PubMed:23556448 JSONTXT

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":471,"end":475},"obj":"gene:2166"},{"id":"T1","span":{"begin":568,"end":582},"obj":"disease:C1868649"},{"id":"T2","span":{"begin":471,"end":475},"obj":"gene:2166"},{"id":"T3","span":{"begin":486,"end":512},"obj":"disease:C1533217"},{"id":"T4","span":{"begin":471,"end":475},"obj":"gene:2166"},{"id":"T5","span":{"begin":568,"end":582},"obj":"disease:C0030319"},{"id":"T6","span":{"begin":1041,"end":1045},"obj":"gene:2166"},{"id":"T7","span":{"begin":1115,"end":1141},"obj":"disease:C1533217"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population.\nAIM: FAAH is a membrane enzyme that terminates the activity of a large class of endogenous signaling lipids. Recent studies suggest that the FAAH Pro129Thr polymorphism is a common mutation in the FAAH gene that is significantly associated with drug-addictive traits. This study investigated the association of the Pro129Thr polymorphism of the FAAH gene with methamphetamine dependence, methamphetamine-induced psychosis, manic episodes and panic disorder in a Malaysian population.\nMATERIALS \u0026 METHODS: This polymorphism was genotyped in 232 male methamphetamine-dependent subjects and in 241 male controls of four different ethnicities: Malay, Chinese, Kadazan-Dusun and Bajau. Intergroup statistical analyses were performed by using the χ(2)-square test and Fisher's exact test, where necessary. In cases of multiple comparisons, the Bonferroni correction was performed.\nRESULTS: Our results indicated that the FAAH Pro129Thr polymorphism showed a significant association with risk of methamphetamine dependence in the pooled subjects (odds ratio [OR]: 2.017; p \u003c 0.001) and in the Malay (OR: 2.829; p \u003c 0.001) and Chinese (OR: 3.685; p \u003c 0.001) groups. We also found an association of this polymorphism with episodes of methamphetamine-induced mania in the Malay group (OR: 2.836; p = 0.035). However, there was no association between this polymorphism and age of onset of drug use or the occurrence of methamphetamine-induced psychosis or of panic disorder.\nCONCLUSION: Our findings suggest that the FAAH Pro129Thr polymorphism may contribute to methamphetamine dependence in the Malay and Chinese ethnic groups."}

{"project":"Allie","denotations":[{"id":"SS1_23556448_10_0","span":{"begin":1166,"end":1176},"obj":"expanded"},{"id":"SS2_23556448_10_0","span":{"begin":1178,"end":1180},"obj":"abbr"}],"relations":[{"id":"AE1_23556448_10_0","pred":"abbreviatedTo","subj":"SS1_23556448_10_0","obj":"SS2_23556448_10_0"}],"text":"Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population.\nAIM: FAAH is a membrane enzyme that terminates the activity of a large class of endogenous signaling lipids. Recent studies suggest that the FAAH Pro129Thr polymorphism is a common mutation in the FAAH gene that is significantly associated with drug-addictive traits. This study investigated the association of the Pro129Thr polymorphism of the FAAH gene with methamphetamine dependence, methamphetamine-induced psychosis, manic episodes and panic disorder in a Malaysian population.\nMATERIALS \u0026 METHODS: This polymorphism was genotyped in 232 male methamphetamine-dependent subjects and in 241 male controls of four different ethnicities: Malay, Chinese, Kadazan-Dusun and Bajau. Intergroup statistical analyses were performed by using the χ(2)-square test and Fisher's exact test, where necessary. In cases of multiple comparisons, the Bonferroni correction was performed.\nRESULTS: Our results indicated that the FAAH Pro129Thr polymorphism showed a significant association with risk of methamphetamine dependence in the pooled subjects (odds ratio [OR]: 2.017; p \u003c 0.001) and in the Malay (OR: 2.829; p \u003c 0.001) and Chinese (OR: 3.685; p \u003c 0.001) groups. We also found an association of this polymorphism with episodes of methamphetamine-induced mania in the Malay group (OR: 2.836; p = 0.035). However, there was no association between this polymorphism and age of onset of drug use or the occurrence of methamphetamine-induced psychosis or of panic disorder.\nCONCLUSION: Our findings suggest that the FAAH Pro129Thr polymorphism may contribute to methamphetamine dependence in the Malay and Chinese ethnic groups."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":538,"end":547},"obj":"HP_0000709"},{"id":"T2","span":{"begin":549,"end":554},"obj":"HP_0100754"}],"text":"Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population.