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PubMed:23599431 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-175 Sentence denotes Induction of C-X-C chemokine receptor type 7 (CXCR7) switches stromal cell-derived factor-1 (SDF-1) signaling and phagocytic activity in macrophages linked to atherosclerosis.
T2 176-389 Sentence denotes The discovery of CXCR7 as a new receptor for SDF-1 places many previously described SDF-1 functions attributed to CXCR4 in question, though whether CXCR7 acts as a signaling or "decoy" receptor has been in debate.
T3 390-546 Sentence denotes It is known that CXCR7 is not expressed in normal blood leukocytes; however, the potential role of leukocyte CXCR7 in disease states has not been addressed.
T4 547-660 Sentence denotes The aim of this study was to determine the expression and function of macrophage CXCR7 linked to atherosclerosis.
T5 661-790 Sentence denotes Here, we show that CXCR7 was detected in macrophage-positive area of aortic atheroma of ApoE-null mice, but not in healthy aorta.
T6 791-938 Sentence denotes During monocyte differentiation to macrophages, CXCR7 was up-regulated at mRNA and protein levels, with more expression in M1 than in M2 phenotype.
T7 939-1129 Sentence denotes In addition, CXCR7 induction was associated with a SDF-1 signaling switch from the pro-survival ERK and AKT pathways in monocytes to the pro-inflammatory JNK and p38 pathways in macrophages.
T8 1130-1240 Sentence denotes The latter effect was mimicked by a CXCR7-selective agonist TC14012 and abolished by siRNA knockdown of CXCR7.
T9 1241-1447 Sentence denotes Furthermore, CXCR7 activation increased macrophage phagocytic activity, which was suppressed by CXCR7 siRNA silencing or by inhibiting either the JNK or p38 pathways, but was not affected by blocking CXCR4.
T10 1448-1577 Sentence denotes Finally, activation of CXCR7 by I-TAC showed a similar signaling and phagocytic activity in macrophages with no detectable CXCR3.
T11 1578-1821 Sentence denotes We conclude that CXCR7 is induced during monocyte-to-macrophage differentiation, which is required for SDF-1 and I-TAC signaling to JNK and p38 pathways, leading to enhanced macrophage phagocytosis, thus possibly contributing to atherogenesis.
T1 0-175 Sentence denotes Induction of C-X-C chemokine receptor type 7 (CXCR7) switches stromal cell-derived factor-1 (SDF-1) signaling and phagocytic activity in macrophages linked to atherosclerosis.
T2 176-389 Sentence denotes The discovery of CXCR7 as a new receptor for SDF-1 places many previously described SDF-1 functions attributed to CXCR4 in question, though whether CXCR7 acts as a signaling or "decoy" receptor has been in debate.
T3 390-546 Sentence denotes It is known that CXCR7 is not expressed in normal blood leukocytes; however, the potential role of leukocyte CXCR7 in disease states has not been addressed.
T4 547-660 Sentence denotes The aim of this study was to determine the expression and function of macrophage CXCR7 linked to atherosclerosis.
T5 661-790 Sentence denotes Here, we show that CXCR7 was detected in macrophage-positive area of aortic atheroma of ApoE-null mice, but not in healthy aorta.
T6 791-938 Sentence denotes During monocyte differentiation to macrophages, CXCR7 was up-regulated at mRNA and protein levels, with more expression in M1 than in M2 phenotype.
T7 939-1129 Sentence denotes In addition, CXCR7 induction was associated with a SDF-1 signaling switch from the pro-survival ERK and AKT pathways in monocytes to the pro-inflammatory JNK and p38 pathways in macrophages.
T8 1130-1240 Sentence denotes The latter effect was mimicked by a CXCR7-selective agonist TC14012 and abolished by siRNA knockdown of CXCR7.
T9 1241-1447 Sentence denotes Furthermore, CXCR7 activation increased macrophage phagocytic activity, which was suppressed by CXCR7 siRNA silencing or by inhibiting either the JNK or p38 pathways, but was not affected by blocking CXCR4.
T10 1448-1577 Sentence denotes Finally, activation of CXCR7 by I-TAC showed a similar signaling and phagocytic activity in macrophages with no detectable CXCR3.
T11 1578-1821 Sentence denotes We conclude that CXCR7 is induced during monocyte-to-macrophage differentiation, which is required for SDF-1 and I-TAC signaling to JNK and p38 pathways, leading to enhanced macrophage phagocytosis, thus possibly contributing to atherogenesis.

