> top > docs > PubMed:23548897 > annotations

PubMed:23548897 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-140 Sentence denotes G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells.
T2 141-152 Sentence denotes BACKGROUND:
T3 153-223 Sentence denotes Signaling pathways underlying BV8-mediated oncogenesis remain unknown.
T4 224-338 Sentence denotes RESULTS: BV8-STAT3 forms a feed-forward loop in both normal and malignant myeloid cells and promotes tumor growth.
T5 339-444 Sentence denotes CONCLUSION: JAK2/STAT3 signaling plays critical roles in BV8-mediated myeloid cell-dependent oncogenesis.
T6 445-458 Sentence denotes SIGNIFICANCE:
T7 459-588 Sentence denotes This study identifies a novel role of BV8-STAT3 signaling in mediating cross-talk between tumor microenvironment and tumor cells.
T8 589-708 Sentence denotes An important role of BV8 in mobilization of myeloid cells and myeloid cell-dependent angiogenesis has been established.
T9 709-867 Sentence denotes Recently, it has also been shown that granulocyte colony-stimulating factor (G-CSF)-induced BV8 expression is STAT3 dependent in CD11b(+)Gr1(+) myeloid cells.
T10 868-1061 Sentence denotes However, the BV8 downstream signaling pathway(s) intrinsic to myeloid cells crucial for angiogenesis, and potentially also for development of cancers of myeloid origin, remains largely unknown.
T11 1062-1260 Sentence denotes Here we show that BV8 activates STAT3, which is critical for regulating genes important for both tumor cell proliferation/survival and tumor angiogenesis, in both normal and malignant myeloid cells.
T12 1261-1403 Sentence denotes Further, BV8-induced STAT3 activation requires Janus-activated kinase 2 (JAK2) activity as shown by both genetic and pharmacologic inhibition.
T13 1404-1608 Sentence denotes Knocking down BV8 in human myeloid leukemia cells inhibits STAT3 activity and expression of STAT3 downstream angiogenic and pro-proliferation/survival genes, leading to a decrease in tumor cell viability.
T14 1609-1701 Sentence denotes BV8 shRNA expressing leukemia cells exhibit reduced STAT3 activity and tumor growth in vivo.
T15 1702-1919 Sentence denotes Taken together, we have delineated a signaling pathway downstream of BV8 that plays critical roles in both the tumor microenvironment and malignant myeloid cells for angiogenesis and tumor cell proliferation/survival.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 351-355 gene:3717 denotes JAK2
T1 432-443 disease:C0596263 denotes oncogenesis
T2 1094-1099 gene:6774 denotes STAT3
T3 1197-1215 disease:C1519670 denotes tumor angiogenesis
R1 T0 T1 associated_with JAK2,oncogenesis
R2 T2 T3 associated_with STAT3,tumor angiogenesis

Allie

Id Subject Object Predicate Lexical cue
SS1_23548897_10_0 747-784 expanded denotes granulocyte colony-stimulating factor
SS2_23548897_10_0 786-791 abbr denotes G-CSF
SS1_23548897_13_0 1308-1332 expanded denotes Janus-activated kinase 2
SS2_23548897_13_0 1334-1338 abbr denotes JAK2
AE1_23548897_10_0 SS1_23548897_10_0 SS2_23548897_10_0 abbreviatedTo granulocyte colony-stimulating factor,G-CSF
AE1_23548897_13_0 SS1_23548897_13_0 SS2_23548897_13_0 abbreviatedTo Janus-activated kinase 2,JAK2

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23548897-10#92#97#gene6774 1496-1501 gene6774 denotes STAT3
23548897-10#27#43#diseaseC0023470 1431-1447 diseaseC0023470 denotes myeloid leukemia
23548897-3#0#4#gene3717 351-355 gene3717 denotes JAK2
23548897-3#81#92#diseaseC0596263 432-443 diseaseC0596263 denotes oncogenesis
23548897-8#32#37#gene6774 1094-1099 gene6774 denotes STAT3
23548897-8#135#153#diseaseC1519670 1197-1215 diseaseC1519670 denotes tumor angiogenesis
92#97#gene677427#43#diseaseC0023470 23548897-10#92#97#gene6774 23548897-10#27#43#diseaseC0023470 associated_with STAT3,myeloid leukemia
0#4#gene371781#92#diseaseC0596263 23548897-3#0#4#gene3717 23548897-3#81#92#diseaseC0596263 associated_with JAK2,oncogenesis
32#37#gene6774135#153#diseaseC1519670 23548897-8#32#37#gene6774 23548897-8#135#153#diseaseC1519670 associated_with STAT3,tumor angiogenesis

