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PubMed:23609450 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 93-104 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T3 358-369 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T5 822-856 Cell denotes peripheral blood mononuclear cells http://purl.obolibrary.org/obo/CL:0000842|http://purl.obolibrary.org/obo/CL:2000001
T7 903-914 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T9 1040-1051 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394

sentences

Id Subject Object Predicate Lexical cue
T1 0-137 Sentence denotes Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species.
T2 138-343 Sentence denotes Sepsis-associated immunosuppression (SAIS) is regarded as one of main causes for the death of septic patients at the late stage because of the decreased innate immunity with a more opportunistic infection.
T3 344-496 Sentence denotes LPS-tolerized macrophages, which are re-challenged by LPS after prior exposure to LPS, are regarded as the common model of hypo-responsiveness for SAIS.
T4 497-593 Sentence denotes However, the molecular mechanisms of endotoxin tolerance and SAIS remain to be fully elucidated.
T5 594-726 Sentence denotes In addition, negative regulation of the Toll-like receptor (TLR)-triggered innate inflammatory response needs further investigation.
T6 727-915 Sentence denotes Here we show that expression of immune responsive gene 1 (IRG1) was highly up-regulated in the peripheral blood mononuclear cells of septic patients and in LPS-tolerized mouse macrophages.
T7 916-1123 Sentence denotes IRG1 significantly suppressed TLR-triggered production of proinflammatory cytokines TNF-α, IL-6, and IFN-β in LPS-tolerized macrophages, with the elevated expression of reactive oxygen species (ROS) and A20.
T8 1124-1365 Sentence denotes Moreover, ROS enhanced A20 expression by increasing the H3K4me3 modification of histone on the A20 promoter domain, and supplement of the ROS abrogated the IRG1 knockdown function in breaking endotoxin tolerance by increasing A20 expression.
T9 1366-1580 Sentence denotes Our results demonstrate that inducible IRG1 promotes endotoxin tolerance by increasing A20 expression through ROS, indicating a new molecular mechanism regulating hypoinflammation of sepsis and endotoxin tolerance.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 833-838 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T2 833-838 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-137 Sentence denotes Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species.
T2 138-343 Sentence denotes Sepsis-associated immunosuppression (SAIS) is regarded as one of main causes for the death of septic patients at the late stage because of the decreased innate immunity with a more opportunistic infection.
T3 344-496 Sentence denotes LPS-tolerized macrophages, which are re-challenged by LPS after prior exposure to LPS, are regarded as the common model of hypo-responsiveness for SAIS.
T4 497-593 Sentence denotes However, the molecular mechanisms of endotoxin tolerance and SAIS remain to be fully elucidated.
T5 594-726 Sentence denotes In addition, negative regulation of the Toll-like receptor (TLR)-triggered innate inflammatory response needs further investigation.
T6 727-915 Sentence denotes Here we show that expression of immune responsive gene 1 (IRG1) was highly up-regulated in the peripheral blood mononuclear cells of septic patients and in LPS-tolerized mouse macrophages.
T7 916-1123 Sentence denotes IRG1 significantly suppressed TLR-triggered production of proinflammatory cytokines TNF-α, IL-6, and IFN-β in LPS-tolerized macrophages, with the elevated expression of reactive oxygen species (ROS) and A20.
T8 1124-1365 Sentence denotes Moreover, ROS enhanced A20 expression by increasing the H3K4me3 modification of histone on the A20 promoter domain, and supplement of the ROS abrogated the IRG1 knockdown function in breaking endotoxin tolerance by increasing A20 expression.
T9 1366-1580 Sentence denotes Our results demonstrate that inducible IRG1 promotes endotoxin tolerance by increasing A20 expression through ROS, indicating a new molecular mechanism regulating hypoinflammation of sepsis and endotoxin tolerance.
T1 0-137 Sentence denotes Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species.
T2 138-343 Sentence denotes Sepsis-associated immunosuppression (SAIS) is regarded as one of main causes for the death of septic patients at the late stage because of the decreased innate immunity with a more opportunistic infection.
T3 344-496 Sentence denotes LPS-tolerized macrophages, which are re-challenged by LPS after prior exposure to LPS, are regarded as the common model of hypo-responsiveness for SAIS.
T4 497-593 Sentence denotes However, the molecular mechanisms of endotoxin tolerance and SAIS remain to be fully elucidated.
T5 594-726 Sentence denotes In addition, negative regulation of the Toll-like receptor (TLR)-triggered innate inflammatory response needs further investigation.
T6 727-915 Sentence denotes Here we show that expression of immune responsive gene 1 (IRG1) was highly up-regulated in the peripheral blood mononuclear cells of septic patients and in LPS-tolerized mouse macrophages.
T7 916-1123 Sentence denotes IRG1 significantly suppressed TLR-triggered production of proinflammatory cytokines TNF-α, IL-6, and IFN-β in LPS-tolerized macrophages, with the elevated expression of reactive oxygen species (ROS) and A20.
T8 1124-1365 Sentence denotes Moreover, ROS enhanced A20 expression by increasing the H3K4me3 modification of histone on the A20 promoter domain, and supplement of the ROS abrogated the IRG1 knockdown function in breaking endotoxin tolerance by increasing A20 expression.
T9 1366-1580 Sentence denotes Our results demonstrate that inducible IRG1 promotes endotoxin tolerance by increasing A20 expression through ROS, indicating a new molecular mechanism regulating hypoinflammation of sepsis and endotoxin tolerance.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 138-144 HP_0100806 denotes Sepsis
T2 1549-1555 HP_0100806 denotes sepsis

