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PubMed:23558898 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-150 Sentence denotes Tumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma.
TextSentencer_T2 151-162 Sentence denotes BACKGROUND:
TextSentencer_T3 163-405 Sentence denotes Our recent studies of microRNA (miRNA) expression signature demonstrated that microRNA-874 (miR-874) was significantly downregulated in maxillary sinus squamous cell carcinoma (MSSCC), and a putative tumour-suppressive miRNA in human cancers.
TextSentencer_T4 406-628 Sentence denotes Our aim of this study was to investigate the functional significance of miR-874 in cancer cells and to identify novel miR-874-mediated cancer pathways and responsible genes in head and neck squamous cell carcinoma (HNSCC).
TextSentencer_T5 629-637 Sentence denotes METHODS:
TextSentencer_T6 638-796 Sentence denotes Gain-of-function studies using mature miR-874 were performed to investigate cell proliferation and cell cycle distribution in HNSCC cell lines (SAS and FaDu).
TextSentencer_T7 797-927 Sentence denotes To identify miR-874-mediated molecular pathways and targets, we utilised gene expression analysis and in silico database analysis.
TextSentencer_T8 928-1034 Sentence denotes Loss-of-function assays were performed to investigate the functional significance of miR-874 target genes.
TextSentencer_T9 1035-1043 Sentence denotes RESULTS:
TextSentencer_T10 1044-1214 Sentence denotes Expression levels of miR-874 were significantly downregulated in HNSCC tissues (including oral, pharyngeal and laryngeal SCCs) compared with normal counterpart epithelia.
TextSentencer_T11 1215-1367 Sentence denotes Restoration of miR-874 in SAS and FaDu cell lines revealed significant inhibition of cell proliferation and induction of G2/M arrest and cell apoptosis.
TextSentencer_T12 1368-1470 Sentence denotes Our expression data and in silico analysis demonstrated that miR-874 modulated the cell cycle pathway.
TextSentencer_T13 1471-1556 Sentence denotes Moreover, histone deacetylase 1 (HDAC1) was a candidate target of miR-874 regulation.
TextSentencer_T14 1557-1629 Sentence denotes Luciferase reporter assays showed that miR-874 directly regulated HDAC1.
TextSentencer_T15 1630-1757 Sentence denotes Silencing of the HDAC1 gene significantly inhibited cell proliferation and induced G2/M arrest and cell apoptosis in SAS cells.
TextSentencer_T16 1758-1770 Sentence denotes CONCLUSIONS:
TextSentencer_T17 1771-1893 Sentence denotes Downregulation of miR-874 was a frequent event in HNSCC. miR-874 acted as a tumour suppressor and directly targeted HDAC1.
TextSentencer_T18 1894-2090 Sentence denotes Recognition of tumour-suppressive miRNA-mediated cancer pathways provides new insights into the potential mechanisms of HNSCC oncogenesis and suggests novel therapeutic strategies for the disease.
T1 0-150 Sentence denotes Tumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma.
T2 151-162 Sentence denotes BACKGROUND:
T3 163-405 Sentence denotes Our recent studies of microRNA (miRNA) expression signature demonstrated that microRNA-874 (miR-874) was significantly downregulated in maxillary sinus squamous cell carcinoma (MSSCC), and a putative tumour-suppressive miRNA in human cancers.
T4 406-628 Sentence denotes Our aim of this study was to investigate the functional significance of miR-874 in cancer cells and to identify novel miR-874-mediated cancer pathways and responsible genes in head and neck squamous cell carcinoma (HNSCC).
T5 629-637 Sentence denotes METHODS:
T6 638-796 Sentence denotes Gain-of-function studies using mature miR-874 were performed to investigate cell proliferation and cell cycle distribution in HNSCC cell lines (SAS and FaDu).
T7 797-927 Sentence denotes To identify miR-874-mediated molecular pathways and targets, we utilised gene expression analysis and in silico database analysis.
T8 928-1034 Sentence denotes Loss-of-function assays were performed to investigate the functional significance of miR-874 target genes.
