PubMed:2352328
Annnotations
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 478-482 | gene:9260 | denotes | LMP1 |
| T1 | 431-439 | disease:C0023418 | denotes | leukemia |
| T2 | 478-482 | gene:9260 | denotes | LMP1 |
| T3 | 523-531 | disease:C0024299 | denotes | lymphoma |
| R1 | T0 | T1 | associated_with | LMP1,leukemia |
| R2 | T2 | T3 | associated_with | LMP1,lymphoma |
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-36 | protein | denotes | Epstein-Barr virus nuclear antigen 2 |
| T2 | 52-75 | protein | denotes | latent membrane protein |
| T3 | 76-80 | protein | denotes | LMP1 |
| T4 | 148-190 | protein | denotes | Epstein-Barr virus (EBV) nuclear antigen 2 |
| T5 | 192-198 | protein | denotes | EBNA-2 |
| T6 | 203-217 | protein | denotes | leader protein |
| T7 | 219-226 | protein | denotes | EBNA-LP |
| T8 | 254-291 | protein | denotes | EBV latent infection membrane protein |
| T9 | 292-296 | protein | denotes | LMP1 |
| T10 | 373-379 | protein | denotes | EBNA-2 |
| T11 | 397-455 | DNA | denotes | simian virus 40 or Moloney murine leukemia virus promoters |
| T12 | 478-482 | protein | denotes | LMP1 |
| T13 | 497-537 | cell_line | denotes | P3HR-1-infected Burkitt's lymphoma cells |
| T14 | 546-552 | cell_line | denotes | P3HR-1 |
| T15 | 556-571 | cell_line | denotes | Daudi cell line |
| T16 | 609-616 | protein | denotes | EBNA-LP |
| T17 | 640-644 | protein | denotes | LMP1 |
| T18 | 693-699 | protein | denotes | EBNA-2 |
| T19 | 710-714 | protein | denotes | LMP1 |
| T20 | 733-737 | protein | denotes | LMP1 |
| T21 | 752-757 | cell_line | denotes | Daudi |
| T22 | 762-783 | cell_line | denotes | P3HR-1-infected cells |
| T23 | 806-810 | RNA | denotes | mRNA |
| T24 | 822-828 | protein | denotes | EBNA-2 |
| T25 | 843-854 | cell_line | denotes | Daudi cells |
| T26 | 865-874 | RNA | denotes | LMP1 mRNA |
| T27 | 890-899 | DNA | denotes | EBV genes |
| T28 | 918-924 | protein | denotes | EBNA-2 |
| T29 | 944-948 | protein | denotes | LMP1 |
| T30 | 973-1010 | DNA | denotes | recombinant EBNA-2 expression vectors |
| T31 | 1023-1041 | DNA | denotes | LMP1 DNA fragments |
| T32 | 1051-1055 | protein | denotes | LMP1 |
| T33 | 1074-1108 | cell_line | denotes | EBV-negative B-lymphoma cell lines |
| T34 | 1109-1113 | cell_line | denotes | BJAB |
| T35 | 1115-1122 | cell_line | denotes | Louckes |
| T36 | 1128-1132 | cell_line | denotes | BL30 |
| T37 | 1141-1166 | DNA | denotes | EBNA-2-responsive element |
| T38 | 1188-1208 | DNA | denotes | -512 to +40 LMP1 DNA |
| T39 | 1236-1283 | DNA | denotes | chloramphenicol acetyltransferase reporter gene |
| T40 | 1329-1353 | DNA | denotes | EBNA-2 expression vector |
| T41 | 1375-1381 | protein | denotes | EBNA-2 |
| T42 | 1397-1401 | protein | denotes | LMP1 |
| T43 | 1417-1434 | protein | denotes | EBV type 1 EBNA-2 |
| T44 | 1467-1473 | protein | denotes | EBNA-2 |
| T45 | 1547-1551 | protein | denotes | LMP1 |
| T46 | 1563-1610 | DNA | denotes | transformation-competent EBNA-2 deletion mutant |
| T47 | 1629-1633 | protein | denotes | LMP1 |
| T48 | 1635-1639 | protein | denotes | LMP1 |
| T49 | 1721-1727 | protein | denotes | EBNA-2 |
| T50 | 1775-1781 | protein | denotes | EBNA-2 |
| T51 | 1801-1805 | protein | denotes | LMP1 |
| T52 | 1841-1847 | protein | denotes | EBNA-2 |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 431-439 | HP_0001909 | denotes | leukemia |
| T2 | 513-531 | HP_0030080 | denotes | Burkitt's lymphoma |
| T3 | 523-531 | HP_0002665 | denotes | lymphoma |
