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PubMed:23530032 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-150 Sentence denotes The central nervous system (CNS)-independent anti-bone-resorptive activity of muscle contraction and the underlying molecular and cellular signatures.
T2 151-162 Sentence denotes BACKGROUND:
T3 163-227 Sentence denotes Mechanisms by which muscle regulates bone are poorly understood.
T4 228-236 Sentence denotes RESULTS:
T5 237-399 Sentence denotes Electrically stimulated muscle contraction reversed elevations in bone resorption and increased Wnt signaling in bone-derived cells after spinal cord transection.
T6 400-411 Sentence denotes CONCLUSION:
T7 412-576 Sentence denotes Muscle contraction reduced resorption of unloaded bone independently of the CNS, through mechanical effects and, potentially, nonmechanical signals (e.g. myokines).
T8 577-590 Sentence denotes SIGNIFICANCE:
T9 591-658 Sentence denotes The study provides new insights regarding muscle-bone interactions.
T10 659-701 Sentence denotes Muscle and bone work as a functional unit.
T11 702-807 Sentence denotes Cellular and molecular mechanisms underlying effects of muscle activity on bone mass are largely unknown.
T12 808-975 Sentence denotes Spinal cord injury (SCI) causes muscle paralysis and extensive sublesional bone loss and disrupts neural connections between the central nervous system (CNS) and bone.
T13 976-1094 Sentence denotes Muscle contraction elicited by electrical stimulation (ES) of nerves partially protects against SCI-related bone loss.
T14 1095-1280 Sentence denotes Thus, application of ES after SCI provides an opportunity to study the effects of muscle activity on bone and roles of the CNS in this interaction, as well as the underlying mechanisms.
T15 1281-1379 Sentence denotes Using a rat model of SCI, the effects on bone of ES-induced muscle contraction were characterized.
T16 1380-1493 Sentence denotes The SCI-mediated increase in serum C-terminal telopeptide of type I collagen (CTX) was completely reversed by ES.
T17 1494-1904 Sentence denotes In ex vivo bone marrow cell cultures, SCI increased the number of osteoclasts and their expression of mRNA for several osteoclast differentiation markers, whereas ES significantly reduced these changes; SCI decreased osteoblast numbers, but increased expression in these cells of receptor activator of NF-κB ligand (RANKL) mRNA, whereas ES increased expression of osteoprotegerin (OPG) and the OPG/RANKL ratio.
T18 1905-2155 Sentence denotes A microarray analysis revealed that ES partially reversed SCI-induced alterations in expression of genes involved in signaling through Wnt, FSH, parathyroid hormone (PTH), oxytocin, and calcineurin/nuclear factor of activated T-cells (NFAT) pathways.
T19 2156-2290 Sentence denotes ES mitigated SCI-mediated increases in mRNA levels for the Wnt inhibitors DKK1, sFRP2, and sclerostin in ex vivo cultured osteoblasts.
T20 2291-2428 Sentence denotes Our results demonstrate an anti-bone-resorptive activity of muscle contraction by ES that develops rapidly and is independent of the CNS.
T21 2429-2549 Sentence denotes The pathways involved, particularly Wnt signaling, suggest future strategies to minimize bone loss after immobilization.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 4-26 http://purl.obolibrary.org/obo/MAT_0000457 denotes central nervous system
T2 12-26 http://purl.obolibrary.org/obo/MAT_0000026 denotes nervous system
T3 50-54 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T4 78-84 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T5 183-189 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T6 200-204 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T7 261-267 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T8 303-307 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T9 350-354 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T10 375-386 http://purl.obolibrary.org/obo/MAT_0000183 denotes spinal cord
T11 412-418 http://purl.obolibrary.org/obo/MAT_0000025 denotes Muscle
T12 462-466 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T13 633-639 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T14 640-644 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T15 659-665 http://purl.obolibrary.org/obo/MAT_0000025 denotes Muscle
T16 670-674 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T17 758-764 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T18 777-781 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T19 808-819 http://purl.obolibrary.org/obo/MAT_0000183 denotes Spinal cord
T20 840-846 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T21 883-887 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T22 937-959 http://purl.obolibrary.org/obo/MAT_0000457 denotes central nervous system
T23 945-959 http://purl.obolibrary.org/obo/MAT_0000026 denotes nervous system
T24 970-974 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T25 976-982 http://purl.obolibrary.org/obo/MAT_0000025 denotes Muscle
T26 1084-1088 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T27 1177-1183 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T28 1196-1200 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T29 1322-1326 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T30 1341-1347 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T31 1505-1516 http://purl.obolibrary.org/obo/MAT_0000084 denotes bone marrow
T32 1505-1509 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T33 2050-2061 http://purl.obolibrary.org/obo/MAT_0000082 denotes parathyroid
T34 2323-2327 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T35 2351-2357 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T36 2518-2522 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone

