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PubMed:23592772 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 383-390 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T2 500-519 Glycan_Motif denotes N-acetylglucosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP
T3 639-658 Glycan_Motif denotes N-acetylglucosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP
T4 660-668 Glycan_Motif denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO
T6 889-897 Glycan_Motif denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO
T8 899-902 Glycan_Motif denotes OGA https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL
T9 1528-1531 Glycan_Motif denotes OGA https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL
T10 1741-1749 Glycan_Motif denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G89565QL|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G49108TO

sentences

Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells.
T2 110-346 Sentence denotes Cancer cell metabolic reprogramming includes a shift in energy production from oxidative phosphorylation to less efficient glycolysis even in the presence of oxygen (Warburg effect) and use of glutamine for increased biosynthetic needs.
T3 347-475 Sentence denotes This necessitates greatly increased glucose and glutamine uptake, both of which enter the hexosamine biosynthetic pathway (HBP).
T4 476-670 Sentence denotes The HBP end product UDP-N-acetylglucosamine (UDP-GlcNAc) is used in enzymatic post-translational modification of many cytosolic and nuclear proteins by O-linked β-N-acetylglucosamine (O-GlcNAc).
T5 671-783 Sentence denotes Here, we observed increased HBP flux and hyper-O-GlcNAcylation in human pancreatic ductal adenocarcinoma (PDAC).
T6 784-904 Sentence denotes PDAC hyper-O-GlcNAcylation was associated with elevation of OGT and reduction of the enzyme that removes O-GlcNAc (OGA).
T7 905-1122 Sentence denotes Reducing hyper-O-GlcNAcylation had no effect on non-transformed pancreatic epithelial cell growth, but inhibited PDAC cell proliferation, anchorage-independent growth, orthotopic tumor growth, and triggered apoptosis.
T8 1123-1185 Sentence denotes PDAC is supported by oncogenic NF-κB transcriptional activity.
T9 1186-1267 Sentence denotes The NF-κB p65 subunit and upstream kinases IKKα/IKKβ were O-GlcNAcylated in PDAC.
T10 1268-1440 Sentence denotes Reducing hyper-O-GlcNAcylation decreased PDAC cell p65 activating phosphorylation (S536), nuclear translocation, NF-κB transcriptional activity, and target gene expression.
T11 1441-1669 Sentence denotes Conversely, mimicking PDAC hyper-O-GlcNAcylation through pharmacological inhibition of OGA suppressed suspension culture-induced apoptosis and increased IKKα and p65 O-GlcNAcylation, accompanied by activation of NF-κB signaling.
T12 1670-1841 Sentence denotes Finally, reducing p65 O-GlcNAcylation specifically by mutating two p65 O-GlcNAc sites (T322A and T352A) attenuated the induction of PDAC cell anchorage-independent growth.
T13 1842-1959 Sentence denotes Our data indicate that hyper-O-GlcNAcylation is anti-apoptotic and contributes to NF-κB oncogenic activation in PDAC.

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 660-668 GlycoEpitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T2 889-897 GlycoEpitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T3 1741-1749 GlycoEpitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 383-390 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T2 500-519 https://glytoucan.org/Structures/Glycans/G64581RP denotes N-acetylglucosamine
T3 639-658 https://glytoucan.org/Structures/Glycans/G64581RP denotes N-acetylglucosamine
T4 660-668 https://glytoucan.org/Structures/Glycans/G49108TO denotes O-GlcNAc
T5 660-668 https://glytoucan.org/Structures/Glycans/G89565QL denotes O-GlcNAc
T6 889-897 https://glytoucan.org/Structures/Glycans/G49108TO denotes O-GlcNAc
T7 889-897 https://glytoucan.org/Structures/Glycans/G89565QL denotes O-GlcNAc
T8 1741-1749 https://glytoucan.org/Structures/Glycans/G49108TO denotes O-GlcNAc
T9 1741-1749 https://glytoucan.org/Structures/Glycans/G89565QL denotes O-GlcNAc