| T4 | 1087-1102 | HP_0012191 | denotes | B-lymphoma cell |
| T5 | 1089-1097 | HP_0002665 | denotes | lymphoma |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 2352328-2#146#150#gene9260 | 478-482 | gene9260 | denotes | LMP1 |
| 2352328-2#99#107#diseaseC0023418 | 431-439 | diseaseC0023418 | denotes | leukemia |
| 2352328-5#147#151#gene9260 | 1023-1027 | gene9260 | denotes | LMP1 |
| 2352328-5#175#179#gene9260 | 1051-1055 | gene9260 | denotes | LMP1 |
| 2352328-5#213#221#diseaseC0024299 | 1089-1097 | diseaseC0024299 | denotes | lymphoma |
| 146#150#gene926099#107#diseaseC0023418 | 2352328-2#146#150#gene9260 | 2352328-2#99#107#diseaseC0023418 | associated_with | LMP1,leukemia |
| 147#151#gene9260213#221#diseaseC0024299 | 2352328-5#147#151#gene9260 | 2352328-5#213#221#diseaseC0024299 | associated_with | LMP1,lymphoma |
| 175#179#gene9260213#221#diseaseC0024299 | 2352328-5#175#179#gene9260 | 2352328-5#213#221#diseaseC0024299 | associated_with | LMP1,lymphoma |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 0-36 | NP | denotes | Epstein-Barr virus nuclear antigen 2 |
| C2 | 52-80 | NP | denotes | latent membrane protein LMP1 |
| C3 | 128-142 | NP | denotes | the hypothesis |
| C4 | 143-147 | NP | denotes | that |
| C5 | 148-199 | NP | denotes | Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA-2) |
| C6 | 203-227 | NP | denotes | leader protein (EBNA-LP) |
| C7 | 250-296 | NP | denotes | the EBV latent infection membrane protein LMP1 |
| C8 | 373-379 | NP | denotes | EBNA-2 |
| C10 | 609-616 | NP | denotes | EBNA-LP |
| C9 | 595-616 | NP | denotes | expression of EBNA-LP |
| C11 | 640-655 | NP | denotes | LMP1 expression |
| C12 | 693-699 | NP | denotes | EBNA-2 |
| C13 | 710-725 | NP | denotes | LMP1 expression |
| C14 | 733-748 | NP | denotes | LMP1 expression |
| C15 | 822-839 | NP | denotes | EBNA-2 expression |
| C17 | 944-948 | NP | denotes | LMP1 |
| C16 | 918-948 | NP | denotes | EBNA-2 transactivation of LMP1 |
| C18 | 985-1010 | NP | denotes | EBNA-2 expression vectors |
| C19 | 1051-1066 | NP | denotes | LMP1 expression |
| C20 | 1184-1208 | NP | denotes | the -512 to +40 LMP1 DNA |
| C21 | 1215-1223 | NP | denotes | this DNA |
| C22 | 1326-1353 | NP | denotes | an EBNA-2 expression vector |
| C23 | 1397-1401 | NP | denotes | LMP1 |
| C24 | 1442-1455 | NP | denotes | Two deletions |
| C25 | 1463-1478 | NP | denotes | the EBNA-2 gene |
| C26 | 1479-1484 | NP | denotes | which |
| C27 | 1547-1551 | NP | denotes | LMP1 |
| C28 | 1629-1633 | NP | denotes | LMP1 |
| C29 | 1635-1639 | NP | denotes | LMP1 |
| C30 | 1721-1727 | NP | denotes | EBNA-2 |
| C32 | 1801-1805 | NP | denotes | LMP1 |
| C31 | 1775-1805 | NP | denotes | EBNA-2 transactivation of LMP1 |
| C33 | 1841-1847 | NP | denotes | EBNA-2 |
| C34 | 1864-1867 | NP | denotes | its |
| R1 | C4 | C3 | coref-relat | that,the hypothesis |
| R2 | C5 | C1 | coref-ident | Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA-2),Epstein-Barr virus nuclear antigen 2 |
| R3 | C7 | C2 | coref-ident | the EBV latent infection membrane protein LMP1,latent membrane protein LMP1 |
| R4 | C8 | C5 | coref-ident | EBNA-2,Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA-2) |
| R5 | C10 | C6 | coref-ident | EBNA-LP,leader protein (EBNA-LP) |
| R6 | C12 | C8 | coref-ident | EBNA-2,EBNA-2 |
| R7 | C13 | C11 | coref-ident | LMP1 expression,LMP1 expression |
| R8 | C14 | C13 | coref-ident | LMP1 expression,LMP1 expression |
| R9 | C15 | C9 | coref-ident | EBNA-2 expression,expression of EBNA-LP |
| R10 | C17 | C7 | coref-ident | LMP1,the EBV latent infection membrane protein LMP1 |
