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sentences

Id Subject Object Predicate Lexical cue
T1 0-168 Sentence denotes The intermediate conductance calcium-activated potassium channel KCa3.1 regulates vascular smooth muscle cell proliferation via controlling calcium-dependent signaling.
T2 169-372 Sentence denotes The intermediate conductance calcium-activated potassium channel KCa3.1 contributes to a variety of cell activation processes in pathologies such as inflammation, carcinogenesis, and vascular remodeling.
T3 373-516 Sentence denotes We examined the electrophysiological and transcriptional mechanisms by which KCa3.1 regulates vascular smooth muscle cell (VSMC) proliferation.
T4 517-725 Sentence denotes Platelet-derived growth factor-BB (PDGF)-induced proliferation of human coronary artery VSMCs was attenuated by lowering intracellular Ca(2+) concentration ([Ca(2+)]i) and was enhanced by elevating [Ca(2+)]i.
T5 726-963 Sentence denotes KCa3.1 blockade or knockdown inhibited proliferation by suppressing the rise in [Ca(2+)]i and attenuating the expression of phosphorylated cAMP-response element-binding protein (CREB), c-Fos, and neuron-derived orphan receptor-1 (NOR-1).
T6 964-1031 Sentence denotes This antiproliferative effect was abolished by elevating [Ca(2+)]i.
T7 1032-1177 Sentence denotes KCa3.1 overexpression induced VSMC proliferation, and potentiated PDGF-induced proliferation, by inducing CREB phosphorylation, c-Fos, and NOR-1.
T8 1178-1364 Sentence denotes Pharmacological stimulation of KCa3.1 unexpectedly suppressed proliferation by abolishing the expression and activity of KCa3.1 and PDGF β-receptors and inhibiting the rise in [Ca(2+)]i.
T9 1365-1461 Sentence denotes The stimulation also attenuated the levels of phosphorylated CREB, c-Fos, and cyclin expression.
T10 1462-1728 Sentence denotes After KCa3.1 blockade, the characteristic round shape of VSMCs expressing high l-caldesmon and low calponin-1 (dedifferentiation state) was maintained, whereas KCa3.1 stimulation induced a spindle-shaped cellular appearance, with low l-caldesmon and high calponin-1.
T11 1729-1975 Sentence denotes In conclusion, KCa3.1 plays an important role in VSMC proliferation via controlling Ca(2+)-dependent signaling pathways, and its modulation may therefore constitute a new therapeutic target for cell proliferative diseases such as atherosclerosis.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 91-104 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T2 98-104 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T3 476-489 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T4 483-489 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T5 598-604 http://purl.obolibrary.org/obo/MAT_0000034 denotes artery