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1737-1740 gene:65125 denotes p65
T1 1802-1806 disease:C1335302 denotes PDAC
T2 1737-1740 gene:64689 denotes p65
T3 1802-1806 disease:C1335302 denotes PDAC
T4 1737-1740 gene:5970 denotes p65
T5 1802-1806 disease:C1335302 denotes PDAC
T6 1737-1740 gene:6857 denotes p65
T7 1802-1806 disease:C1335302 denotes PDAC
T8 1924-1929 gene:4790 denotes NF-κB
T9 1954-1958 disease:C1335302 denotes PDAC
R1 T0 T1 associated_with p65,PDAC
R2 T2 T3 associated_with p65,PDAC
R3 T4 T5 associated_with p65,PDAC
R4 T6 T7 associated_with p65,PDAC
R5 T8 T9 associated_with NF-κB,PDAC

Allie

Id Subject Object Predicate Lexical cue
SS1_23592772_2_0 437-468 expanded denotes hexosamine biosynthetic pathway
SS2_23592772_2_0 470-473 abbr denotes HBP
SS1_23592772_3_0 496-519 expanded denotes UDP-N-acetylglucosamine
SS2_23592772_3_0 521-531 abbr denotes UDP-GlcNAc
SS1_23592772_3_1 628-658 expanded denotes O-linked β-N-acetylglucosamine
SS2_23592772_3_1 660-668 abbr denotes O-GlcNAc
SS1_23592772_4_0 743-775 expanded denotes pancreatic ductal adenocarcinoma
SS2_23592772_4_0 777-781 abbr denotes PDAC
SS1_23592772_5_0 795-803 expanded denotes O-GlcNAc
SS2_23592772_5_0 899-902 abbr denotes OGA
AE1_23592772_2_0 SS1_23592772_2_0 SS2_23592772_2_0 abbreviatedTo hexosamine biosynthetic pathway,HBP
AE1_23592772_3_0 SS1_23592772_3_0 SS2_23592772_3_0 abbreviatedTo UDP-N-acetylglucosamine,UDP-GlcNAc
AE1_23592772_3_1 SS1_23592772_3_1 SS2_23592772_3_1 abbreviatedTo O-linked β-N-acetylglucosamine,O-GlcNAc
AE1_23592772_4_0 SS1_23592772_4_0 SS2_23592772_4_0 abbreviatedTo pancreatic ductal adenocarcinoma,PDAC
AE1_23592772_5_0 SS1_23592772_5_0 SS2_23592772_5_0 abbreviatedTo O-GlcNAc,OGA

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 110-116 HP_0002664 denotes Cancer
T2 1084-1089 HP_0002664 denotes tumor

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
PD-NGLY1-deficiency-B_T1 500-519 chem:24139 denotes N-acetylglucosamine
PD-NGLY1-deficiency-B_T2 525-531 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T3 639-658 chem:24139 denotes N-acetylglucosamine
PD-NGLY1-deficiency-B_T4 662-668 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T5 891-897 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T6 1743-1749 chem:24139 denotes GlcNAc

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
23592772-11#87#92#geners770882250 1757-1762 geners770882250 denotes T322A
23592772-11#132#136#diseaseC1335302 1802-1806 diseaseC1335302 denotes PDAC
87#92#geners770882250132#136#diseaseC1335302 23592772-11#87#92#geners770882250 23592772-11#132#136#diseaseC1335302 associated_with T322A,PDAC

