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Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 612-632 http://purl.obolibrary.org/obo/MAT_0000162 denotes dorsal root ganglion
T2 612-618 http://purl.obolibrary.org/obo/MAT_0000487 denotes dorsal
T3 624-632 http://purl.obolibrary.org/obo/MAT_0000343 denotes ganglion
T4 1176-1196 http://purl.obolibrary.org/obo/MAT_0000162 denotes dorsal root ganglion
T5 1176-1182 http://purl.obolibrary.org/obo/MAT_0000487 denotes dorsal
T6 1188-1196 http://purl.obolibrary.org/obo/MAT_0000343 denotes ganglion

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-118 Sentence denotes Excitation and modulation of TRPA1, TRPV1, and TRPM8 channel-expressing sensory neurons by the pruritogen chloroquine.
TextSentencer_T2 119-189 Sentence denotes The sensations of pain, itch, and cold often interact with each other.
TextSentencer_T3 190-251 Sentence denotes Pain inhibits itch, whereas cold inhibits both pain and itch.
TextSentencer_T4 252-332 Sentence denotes TRPV1 and TRPA1 channels transduce pain and itch, whereas TRPM8 transduces cold.
TextSentencer_T5 333-428 Sentence denotes The pruritogen chloroquine (CQ) was reported to excite TRPA1, leading to the sensation of itch.
TextSentencer_T6 429-569 Sentence denotes It is unclear how CQ excites and modulates TRPA1(+), TRPV1(+), and TRPM8(+) neurons and thus affects the sensations of pain, itch, and cold.
TextSentencer_T7 570-762 Sentence denotes Here, we show that only 43% of CQ-excited dorsal root ganglion neurons expressed TRPA1; as expected, the responses of these neurons were completely prevented by the TRPA1 antagonist HC-030031.
TextSentencer_T8 763-1036 Sentence denotes The remaining 57% of CQ-excited neurons did not express TRPA1, and excitation was not prevented by either a TRPA1 or TRPV1 antagonist but was prevented by the general transient receptor potential canonical (TRPC) channel blocker BTP2 and the selective TRPC3 inhibitor Pyr3.
TextSentencer_T9 1037-1205 Sentence denotes Furthermore, CQ caused potent sensitization of TRPV1 in 51.9% of TRPV1(+) neurons and concomitant inhibition of TRPM8 in 48.8% of TRPM8(+) dorsal root ganglion neurons.
TextSentencer_T10 1206-1343 Sentence denotes Sensitization of TRPV1 is caused mainly by activation of the phospholipase C-PKC pathway following activation of the CQ receptor MrgprA3.
TextSentencer_T11 1344-1466 Sentence denotes By contrast, inhibition of TRPM8 is caused by a direct action of activated Gαq independent of the phospholipase C pathway.
TextSentencer_T12 1467-1575 Sentence denotes Our data suggest the involvement of the TRPC3 channel acting together with TRPA1 to mediate CQ-induced itch.
TextSentencer_T13 1576-1781 Sentence denotes CQ not only elicits itch by directly exciting itch-encoding neurons but also exerts previously unappreciated widespread actions on pain-, itch-, and cold-sensing neurons, leading to enhanced pain and itch.
T1 0-118 Sentence denotes Excitation and modulation of TRPA1, TRPV1, and TRPM8 channel-expressing sensory neurons by the pruritogen chloroquine.