T9 1035-1043 Sentence denotes RESULTS:
T10 1044-1214 Sentence denotes Expression levels of miR-874 were significantly downregulated in HNSCC tissues (including oral, pharyngeal and laryngeal SCCs) compared with normal counterpart epithelia.
T11 1215-1367 Sentence denotes Restoration of miR-874 in SAS and FaDu cell lines revealed significant inhibition of cell proliferation and induction of G2/M arrest and cell apoptosis.
T12 1368-1470 Sentence denotes Our expression data and in silico analysis demonstrated that miR-874 modulated the cell cycle pathway.
T13 1471-1556 Sentence denotes Moreover, histone deacetylase 1 (HDAC1) was a candidate target of miR-874 regulation.
T14 1557-1629 Sentence denotes Luciferase reporter assays showed that miR-874 directly regulated HDAC1.
T15 1630-1757 Sentence denotes Silencing of the HDAC1 gene significantly inhibited cell proliferation and induced G2/M arrest and cell apoptosis in SAS cells.
T16 1758-1770 Sentence denotes CONCLUSIONS:
T17 1771-1893 Sentence denotes Downregulation of miR-874 was a frequent event in HNSCC. miR-874 acted as a tumour suppressor and directly targeted HDAC1.
T18 1894-2090 Sentence denotes Recognition of tumour-suppressive miRNA-mediated cancer pathways provides new insights into the potential mechanisms of HNSCC oncogenesis and suggests novel therapeutic strategies for the disease.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 87-108 gene:3065 denotes histone deacetylase 1
T1 112-149 disease:C1168401 denotes head and neck squamous cell carcinoma
T2 19-31 gene:100126343 denotes microRNA-874
T3 112-149 disease:C1168401 denotes head and neck squamous cell carcinoma
T4 241-253 gene:100126343 denotes microRNA-874
T5 340-345 disease:C1334647 denotes MSSCC
T6 241-253 gene:100126343 denotes microRNA-874
T7 397-404 disease:C0006826 denotes cancers
T8 241-253 gene:100126343 denotes microRNA-874
T9 299-338 disease:C1334647 denotes maxillary sinus squamous cell carcinoma
T10 255-262 gene:100126343 denotes miR-874
T11 340-345 disease:C1334647 denotes MSSCC
T12 255-262 gene:100126343 denotes miR-874
T13 397-404 disease:C0006826 denotes cancers
T14 255-262 gene:100126343 denotes miR-874
T15 299-338 disease:C1334647 denotes maxillary sinus squamous cell carcinoma
T16 524-531 gene:100126343 denotes miR-874
T17 621-626 disease:C1168401 denotes HNSCC
T18 524-531 gene:100126343 denotes miR-874
T19 582-619 disease:C1168401 denotes head and neck squamous cell carcinoma
T20 478-485 gene:100126343 denotes miR-874
T21 621-626 disease:C1168401 denotes HNSCC
T22 478-485 gene:100126343 denotes miR-874
T23 582-619 disease:C1168401 denotes head and neck squamous cell carcinoma
T24 478-485 gene:100126343 denotes miR-874
T25 489-495 disease:C1306459 denotes cancer
T26 478-485 gene:100126343 denotes miR-874
T27 489-495 disease:C0006826 denotes cancer
T28 782-785 gene:6302 denotes SAS
T29 764-769 disease:C1168401 denotes HNSCC
T30 782-785 gene:54187 denotes SAS
T31 764-769 disease:C1168401 denotes HNSCC
T32 676-683 gene:100126343 denotes miR-874
T33 764-769 disease:C1168401 denotes HNSCC
T34 1065-1072 gene:100126343 denotes miR-874
T35 1109-1114 disease:C1168401 denotes HNSCC
R1 T0 T1 associated_with histone deacetylase 1,head and neck squamous cell carcinoma
R2 T2 T3 associated_with microRNA-874,head and neck squamous cell carcinoma