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23592772-0#67#72#gene4790 67-72 gene4790 denotes NF-κB
23592772-0#67#72#gene4790 67-72 gene4790 denotes NF-κB
23592772-0#85#102#diseaseC0235974 85-102 diseaseC0235974 denotes pancreatic cancer
23592772-0#85#102#diseaseC0346647 85-102 diseaseC0346647 denotes pancreatic cancer
23592772-0#0#5#diseaseC0424295 0-5 diseaseC0424295 denotes Hyper
23592772-11#18#21#gene64689 1688-1691 gene64689 denotes p65
23592772-11#18#21#gene5970 1688-1691 gene5970 denotes p65
23592772-11#18#21#gene6857 1688-1691 gene6857 denotes p65
23592772-11#18#21#gene65125 1688-1691 gene65125 denotes p65
23592772-11#67#70#gene64689 1737-1740 gene64689 denotes p65
23592772-11#67#70#gene5970 1737-1740 gene5970 denotes p65
23592772-11#67#70#gene6857 1737-1740 gene6857 denotes p65
23592772-11#67#70#gene65125 1737-1740 gene65125 denotes p65
23592772-11#132#136#diseaseC1335302 1802-1806 diseaseC1335302 denotes PDAC
23592772-12#82#87#gene4790 1924-1929 gene4790 denotes NF-κB
23592772-12#112#116#diseaseC1335302 1954-1958 diseaseC1335302 denotes PDAC
23592772-5#60#63#gene8473 844-847 gene8473 denotes OGT
23592772-5#115#118#gene10724 899-902 gene10724 denotes OGA
23592772-5#5#10#diseaseC0424295 789-794 diseaseC0424295 denotes hyper
23592772-8#43#47#gene1147 1229-1233 gene1147 denotes IKKα
23592772-8#48#52#gene3551 1234-1238 gene3551 denotes IKKβ
23592772-8#76#80#diseaseC1335302 1262-1266 diseaseC1335302 denotes PDAC
23592772-9#51#54#gene64689 1319-1322 gene64689 denotes p65
23592772-9#51#54#gene5970 1319-1322 gene5970 denotes p65
23592772-9#51#54#gene6857 1319-1322 gene6857 denotes p65
23592772-9#51#54#gene65125 1319-1322 gene65125 denotes p65
23592772-9#9#14#diseaseC0424295 1277-1282 diseaseC0424295 denotes hyper
67#72#gene479085#102#diseaseC0235974 23592772-0#67#72#gene4790 23592772-0#85#102#diseaseC0235974 associated_with NF-κB,pancreatic cancer
67#72#gene479085#102#diseaseC0346647 23592772-0#67#72#gene4790 23592772-0#85#102#diseaseC0346647 associated_with NF-κB,pancreatic cancer
67#72#gene47900#5#diseaseC0424295 23592772-0#67#72#gene4790 23592772-0#0#5#diseaseC0424295 associated_with NF-κB,Hyper
67#72#gene479085#102#diseaseC0235974 23592772-0#67#72#gene4790 23592772-0#85#102#diseaseC0235974 associated_with NF-κB,pancreatic cancer
67#72#gene479085#102#diseaseC0346647 23592772-0#67#72#gene4790 23592772-0#85#102#diseaseC0346647 associated_with NF-κB,pancreatic cancer
67#72#gene47900#5#diseaseC0424295 23592772-0#67#72#gene4790 23592772-0#0#5#diseaseC0424295 associated_with NF-κB,Hyper
18#21#gene64689132#136#diseaseC1335302 23592772-11#18#21#gene64689 23592772-11#132#136#diseaseC1335302 associated_with p65,PDAC
18#21#gene5970132#136#diseaseC1335302 23592772-11#18#21#gene5970 23592772-11#132#136#diseaseC1335302 associated_with p65,PDAC
18#21#gene6857132#136#diseaseC1335302 23592772-11#18#21#gene6857 23592772-11#132#136#diseaseC1335302 associated_with p65,PDAC
18#21#gene65125132#136#diseaseC1335302 23592772-11#18#21#gene65125 23592772-11#132#136#diseaseC1335302 associated_with p65,PDAC
67#70#gene64689132#136#diseaseC1335302 23592772-11#67#70#gene64689 23592772-11#132#136#diseaseC1335302 associated_with p65,PDAC
67#70#gene5970132#136#diseaseC1335302 23592772-11#67#70#gene5970 23592772-11#132#136#diseaseC1335302 associated_with p65,PDAC
67#70#gene6857132#136#diseaseC1335302 23592772-11#67#70#gene6857 23592772-11#132#136#diseaseC1335302 associated_with p65,PDAC
67#70#gene65125132#136#diseaseC1335302 23592772-11#67#70#gene65125 23592772-11#132#136#diseaseC1335302 associated_with p65,PDAC
82#87#gene4790112#116#diseaseC1335302 23592772-12#82#87#gene4790 23592772-12#112#116#diseaseC1335302 associated_with NF-κB,PDAC
60#63#gene84735#10#diseaseC0424295 23592772-5#60#63#gene8473 23592772-5#5#10#diseaseC0424295 associated_with OGT,hyper
115#118#gene107245#10#diseaseC0424295 23592772-5#115#118#gene10724 23592772-5#5#10#diseaseC0424295 associated_with OGA,hyper
43#47#gene114776#80#diseaseC1335302 23592772-8#43#47#gene1147 23592772-8#76#80#diseaseC1335302 associated_with IKKα,PDAC
48#52#gene355176#80#diseaseC1335302 23592772-8#48#52#gene3551 23592772-8#76#80#diseaseC1335302 associated_with IKKβ,PDAC
51#54#gene646899#14#diseaseC0424295 23592772-9#51#54#gene64689 23592772-9#9#14#diseaseC0424295 associated_with p65,hyper
51#54#gene59709#14#diseaseC0424295 23592772-9#51#54#gene5970 23592772-9#9#14#diseaseC0424295 associated_with p65,hyper
51#54#gene68579#14#diseaseC0424295 23592772-9#51#54#gene6857 23592772-9#9#14#diseaseC0424295 associated_with p65,hyper
51#54#gene651259#14#diseaseC0424295 23592772-9#51#54#gene65125 23592772-9#9#14#diseaseC0424295 associated_with p65,hyper