T2 119-189 Sentence denotes The sensations of pain, itch, and cold often interact with each other.
T3 190-251 Sentence denotes Pain inhibits itch, whereas cold inhibits both pain and itch.
T4 252-332 Sentence denotes TRPV1 and TRPA1 channels transduce pain and itch, whereas TRPM8 transduces cold.
T5 333-428 Sentence denotes The pruritogen chloroquine (CQ) was reported to excite TRPA1, leading to the sensation of itch.
T6 429-569 Sentence denotes It is unclear how CQ excites and modulates TRPA1(+), TRPV1(+), and TRPM8(+) neurons and thus affects the sensations of pain, itch, and cold.
T7 570-762 Sentence denotes Here, we show that only 43% of CQ-excited dorsal root ganglion neurons expressed TRPA1; as expected, the responses of these neurons were completely prevented by the TRPA1 antagonist HC-030031.
T8 763-1036 Sentence denotes The remaining 57% of CQ-excited neurons did not express TRPA1, and excitation was not prevented by either a TRPA1 or TRPV1 antagonist but was prevented by the general transient receptor potential canonical (TRPC) channel blocker BTP2 and the selective TRPC3 inhibitor Pyr3.
T9 1037-1205 Sentence denotes Furthermore, CQ caused potent sensitization of TRPV1 in 51.9% of TRPV1(+) neurons and concomitant inhibition of TRPM8 in 48.8% of TRPM8(+) dorsal root ganglion neurons.
T10 1206-1343 Sentence denotes Sensitization of TRPV1 is caused mainly by activation of the phospholipase C-PKC pathway following activation of the CQ receptor MrgprA3.
T11 1344-1466 Sentence denotes By contrast, inhibition of TRPM8 is caused by a direct action of activated Gαq independent of the phospholipase C pathway.
T12 1467-1575 Sentence denotes Our data suggest the involvement of the TRPC3 channel acting together with TRPA1 to mediate CQ-induced itch.
T13 1576-1781 Sentence denotes CQ not only elicits itch by directly exciting itch-encoding neurons but also exerts previously unappreciated widespread actions on pain-, itch-, and cold-sensing neurons, leading to enhanced pain and itch.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1084-1089 gene:7442 denotes TRPV1
T1 1188-1196 disease:C0085648 denotes ganglion
T2 1084-1089 gene:7442 denotes TRPV1
T3 1188-1196 disease:C1258666 denotes ganglion
T4 1102-1107 gene:7442 denotes TRPV1
T5 1188-1196 disease:C0085648 denotes ganglion
T6 1102-1107 gene:7442 denotes TRPV1
T7 1188-1196 disease:C1258666 denotes ganglion
T8 1149-1154 gene:79054 denotes TRPM8
T9 1188-1196 disease:C0085648 denotes ganglion
T10 1149-1154 gene:79054 denotes TRPM8
T11 1188-1196 disease:C1258666 denotes ganglion
T12 1167-1172 gene:79054 denotes TRPM8
T13 1188-1196 disease:C0085648 denotes ganglion
T14 1167-1172 gene:79054 denotes TRPM8
T15 1188-1196 disease:C1258666 denotes ganglion
R1 T0 T1 associated_with TRPV1,ganglion
R2 T2 T3 associated_with TRPV1,ganglion
R3 T4 T5 associated_with TRPV1,ganglion
R4 T6 T7 associated_with TRPV1,ganglion
R5 T8 T9 associated_with TRPM8,ganglion
R6 T10 T11 associated_with TRPM8,ganglion
R7 T12 T13 associated_with TRPM8,ganglion
R8 T14 T15 associated_with TRPM8,ganglion