sentences

Id Subject Object Predicate Lexical cue
T1 0-175 Sentence denotes Induction of C-X-C chemokine receptor type 7 (CXCR7) switches stromal cell-derived factor-1 (SDF-1) signaling and phagocytic activity in macrophages linked to atherosclerosis.
T2 176-389 Sentence denotes The discovery of CXCR7 as a new receptor for SDF-1 places many previously described SDF-1 functions attributed to CXCR4 in question, though whether CXCR7 acts as a signaling or "decoy" receptor has been in debate.
T3 390-546 Sentence denotes It is known that CXCR7 is not expressed in normal blood leukocytes; however, the potential role of leukocyte CXCR7 in disease states has not been addressed.
T4 547-660 Sentence denotes The aim of this study was to determine the expression and function of macrophage CXCR7 linked to atherosclerosis.
T5 661-790 Sentence denotes Here, we show that CXCR7 was detected in macrophage-positive area of aortic atheroma of ApoE-null mice, but not in healthy aorta.
T6 791-938 Sentence denotes During monocyte differentiation to macrophages, CXCR7 was up-regulated at mRNA and protein levels, with more expression in M1 than in M2 phenotype.
T7 939-1129 Sentence denotes In addition, CXCR7 induction was associated with a SDF-1 signaling switch from the pro-survival ERK and AKT pathways in monocytes to the pro-inflammatory JNK and p38 pathways in macrophages.
T8 1130-1240 Sentence denotes The latter effect was mimicked by a CXCR7-selective agonist TC14012 and abolished by siRNA knockdown of CXCR7.
T9 1241-1447 Sentence denotes Furthermore, CXCR7 activation increased macrophage phagocytic activity, which was suppressed by CXCR7 siRNA silencing or by inhibiting either the JNK or p38 pathways, but was not affected by blocking CXCR4.
T10 1448-1577 Sentence denotes Finally, activation of CXCR7 by I-TAC showed a similar signaling and phagocytic activity in macrophages with no detectable CXCR3.
T11 1578-1821 Sentence denotes We conclude that CXCR7 is induced during monocyte-to-macrophage differentiation, which is required for SDF-1 and I-TAC signaling to JNK and p38 pathways, leading to enhanced macrophage phagocytosis, thus possibly contributing to atherogenesis.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 440-445 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T2 440-445 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T3 784-789 http://purl.obolibrary.org/obo/MAT_0000035 denotes aorta

DisGeNET

Id Subject Object Predicate Lexical cue
T0 13-44 gene:57007 denotes C-X-C chemokine receptor type 7
T1 159-174 disease:C0003850 denotes atherosclerosis
T2 13-44 gene:57007 denotes C-X-C chemokine receptor type 7
T3 159-174 disease:C0004153 denotes atherosclerosis
T4 46-51 gene:57007 denotes CXCR7
T5 159-174 disease:C0003850 denotes atherosclerosis
T6 46-51 gene:57007 denotes CXCR7
T7 159-174 disease:C0004153 denotes atherosclerosis
R1 T0 T1 associated_with C-X-C chemokine receptor type 7,atherosclerosis
R2 T2 T3 associated_with C-X-C chemokine receptor type 7,atherosclerosis
R3 T4 T5 associated_with CXCR7,atherosclerosis
R4 T6 T7 associated_with CXCR7,atherosclerosis

Allie

Id Subject Object Predicate Lexical cue
SS1_23599431_0_0 13-44 expanded denotes C-X-C chemokine receptor type 7
SS2_23599431_0_0 46-51 abbr denotes CXCR7
SS1_23599431_0_1 62-91 expanded denotes stromal cell-derived factor-1
SS2_23599431_0_1 93-98 abbr denotes SDF-1
AE1_23599431_0_0 SS1_23599431_0_0 SS2_23599431_0_0 abbreviatedTo C-X-C chemokine receptor type 7,CXCR7
AE1_23599431_0_1 SS1_23599431_0_1 SS2_23599431_0_1 abbreviatedTo stromal cell-derived factor-1,SDF-1

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 644-659 HP_0002621 denotes atherosclerosis

