PubMed:23528904 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/23528904","sourcedb":"PubMed","sourceid":"23528904","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/23528904","text":"Management of stage 4S composite neuroblastoma with a MYCN-amplified nodule.\nMYCN amplification in neuroblastoma is usually associated with a poor prognosis. Very few cases of heterogenous MYCN amplification have been previously reported, and the clinical significance of heterogeneity is unclear. We report a neonate with an adrenal stage 4S neuroblastoma with a small focus of MYCN-amplified cells within a nonamplified background. After adrenalectomy, the patient has been observed without use of chemotherapy and has no evidence of disease 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