Allie

Id Subject Object Predicate Lexical cue
SS1_23508958_4_0 348-359 expanded denotes chloroquine
SS2_23508958_4_0 361-363 abbr denotes CQ
SS1_23508958_7_0 930-968 expanded denotes transient receptor potential canonical
SS2_23508958_7_0 970-974 abbr denotes TRPC
AE1_23508958_4_0 SS1_23508958_4_0 SS2_23508958_4_0 abbreviatedTo chloroquine,CQ
AE1_23508958_7_0 SS1_23508958_7_0 SS2_23508958_7_0 abbreviatedTo transient receptor potential canonical,TRPC

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 137-141 HP_0012531 denotes pain
T2 190-194 HP_0012531 denotes Pain
T3 237-241 HP_0012531 denotes pain
T4 287-291 HP_0012531 denotes pain
T5 548-552 HP_0012531 denotes pain
T6 1707-1711 HP_0012531 denotes pain
T7 1767-1771 HP_0012531 denotes pain

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23508958-3#0#5#gene7442 252-257 gene7442 denotes TRPV1
23508958-3#10#15#gene8989 262-267 gene8989 denotes TRPA1
23508958-3#35#39#diseaseC0030193 287-291 diseaseC0030193 denotes pain
23508958-5#67#72#gene79054 496-501 gene79054 denotes TRPM8
23508958-5#119#123#diseaseC0030193 548-552 diseaseC0030193 denotes pain
23508958-6#81#86#gene8989 651-656 gene8989 denotes TRPA1
23508958-6#54#62#diseaseC0085648 624-632 diseaseC0085648 denotes ganglion
23508958-6#54#62#diseaseC1258666 624-632 diseaseC1258666 denotes ganglion
23508958-8#47#52#gene7442 1084-1089 gene7442 denotes TRPV1
23508958-8#65#70#gene7442 1102-1107 gene7442 denotes TRPV1
23508958-8#112#117#gene79054 1149-1154 gene79054 denotes TRPM8
23508958-8#130#135#gene79054 1167-1172 gene79054 denotes TRPM8
23508958-8#151#159#diseaseC0085648 1188-1196 diseaseC0085648 denotes ganglion
23508958-8#151#159#diseaseC1258666 1188-1196 diseaseC1258666 denotes ganglion
23508958-8#151#159#diseaseC0085648 1188-1196 diseaseC0085648 denotes ganglion
23508958-8#151#159#diseaseC1258666 1188-1196 diseaseC1258666 denotes ganglion
23508958-8#151#159#diseaseC0085648 1188-1196 diseaseC0085648 denotes ganglion
23508958-8#151#159#diseaseC1258666 1188-1196 diseaseC1258666 denotes ganglion
23508958-8#151#159#diseaseC0085648 1188-1196 diseaseC0085648 denotes ganglion
23508958-8#151#159#diseaseC1258666 1188-1196 diseaseC1258666 denotes ganglion
0#5#gene744235#39#diseaseC0030193 23508958-3#0#5#gene7442 23508958-3#35#39#diseaseC0030193 associated_with TRPV1,pain
10#15#gene898935#39#diseaseC0030193 23508958-3#10#15#gene8989 23508958-3#35#39#diseaseC0030193 associated_with TRPA1,pain
67#72#gene79054119#123#diseaseC0030193 23508958-5#67#72#gene79054 23508958-5#119#123#diseaseC0030193 associated_with TRPM8,pain
81#86#gene898954#62#diseaseC0085648 23508958-6#81#86#gene8989 23508958-6#54#62#diseaseC0085648 associated_with TRPA1,ganglion
81#86#gene898954#62#diseaseC1258666 23508958-6#81#86#gene8989 23508958-6#54#62#diseaseC1258666 associated_with TRPA1,ganglion
47#52#gene7442151#159#diseaseC0085648 23508958-8#47#52#gene7442 23508958-8#151#159#diseaseC0085648 associated_with TRPV1,ganglion
47#52#gene7442151#159#diseaseC1258666 23508958-8#47#52#gene7442 23508958-8#151#159#diseaseC1258666 associated_with TRPV1,ganglion
47#52#gene7442151#159#diseaseC0085648 23508958-8#47#52#gene7442 23508958-8#151#159#diseaseC0085648 associated_with TRPV1,ganglion
47#52#gene7442151#159#diseaseC1258666 23508958-8#47#52#gene7442 23508958-8#151#159#diseaseC1258666 associated_with TRPV1,ganglion
47#52#gene7442151#159#diseaseC0085648 23508958-8#47#52#gene7442 23508958-8#151#159#diseaseC0085648 associated_with TRPV1,ganglion
47#52#gene7442151#159#diseaseC1258666 23508958-8#47#52#gene7442 23508958-8#151#159#diseaseC1258666 associated_with TRPV1,ganglion
