PubMed:23537750 JSONTXT

{"project":"Allie","denotations":[{"id":"SS1_23537750_4_0","span":{"begin":430,"end":440},"obj":"expanded"},{"id":"SS2_23537750_4_0","span":{"begin":442,"end":444},"obj":"abbr"}],"relations":[{"id":"AE1_23537750_4_0","pred":"abbreviatedTo","subj":"SS1_23537750_4_0","obj":"SS2_23537750_4_0"}],"text":"[Split-dose sodium picosulphate/magnesium citrate for morning colonoscopies performed 2 to 6 hours after fluid intake].\nPreparación con picosulfato sódico/citrato de magnesio en dosis fraccionadas para colonoscopias en turno de mañana realizadas entre las 2 y 6 horas posteriores a la ingesta de líquidos.\nBACKGROUND: Split dosage of bowel preparations has been shown to substantially improve bowel cleansing.\nAIM: To compare the split dose (SD) sodium picosulphate/magnesium oxide/anhydrous citric acid (Citrafleet(®)) regimen for morning colonoscopies with standard cleansing the day before.\nMETHODS: Consecutive outpatients were randomized to receive Citrafleet(®) the day before colonoscopy or SD, in whom the second half was administered on an individual basis from 2 to 6 hours before the procedure. No bisacodyl was administered. All procedures were performed with non-anesthesiologist administered propofol sedation. The Boston scale was used to assess the quality of bowel preparation (adequate cleansing if score ≥ 6, with no score of 0/1 in any segment).\nRESULTS: A total of 193 patients were included. Overall bowel cleansing was significantly better in the SD group (7 vs. 5.2, p\u003c0.001), as well as in the cecum (2.4 vs. 1.4, p \u003c 0.001), ascending colon (2.5 vs. 1.6, p\u003c0.001) and transverse colon (2.4 vs. 2, p=0.004). A significant proportion of SD patients had adequate bowel cleansing (71% vs. 30%, p\u003c0.001). Patients in the SD group drank a greater amount of liquid (4.9 vs. 4 liters, p=0.006) and more frequently perceived the cleansing process to be easy or very easy to complete (89 vs. 68%, p=0.04), although they slept significantly fewer hours (6.5 vs. 7.9, p\u003c0.001). No bronchoaspiration pneumonia was reported.\nCONCLUSIONS: SD Citrafleet(®) 2 to 6 hours before colonoscopy increased the rate of procedures with adequate bowel cleansing by 40%, especially in the proximal colon, allowed more liquids to be drunk and increased the perception of ease in completing the preparation, with no sedation-related complications."}