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 325-330 Phenotype denotes tumor HP:0002664
T2 549-554 Phenotype denotes tumor HP:0002664
T3 576-581 Phenotype denotes tumor HP:0002664
T4 1159-1164 Phenotype denotes tumor HP:0002664
T5 1197-1202 Phenotype denotes tumor HP:0002664
T6 1431-1447 Phenotype denotes myeloid leukemia HP:0012324
T7 1587-1592 Phenotype denotes tumor HP:0002664
T8 1630-1638 Phenotype denotes leukemia HP:0001909
T9 1680-1685 Phenotype denotes tumor HP:0002664
T10 1813-1818 Phenotype denotes tumor HP:0002664
T11 1885-1890 Phenotype denotes tumor HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 325-330 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 549-554 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T3 576-581 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T4 1159-1164 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T5 1197-1202 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T6 1431-1447 Disease denotes myeloid leukemia http://purl.obolibrary.org/obo/MONDO_0004643
T7 1587-1592 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T8 1630-1638 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059
T9 1680-1685 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T10 1813-1818 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T11 1885-1890 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1308-1313 OrganismTaxon denotes Janus 1385265
T2 1425-1430 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 126-139 Body_part denotes myeloid cells http://purl.obolibrary.org/obo/CL_0000763
T2 298-311 Body_part denotes myeloid cells http://purl.obolibrary.org/obo/CL_0000763
T3 409-421 Body_part denotes myeloid cell http://purl.obolibrary.org/obo/CL_0000763
T4 633-646 Body_part denotes myeloid cells http://purl.obolibrary.org/obo/CL_0000763
T5 651-663 Body_part denotes myeloid cell http://purl.obolibrary.org/obo/CL_0000763
T6 747-758 Body_part denotes granulocyte http://purl.obolibrary.org/obo/CL_0000094
T7 853-866 Body_part denotes myeloid cells http://purl.obolibrary.org/obo/CL_0000763
T8 930-943 Body_part denotes myeloid cells http://purl.obolibrary.org/obo/CL_0000763
T9 1246-1259 Body_part denotes myeloid cells http://purl.obolibrary.org/obo/CL_0000763
T10 1850-1863 Body_part denotes myeloid cells http://purl.obolibrary.org/obo/CL_0000763

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 126-139 Cell denotes myeloid cells http://purl.obolibrary.org/obo/CL:0000763
T2 298-311 Cell denotes myeloid cells http://purl.obolibrary.org/obo/CL:0000763
T3 409-421 Cell denotes myeloid cell http://purl.obolibrary.org/obo/CL:0000763
T4 576-587 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063
T5 633-646 Cell denotes myeloid cells http://purl.obolibrary.org/obo/CL:0000763
T6 651-663 Cell denotes myeloid cell http://purl.obolibrary.org/obo/CL:0000763
T7 747-758 Cell denotes granulocyte http://purl.obolibrary.org/obo/CL:0000094
T8 853-866 Cell denotes myeloid cells http://purl.obolibrary.org/obo/CL:0000763
T9 930-943 Cell denotes myeloid cells http://purl.obolibrary.org/obo/CL:0000763
T10 1159-1169 Cell denotes tumor cell http://purl.obolibrary.org/obo/CL:0001063
T11 1246-1259 Cell denotes myeloid cells http://purl.obolibrary.org/obo/CL:0000763
T12 1587-1597 Cell denotes tumor cell http://purl.obolibrary.org/obo/CL:0001063
T13 1850-1863 Cell denotes myeloid cells http://purl.obolibrary.org/obo/CL:0000763
T14 1885-1895 Cell denotes tumor cell http://purl.obolibrary.org/obo/CL:0001063