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PubMed:23477322 JSONTXT

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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 85-101 HP_0003002 denotes breast carcinoma
T2 354-363 HP_0002664 denotes neoplasms
T3 473-486 HP_0003002 denotes breast cancer
T4 473-486 HP_0100013 denotes breast cancer
T5 480-486 HP_0002664 denotes cancer
T6 895-908 HP_0003002 denotes breast cancer
T7 895-908 HP_0100013 denotes breast cancer
T8 902-908 HP_0002664 denotes cancer

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-72 DRI_Approach denotes Attacking breast cancer at the preinvasion stage by targeting autophagy.
T2 73-235 DRI_Background denotes Preinvasive breast carcinoma cells that proliferate and accumulate within the nonvascular, closed intraductal niche are under severe hypoxic and metabolic stress.
T3 236-364 DRI_Background denotes Understanding the survival mechanisms used by these cells has revealed therapeutic strategies for killing preinvasive neoplasms.
T4 365-503 DRI_Approach denotes We have found that autophagy ('self-eating') is a major survival strategy used by preinvasive carcinoma and breast cancer stem-like cells.
T5 504-657 DRI_Approach denotes Based on this finding, we have opened a clinical trial that is exploring neoadjuvant oral chloroquine antiautophagy therapy for ductal carcinoma in situ.
T6 658-926 DRI_Challenge denotes We envision that antiautophagy therapy can be administered in combination with other treatments such as those that elevate intracellular calcium, to create a state of intolerable stress for preinvasive neoplastic cells, and thereby stop breast cancer before it starts.