47#52#gene7442151#159#diseaseC0085648 23508958-8#47#52#gene7442 23508958-8#151#159#diseaseC0085648 associated_with TRPV1,ganglion
47#52#gene7442151#159#diseaseC1258666 23508958-8#47#52#gene7442 23508958-8#151#159#diseaseC1258666 associated_with TRPV1,ganglion
65#70#gene7442151#159#diseaseC0085648 23508958-8#65#70#gene7442 23508958-8#151#159#diseaseC0085648 associated_with TRPV1,ganglion
65#70#gene7442151#159#diseaseC1258666 23508958-8#65#70#gene7442 23508958-8#151#159#diseaseC1258666 associated_with TRPV1,ganglion
65#70#gene7442151#159#diseaseC0085648 23508958-8#65#70#gene7442 23508958-8#151#159#diseaseC0085648 associated_with TRPV1,ganglion
65#70#gene7442151#159#diseaseC1258666 23508958-8#65#70#gene7442 23508958-8#151#159#diseaseC1258666 associated_with TRPV1,ganglion
65#70#gene7442151#159#diseaseC0085648 23508958-8#65#70#gene7442 23508958-8#151#159#diseaseC0085648 associated_with TRPV1,ganglion
65#70#gene7442151#159#diseaseC1258666 23508958-8#65#70#gene7442 23508958-8#151#159#diseaseC1258666 associated_with TRPV1,ganglion
65#70#gene7442151#159#diseaseC0085648 23508958-8#65#70#gene7442 23508958-8#151#159#diseaseC0085648 associated_with TRPV1,ganglion
65#70#gene7442151#159#diseaseC1258666 23508958-8#65#70#gene7442 23508958-8#151#159#diseaseC1258666 associated_with TRPV1,ganglion
112#117#gene79054151#159#diseaseC0085648 23508958-8#112#117#gene79054 23508958-8#151#159#diseaseC0085648 associated_with TRPM8,ganglion
112#117#gene79054151#159#diseaseC1258666 23508958-8#112#117#gene79054 23508958-8#151#159#diseaseC1258666 associated_with TRPM8,ganglion
112#117#gene79054151#159#diseaseC0085648 23508958-8#112#117#gene79054 23508958-8#151#159#diseaseC0085648 associated_with TRPM8,ganglion
112#117#gene79054151#159#diseaseC1258666 23508958-8#112#117#gene79054 23508958-8#151#159#diseaseC1258666 associated_with TRPM8,ganglion
112#117#gene79054151#159#diseaseC0085648 23508958-8#112#117#gene79054 23508958-8#151#159#diseaseC0085648 associated_with TRPM8,ganglion
112#117#gene79054151#159#diseaseC1258666 23508958-8#112#117#gene79054 23508958-8#151#159#diseaseC1258666 associated_with TRPM8,ganglion
112#117#gene79054151#159#diseaseC0085648 23508958-8#112#117#gene79054 23508958-8#151#159#diseaseC0085648 associated_with TRPM8,ganglion
112#117#gene79054151#159#diseaseC1258666 23508958-8#112#117#gene79054 23508958-8#151#159#diseaseC1258666 associated_with TRPM8,ganglion
130#135#gene79054151#159#diseaseC0085648 23508958-8#130#135#gene79054 23508958-8#151#159#diseaseC0085648 associated_with TRPM8,ganglion
130#135#gene79054151#159#diseaseC1258666 23508958-8#130#135#gene79054 23508958-8#151#159#diseaseC1258666 associated_with TRPM8,ganglion
130#135#gene79054151#159#diseaseC0085648 23508958-8#130#135#gene79054 23508958-8#151#159#diseaseC0085648 associated_with TRPM8,ganglion
130#135#gene79054151#159#diseaseC1258666 23508958-8#130#135#gene79054 23508958-8#151#159#diseaseC1258666 associated_with TRPM8,ganglion
130#135#gene79054151#159#diseaseC0085648 23508958-8#130#135#gene79054 23508958-8#151#159#diseaseC0085648 associated_with TRPM8,ganglion
130#135#gene79054151#159#diseaseC1258666 23508958-8#130#135#gene79054 23508958-8#151#159#diseaseC1258666 associated_with TRPM8,ganglion
130#135#gene79054151#159#diseaseC0085648 23508958-8#130#135#gene79054 23508958-8#151#159#diseaseC0085648 associated_with TRPM8,ganglion
130#135#gene79054151#159#diseaseC1258666 23508958-8#130#135#gene79054 23508958-8#151#159#diseaseC1258666 associated_with TRPM8,ganglion