Allie

Id Subject Object Predicate Lexical cue
SS1_23530032_0_0 4-26 expanded denotes central nervous system
SS2_23530032_0_0 28-31 abbr denotes CNS
SS1_23530032_11_0 808-826 expanded denotes Spinal cord injury
SS2_23530032_11_0 828-831 abbr denotes SCI
SS1_23530032_11_1 937-959 expanded denotes central nervous system
SS2_23530032_11_1 961-964 abbr denotes CNS
SS1_23530032_12_0 1007-1029 expanded denotes electrical stimulation
SS2_23530032_12_0 1031-1033 abbr denotes ES
SS1_23530032_16_0 1774-1808 expanded denotes receptor activator of NF-κB ligand
SS2_23530032_16_0 1810-1815 abbr denotes RANKL
SS1_23530032_16_1 1858-1873 expanded denotes osteoprotegerin
SS2_23530032_16_1 1875-1878 abbr denotes OPG
SS1_23530032_17_0 2050-2069 expanded denotes parathyroid hormone
SS2_23530032_17_0 2071-2074 abbr denotes PTH
SS1_23530032_17_1 2103-2138 expanded denotes nuclear factor of activated T-cells
SS2_23530032_17_1 2140-2144 abbr denotes NFAT
AE1_23530032_0_0 SS1_23530032_0_0 SS2_23530032_0_0 abbreviatedTo central nervous system,CNS
AE1_23530032_11_0 SS1_23530032_11_0 SS2_23530032_11_0 abbreviatedTo Spinal cord injury,SCI
AE1_23530032_11_1 SS1_23530032_11_1 SS2_23530032_11_1 abbreviatedTo central nervous system,CNS
AE1_23530032_12_0 SS1_23530032_12_0 SS2_23530032_12_0 abbreviatedTo electrical stimulation,ES
AE1_23530032_16_0 SS1_23530032_16_0 SS2_23530032_16_0 abbreviatedTo receptor activator of NF-κB ligand,RANKL
AE1_23530032_16_1 SS1_23530032_16_1 SS2_23530032_16_1 abbreviatedTo osteoprotegerin,OPG
AE1_23530032_17_0 SS1_23530032_17_0 SS2_23530032_17_0 abbreviatedTo parathyroid hormone,PTH
AE1_23530032_17_1 SS1_23530032_17_1 SS2_23530032_17_1 abbreviatedTo nuclear factor of activated T-cells,NFAT

PMID_GLOBAL

Id Subject Object Predicate Lexical cue uberon_id
T1 4-26 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T2 375-386 Body_part denotes spinal cord http://purl.obolibrary.org/obo/UBERON_0002240
T3 808-819 Body_part denotes Spinal cord http://purl.obolibrary.org/obo/UBERON_0002240
T4 937-959 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T5 1409-1414 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T6 1505-1516 Body_part denotes bone marrow http://purl.obolibrary.org/obo/UBERON_0002371