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23599431-0#13#44#gene57007 13-44 gene57007 denotes C-X-C chemokine receptor type 7
23599431-0#46#51#gene57007 46-51 gene57007 denotes CXCR7
23599431-0#159#174#diseaseC0003850 159-174 diseaseC0003850 denotes atherosclerosis
23599431-0#159#174#diseaseC0004153 159-174 diseaseC0004153 denotes atherosclerosis
23599431-0#159#174#diseaseC0003850 159-174 diseaseC0003850 denotes atherosclerosis
23599431-0#159#174#diseaseC0004153 159-174 diseaseC0004153 denotes atherosclerosis
13#44#gene57007159#174#diseaseC0003850 23599431-0#13#44#gene57007 23599431-0#159#174#diseaseC0003850 associated_with C-X-C chemokine receptor type 7,atherosclerosis
13#44#gene57007159#174#diseaseC0004153 23599431-0#13#44#gene57007 23599431-0#159#174#diseaseC0004153 associated_with C-X-C chemokine receptor type 7,atherosclerosis
13#44#gene57007159#174#diseaseC0003850 23599431-0#13#44#gene57007 23599431-0#159#174#diseaseC0003850 associated_with C-X-C chemokine receptor type 7,atherosclerosis
13#44#gene57007159#174#diseaseC0004153 23599431-0#13#44#gene57007 23599431-0#159#174#diseaseC0004153 associated_with C-X-C chemokine receptor type 7,atherosclerosis
46#51#gene57007159#174#diseaseC0003850 23599431-0#46#51#gene57007 23599431-0#159#174#diseaseC0003850 associated_with CXCR7,atherosclerosis
46#51#gene57007159#174#diseaseC0004153 23599431-0#46#51#gene57007 23599431-0#159#174#diseaseC0004153 associated_with CXCR7,atherosclerosis
46#51#gene57007159#174#diseaseC0003850 23599431-0#46#51#gene57007 23599431-0#159#174#diseaseC0003850 associated_with CXCR7,atherosclerosis
46#51#gene57007159#174#diseaseC0004153 23599431-0#46#51#gene57007 23599431-0#159#174#diseaseC0004153 associated_with CXCR7,atherosclerosis

CHEMDNER-training-test

Id Subject Object Predicate Lexical cue
T1 1190-1197 IDENTIFIER denotes TC14012

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 159-174 Phenotype denotes atherosclerosis HP:0002621
T2 644-659 Phenotype denotes atherosclerosis HP:0002621

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 159-174 Disease denotes atherosclerosis http://purl.obolibrary.org/obo/MONDO_0005311
T2 644-659 Disease denotes atherosclerosis http://purl.obolibrary.org/obo/MONDO_0005311
T3 1482-1485 Disease denotes TAC http://purl.obolibrary.org/obo/MONDO_0018072
T4 1693-1696 Disease denotes TAC http://purl.obolibrary.org/obo/MONDO_0018072

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 759-763 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 62-74 Body_part denotes stromal cell http://purl.obolibrary.org/obo/CL_0000499
T2 137-148 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T3 440-445 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T4 446-456 Body_part denotes leukocytes http://purl.obolibrary.org/obo/CL_0000738
T5 489-498 Body_part denotes leukocyte http://purl.obolibrary.org/obo/CL_0000738
T6 617-627 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T7 702-712 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T8 784-789 Body_part denotes aorta http://purl.obolibrary.org/obo/UBERON_0000947
T9 798-806 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T11 826-837 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T12 1059-1068 Body_part denotes monocytes http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T14 1117-1128 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T15 1281-1291 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T16 1540-1551 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T17 1619-1627 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T19 1631-1641 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T20 1752-1762 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 440-445 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315
T3 784-789 Body_part denotes aorta http://purl.obolibrary.org/obo/MAT_0000035

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 62-74 Cell denotes stromal cell http://purl.obolibrary.org/obo/CL:0000499
T2 114-124 Cell denotes phagocytic http://purl.obolibrary.org/obo/CL:0000234
T3 137-148 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T5 446-456 Cell denotes leukocytes http://purl.obolibrary.org/obo/CL:0000738
T6 489-498 Cell denotes leukocyte http://purl.obolibrary.org/obo/CL:0000738
T7 617-627 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T9 702-712 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T11 798-806 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T13 826-837 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T15 1059-1068 Cell denotes monocytes http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T17 1117-1128 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T19 1281-1291 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T21 1292-1302 Cell denotes phagocytic http://purl.obolibrary.org/obo/CL:0000234
T22 1517-1527 Cell denotes phagocytic http://purl.obolibrary.org/obo/CL:0000234
T23 1540-1551 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T25 1619-1627 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T27 1631-1641 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T29 1752-1762 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394