R3 T4 T5 associated_with microRNA-874,MSSCC
R4 T6 T7 associated_with microRNA-874,cancers
R5 T8 T9 associated_with microRNA-874,maxillary sinus squamous cell carcinoma
R6 T10 T11 associated_with miR-874,MSSCC
R7 T12 T13 associated_with miR-874,cancers
R8 T14 T15 associated_with miR-874,maxillary sinus squamous cell carcinoma
R9 T16 T17 associated_with miR-874,HNSCC
R10 T18 T19 associated_with miR-874,head and neck squamous cell carcinoma
R11 T20 T21 associated_with miR-874,HNSCC
R12 T22 T23 associated_with miR-874,head and neck squamous cell carcinoma
R13 T24 T25 associated_with miR-874,cancer
R14 T26 T27 associated_with miR-874,cancer
R15 T28 T29 associated_with SAS,HNSCC
R16 T30 T31 associated_with SAS,HNSCC
R17 T32 T33 associated_with miR-874,HNSCC
R18 T34 T35 associated_with miR-874,HNSCC

Allie

Id Subject Object Predicate Lexical cue
SS1_23558898_2_0 185-193 expanded denotes microRNA
SS2_23558898_2_0 195-200 abbr denotes miRNA
SS1_23558898_2_1 241-253 expanded denotes microRNA-874
SS2_23558898_2_1 255-262 abbr denotes miR-874
SS1_23558898_2_2 299-338 expanded denotes maxillary sinus squamous cell carcinoma
SS2_23558898_2_2 340-345 abbr denotes MSSCC
SS1_23558898_3_0 582-619 expanded denotes head and neck squamous cell carcinoma
SS2_23558898_3_0 621-626 abbr denotes HNSCC
SS1_23558898_12_0 1481-1502 expanded denotes histone deacetylase 1
SS2_23558898_12_0 1504-1509 abbr denotes HDAC1
AE1_23558898_2_0 SS1_23558898_2_0 SS2_23558898_2_0 abbreviatedTo microRNA,miRNA
AE1_23558898_2_1 SS1_23558898_2_1 SS2_23558898_2_1 abbreviatedTo microRNA-874,miR-874
AE1_23558898_2_2 SS1_23558898_2_2 SS2_23558898_2_2 abbreviatedTo maxillary sinus squamous cell carcinoma,MSSCC
AE1_23558898_3_0 SS1_23558898_3_0 SS2_23558898_3_0 abbreviatedTo head and neck squamous cell carcinoma,HNSCC
AE1_23558898_12_0 SS1_23558898_12_0 SS2_23558898_12_0 abbreviatedTo histone deacetylase 1,HDAC1

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 315-338 HP_0002860 denotes squamous cell carcinoma
T2 363-369 HP_0002664 denotes tumour
T3 397-404 HP_0002664 denotes cancers
T4 489-495 HP_0002664 denotes cancer
T5 541-547 HP_0002664 denotes cancer
T6 596-619 HP_0002860 denotes squamous cell carcinoma

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23558898-0#19#31#gene100126343 19-31 gene100126343 denotes microRNA-874
23558898-0#87#108#gene3065 87-108 gene3065 denotes histone deacetylase 1
23558898-0#112#149#diseaseC1168401 112-149 diseaseC1168401 denotes head and neck squamous cell carcinoma
23558898-1#78#90#gene100126343 241-253 gene100126343 denotes microRNA-874
23558898-1#92#99#gene100126343 255-262 gene100126343 denotes miR-874
23558898-1#136#175#diseaseC1334647 299-338 diseaseC1334647 denotes maxillary sinus squamous cell carcinoma
23558898-1#177#182#diseaseC1334647 340-345 diseaseC1334647 denotes MSSCC
23558898-1#136#175#diseaseC1334647 299-338 diseaseC1334647 denotes maxillary sinus squamous cell carcinoma
23558898-1#177#182#diseaseC1334647 340-345 diseaseC1334647 denotes MSSCC
23558898-12#76#93#gene7248 1847-1864 gene7248 denotes tumour suppressor
23558898-12#50#55#diseaseC1168401 1821-1826 diseaseC1168401 denotes HNSCC
23558898-3#144#147#gene54187 782-785 gene54187 denotes SAS
23558898-3#144#147#gene6302 782-785 gene6302 denotes SAS
