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PubMed:23580652 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-121 Sentence denotes A lipoprotein receptor cluster IV mutant preferentially binds amyloid-β and regulates its clearance from the mouse brain.
T2 122-242 Sentence denotes Soluble low density lipoprotein receptor-related protein-1 (sLRP1) binds ~70% of amyloid β-peptide (Aβ) in human plasma.
T3 243-478 Sentence denotes In Alzheimer disease (AD) and individuals with mild cognitive impairment converting to AD, plasma sLRP1 levels are reduced and sLRP1 is oxidized, which results in diminished Aβ peripheral binding and higher levels of free Aβ in plasma.
T4 479-661 Sentence denotes Experimental studies have shown that free circulating Aβ re-enters the brain and that sLRP1 and/or its recombinant wild type cluster IV (WT-LRPIV) prevent Aβ from entering the brain.
T5 662-759 Sentence denotes Treatment of Alzheimer APPsw(+/0) mice with WT-LRPIV has been shown to reduce brain Aβ pathology.
T6 760-808 Sentence denotes In addition to Aβ, LRPIV binds multiple ligands.
T7 809-1050 Sentence denotes To enhance LRPIV binding for Aβ relative to other LRP1 ligands, we generated a library of LRPIV-derived fragments and full-length LRPIV variants with glycine replacing aspartic acid residues 3394, 3556, and 3674 in the calcium binding sites.
T8 1051-1400 Sentence denotes Compared with WT-LRPIV, a lead LRPIV-D3674G mutant had 1.6- and 2.7-fold higher binding affinity for Aβ40 and Aβ42 in vitro, respectively, and a lower binding affinity for other LRP1 ligands (e.g. apolipoprotein E2, E3, and E4 (1.3-1.8-fold), tissue plasminogen activator (2.7-fold), matrix metalloproteinase-9 (4.1-fold), and Factor Xa (3.8-fold)).
T9 1401-1487 Sentence denotes LRPIV-D3674G cleared mouse endogenous brain Aβ40 and Aβ42 25-27% better than WT-LRPIV.
T10 1488-1751 Sentence denotes A 3-month subcutaneous treatment of APPsw(+/0) mice with LRPIV-D3674G (40 μg/kg/day) reduced Aβ40 and Αβ42 levels in the hippocampus, cortex, and cerebrospinal fluid by 60-80% and improved cerebral blood flow responses and hippocampal function at 9 months of age.
T11 1752-1812 Sentence denotes Thus, LRPIV-D3674G is an efficient new Aβ clearance therapy.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 115-120 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T2 550-555 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T3 655-660 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T4 740-745 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T5 1439-1444 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T6 1609-1620 http://purl.obolibrary.org/obo/MAT_0000114 denotes hippocampus
T7 1634-1653 http://purl.obolibrary.org/obo/MAT_0000499 denotes cerebrospinal fluid
T8 1686-1691 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T9 1686-1691 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

Allie

Id Subject Object Predicate Lexical cue
SS1_23580652_1_0 122-180 expanded denotes Soluble low density lipoprotein receptor-related protein-1
SS2_23580652_1_0 182-187 abbr denotes sLRP1
SS1_23580652_2_0 246-263 expanded denotes Alzheimer disease
SS2_23580652_2_0 265-267 abbr denotes AD
SS1_23580652_3_0 594-614 expanded denotes wild type cluster IV
SS2_23580652_3_0 616-624 abbr denotes WT-LRPIV
AE1_23580652_1_0 SS1_23580652_1_0 SS2_23580652_1_0 abbreviatedTo Soluble low density lipoprotein receptor-related protein-1,sLRP1
AE1_23580652_2_0 SS1_23580652_2_0 SS2_23580652_2_0 abbreviatedTo Alzheimer disease,AD
AE1_23580652_3_0 SS1_23580652_3_0 SS2_23580652_3_0 abbreviatedTo wild type cluster IV,WT-LRPIV

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 203-210 HP_0011034 denotes amyloid
T2 246-263 HP_0002511 denotes Alzheimer disease
T3 295-315 HP_0100543 denotes cognitive impairment

CHEMDNER-training-test

Id Subject Object Predicate Lexical cue
T1 959-966 TRIVIAL denotes glycine
T2 977-990 TRIVIAL denotes aspartic acid
T3 1028-1035 SYSTEMATIC denotes calcium

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 246-263 Phenotype denotes Alzheimer disease HP:0002511
T2 265-267 Phenotype denotes AD HP:0002511
T3 295-315 Phenotype denotes cognitive impairment HP:0100543
T4 330-332 Phenotype denotes AD HP:0002511

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 62-69 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T2 203-210 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T3 246-263 Disease denotes Alzheimer disease http://purl.obolibrary.org/obo/MONDO_0004975
T4 265-267 Disease denotes AD http://purl.obolibrary.org/obo/MONDO_0004975
T5 330-332 Disease denotes AD http://purl.obolibrary.org/obo/MONDO_0004975

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 109-114 OrganismTaxon denotes mouse 10088|10090
T3 229-234 OrganismTaxon denotes human 9606
T4 696-700 OrganismTaxon denotes mice 10088
T5 959-966 OrganismTaxon denotes glycine 3846
T6 1422-1427 OrganismTaxon denotes mouse 10088|10090
T8 1535-1539 OrganismTaxon denotes mice 10088
T9 1609-1620 OrganismTaxon denotes hippocampus 72046

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 115-120 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T3 235-241 Body_part denotes plasma http://purl.obolibrary.org/obo/UBERON_0001969
T4 334-340 Body_part denotes plasma http://purl.obolibrary.org/obo/UBERON_0001969
T5 471-477 Body_part denotes plasma http://purl.obolibrary.org/obo/UBERON_0001969
T6 550-555 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T8 655-660 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T10 740-745 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T12 1294-1300 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T13 1439-1444 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T15 1609-1620 Body_part denotes hippocampus http://purl.obolibrary.org/obo/UBERON_0001954|http://purl.obolibrary.org/obo/UBERON_0002421|http://purl.obolibrary.org/obo/UBERON_0002961
T18 1622-1628 Body_part denotes cortex http://purl.obolibrary.org/obo/UBERON_0001851
T19 1634-1653 Body_part denotes cerebrospinal fluid http://purl.obolibrary.org/obo/UBERON_0001359
T20 1686-1691 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 115-120 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T2 550-555 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T3 655-660 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T4 740-745 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T5 1439-1444 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T6 1609-1620 Body_part denotes hippocampus http://purl.obolibrary.org/obo/MAT_0000114
T7 1634-1653 Body_part denotes cerebrospinal fluid http://purl.obolibrary.org/obo/MAT_0000499
T8 1686-1691 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315