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 85-102 Disease denotes pancreatic cancer http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831
T3 110-116 Disease denotes Cancer http://purl.obolibrary.org/obo/MONDO_0004992
T4 743-775 Disease denotes pancreatic ductal adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0005184
T5 777-781 Disease denotes PDAC http://purl.obolibrary.org/obo/MONDO_0005184
T6 784-788 Disease denotes PDAC http://purl.obolibrary.org/obo/MONDO_0005184
T7 1018-1022 Disease denotes PDAC http://purl.obolibrary.org/obo/MONDO_0005184
T8 1084-1089 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T9 1123-1127 Disease denotes PDAC http://purl.obolibrary.org/obo/MONDO_0005184
T10 1262-1266 Disease denotes PDAC http://purl.obolibrary.org/obo/MONDO_0005184
T11 1309-1313 Disease denotes PDAC http://purl.obolibrary.org/obo/MONDO_0005184
T12 1463-1467 Disease denotes PDAC http://purl.obolibrary.org/obo/MONDO_0005184
T13 1802-1806 Disease denotes PDAC http://purl.obolibrary.org/obo/MONDO_0005184
T14 1954-1958 Disease denotes PDAC http://purl.obolibrary.org/obo/MONDO_0005184

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 660-668 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T2 889-897 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T3 899-902 Glycan denotes OGA https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T4 1528-1531 Glycan denotes OGA https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T5 1741-1749 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 660-668 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T2 889-897 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T3 899-902 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes OGA http://www.glycoepitope.jp/epitopes/EP0004
T4 1528-1531 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes OGA http://www.glycoepitope.jp/epitopes/EP0004
T5 1741-1749 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 85-102 Phenotype denotes pancreatic cancer HP:0002894
T2 110-116 Phenotype denotes Cancer HP:0002664
T3 743-775 Phenotype denotes pancreatic ductal adenocarcinoma HP:0006725
T4 777-781 Phenotype denotes PDAC HP:0006725
T5 784-788 Phenotype denotes PDAC HP:0006725
T6 1018-1022 Phenotype denotes PDAC HP:0006725
T7 1084-1089 Phenotype denotes tumor HP:0002664
T8 1123-1127 Phenotype denotes PDAC HP:0006725
T9 1262-1266 Phenotype denotes PDAC HP:0006725
T10 1309-1313 Phenotype denotes PDAC HP:0006725
T11 1463-1467 Phenotype denotes PDAC HP:0006725
T12 1802-1806 Phenotype denotes PDAC HP:0006725
T13 1954-1958 Phenotype denotes PDAC HP:0006725