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 4-26 Body_part denotes central nervous system http://purl.obolibrary.org/obo/MAT_0000457
T2 28-31 Body_part denotes CNS http://purl.obolibrary.org/obo/MAT_0000457
T3 50-54 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T4 78-84 Body_part denotes muscle http://purl.obolibrary.org/obo/MAT_0000025
T5 183-189 Body_part denotes muscle http://purl.obolibrary.org/obo/MAT_0000025
T6 200-204 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T7 261-267 Body_part denotes muscle http://purl.obolibrary.org/obo/MAT_0000025
T8 303-307 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T9 350-354 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T10 375-386 Body_part denotes spinal cord http://purl.obolibrary.org/obo/MAT_0000183
T11 412-418 Body_part denotes Muscle http://purl.obolibrary.org/obo/MAT_0000025
T12 462-466 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T13 488-491 Body_part denotes CNS http://purl.obolibrary.org/obo/MAT_0000457
T14 633-639 Body_part denotes muscle http://purl.obolibrary.org/obo/MAT_0000025
T15 640-644 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T16 659-665 Body_part denotes Muscle http://purl.obolibrary.org/obo/MAT_0000025
T17 670-674 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T18 758-764 Body_part denotes muscle http://purl.obolibrary.org/obo/MAT_0000025
T19 777-781 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T20 808-819 Body_part denotes Spinal cord http://purl.obolibrary.org/obo/MAT_0000183
T21 840-846 Body_part denotes muscle http://purl.obolibrary.org/obo/MAT_0000025
T22 883-887 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T23 937-959 Body_part denotes central nervous system http://purl.obolibrary.org/obo/MAT_0000457
T24 961-964 Body_part denotes CNS http://purl.obolibrary.org/obo/MAT_0000457
T25 970-974 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T26 976-982 Body_part denotes Muscle http://purl.obolibrary.org/obo/MAT_0000025
T27 1084-1088 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T28 1177-1183 Body_part denotes muscle http://purl.obolibrary.org/obo/MAT_0000025
T29 1196-1200 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T30 1218-1221 Body_part denotes CNS http://purl.obolibrary.org/obo/MAT_0000457
T31 1322-1326 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T32 1341-1347 Body_part denotes muscle http://purl.obolibrary.org/obo/MAT_0000025
T33 1505-1516 Body_part denotes bone marrow http://purl.obolibrary.org/obo/MAT_0000084
T34 2050-2061 Body_part denotes parathyroid http://purl.obolibrary.org/obo/MAT_0000082
T35 2323-2327 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T36 2351-2357 Body_part denotes muscle http://purl.obolibrary.org/obo/MAT_0000025
T37 2424-2427 Body_part denotes CNS http://purl.obolibrary.org/obo/MAT_0000457
T38 2518-2522 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 847-856 Phenotype denotes paralysis HP:0003470

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 375-398 Disease denotes spinal cord transection http://purl.obolibrary.org/obo/MONDO_0043797
T2 808-826 Disease denotes Spinal cord injury http://purl.obolibrary.org/obo/MONDO_0043797
T3 828-831 Disease denotes SCI http://purl.obolibrary.org/obo/MONDO_0043797
T4 1072-1075 Disease denotes SCI http://purl.obolibrary.org/obo/MONDO_0043797
T5 1125-1128 Disease denotes SCI http://purl.obolibrary.org/obo/MONDO_0043797
T6 1302-1305 Disease denotes SCI http://purl.obolibrary.org/obo/MONDO_0043797
T7 1384-1387 Disease denotes SCI http://purl.obolibrary.org/obo/MONDO_0043797
T8 1532-1535 Disease denotes SCI http://purl.obolibrary.org/obo/MONDO_0043797
T9 1697-1700 Disease denotes SCI http://purl.obolibrary.org/obo/MONDO_0043797
T10 1963-1966 Disease denotes SCI http://purl.obolibrary.org/obo/MONDO_0043797
T11 2169-2172 Disease denotes SCI http://purl.obolibrary.org/obo/MONDO_0043797

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1289-1292 OrganismTaxon denotes rat 10114|10116