Allie

Id Subject Object Predicate Lexical cue
SS1_23609450_0_0 0-24 expanded denotes Immune responsive gene 1
SS2_23609450_0_0 26-30 abbr denotes IRG1
SS1_23609450_1_0 138-173 expanded denotes Sepsis-associated immunosuppression
SS2_23609450_1_0 175-179 abbr denotes SAIS
SS1_23609450_4_0 634-652 expanded denotes Toll-like receptor
SS2_23609450_4_0 654-657 abbr denotes TLR
SS1_23609450_5_0 759-783 expanded denotes immune responsive gene 1
SS2_23609450_5_0 785-789 abbr denotes IRG1
SS1_23609450_6_0 1085-1108 expanded denotes reactive oxygen species
SS2_23609450_6_0 1110-1113 abbr denotes ROS
AE1_23609450_0_0 SS1_23609450_0_0 SS2_23609450_0_0 abbreviatedTo Immune responsive gene 1,IRG1
AE1_23609450_1_0 SS1_23609450_1_0 SS2_23609450_1_0 abbreviatedTo Sepsis-associated immunosuppression,SAIS
AE1_23609450_4_0 SS1_23609450_4_0 SS2_23609450_4_0 abbreviatedTo Toll-like receptor,TLR
AE1_23609450_5_0 SS1_23609450_5_0 SS2_23609450_5_0 abbreviatedTo immune responsive gene 1,IRG1
AE1_23609450_6_0 SS1_23609450_6_0 SS2_23609450_6_0 abbreviatedTo reactive oxygen species,ROS

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23609450-8#39#43#gene730249 1405-1409 gene730249 denotes IRG1
23609450-8#183#189#diseaseC0036690 1549-1555 diseaseC0036690 denotes sepsis
23609450-8#183#189#diseaseC0243026 1549-1555 diseaseC0243026 denotes sepsis
39#43#gene730249183#189#diseaseC0036690 23609450-8#39#43#gene730249 23609450-8#183#189#diseaseC0036690 associated_with IRG1,sepsis
39#43#gene730249183#189#diseaseC0243026 23609450-8#39#43#gene730249 23609450-8#183#189#diseaseC0243026 associated_with IRG1,sepsis

PubCasesHPO

Id Subject Object Predicate Lexical cue
AB1 138-144 HP:0100806 denotes Sepsis
AB2 1549-1555 HP:0100806 denotes sepsis

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 333-342 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 138-144 Phenotype denotes Sepsis HP:0100806
T2 319-342 Phenotype denotes opportunistic infection HP:0031690
T3 1549-1555 Phenotype denotes sepsis HP:0100806

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 138-144 OrganismTaxon denotes Sepsis 137507
T2 897-902 OrganismTaxon denotes mouse 10088|10090
T4 1549-1555 OrganismTaxon denotes sepsis 137507

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 833-838 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 93-104 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T2 358-369 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T3 822-856 Body_part denotes peripheral blood mononuclear cells http://purl.obolibrary.org/obo/CL_0000842|http://purl.obolibrary.org/obo/CL_2000001
T5 903-914 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T6 1040-1051 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235