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PubMed:23523949 JSONTXT

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Allie

Id Subject Object Predicate Lexical cue
SS1_23523949_3_0 237-245 expanded denotes diazinon
SS2_23523949_3_0 247-250 abbr denotes DZN
SS1_23523949_7_0 568-593 expanded denotes Creatine phosphokinase MB
SS2_23523949_7_0 595-600 abbr denotes CK-MB
SS1_23523949_7_1 603-618 expanded denotes malondealdehyde
SS2_23523949_7_1 620-623 abbr denotes MDA
AE1_23523949_3_0 SS1_23523949_3_0 SS2_23523949_3_0 abbreviatedTo diazinon,DZN
AE1_23523949_7_0 SS1_23523949_7_0 SS2_23523949_7_0 abbreviatedTo Creatine phosphokinase MB,CK-MB
AE1_23523949_7_1 SS1_23523949_7_1 SS2_23523949_7_1 abbreviatedTo malondealdehyde,MDA

CHEMDNER-training-test

Id Subject Object Predicate Lexical cue
T1 164-170 TRIVIAL denotes crocin
T2 237-245 TRIVIAL denotes diazinon
T3 247-250 ABBREVIATION denotes DZN
T4 383-389 TRIVIAL denotes crocin
T5 427-430 ABBREVIATION denotes DZN
T6 432-441 FAMILY denotes vitamin E
T7 486-489 ABBREVIATION denotes DZN
T8 494-500 TRIVIAL denotes crocin
T9 568-576 TRIVIAL denotes Creatine
T10 603-618 TRIVIAL denotes malondealdehyde
T11 620-623 ABBREVIATION denotes MDA
T12 629-640 TRIVIAL denotes glutathione
T13 642-645 ABBREVIATION denotes GSH
T14 904-907 ABBREVIATION denotes DZN
T15 1035-1038 ABBREVIATION denotes MDA
T16 1069-1072 ABBREVIATION denotes GSH
T17 1248-1254 TRIVIAL denotes Crocin
T18 1276-1285 FAMILY denotes vitamin E
T19 1332-1335 ABBREVIATION denotes MDA
T20 1357-1360 ABBREVIATION denotes GSH
T21 1494-1497 ABBREVIATION denotes DZN
T22 1511-1514 ABBREVIATION denotes DZN
T23 1610-1616 TRIVIAL denotes Crocin
T24 1671-1674 ABBREVIATION denotes DZN
T1 21-27 TRIVIAL denotes crocin
T2 31-39 TRIVIAL denotes diazinon

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 107-283 UNLABELLED denotes This study was designed to evaluate the effectiveness of crocin, main component of Crocus sativus L. (Saffron) against subchronic diazinon (DZN) induced cardiotoxicity in rats.
T2 293-894 METHODS denotes Rats were divided into 7 groups; control (corn oil, gavage), DZN (15 mg/kg/day, gavage,), crocin (12.5, 25 or 50 mg/kg/day, i.p) plus DZN, vitamin E (200 IU/kg, i.p, three times per week) plus DZN and crocin (50 mg/kg/day, i.p) groups. Treatments were continued for 4 weeks. Creatine phosphokinase MB (CK-MB), malondealdehyde (MDA) and glutathione (GSH) levels were evaluated in heart tissue at the end of treatments. Levels of apoptotic proteins (Bax, Bcl2, caspase 3) and cytosolic cytochrome c were analyzed by Western blotting. Transcript levels of Bax and Bcl2 were also determined using qRT PCR.
T3 904-1747 RESULTS denotes DZN induced histophatological damages and elevated the level of cardiac marker CK-MB. These effects were associated with increased MDA level, lower level of reduced GSH and induction of apoptosis through elevation of Bax/Bcl2 ratio (both protein and mRNA levels), cytochrome c release to the cytosol and activation caspase 3 in cardiac tissue. Crocin (25 and 50 mg/kg) or vitamin E improved histopathological damages, decreased MDA and CK-MB, increased GSH content and attenuated the increase of Bax/Bcl2 ratio, activation of caspase 3 and release of cytochrome c to the cytosol induced by DZN. In summary, DZN induced mitochondrial-mediated apoptosis in heart tissue of rat following subchronic exposure. Crocin, as an antioxidant, showed protective effects against DZN cardiotoxicity by reducing lipid peroxidation and alleviating apoptosis.