| R11 | C19 | C14 | coref-ident | LMP1 expression,LMP1 expression |
| R12 | C21 | C20 | coref-ident | this DNA,the -512 to +40 LMP1 DNA |
| R13 | C22 | C18 | coref-ident | an EBNA-2 expression vector,EBNA-2 expression vectors |
| R14 | C23 | C17 | coref-ident | LMP1,LMP1 |
| R15 | C25 | C12 | coref-ident | the EBNA-2 gene,EBNA-2 |
| R16 | C26 | C24 | coref-ident | which,Two deletions |
| R17 | C27 | C23 | coref-ident | LMP1,LMP1 |
| R18 | C28 | C27 | coref-ident | LMP1,LMP1 |
| R19 | C29 | C28 | coref-ident | LMP1,LMP1 |
| R20 | C30 | C25 | coref-ident | EBNA-2,the EBNA-2 gene |
| R21 | C32 | C29 | coref-ident | LMP1,LMP1 |
| R22 | C31 | C16 | coref-ident | EBNA-2 transactivation of LMP1,EBNA-2 transactivation of LMP1 |
| R23 | C33 | C30 | coref-ident | EBNA-2,EBNA-2 |
| R24 | C34 | C33 | coref-pron | its,EBNA-2 |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-81 | Sentence | denotes | Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1. |
| S2 | 82-297 | Sentence | denotes | Several lines of evidence are compatible with the hypothesis that Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA-2) or leader protein (EBNA-LP) affects expression of the EBV latent infection membrane protein LMP1. |
| S3 | 298-331 | Sentence | denotes | We now demonstrate the following. |
| S4 | 332-572 | Sentence | denotes | (i) Acute transfection and expression of EBNA-2 under control of simian virus 40 or Moloney murine leukemia virus promoters resulted in increased LMP1 expression in P3HR-1-infected Burkitt's lymphoma cells and the P3HR-1 or Daudi cell line. |
| S5 | 573-726 | Sentence | denotes | (ii) Transfection and expression of EBNA-LP alone had no effect on LMP1 expression and did not act synergistically with EBNA-2 to affect LMP1 expression. |
| S6 | 727-875 | Sentence | denotes | (iii) LMP1 expression in Daudi and P3HR-1-infected cells was controlled at the mRNA level, and EBNA-2 expression in Daudi cells increased LMP1 mRNA. |
| S7 | 876-1133 | Sentence | denotes | (iv) No other EBV genes were required for EBNA-2 transactivation of LMP1 since cotransfection of recombinant EBNA-2 expression vectors and genomic LMP1 DNA fragments enhanced LMP1 expression in the EBV-negative B-lymphoma cell lines BJAB, Louckes, and BL30. |
| S8 | 1134-1354 | Sentence | denotes | (v) An EBNA-2-responsive element was found within the -512 to +40 LMP1 DNA since this DNA linked to a chloramphenicol acetyltransferase reporter gene was transactivated by cotransfection with an EBNA-2 expression vector. |
| S9 | 1355-1435 | Sentence | denotes | (vi) The EBV type 2 EBNA-2 transactivated LMP1 as well as the EBV type 1 EBNA-2. |
| S10 | 1436-1634 | Sentence | denotes | (vii) Two deletions within the EBNA-2 gene which rendered EBV transformation incompetent did not transactivate LMP1, whereas a transformation-competent EBNA-2 deletion mutant did transactivate LMP1. |
| S11 | 1635-1768 | Sentence | denotes | LMP1 is a potent effector of B-lymphocyte activation and can act synergistically with EBNA-2 to induce cellular CD23 gene expression. |
| S12 | 1769-1918 | Sentence | denotes | Thus, EBNA-2 transactivation of LMP1 amplifies the biological impact of EBNA-2 and underscores its central role in EBV-induced growth transformation. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-18 | virus | denotes | Epstein-Barr virus |
| T2 | 52-75 | protein_family_or_group | denotes | latent membrane protein |
| T3 | 76-80 | protein_molecule | denotes | LMP1 |
| T4 | 148-166 | virus | denotes | Epstein-Barr virus |