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T453 651-656 gene:8989 denotes TRPA1
T454 624-632 disease:C0085648 denotes ganglion
T455 1084-1089 gene:7442 denotes TRPV1
T456 1188-1196 disease:C0085648 denotes ganglion
T457 1102-1107 gene:7442 denotes TRPV1
T458 1149-1154 gene:79054 denotes TRPM8
T459 1167-1172 gene:79054 denotes TRPM8
R1 T453 T454 associated_with TRPA1,ganglion
R2 T453 T454 associated_with TRPA1,ganglion
R3 T455 T456 associated_with TRPV1,ganglion
R4 T455 T456 associated_with TRPV1,ganglion
R5 T457 T456 associated_with TRPV1,ganglion
R6 T457 T456 associated_with TRPV1,ganglion
R7 T458 T456 associated_with TRPM8,ganglion
R8 T458 T456 associated_with TRPM8,ganglion
R9 T459 T456 associated_with TRPM8,ganglion
R10 T459 T456 associated_with TRPM8,ganglion

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 612-632 http://purl.obolibrary.org/obo/UBERON_0000044 denotes dorsal root ganglion
PD-UBERON-AE-B_T2 1176-1196 http://purl.obolibrary.org/obo/UBERON_0000044 denotes dorsal root ganglion
PD-UBERON-AE-B_T3 624-632 http://purl.obolibrary.org/obo/UBERON_0000045 denotes ganglion
PD-UBERON-AE-B_T4 1188-1196 http://purl.obolibrary.org/obo/UBERON_0000045 denotes ganglion

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 80-87 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neurons
PD-UBERON-AE-B_T2 505-512 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neurons
PD-UBERON-AE-B_T3 633-640 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neurons
PD-UBERON-AE-B_T4 694-701 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neurons
PD-UBERON-AE-B_T5 795-802 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neurons
PD-UBERON-AE-B_T6 1111-1118 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neurons
PD-UBERON-AE-B_T7 1197-1204 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neurons
PD-UBERON-AE-B_T8 1636-1643 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neurons
PD-UBERON-AE-B_T9 1738-1745 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neurons
PD-UBERON-AE-B_T10 612-632 http://purl.obolibrary.org/obo/UBERON_0000044 denotes dorsal root ganglion
PD-UBERON-AE-B_T11 1176-1196 http://purl.obolibrary.org/obo/UBERON_0000044 denotes dorsal root ganglion
PD-UBERON-AE-B_T12 624-632 http://purl.obolibrary.org/obo/UBERON_0000045 denotes ganglion
PD-UBERON-AE-B_T13 1188-1196 http://purl.obolibrary.org/obo/UBERON_0000045 denotes ganglion

PMID_GLOBAL

Id Subject Object Predicate Lexical cue uberon_id
T1 612-632 Body_part denotes dorsal root ganglion http://purl.obolibrary.org/obo/UBERON_0000044
T2 1176-1196 Body_part denotes dorsal root ganglion http://purl.obolibrary.org/obo/UBERON_0000044

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 612-632 Body_part denotes dorsal root ganglion http://purl.obolibrary.org/obo/MAT_0000162
T2 1176-1196 Body_part denotes dorsal root ganglion http://purl.obolibrary.org/obo/MAT_0000162

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 137-141 Phenotype denotes pain HP:0012531
T2 190-194 Phenotype denotes Pain HP:0012531
T3 237-241 Phenotype denotes pain HP:0012531
T4 287-291 Phenotype denotes pain HP:0012531
T5 548-552 Phenotype denotes pain HP:0012531
T6 1707-1711 Phenotype denotes pain HP:0012531
T7 1767-1771 Phenotype denotes pain HP:0012531

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 72-87 Body_part denotes sensory neurons http://purl.obolibrary.org/obo/CL_0000101
T2 612-632 Body_part denotes dorsal root ganglion http://purl.obolibrary.org/obo/UBERON_0000044
T3 1176-1196 Body_part denotes dorsal root ganglion http://purl.obolibrary.org/obo/UBERON_0000044

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 72-87 Cell denotes sensory neurons http://purl.obolibrary.org/obo/CL:0000101
T2 505-512 Cell denotes neurons http://purl.obolibrary.org/obo/CL:0000540
T3 633-640 Cell denotes neurons http://purl.obolibrary.org/obo/CL:0000540
T4 694-701 Cell denotes neurons http://purl.obolibrary.org/obo/CL:0000540
T5 795-802 Cell denotes neurons http://purl.obolibrary.org/obo/CL:0000540
T6 1111-1118 Cell denotes neurons http://purl.obolibrary.org/obo/CL:0000540
T7 1197-1204 Cell denotes neurons http://purl.obolibrary.org/obo/CL:0000540
T8 1636-1643 Cell denotes neurons http://purl.obolibrary.org/obo/CL:0000540
T9 1738-1745 Cell denotes neurons http://purl.obolibrary.org/obo/CL:0000540