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-168 Sentence denotes The intermediate conductance calcium-activated potassium channel KCa3.1 regulates vascular smooth muscle cell proliferation via controlling calcium-dependent signaling.
T2 169-372 Sentence denotes The intermediate conductance calcium-activated potassium channel KCa3.1 contributes to a variety of cell activation processes in pathologies such as inflammation, carcinogenesis, and vascular remodeling.
T3 373-516 Sentence denotes We examined the electrophysiological and transcriptional mechanisms by which KCa3.1 regulates vascular smooth muscle cell (VSMC) proliferation.
T4 517-725 Sentence denotes Platelet-derived growth factor-BB (PDGF)-induced proliferation of human coronary artery VSMCs was attenuated by lowering intracellular Ca(2+) concentration ([Ca(2+)]i) and was enhanced by elevating [Ca(2+)]i.
T5 726-963 Sentence denotes KCa3.1 blockade or knockdown inhibited proliferation by suppressing the rise in [Ca(2+)]i and attenuating the expression of phosphorylated cAMP-response element-binding protein (CREB), c-Fos, and neuron-derived orphan receptor-1 (NOR-1).
T6 964-1031 Sentence denotes This antiproliferative effect was abolished by elevating [Ca(2+)]i.
T7 1032-1177 Sentence denotes KCa3.1 overexpression induced VSMC proliferation, and potentiated PDGF-induced proliferation, by inducing CREB phosphorylation, c-Fos, and NOR-1.
T8 1178-1364 Sentence denotes Pharmacological stimulation of KCa3.1 unexpectedly suppressed proliferation by abolishing the expression and activity of KCa3.1 and PDGF β-receptors and inhibiting the rise in [Ca(2+)]i.
T9 1365-1461 Sentence denotes The stimulation also attenuated the levels of phosphorylated CREB, c-Fos, and cyclin expression.
T10 1462-1728 Sentence denotes After KCa3.1 blockade, the characteristic round shape of VSMCs expressing high l-caldesmon and low calponin-1 (dedifferentiation state) was maintained, whereas KCa3.1 stimulation induced a spindle-shaped cellular appearance, with low l-caldesmon and high calponin-1.
T11 1729-1975 Sentence denotes In conclusion, KCa3.1 plays an important role in VSMC proliferation via controlling Ca(2+)-dependent signaling pathways, and its modulation may therefore constitute a new therapeutic target for cell proliferative diseases such as atherosclerosis.
T1 0-168 Sentence denotes The intermediate conductance calcium-activated potassium channel KCa3.1 regulates vascular smooth muscle cell proliferation via controlling calcium-dependent signaling.
T2 169-372 Sentence denotes The intermediate conductance calcium-activated potassium channel KCa3.1 contributes to a variety of cell activation processes in pathologies such as inflammation, carcinogenesis, and vascular remodeling.
T3 373-516 Sentence denotes We examined the electrophysiological and transcriptional mechanisms by which KCa3.1 regulates vascular smooth muscle cell (VSMC) proliferation.
T4 517-725 Sentence denotes Platelet-derived growth factor-BB (PDGF)-induced proliferation of human coronary artery VSMCs was attenuated by lowering intracellular Ca(2+) concentration ([Ca(2+)]i) and was enhanced by elevating [Ca(2+)]i.
T5 726-963 Sentence denotes KCa3.1 blockade or knockdown inhibited proliferation by suppressing the rise in [Ca(2+)]i and attenuating the expression of phosphorylated cAMP-response element-binding protein (CREB), c-Fos, and neuron-derived orphan receptor-1 (NOR-1).
T6 964-1031 Sentence denotes This antiproliferative effect was abolished by elevating [Ca(2+)]i.
T7 1032-1177 Sentence denotes KCa3.1 overexpression induced VSMC proliferation, and potentiated PDGF-induced proliferation, by inducing CREB phosphorylation, c-Fos, and NOR-1.
T8 1178-1364 Sentence denotes Pharmacological stimulation of KCa3.1 unexpectedly suppressed proliferation by abolishing the expression and activity of KCa3.1 and PDGF β-receptors and inhibiting the rise in [Ca(2+)]i.
T9 1365-1461 Sentence denotes The stimulation also attenuated the levels of phosphorylated CREB, c-Fos, and cyclin expression.
T10 1462-1728 Sentence denotes After KCa3.1 blockade, the characteristic round shape of VSMCs expressing high l-caldesmon and low calponin-1 (dedifferentiation state) was maintained, whereas KCa3.1 stimulation induced a spindle-shaped cellular appearance, with low l-caldesmon and high calponin-1.
T11 1729-1975 Sentence denotes In conclusion, KCa3.1 plays an important role in VSMC proliferation via controlling Ca(2+)-dependent signaling pathways, and its modulation may therefore constitute a new therapeutic target for cell proliferative diseases such as atherosclerosis.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1744-1750 gene:3783 denotes KCa3.1
T1 1959-1974 disease:C0003850 denotes atherosclerosis
T2 1744-1750 gene:3783 denotes KCa3.1
T3 1959-1974 disease:C0004153 denotes atherosclerosis
R1 T0 T1 associated_with KCa3.1,atherosclerosis
R2 T2 T3 associated_with KCa3.1,atherosclerosis

Allie

Id Subject Object Predicate Lexical cue
SS1_23609438_2_0 467-494 expanded denotes vascular smooth muscle cell
SS2_23609438_2_0 496-500 abbr denotes VSMC
SS1_23609438_3_0 517-550 expanded denotes Platelet-derived growth factor-BB
SS2_23609438_3_0 552-556 abbr denotes PDGF
SS1_23609438_4_0 865-902 expanded denotes cAMP-response element-binding protein
SS2_23609438_4_0 904-908 abbr denotes CREB
SS1_23609438_4_1 922-954 expanded denotes neuron-derived orphan receptor-1
SS2_23609438_4_1 956-961 abbr denotes NOR-1
AE1_23609438_2_0 SS1_23609438_2_0 SS2_23609438_2_0 abbreviatedTo vascular smooth muscle cell,VSMC
AE1_23609438_3_0 SS1_23609438_3_0 SS2_23609438_3_0 abbreviatedTo Platelet-derived growth factor-BB,PDGF
AE1_23609438_4_0 SS1_23609438_4_0 SS2_23609438_4_0 abbreviatedTo cAMP-response element-binding protein,CREB
AE1_23609438_4_1 SS1_23609438_4_1 SS2_23609438_4_1 abbreviatedTo neuron-derived orphan receptor-1,NOR-1

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1959-1974 HP_0002621 denotes atherosclerosis