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 85-102 Disease denotes pancreatic cancer http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831
T3 110-116 Disease denotes Cancer http://purl.obolibrary.org/obo/MONDO_0004992
T4 743-775 Disease denotes pancreatic ductal adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0005184
T5 777-781 Disease denotes PDAC http://purl.obolibrary.org/obo/MONDO_0005184
T6 784-788 Disease denotes PDAC http://purl.obolibrary.org/obo/MONDO_0005184
T7 1018-1022 Disease denotes PDAC http://purl.obolibrary.org/obo/MONDO_0005184
T8 1084-1089 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T9 1123-1127 Disease denotes PDAC http://purl.obolibrary.org/obo/MONDO_0005184
T10 1262-1266 Disease denotes PDAC http://purl.obolibrary.org/obo/MONDO_0005184
T11 1309-1313 Disease denotes PDAC http://purl.obolibrary.org/obo/MONDO_0005184
T12 1463-1467 Disease denotes PDAC http://purl.obolibrary.org/obo/MONDO_0005184
T13 1802-1806 Disease denotes PDAC http://purl.obolibrary.org/obo/MONDO_0005184
T14 1954-1958 Disease denotes PDAC http://purl.obolibrary.org/obo/MONDO_0005184

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 737-742 OrganismTaxon denotes human 9606

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 96-108 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T2 110-121 Cell denotes Cancer cell http://purl.obolibrary.org/obo/CL:0001064
T3 969-995 Cell denotes pancreatic epithelial cell http://purl.obolibrary.org/obo/CL:0000083
T4 980-995 Cell denotes epithelial cell http://purl.obolibrary.org/obo/CL:0000066

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 969-995 Body_part denotes pancreatic epithelial cell http://purl.obolibrary.org/obo/CL_0000083

