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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-127 Sentence denotes Association of polymorphisms in the leptin and leptin receptor genes with inflammatory mediators in patients with osteoporosis.
T2 128-206 Sentence denotes Bone mass and inflammation are implicated in the pathogenesis of osteoporosis.
T3 207-337 Sentence denotes We hypothesized that leptin and leptin receptor gene might be associated with osteoporosis by activating the inflammatory pathway.
T4 338-555 Sentence denotes Therefore, we analyzed polymorphisms of the leptin (gene symbol, LEP) and leptin receptor (gene symbol, LEPR) genes and determined their associations with proinflammatory cytokine levels in patients with osteoporosis.
T5 556-748 Sentence denotes We assessed polymorphisms in LEP (-2548G > A) and LEPR (Lys109Arg, Gln223Arg, and Lys656Asn) and calculated odds ratios for the genotype and allele distributions between patients and controls.
T6 749-992 Sentence denotes Serum leptin, soluble leptin receptor, interleukin (IL)-1, IL-6, IL-7, and tumor necrosis factor (TNF) levels were measured by enzyme-linked immunosorbent assays (ELISA) and were verified by in vitro lymphocyte proliferation assays and ELISAs.
T7 993-1116 Sentence denotes We found a higher frequency of the A allele for LEP at -2548 in patients with osteoporosis compared with the control group.
T8 1117-1279 Sentence denotes The A allele was associated with differences in serum leptin, soluble leptin receptor, IL-1, IL-6, and TNF levels compared with the wild-type G allele (p < 0.05).
T9 1280-1509 Sentence denotes The G allele in Lys109Arg and Gln223Arg was associated with increased risk of osteoporosis and with differences in serum leptin, soluble leptin receptor, IL-1, IL-6, and TNF levels compared with the wild-type A allele (p < 0.05).
T10 1510-1582 Sentence denotes The Lys656Asn genotype was not associated with the risk of osteoporosis.
T11 1583-1659 Sentence denotes In vitro lymphocyte proliferation assays and ELISAs confirmed these results.
T12 1660-1809 Sentence denotes Polymorphisms in LEP and LEPR are associated with increased risk of osteoporosis, possibly by increasing the expression of proinflammatory cytokines.
T1 0-127 Sentence denotes Association of polymorphisms in the leptin and leptin receptor genes with inflammatory mediators in patients with osteoporosis.
T2 128-206 Sentence denotes Bone mass and inflammation are implicated in the pathogenesis of osteoporosis.
T3 207-337 Sentence denotes We hypothesized that leptin and leptin receptor gene might be associated with osteoporosis by activating the inflammatory pathway.
T4 338-555 Sentence denotes Therefore, we analyzed polymorphisms of the leptin (gene symbol, LEP) and leptin receptor (gene symbol, LEPR) genes and determined their associations with proinflammatory cytokine levels in patients with osteoporosis.
T5 556-748 Sentence denotes We assessed polymorphisms in LEP (-2548G > A) and LEPR (Lys109Arg, Gln223Arg, and Lys656Asn) and calculated odds ratios for the genotype and allele distributions between patients and controls.
T6 749-992 Sentence denotes Serum leptin, soluble leptin receptor, interleukin (IL)-1, IL-6, IL-7, and tumor necrosis factor (TNF) levels were measured by enzyme-linked immunosorbent assays (ELISA) and were verified by in vitro lymphocyte proliferation assays and ELISAs.
T7 993-1116 Sentence denotes We found a higher frequency of the A allele for LEP at -2548 in patients with osteoporosis compared with the control group.
T8 1117-1279 Sentence denotes The A allele was associated with differences in serum leptin, soluble leptin receptor, IL-1, IL-6, and TNF levels compared with the wild-type G allele (p < 0.05).
T9 1280-1509 Sentence denotes The G allele in Lys109Arg and Gln223Arg was associated with increased risk of osteoporosis and with differences in serum leptin, soluble leptin receptor, IL-1, IL-6, and TNF levels compared with the wild-type A allele (p < 0.05).
T10 1510-1582 Sentence denotes The Lys656Asn genotype was not associated with the risk of osteoporosis.
T11 1583-1659 Sentence denotes In vitro lymphocyte proliferation assays and ELISAs confirmed these results.
T12 1660-1809 Sentence denotes Polymorphisms in LEP and LEPR are associated with increased risk of osteoporosis, possibly by increasing the expression of proinflammatory cytokines.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 36-42 gene:3952 denotes leptin
T1 114-126 disease:C0029456 denotes osteoporosis
T2 47-62 gene:3953 denotes leptin receptor
T3 114-126 disease:C0029456 denotes osteoporosis
T4 239-254 gene:3953 denotes leptin receptor
T5 285-297 disease:C0029456 denotes osteoporosis
T6 228-234 gene:3952 denotes leptin
T7 285-297 disease:C0029456 denotes osteoporosis
T8 442-446 gene:3953 denotes LEPR
T9 542-554 disease:C0029456 denotes osteoporosis
T10 412-427 gene:3953 denotes leptin receptor
T11 542-554 disease:C0029456 denotes osteoporosis
T12 403-406 gene:3952 denotes LEP
T13 542-554 disease:C0029456 denotes osteoporosis
T14 382-388 gene:3952 denotes leptin
T15 542-554 disease:C0029456 denotes osteoporosis
T16 442-446 gene:54741 denotes LEPR
T17 542-554 disease:C0029456 denotes osteoporosis
T18 1041-1044 gene:3952 denotes LEP
T19 1071-1083 disease:C0029456 denotes osteoporosis
T20 1401-1407 gene:3952 denotes leptin
T21 1358-1370 disease:C0029456 denotes osteoporosis
R1 T0 T1 associated_with leptin,osteoporosis
R2 T2 T3 associated_with leptin receptor,osteoporosis
R3 T4 T5 associated_with leptin receptor,osteoporosis
R4 T6 T7 associated_with leptin,osteoporosis
R5 T8 T9 associated_with LEPR,osteoporosis
R6 T10 T11 associated_with leptin receptor,osteoporosis
R7 T12 T13 associated_with LEP,osteoporosis
R8 T14 T15 associated_with leptin,osteoporosis
R9 T16 T17 associated_with LEPR,osteoporosis
R10 T18 T19 associated_with LEP,osteoporosis
R11 T20 T21 associated_with leptin,osteoporosis