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23609438-7#81#90#gene800 1543-1552 gene800 denotes caldesmon
23609438-7#99#109#gene1264 1561-1571 gene1264 denotes calponin-1
23609438-7#236#245#gene800 1698-1707 gene800 denotes caldesmon
23609438-7#255#265#gene1264 1717-1727 gene1264 denotes calponin-1
23609438-7#111#128#diseaseC0002793 1573-1590 diseaseC0002793 denotes dedifferentiation
81#90#gene800111#128#diseaseC0002793 23609438-7#81#90#gene800 23609438-7#111#128#diseaseC0002793 associated_with caldesmon,dedifferentiation
99#109#gene1264111#128#diseaseC0002793 23609438-7#99#109#gene1264 23609438-7#111#128#diseaseC0002793 associated_with calponin-1,dedifferentiation
236#245#gene800111#128#diseaseC0002793 23609438-7#236#245#gene800 23609438-7#111#128#diseaseC0002793 associated_with caldesmon,dedifferentiation
255#265#gene1264111#128#diseaseC0002793 23609438-7#255#265#gene1264 23609438-7#111#128#diseaseC0002793 associated_with calponin-1,dedifferentiation

CHEMDNER-training-test

Id Subject Object Predicate Lexical cue
T1 198-205 SYSTEMATIC denotes calcium
T2 216-225 SYSTEMATIC denotes potassium
T3 652-658 FORMULA denotes Ca(2+)
T4 675-681 FORMULA denotes Ca(2+)
T5 716-722 FORMULA denotes Ca(2+)
T6 807-813 FORMULA denotes Ca(2+)
T7 865-869 ABBREVIATION denotes cAMP
T8 1022-1028 FORMULA denotes Ca(2+)
T9 1257-1258 FORMULA denotes a
T10 1813-1819 FORMULA denotes Ca(2+)
T1 66-147 SYSTEMATIC denotes Ca3.1 regulates vascular smooth muscle cell proliferation via controlling calcium
T2 216-225 SYSTEMATIC denotes potassium
T3 1300-1550 SYSTEMATIC denotes Ca3.1 and PDGF β-receptors and inhibiting the rise in [Ca(2+)]i. The stimulation also attenuated the levels of phosphorylated CREB, c-Fos, and cyclin expression. After KCa3.1 blockade, the characteristic round shape of VSMCs expressing high l-caldesm

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 318-330 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T2 1959-1974 Disease denotes atherosclerosis http://purl.obolibrary.org/obo/MONDO_0005311

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 91-104 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T2 476-489 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303
T3 598-604 Body_part denotes artery http://purl.obolibrary.org/obo/MAT_0000034

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1959-1974 Phenotype denotes atherosclerosis HP:0002621

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 583-588 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 82-109 Body_part denotes vascular smooth muscle cell http://purl.obolibrary.org/obo/CL_0000359
T2 467-494 Body_part denotes vascular smooth muscle cell http://purl.obolibrary.org/obo/CL_0000359
T3 496-500 Body_part denotes VSMC http://purl.obolibrary.org/obo/CL_0000359
T4 517-525 Body_part denotes Platelet http://purl.obolibrary.org/obo/CL_0000233
T5 589-604 Body_part denotes coronary artery http://purl.obolibrary.org/obo/UBERON_0001621
T6 638-651 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T7 922-928 Body_part denotes neuron http://purl.obolibrary.org/obo/CL_0000540
T8 1062-1066 Body_part denotes VSMC http://purl.obolibrary.org/obo/CL_0000359
T9 1778-1782 Body_part denotes VSMC http://purl.obolibrary.org/obo/CL_0000359

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 82-109 Cell denotes vascular smooth muscle cell http://purl.obolibrary.org/obo/CL:0000359
T2 91-109 Cell denotes smooth muscle cell http://purl.obolibrary.org/obo/CL:0000192
T3 98-109 Cell denotes muscle cell http://purl.obolibrary.org/obo/CL:0000187
T4 467-494 Cell denotes vascular smooth muscle cell http://purl.obolibrary.org/obo/CL:0000359
T5 476-494 Cell denotes smooth muscle cell http://purl.obolibrary.org/obo/CL:0000192
T6 483-494 Cell denotes muscle cell http://purl.obolibrary.org/obo/CL:0000187
T7 496-500 Cell denotes VSMC http://purl.obolibrary.org/obo/CL:0000359
T8 517-525 Cell denotes Platelet http://purl.obolibrary.org/obo/CL:0000233
T9 922-928 Cell denotes neuron http://purl.obolibrary.org/obo/CL:0000540
T10 1062-1066 Cell denotes VSMC http://purl.obolibrary.org/obo/CL:0000359
T11 1778-1782 Cell denotes VSMC http://purl.obolibrary.org/obo/CL:0000359