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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 124-539 BACKGROUND denotes Recent studies have demonstrated an association between insulin growth factor (IGF) and insulin growth factor binding protein-3 (IGFBP-III) serum levels and increased risk for various cancers. However, little information is available on clinical implications of the IGF system in Indian patients with cervical cancer. This study explored associations by analyzing their expression profiles in cervical cancer cases.
T2 563-868 METHODS denotes Totals of 50 patients with advanced cervical cancer and 40 healthy controls were enrolled. Human papillomavirus (HPV) and cervical biopsy sample were obtained from all participating women. Circulatory levels were estimated by ELISA and the tissue expression was assessed using RT-PCR and Western blotting.
T3 878-1105 RESULTS denotes Levels of IGF-I and II showed significant increase whereas IGFBP-III showed significant decline in all patients as compared to controls. Spearman correlation analysis between IGFs and HPV status showed significant correlations.
T4 1119-1553 CONCLUSIONS denotes We demonstrated elevated circulating levels and tissue expression of IGF-I and IGF-II in advancer cancer cervix patients, as compared with controls, with a converse trend being apparent for IGFBP-III. In future, associations of the IGF system and clinical outcome of cervical cancer patients in post treatment samples might point to significance in disease mapping as a prognostic marker after validation with a larger patient series.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 40-47 gene:723961 denotes insulin
T1 95-110 disease:C0007847 denotes cervical cancer
T2 40-47 gene:723961 denotes insulin
T3 95-110 disease:C0302592 denotes cervical cancer
T4 40-47 gene:3630 denotes insulin
T5 95-110 disease:C0007847 denotes cervical cancer
T6 40-47 gene:3630 denotes insulin
T7 95-110 disease:C0302592 denotes cervical cancer
T8 180-187 gene:723961 denotes insulin
T9 308-315 disease:C0006826 denotes cancers
T10 253-262 gene:3486 denotes IGFBP-III
T11 308-315 disease:C0006826 denotes cancers
T12 212-219 gene:723961 denotes insulin
T13 308-315 disease:C0006826 denotes cancers
T14 212-219 gene:3630 denotes insulin
T15 308-315 disease:C0006826 denotes cancers
T16 242-251 gene:8988 denotes protein-3
T17 308-315 disease:C0006826 denotes cancers
T18 180-187 gene:3630 denotes insulin
T19 308-315 disease:C0006826 denotes cancers
T20 1198-1204 gene:3481 denotes IGF-II
T21 1217-1230 disease:C0302592 denotes cancer cervix
R1 T0 T1 associated_with insulin,cervical cancer
R2 T2 T3 associated_with insulin,cervical cancer
R3 T4 T5 associated_with insulin,cervical cancer
R4 T6 T7 associated_with insulin,cervical cancer
R5 T8 T9 associated_with insulin,cancers
R6 T10 T11 associated_with IGFBP-III,cancers
R7 T12 T13 associated_with insulin,cancers
R8 T14 T15 associated_with insulin,cancers
R9 T16 T17 associated_with protein-3,cancers
R10 T18 T19 associated_with insulin,cancers
R11 T20 T21 associated_with IGF-II,cancer cervix

Allie

Id Subject Object Predicate Lexical cue
SS1_23464477_2_0 180-201 expanded denotes insulin growth factor
SS2_23464477_2_0 203-206 abbr denotes IGF
SS1_23464477_2_1 212-251 expanded denotes insulin growth factor binding protein-3
SS2_23464477_2_1 253-262 abbr denotes IGFBP-III
SS1_23464477_7_0 654-674 expanded denotes Human papillomavirus
SS2_23464477_7_0 676-679 abbr denotes HPV
AE1_23464477_2_0 SS1_23464477_2_0 SS2_23464477_2_0 abbreviatedTo insulin growth factor,IGF
AE1_23464477_2_1 SS1_23464477_2_1 SS2_23464477_2_1 abbreviatedTo insulin growth factor binding protein-3,IGFBP-III
AE1_23464477_7_0 SS1_23464477_7_0 SS2_23464477_7_0 abbreviatedTo Human papillomavirus,HPV

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 308-315 HP_0002664 denotes cancers
T2 425-440 HP_0030079 denotes cervical cancer
T3 434-440 HP_0002664 denotes cancer
T4 517-532 HP_0030079 denotes cervical cancer
T5 526-532 HP_0002664 denotes cancer