-DMRs occupied by O-GlcNAc transferase and Sirt1.
T11 1523-1734 Sentence denotes Therefore, the results of the present study suggest that the glucose metabolite, ManNAc, induces switching from the inactive state by Ogt-Sirt1 to the active state by Mgea5, p300, and CBP at the Hcrt gene locus.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-123 Sentence denotes Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells.
T2 124-269 Sentence denotes The orexin system plays a central role in the integration of sleep/wake and feeding behaviors in a broad spectrum of neural-metabolic physiology.
T3 270-373 Sentence denotes Orexin-A and orexin-B are produced by the cleavage of prepro-orexin, which is encoded on the Hcrt gene.
T4 374-488 Sentence denotes To date, methods for generating other peptide neurons could not induce orexin neurons from pluripotent stem cells.
T5 489-695 Sentence denotes Considering that the metabolic status affects orexin expression, we supplemented the culture medium with a nutrient factor, ManNAc, and succeeded in generating functional orexin neurons from mouse ES cells.
T6 696-883 Sentence denotes Because DNA methylation inhibitors and histone deacetylase inhibitors could induce Hcrt expression in mouse ES cells, the epigenetic mechanism may be involved in this orexin neurogenesis.
T7 884-1045 Sentence denotes DNA methylation analysis showed the presence of a tissue-dependent differentially methylated region (T-DMR) around the transcription start site of the Hcrt gene.
T8 1046-1197 Sentence denotes In the orexin neurons induced by supplementation of ManNAc, the T-DMR of the Hcrt gene was hypomethylated in association with higher H3/H4 acetylation.
T9 1198-1364 Sentence denotes Concomitantly, the histone acetyltransferases p300, CREB-binding protein (CBP), and Mgea5 (also called O-GlcNAcase) were localized to the T-DMR in the orexin neurons.
T10 1365-1522 Sentence denotes In non-orexin-expressing cells, H3/H4 hypoacetylation and hyper-O-GlcNAc modification were observed at the T-DMRs occupied by O-GlcNAc transferase and Sirt1.
T11 1523-1734 Sentence denotes Therefore, the results of the present study suggest that the glucose metabolite, ManNAc, induces switching from the inactive state by Ogt-Sirt1 to the active state by Mgea5, p300, and CBP at the Hcrt gene locus.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 1429-1437 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T2 1491-1499 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1429-1437 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T2 1491-1499 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 96-101 OrganismTaxon denotes mouse 10088|10090
T3 680-685 OrganismTaxon denotes mouse 10088|10090
T5 798-803 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 112-122 Body_part denotes stem cells http://purl.obolibrary.org/obo/CL_0000034
T2 465-487 Body_part denotes pluripotent stem cells http://purl.obolibrary.org/obo/CL_0002248
T3 934-940 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479