\nAIM: FAAH is a membrane enzyme that terminates the activity of a large class of endogenous signaling lipids. Recent studies suggest that the FAAH Pro129Thr polymorphism is a common mutation in the FAAH gene that is significantly associated with drug-addictive traits. This study investigated the association of the Pro129Thr polymorphism of the FAAH gene with methamphetamine dependence, methamphetamine-induced psychosis, manic episodes and panic disorder in a Malaysian population.\nMATERIALS \u0026 METHODS: This polymorphism was genotyped in 232 male methamphetamine-dependent subjects and in 241 male controls of four different ethnicities: Malay, Chinese, Kadazan-Dusun and Bajau. Intergroup statistical analyses were performed by using the χ(2)-square test and Fisher's exact test, where necessary. In cases of multiple comparisons, the Bonferroni correction was performed.\nRESULTS: Our results indicated that the FAAH Pro129Thr polymorphism showed a significant association with risk of methamphetamine dependence in the pooled subjects (odds ratio [OR]: 2.017; p \u003c 0.001) and in the Malay (OR: 2.829; p \u003c 0.001) and Chinese (OR: 3.685; p \u003c 0.001) groups. We also found an association of this polymorphism with episodes of methamphetamine-induced mania in the Malay group (OR: 2.836; p = 0.035). However, there was no association between this polymorphism and age of onset of drug use or the occurrence of methamphetamine-induced psychosis or of panic disorder.\nCONCLUSION: Our findings suggest that the FAAH Pro129Thr polymorphism may contribute to methamphetamine dependence in the Malay and Chinese ethnic groups."}

{"project":"DisGeNET5_variant_disease","denotations":[{"id":"23556448-10#35#44#geners324420","span":{"begin":1637,"end":1646},"obj":"geners324420"},{"id":"23556448-10#76#102#diseaseC1533217","span":{"begin":1678,"end":1704},"obj":"diseaseC1533217"},{"id":"23556448-3#47#56#geners324420","span":{"begin":441,"end":450},"obj":"geners324420"},{"id":"23556448-3#174#188#diseaseC0030319","span":{"begin":568,"end":582},"obj":"diseaseC0030319"},{"id":"23556448-3#174#188#diseaseC1868649","span":{"begin":568,"end":582},"obj":"diseaseC1868649"}],"relations":[{"id":"35#44#geners32442076#102#diseaseC1533217","pred":"associated_with","subj":"23556448-10#35#44#geners324420","obj":"23556448-10#76#102#diseaseC1533217"},{"id":"47#56#geners324420174#188#diseaseC0030319","pred":"associated_with","subj":"23556448-3#47#56#geners324420","obj":"23556448-3#174#188#diseaseC0030319"},{"id":"47#56#geners324420174#188#diseaseC1868649","pred":"associated_with","subj":"23556448-3#47#56#geners324420","obj":"23556448-3#174#188#diseaseC1868649"}],"text":"Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population.\nAIM: FAAH is a membrane enzyme that terminates the activity of a large class of endogenous signaling lipids. Recent studies suggest that the FAAH Pro129Thr polymorphism is a common mutation in the FAAH gene that is significantly associated with drug-addictive traits. This study investigated the association of the Pro129Thr polymorphism of the FAAH gene with methamphetamine dependence, methamphetamine-induced psychosis, manic episodes and panic disorder in a Malaysian population.\nMATERIALS \u0026 METHODS: This polymorphism was genotyped in 232 male methamphetamine-dependent subjects and in 241 male controls of four different ethnicities: Malay, Chinese, Kadazan-Dusun and Bajau. Intergroup statistical analyses were performed by using the χ(2)-square test and Fisher's exact test, where necessary. In cases of multiple comparisons, the Bonferroni correction was performed.\nRESULTS: Our results indicated that the FAAH Pro129Thr polymorphism showed a significant association with risk of methamphetamine dependence in the pooled subjects (odds ratio [OR]: 2.017; p \u003c 0.001) and in the Malay (OR: 2.829; p \u003c 0.001) and Chinese (OR: 3.685; p \u003c 0.001) groups. We also found an association of this polymorphism with episodes of methamphetamine-induced mania in the Malay group (OR: 2.836; p = 0.035). However, there was no association between this polymorphism and age of onset of drug use or the occurrence of methamphetamine-induced psychosis or of panic disorder.\nCONCLUSION: Our findings suggest that the FAAH Pro129Thr polymorphism may contribute to methamphetamine dependence in the Malay and Chinese ethnic groups."