PubMed:23623788 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/23623788","sourcedb":"PubMed","sourceid":"23623788","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/23623788","text":"The role of AT1-receptor blockade on reactive oxygen species and cardiac autonomic drive in experimental hyperthyroidism.\nThe objective of this study was to explore the influence of the renin-angiotensin system on cardiac prooxidants and antioxidants levels and its association to autonomic imbalance induced by hyperthyroidism. Male Wistar rats were divided into four groups: control, losartan (10mg/kg/day by gavage, 28 day), thyroxine (T4) (12 mg/L in drinking water for 28 days), and T4+losartan. Spectral analysis (autonomic balance), angiotensin II receptor (AT1R), NADPH oxidase, Nrf2 and heme-oxygenase-1 (HO-1) myocardial protein expression, and hydrogen peroxide (H2O2) concentration were quantified. Autonomic imbalance induced by hyperthyroidism (~770%) was attenuated in the T4+losartan group (~32%) (P\u003c0.05). AT1R, NADPH oxidase, H2O2, as well as concentration, Nrf2 and HO-1 protein expression were elevated (~172%, 43%, 40%, 133%, and 154%, respectively) in T4 group (P\u003c0.05). H2O2 and HO-1 levels were returned to control values in the T4+losartan group (P\u003c0.05). The overall results demonstrate a positive impact of RAS blockade in the autonomic control of heart rate, which was associated with an attenuation of H2O2 levels, as well as with a reduced counter-regulatory response of HO-1 in experimental hyperthyroidism.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_23623788_3_0","span":{"begin":596,"end":612},"obj":"expanded"},{"id":"SS2_23623788_3_0","span":{"begin":614,"end":618},"obj":"abbr"}],"relations":[{"id":"AE1_23623788_3_0","pred":"abbreviatedTo","subj":"SS1_23623788_3_0","obj":"SS2_23623788_3_0"}],"attributes":[{"subj":"SS1_23623788_3_0","pred":"source","obj":"Allie"},{"subj":"SS2_23623788_3_0","pred":"source","obj":"Allie"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":312,"end":327},"obj":"HP_0000836"},{"id":"T2","span":{"begin":742,"end":757},"obj":"HP_0000836"},{"id":"T3","span":{"begin":1322,"end":1337},"obj":"HP_0000836"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#93d7ec","default":true},{"id":"PubmedHPO","color":"#ece693"}]}]}}