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PubMed:23571414 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes Therapeutic cleavage of anti-aquaporin-4 autoantibody in neuromyelitis optica by an IgG-selective proteinase.
T2 110-315 Sentence denotes Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system caused by binding of pathogenic IgG autoantibodies (NMO-IgG) to astrocyte water channel aquaporin-4 (AQP4).
T3 316-504 Sentence denotes Astrocyte damage and downstream inflammation require NMO-IgG effector function to initiate complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC).
T4 505-714 Sentence denotes Here, we evaluated the potential therapeutic utility of the bacterial enzyme IdeS (IgG-degrading enzyme of Streptococcus pyogenes), which selectively cleaves IgG antibodies to yield Fc and F(ab')(2) fragments.
T5 715-889 Sentence denotes In AQP4-expressing cell cultures, IdeS treatment of monoclonal NMO-IgGs and NMO patient sera abolished CDC and ADCC, even when IdeS was added after NMO-IgG was bound to AQP4.
T6 890-985 Sentence denotes Binding of NMO-IgG to AQP4 was similar to that of the NMO-F(ab')(2) generated by IdeS cleavage.
T7 986-1138 Sentence denotes NMO-F(ab')(2) competitively displaced pathogenic NMO-IgG, preventing cytotoxicity, and the Fc fragments generated by IdeS cleavage reduced CDC and ADCC.
T8 1139-1271 Sentence denotes IdeS efficiently cleaved NMO-IgG in mice in vivo, and greatly reduced NMO lesions in mice administered NMO-IgG and human complement.
T9 1272-1393 Sentence denotes IgG-selective cleavage by IdeS thus neutralizes NMO-IgG pathogenicity, and yields therapeutic F(ab')(2) and Fc fragments.
T10 1394-1486 Sentence denotes IdeS treatment, by therapeutic apheresis or direct administration, may be beneficial in NMO.
T1 0-109 Sentence denotes Therapeutic cleavage of anti-aquaporin-4 autoantibody in neuromyelitis optica by an IgG-selective proteinase.
T2 110-315 Sentence denotes Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system caused by binding of pathogenic IgG autoantibodies (NMO-IgG) to astrocyte water channel aquaporin-4 (AQP4).
T3 316-504 Sentence denotes Astrocyte damage and downstream inflammation require NMO-IgG effector function to initiate complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC).
T4 505-714 Sentence denotes Here, we evaluated the potential therapeutic utility of the bacterial enzyme IdeS (IgG-degrading enzyme of Streptococcus pyogenes), which selectively cleaves IgG antibodies to yield Fc and F(ab')(2) fragments.
T5 715-889 Sentence denotes In AQP4-expressing cell cultures, IdeS treatment of monoclonal NMO-IgGs and NMO patient sera abolished CDC and ADCC, even when IdeS was added after NMO-IgG was bound to AQP4.
T6 890-985 Sentence denotes Binding of NMO-IgG to AQP4 was similar to that of the NMO-F(ab')(2) generated by IdeS cleavage.
T7 986-1138 Sentence denotes NMO-F(ab')(2) competitively displaced pathogenic NMO-IgG, preventing cytotoxicity, and the Fc fragments generated by IdeS cleavage reduced CDC and ADCC.
T8 1139-1271 Sentence denotes IdeS efficiently cleaved NMO-IgG in mice in vivo, and greatly reduced NMO lesions in mice administered NMO-IgG and human complement.
T9 1272-1393 Sentence denotes IgG-selective cleavage by IdeS thus neutralizes NMO-IgG pathogenicity, and yields therapeutic F(ab')(2) and Fc fragments.
T10 1394-1486 Sentence denotes IdeS treatment, by therapeutic apheresis or direct administration, may be beneficial in NMO.

Allie

Id Subject Object Predicate Lexical cue
SS1_23571414_1_0 110-130 expanded denotes Neuromyelitis optica
SS2_23571414_1_0 132-135 abbr denotes NMO
SS1_23571414_1_1 193-258 expanded denotes nervous system caused by binding of pathogenic IgG autoantibodies
SS2_23571414_1_1 260-267 abbr denotes NMO-IgG
SS1_23571414_1_2 296-307 expanded denotes aquaporin-4
SS2_23571414_1_2 309-313 abbr denotes AQP4
SS1_23571414_2_0 407-440 expanded denotes complement-dependent cytotoxicity
SS2_23571414_2_0 442-445 abbr denotes CDC
SS1_23571414_2_1 451-496 expanded denotes antibody-dependent cell-mediated cytotoxicity
SS2_23571414_2_1 498-502 abbr denotes ADCC
AE1_23571414_1_0 SS1_23571414_1_0 SS2_23571414_1_0 abbreviatedTo Neuromyelitis optica,NMO
AE1_23571414_1_1 SS1_23571414_1_1 SS2_23571414_1_1 abbreviatedTo nervous system caused by binding of pathogenic IgG autoantibodies,NMO-IgG
AE1_23571414_1_2 SS1_23571414_1_2 SS2_23571414_1_2 abbreviatedTo aquaporin-4,AQP4
AE1_23571414_2_0 SS1_23571414_2_0 SS2_23571414_2_0 abbreviatedTo complement-dependent cytotoxicity,CDC
AE1_23571414_2_1 SS1_23571414_2_1 SS2_23571414_2_1 abbreviatedTo antibody-dependent cell-mediated cytotoxicity,ADCC

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 156-169 HP_0011096 denotes demyelinating