sentences

Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells.
T2 110-346 Sentence denotes Cancer cell metabolic reprogramming includes a shift in energy production from oxidative phosphorylation to less efficient glycolysis even in the presence of oxygen (Warburg effect) and use of glutamine for increased biosynthetic needs.
T3 347-475 Sentence denotes This necessitates greatly increased glucose and glutamine uptake, both of which enter the hexosamine biosynthetic pathway (HBP).
T4 476-670 Sentence denotes The HBP end product UDP-N-acetylglucosamine (UDP-GlcNAc) is used in enzymatic post-translational modification of many cytosolic and nuclear proteins by O-linked β-N-acetylglucosamine (O-GlcNAc).
T5 671-783 Sentence denotes Here, we observed increased HBP flux and hyper-O-GlcNAcylation in human pancreatic ductal adenocarcinoma (PDAC).
T6 784-904 Sentence denotes PDAC hyper-O-GlcNAcylation was associated with elevation of OGT and reduction of the enzyme that removes O-GlcNAc (OGA).
T7 905-1122 Sentence denotes Reducing hyper-O-GlcNAcylation had no effect on non-transformed pancreatic epithelial cell growth, but inhibited PDAC cell proliferation, anchorage-independent growth, orthotopic tumor growth, and triggered apoptosis.
T8 1123-1185 Sentence denotes PDAC is supported by oncogenic NF-κB transcriptional activity.
T9 1186-1267 Sentence denotes The NF-κB p65 subunit and upstream kinases IKKα/IKKβ were O-GlcNAcylated in PDAC.
T10 1268-1440 Sentence denotes Reducing hyper-O-GlcNAcylation decreased PDAC cell p65 activating phosphorylation (S536), nuclear translocation, NF-κB transcriptional activity, and target gene expression.
T11 1441-1669 Sentence denotes Conversely, mimicking PDAC hyper-O-GlcNAcylation through pharmacological inhibition of OGA suppressed suspension culture-induced apoptosis and increased IKKα and p65 O-GlcNAcylation, accompanied by activation of NF-κB signaling.
T12 1670-1841 Sentence denotes Finally, reducing p65 O-GlcNAcylation specifically by mutating two p65 O-GlcNAc sites (T322A and T352A) attenuated the induction of PDAC cell anchorage-independent growth.
T13 1842-1959 Sentence denotes Our data indicate that hyper-O-GlcNAcylation is anti-apoptotic and contributes to NF-κB oncogenic activation in PDAC.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells.
T2 110-346 Sentence denotes Cancer cell metabolic reprogramming includes a shift in energy production from oxidative phosphorylation to less efficient glycolysis even in the presence of oxygen (Warburg effect) and use of glutamine for increased biosynthetic needs.
T3 347-475 Sentence denotes This necessitates greatly increased glucose and glutamine uptake, both of which enter the hexosamine biosynthetic pathway (HBP).
T4 476-670 Sentence denotes The HBP end product UDP-N-acetylglucosamine (UDP-GlcNAc) is used in enzymatic post-translational modification of many cytosolic and nuclear proteins by O-linked β-N-acetylglucosamine (O-GlcNAc).
T5 671-783 Sentence denotes Here, we observed increased HBP flux and hyper-O-GlcNAcylation in human pancreatic ductal adenocarcinoma (PDAC).
T6 784-904 Sentence denotes PDAC hyper-O-GlcNAcylation was associated with elevation of OGT and reduction of the enzyme that removes O-GlcNAc (OGA).
T7 905-1122 Sentence denotes Reducing hyper-O-GlcNAcylation had no effect on non-transformed pancreatic epithelial cell growth, but inhibited PDAC cell proliferation, anchorage-independent growth, orthotopic tumor growth, and triggered apoptosis.
T8 1123-1185 Sentence denotes PDAC is supported by oncogenic NF-κB transcriptional activity.
T9 1186-1267 Sentence denotes The NF-κB p65 subunit and upstream kinases IKKα/IKKβ were O-GlcNAcylated in PDAC.
T10 1268-1440 Sentence denotes Reducing hyper-O-GlcNAcylation decreased PDAC cell p65 activating phosphorylation (S536), nuclear translocation, NF-κB transcriptional activity, and target gene expression.
T11 1441-1669 Sentence denotes Conversely, mimicking PDAC hyper-O-GlcNAcylation through pharmacological inhibition of OGA suppressed suspension culture-induced apoptosis and increased IKKα and p65 O-GlcNAcylation, accompanied by activation of NF-κB signaling.
T12 1670-1841 Sentence denotes Finally, reducing p65 O-GlcNAcylation specifically by mutating two p65 O-GlcNAc sites (T322A and T352A) attenuated the induction of PDAC cell anchorage-independent growth.
T13 1842-1959 Sentence denotes Our data indicate that hyper-O-GlcNAcylation is anti-apoptotic and contributes to NF-κB oncogenic activation in PDAC.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 660-668 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T2 889-897 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T3 899-902 Glycan denotes OGA https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T4 1528-1531 Glycan denotes OGA https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO
T5 1741-1749 Glycan denotes O-GlcNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 660-668 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T2 889-897 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004
T3 899-902 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes OGA http://www.glycoepitope.jp/epitopes/EP0004
T4 1528-1531 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes OGA http://www.glycoepitope.jp/epitopes/EP0004
T5 1741-1749 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes O-GlcNAc http://www.glycoepitope.jp/epitopes/EP0004

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 737-742 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 969-995 Body_part denotes pancreatic epithelial cell http://purl.obolibrary.org/obo/CL_0000083

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 85-102 Phenotype denotes pancreatic cancer HP:0002894
T2 110-116 Phenotype denotes Cancer HP:0002664
T3 743-775 Phenotype denotes pancreatic ductal adenocarcinoma HP:0006725
T4 777-781 Phenotype denotes PDAC HP:0006725
T5 784-788 Phenotype denotes PDAC HP:0006725
T6 1018-1022 Phenotype denotes PDAC HP:0006725
T7 1084-1089 Phenotype denotes tumor HP:0002664
T8 1123-1127 Phenotype denotes PDAC HP:0006725
T9 1262-1266 Phenotype denotes PDAC HP:0006725
T10 1309-1313 Phenotype denotes PDAC HP:0006725
T11 1463-1467 Phenotype denotes PDAC HP:0006725
T12 1802-1806 Phenotype denotes PDAC HP:0006725
T13 1954-1958 Phenotype denotes PDAC HP:0006725

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 96-108 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T2 110-121 Cell denotes Cancer cell http://purl.obolibrary.org/obo/CL:0001064
T3 969-995 Cell denotes pancreatic epithelial cell http://purl.obolibrary.org/obo/CL:0000083
T4 980-995 Cell denotes epithelial cell http://purl.obolibrary.org/obo/CL:0000066