| T5 | 168-171 | virus | denotes | EBV |
| T6 | 192-198 | protein_molecule | denotes | EBNA-2 |
| T7 | 203-217 | protein_family_or_group | denotes | leader protein |
| T8 | 219-226 | protein_molecule | denotes | EBNA-LP |
| T9 | 254-291 | protein_molecule | denotes | EBV latent infection membrane protein |
| T10 | 292-296 | protein_molecule | denotes | LMP1 |
| T11 | 342-354 | other_name | denotes | transfection |
| T12 | 359-369 | other_name | denotes | expression |
| T13 | 373-379 | protein_molecule | denotes | EBNA-2 |
| T14 | 478-482 | protein_molecule | denotes | LMP1 |
| T15 | 497-537 | cell_line | denotes | P3HR-1-infected Burkitt's lymphoma cells |
| T16 | 546-552 | cell_line | denotes | P3HR-1 |
| T17 | 556-571 | cell_line | denotes | Daudi cell line |
| T18 | 609-616 | protein_molecule | denotes | EBNA-LP |
| T19 | 640-644 | protein_molecule | denotes | LMP1 |
| T20 | 693-699 | protein_molecule | denotes | EBNA-2 |
| T21 | 710-714 | protein_molecule | denotes | LMP1 |
| T22 | 733-737 | protein_molecule | denotes | LMP1 |
| T23 | 752-757 | cell_line | denotes | Daudi |
| T24 | 762-783 | cell_line | denotes | P3HR-1-infected cells |
| T25 | 806-810 | RNA_family_or_group | denotes | mRNA |
| T26 | 822-828 | protein_molecule | denotes | EBNA-2 |
| T27 | 843-854 | cell_line | denotes | Daudi cells |
| T28 | 865-869 | protein_molecule | denotes | LMP1 |
| T29 | 890-899 | DNA_family_or_group | denotes | EBV genes |
| T30 | 918-924 | protein_molecule | denotes | EBNA-2 |
| T31 | 944-948 | protein_molecule | denotes | LMP1 |
| T32 | 955-969 | other_name | denotes | cotransfection |
| T33 | 973-984 | DNA_family_or_group | denotes | recombinant |
| T34 | 985-991 | protein_molecule | denotes | EBNA-2 |
| T35 | 1023-1027 | protein_molecule | denotes | LMP1 |
| T36 | 1051-1055 | protein_molecule | denotes | LMP1 |
| T37 | 1074-1108 | cell_line | denotes | EBV-negative B-lymphoma cell lines |
| T38 | 1109-1113 | cell_line | denotes | BJAB |
| T39 | 1115-1122 | cell_line | denotes | Louckes |
| T40 | 1128-1132 | cell_line | denotes | BL30 |
| T41 | 1141-1147 | protein_molecule | denotes | EBNA-2 |
| T42 | 1188-1199 | DNA_domain_or_region | denotes | -512 to +40 |
| T43 | 1200-1204 | protein_molecule | denotes | LMP1 |
| T44 | 1236-1269 | protein_molecule | denotes | chloramphenicol acetyltransferase |
| T45 | 1306-1320 | other_name | denotes | cotransfection |
| T46 | 1329-1335 | protein_molecule | denotes | EBNA-2 |
| T47 | 1375-1381 | protein_molecule | denotes | EBNA-2 |
| T48 | 1397-1401 | protein_molecule | denotes | LMP1 |
| T49 | 1417-1427 | virus | denotes | EBV type 1 |
| T50 | 1428-1434 | protein_molecule | denotes | EBNA-2 |
| T51 | 1467-1473 | protein_molecule | denotes | EBNA-2 |
| T52 | 1547-1551 | protein_molecule | denotes | LMP1 |
| T53 | 1563-1587 | DNA_molecule | denotes | transformation-competent |
| T54 | 1588-1594 | protein_molecule | denotes | EBNA-2 |
| T55 | 1629-1633 | protein_molecule | denotes | LMP1 |
| T56 | 1635-1639 | protein_molecule | denotes | LMP1 |
| T57 | 1664-1687 | other_name | denotes | B-lymphocyte activation |
| T58 | 1721-1727 | protein_molecule | denotes | EBNA-2 |
| T59 | 1747-1751 | other_name | denotes | CD23 |
| T60 | 1752-1767 | other_name | denotes | gene expression |
| T61 | 1775-1781 | protein_molecule | denotes | EBNA-2 |
| T62 | 1801-1805 | protein_molecule | denotes | LMP1 |
| T63 | 1841-1847 | protein_molecule | denotes | EBNA-2 |
| T64 | 1884-1917 | other_name | denotes | EBV-induced growth transformation |