23558898-3#126#131#diseaseC1168401 764-769 diseaseC1168401 denotes HNSCC
19#31#gene100126343112#149#diseaseC1168401 23558898-0#19#31#gene100126343 23558898-0#112#149#diseaseC1168401 associated_with microRNA-874,head and neck squamous cell carcinoma
87#108#gene3065112#149#diseaseC1168401 23558898-0#87#108#gene3065 23558898-0#112#149#diseaseC1168401 associated_with histone deacetylase 1,head and neck squamous cell carcinoma
78#90#gene100126343136#175#diseaseC1334647 23558898-1#78#90#gene100126343 23558898-1#136#175#diseaseC1334647 associated_with microRNA-874,maxillary sinus squamous cell carcinoma
78#90#gene100126343177#182#diseaseC1334647 23558898-1#78#90#gene100126343 23558898-1#177#182#diseaseC1334647 associated_with microRNA-874,MSSCC
78#90#gene100126343136#175#diseaseC1334647 23558898-1#78#90#gene100126343 23558898-1#136#175#diseaseC1334647 associated_with microRNA-874,maxillary sinus squamous cell carcinoma
78#90#gene100126343177#182#diseaseC1334647 23558898-1#78#90#gene100126343 23558898-1#177#182#diseaseC1334647 associated_with microRNA-874,MSSCC
92#99#gene100126343136#175#diseaseC1334647 23558898-1#92#99#gene100126343 23558898-1#136#175#diseaseC1334647 associated_with miR-874,maxillary sinus squamous cell carcinoma
92#99#gene100126343177#182#diseaseC1334647 23558898-1#92#99#gene100126343 23558898-1#177#182#diseaseC1334647 associated_with miR-874,MSSCC
92#99#gene100126343136#175#diseaseC1334647 23558898-1#92#99#gene100126343 23558898-1#136#175#diseaseC1334647 associated_with miR-874,maxillary sinus squamous cell carcinoma
92#99#gene100126343177#182#diseaseC1334647 23558898-1#92#99#gene100126343 23558898-1#177#182#diseaseC1334647 associated_with miR-874,MSSCC
76#93#gene724850#55#diseaseC1168401 23558898-12#76#93#gene7248 23558898-12#50#55#diseaseC1168401 associated_with tumour suppressor,HNSCC
144#147#gene54187126#131#diseaseC1168401 23558898-3#144#147#gene54187 23558898-3#126#131#diseaseC1168401 associated_with SAS,HNSCC
144#147#gene6302126#131#diseaseC1168401 23558898-3#144#147#gene6302 23558898-3#126#131#diseaseC1168401 associated_with SAS,HNSCC

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2678 782-785 gene:54187 denotes SAS
T2679 764-769 disease:C1168401 denotes HNSCC
R1 T2678 T2679 associated_with SAS,HNSCC
R2 T2678 T2679 associated_with SAS,HNSCC

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 112-116 http://purl.obolibrary.org/obo/UBERON_0000033 denotes head
PD-UBERON-AE-B_T2 582-586 http://purl.obolibrary.org/obo/UBERON_0000033 denotes head
PD-UBERON-AE-B_T3 121-125 http://purl.obolibrary.org/obo/UBERON_0000974 denotes neck
PD-UBERON-AE-B_T4 591-595 http://purl.obolibrary.org/obo/UBERON_0000974 denotes neck
PD-UBERON-AE-B_T5 299-314 http://purl.obolibrary.org/obo/UBERON_0001764 denotes maxillary sinus
PD-UBERON-AE-B_T6 1115-1122 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1115-1122 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T2 112-116 http://purl.obolibrary.org/obo/UBERON_0000033 denotes head
PD-UBERON-AE-B_T3 582-586 http://purl.obolibrary.org/obo/UBERON_0000033 denotes head
PD-UBERON-AE-B_T4 121-125 http://purl.obolibrary.org/obo/UBERON_0000974 denotes neck
PD-UBERON-AE-B_T5 591-595 http://purl.obolibrary.org/obo/UBERON_0000974 denotes neck
PD-UBERON-AE-B_T6 299-314 http://purl.obolibrary.org/obo/UBERON_0001764 denotes maxillary sinus