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"23556448-10#30#34#gene2166","span":{"begin":1632,"end":1636},"obj":"gene2166"},{"id":"23556448-10#76#102#diseaseC1533217","span":{"begin":1678,"end":1704},"obj":"diseaseC1533217"}],"relations":[{"id":"30#34#gene216676#102#diseaseC1533217","pred":"associated_with","subj":"23556448-10#30#34#gene2166","obj":"23556448-10#76#102#diseaseC1533217"}],"text":"Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population.\nAIM: FAAH is a membrane enzyme that terminates the activity of a large class of endogenous signaling lipids. Recent studies suggest that the FAAH Pro129Thr polymorphism is a common mutation in the FAAH gene that is significantly associated with drug-addictive traits. This study investigated the association of the Pro129Thr polymorphism of the FAAH gene with methamphetamine dependence, methamphetamine-induced psychosis, manic episodes and panic disorder in a Malaysian population.\nMATERIALS \u0026 METHODS: This polymorphism was genotyped in 232 male methamphetamine-dependent subjects and in 241 male controls of four different ethnicities: Malay, Chinese, Kadazan-Dusun and Bajau. Intergroup statistical analyses were performed by using the χ(2)-square test and Fisher's exact test, where necessary. In cases of multiple comparisons, the Bonferroni correction was performed.\nRESULTS: Our results indicated that the FAAH Pro129Thr polymorphism showed a significant association with risk of methamphetamine dependence in the pooled subjects (odds ratio [OR]: 2.017; p \u003c 0.001) and in the Malay (OR: 2.829; p \u003c 0.001) and Chinese (OR: 3.685; p \u003c 0.001) groups. We also found an association of this polymorphism with episodes of methamphetamine-induced mania in the Malay group (OR: 2.836; p = 0.035). However, there was no association between this polymorphism and age of onset of drug use or the occurrence of methamphetamine-induced psychosis or of panic disorder.\nCONCLUSION: Our findings suggest that the FAAH Pro129Thr polymorphism may contribute to methamphetamine dependence in the Malay and Chinese ethnic groups."}

{"project":"CHEMDNER-training-test","denotations":[{"id":"T1","span":{"begin":486,"end":501},"obj":"TRIVIAL"},{"id":"T2","span":{"begin":514,"end":529},"obj":"TRIVIAL"},{"id":"T3","span":{"begin":675,"end":690},"obj":"TRIVIAL"},{"id":"T4","span":{"begin":1115,"end":1130},"obj":"TRIVIAL"},{"id":"T5","span":{"begin":1351,"end":1366},"obj":"TRIVIAL"},{"id":"T6","span":{"begin":1534,"end":1549},"obj":"TRIVIAL"},{"id":"T7","span":{"begin":1678,"end":1693},"obj":"TRIVIAL"},{"id":"T1","span":{"begin":51,"end":66},"obj":"TRIVIAL"}],"text":"Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population.\nAIM: FAAH is a membrane enzyme that terminates the activity of a large class of endogenous signaling lipids. Recent studies suggest that the FAAH Pro129Thr polymorphism is a common mutation in the FAAH gene that is significantly associated with drug-addictive traits. This study investigated the association of the Pro129Thr polymorphism of the FAAH gene with methamphetamine dependence, methamphetamine-induced psychosis, manic episodes and panic disorder in a Malaysian population.\nMATERIALS \u0026 METHODS: This polymorphism was genotyped in 232 male methamphetamine-dependent subjects and in 241 male controls of four different ethnicities: Malay, Chinese, Kadazan-Dusun and Bajau. Intergroup statistical analyses were performed by using the χ(2)-square test and Fisher's exact test, where necessary. In cases of multiple comparisons, the Bonferroni correction was performed.\nRESULTS: Our results indicated that the FAAH Pro129Thr polymorphism showed a significant association with risk of methamphetamine dependence in the pooled subjects (odds ratio [OR]: 2.017; p \u003c 0.001) and in the Malay (OR: 2.829; p \u003c 0.001) and Chinese (OR: 3.685; p \u003c 0.001) groups. We also found an association of this polymorphism with episodes of methamphetamine-induced mania in the Malay group (OR: 2.836; p = 0.035). However, there was no association between this polymorphism and age of onset of drug use or the occurrence of methamphetamine-induced psychosis or of panic disorder.\nCONCLUSION: Our findings suggest that the FAAH Pro129Thr polymorphism may contribute to methamphetamine dependence in the Malay and Chinese ethnic groups."}