Allie

Id Subject Object Predicate Lexical cue
SS1_23460508_5_0 788-799 expanded denotes interleukin
SS2_23460508_5_0 801-803 abbr denotes IL
SS1_23460508_5_1 824-845 expanded denotes tumor necrosis factor
SS2_23460508_5_1 847-850 abbr denotes TNF
SS1_23460508_5_2 876-910 expanded denotes enzyme-linked immunosorbent assays
SS2_23460508_5_2 912-917 abbr denotes ELISA
AE1_23460508_5_0 SS1_23460508_5_0 SS2_23460508_5_0 abbreviatedTo interleukin,IL
AE1_23460508_5_1 SS1_23460508_5_1 SS2_23460508_5_1 abbreviatedTo tumor necrosis factor,TNF
AE1_23460508_5_2 SS1_23460508_5_2 SS2_23460508_5_2 abbreviatedTo enzyme-linked immunosorbent assays,ELISA

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 193-205 HP_0000939 denotes osteoporosis
T2 285-297 HP_0000939 denotes osteoporosis
T3 542-554 HP_0000939 denotes osteoporosis
T4 824-829 HP_0002664 denotes tumor
T5 1071-1083 HP_0000939 denotes osteoporosis
T6 1358-1370 HP_0000939 denotes osteoporosis
T7 1569-1581 HP_0000939 denotes osteoporosis
T8 1728-1740 HP_0000939 denotes osteoporosis

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
23460508-8#16#25#geners1137100 1296-1305 geners1137100 denotes Lys109Arg
23460508-8#30#39#geners1137101 1310-1319 geners1137101 denotes Gln223Arg
23460508-8#78#90#diseaseC0029456 1358-1370 diseaseC0029456 denotes osteoporosis
23460508-9#4#13#geners1805094 1514-1523 geners1805094 denotes Lys656Asn
23460508-9#59#71#diseaseC0029456 1569-1581 diseaseC0029456 denotes osteoporosis
16#25#geners113710078#90#diseaseC0029456 23460508-8#16#25#geners1137100 23460508-8#78#90#diseaseC0029456 associated_with Lys109Arg,osteoporosis
30#39#geners113710178#90#diseaseC0029456 23460508-8#30#39#geners1137101 23460508-8#78#90#diseaseC0029456 associated_with Gln223Arg,osteoporosis
4#13#geners180509459#71#diseaseC0029456 23460508-9#4#13#geners1805094 23460508-9#59#71#diseaseC0029456 associated_with Lys656Asn,osteoporosis

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23460508-0#47#62#gene3953 47-62 gene3953 denotes leptin receptor
23460508-0#114#126#diseaseC0029456 114-126 diseaseC0029456 denotes osteoporosis
23460508-11#17#20#gene3952 1677-1680 gene3952 denotes LEP
23460508-11#68#80#diseaseC0029456 1728-1740 diseaseC0029456 denotes osteoporosis
23460508-8#170#173#gene7124 1450-1453 gene7124 denotes TNF
23460508-8#78#90#diseaseC0029456 1358-1370 diseaseC0029456 denotes osteoporosis
47#62#gene3953114#126#diseaseC0029456 23460508-0#47#62#gene3953 23460508-0#114#126#diseaseC0029456 associated_with leptin receptor,osteoporosis
17#20#gene395268#80#diseaseC0029456 23460508-11#17#20#gene3952 23460508-11#68#80#diseaseC0029456 associated_with LEP,osteoporosis
170#173#gene712478#90#diseaseC0029456 23460508-8#170#173#gene7124 23460508-8#78#90#diseaseC0029456 associated_with TNF,osteoporosis