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 4-26 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T2 28-31 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T3 50-54 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T5 78-84 Body_part denotes muscle http://purl.obolibrary.org/obo/UBERON_0001630|http://purl.obolibrary.org/obo/UBERON_0005090
T7 183-189 Body_part denotes muscle http://purl.obolibrary.org/obo/UBERON_0001630|http://purl.obolibrary.org/obo/UBERON_0005090
T9 200-204 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T11 261-267 Body_part denotes muscle http://purl.obolibrary.org/obo/UBERON_0001630|http://purl.obolibrary.org/obo/UBERON_0005090
T13 303-307 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T15 350-354 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T17 375-386 Body_part denotes spinal cord http://purl.obolibrary.org/obo/UBERON_0002240
T18 412-418 Body_part denotes Muscle http://purl.obolibrary.org/obo/UBERON_0001630|http://purl.obolibrary.org/obo/UBERON_0005090
T20 462-466 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T22 488-491 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T23 633-639 Body_part denotes muscle http://purl.obolibrary.org/obo/UBERON_0001630|http://purl.obolibrary.org/obo/UBERON_0005090
T25 640-644 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T27 659-665 Body_part denotes Muscle http://purl.obolibrary.org/obo/UBERON_0001630|http://purl.obolibrary.org/obo/UBERON_0005090
T29 670-674 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T31 758-764 Body_part denotes muscle http://purl.obolibrary.org/obo/UBERON_0001630|http://purl.obolibrary.org/obo/UBERON_0005090
T33 777-781 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T35 808-819 Body_part denotes Spinal cord http://purl.obolibrary.org/obo/UBERON_0002240
T36 840-846 Body_part denotes muscle http://purl.obolibrary.org/obo/UBERON_0001630|http://purl.obolibrary.org/obo/UBERON_0005090
T38 883-887 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T40 937-959 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T41 961-964 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T42 970-974 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T44 976-982 Body_part denotes Muscle http://purl.obolibrary.org/obo/UBERON_0001630|http://purl.obolibrary.org/obo/UBERON_0005090
T46 1038-1044 Body_part denotes nerves http://purl.obolibrary.org/obo/UBERON_0001021
T47 1084-1088 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T49 1177-1183 Body_part denotes muscle http://purl.obolibrary.org/obo/UBERON_0001630|http://purl.obolibrary.org/obo/UBERON_0005090
T51 1196-1200 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T53 1218-1221 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T54 1322-1326 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T56 1341-1347 Body_part denotes muscle http://purl.obolibrary.org/obo/UBERON_0001630|http://purl.obolibrary.org/obo/UBERON_0005090
T58 1505-1521 Body_part denotes bone marrow cell http://purl.obolibrary.org/obo/CL_0002092
T59 1560-1571 Body_part denotes osteoclasts http://purl.obolibrary.org/obo/CL_0000092
T60 1613-1623 Body_part denotes osteoclast http://purl.obolibrary.org/obo/CL_0000092
T61 1711-1721 Body_part denotes osteoblast http://purl.obolibrary.org/obo/CL_0000062
T62 2050-2061 Body_part denotes parathyroid http://purl.obolibrary.org/obo/UBERON_0001132
T63 2278-2289 Body_part denotes osteoblasts http://purl.obolibrary.org/obo/CL_0000062
T64 2323-2327 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T66 2351-2357 Body_part denotes muscle http://purl.obolibrary.org/obo/UBERON_0001630|http://purl.obolibrary.org/obo/UBERON_0005090
T68 2424-2427 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T69 2518-2522 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481

Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 1441-1447 Cell denotes type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138
T3 1505-1521 Cell denotes bone marrow cell http://purl.obolibrary.org/obo/CL:0002092
T4 1560-1571 Cell denotes osteoclasts http://purl.obolibrary.org/obo/CL:0000092
T5 1613-1623 Cell denotes osteoclast http://purl.obolibrary.org/obo/CL:0000092
T6 1711-1721 Cell denotes osteoblast http://purl.obolibrary.org/obo/CL:0000062
T7 2131-2138 Cell denotes T-cells http://purl.obolibrary.org/obo/CL:0000084
T8 2278-2289 Cell denotes osteoblasts http://purl.obolibrary.org/obo/CL:0000062