PubMed:23443134
Annnotations
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_23443134_0_0 | 18-46 | expanded | denotes | O-linked N-acetylglucosamine |
| SS2_23443134_0_0 | 48-56 | abbr | denotes | O-GlcNAc |
| SS1_23443134_1_0 | 216-246 | expanded | denotes | β-O-linked N-acetylglucosamine |
| SS2_23443134_1_0 | 248-256 | abbr | denotes | O-GlcNAc |
| SS1_23443134_7_0 | 1483-1506 | expanded | denotes | TGFβ-activated kinase 1 |
| SS2_23443134_7_0 | 1508-1512 | abbr | denotes | TAK1 |
| AE1_23443134_0_0 | SS1_23443134_0_0 | SS2_23443134_0_0 | abbreviatedTo | O-linked N-acetylglucosamine,O-GlcNAc |
| AE1_23443134_1_0 | SS1_23443134_1_0 | SS2_23443134_1_0 | abbreviatedTo | β-O-linked N-acetylglucosamine,O-GlcNAc |
| AE1_23443134_7_0 | SS1_23443134_7_0 | SS2_23443134_7_0 | abbreviatedTo | TGFβ-activated kinase 1,TAK1 |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 488-498 | HP_0011846 | denotes | osteoblast |
| T2 | 692-703 | HP_0011846 | denotes | osteoblasts |
NGLY1-deficiency
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-NGLY1-deficiency-B_T1 | 27-46 | chem:24139 | denotes | N-acetylglucosamine |
| PD-NGLY1-deficiency-B_T2 | 50-56 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T3 | 227-246 | chem:24139 | denotes | N-acetylglucosamine |
| PD-NGLY1-deficiency-B_T4 | 250-256 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T5 | 434-440 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T6 | 646-652 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T7 | 707-713 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T8 | 997-1003 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T9 | 1025-1031 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T10 | 1721-1727 | chem:24139 | denotes | GlcNAc |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 48-56 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T2 | 248-256 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T3 | 432-440 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T4 | 644-652 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T5 | 705-713 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T6 | 995-1003 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T7 | 1023-1031 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T8 | 1719-1727 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1797-1805 | Disease | denotes | fracture | http://purl.obolibrary.org/obo/MONDO_0005315 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 48-56 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T2 | 248-256 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T3 | 432-440 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T4 | 644-652 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T5 | 705-713 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T6 | 995-1003 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T7 | 1023-1031 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
| T8 | 1719-1727 | Glycan | denotes | O-GlcNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G49108TO |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 48-56 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T2 | 248-256 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T3 | 432-440 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T4 | 644-652 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T5 | 705-713 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T6 | 995-1003 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T7 | 1023-1031 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T8 | 1719-1727 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 67-77 | Cell | denotes | osteoblast | http://purl.obolibrary.org/obo/CL:0000062 |
| T2 | 488-498 | Cell | denotes | osteoblast | http://purl.obolibrary.org/obo/CL:0000062 |
| T3 | 692-703 | Cell | denotes | osteoblasts | http://purl.obolibrary.org/obo/CL:0000062 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 67-77 | Body_part | denotes | osteoblast | http://purl.obolibrary.org/obo/CL_0000062 |
| T2 | 176-180 | Body_part | denotes | bone | http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481 |
| T4 | 488-498 | Body_part | denotes | osteoblast | http://purl.obolibrary.org/obo/CL_0000062 |
| T5 | 692-703 | Body_part | denotes | osteoblasts | http://purl.obolibrary.org/obo/CL_0000062 |
| T6 | 1765-1769 | Body_part | denotes | bone | http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481 |
GlyCosmos15-Taxon
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 749-754 | Organism | denotes | wheat | 4565 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-191 | Sentence | denotes | Identification of O-linked N-acetylglucosamine (O-GlcNAc)-modified osteoblast proteins by electron transfer dissociation tandem mass spectrometry reveals proteins critical for bone formation. |
| T2 | 192-400 | Sentence | denotes | The nutrient-responsive β-O-linked N-acetylglucosamine (O-GlcNAc) modification of critical effector proteins modulates signaling and transcriptional pathways contributing to cellular development and survival. |
| T3 | 401-611 | Sentence | denotes | An elevation in global protein O-GlcNAc modification occurs during the early stages of osteoblast differentiation and correlates with enhanced transcriptional activity of RUNX2, a key regulator of osteogenesis. |
| T4 | 612-887 | Sentence | denotes | To identify other substrates of O-GlcNAc transferase in differentiating MC3T3E1 osteoblasts, O-GlcNAc-modified peptides were enriched by wheat germ agglutinin lectin weak affinity chromatography and identified by tandem mass spectrometry using electron transfer dissociation. |
| T5 | 888-1022 | Sentence | denotes | This peptide fragmentation approach leaves the labile O-linkage intact permitting direct identification of O-GlcNAc-modified peptides. |
| T6 | 1023-1242 | Sentence | denotes | O-GlcNAc modification was observed on enzymes involved in post-translational regulation, including MAST4 and WNK1 kinases, a ubiquitin-associated protein (UBAP2l), and the histone acetyltransferase CREB-binding protein. |
| T7 | 1243-1431 | Sentence | denotes | CREB-binding protein, a transcriptional co-activator that associates with CREB and RUNX2, is O-GlcNAcylated at Ser-147 and Ser-2360, the latter of which is a known site of phosphorylation. |
| T8 | 1432-1675 | Sentence | denotes | Additionally, O-GlcNAcylation of components of the TGFβ-activated kinase 1 (TAK1) signaling complex, TAB1 and TAB2, occurred in close proximity to known sites of Ser/Thr phosphorylation and a putative nuclear localization sequence within TAB2. |
| T9 | 1676-1897 | Sentence | denotes | These findings demonstrate the presence of O-GlcNAc modification on proteins critical to bone formation, remodeling, and fracture healing and will enable evaluation of this modification on protein function and regulation. |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 48-56 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T2 | 248-256 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T3 | 432-440 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T4 | 644-652 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T5 | 705-713 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T6 | 995-1003 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T7 | 1023-1031 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
| T8 | 1719-1727 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | O-GlcNAc | http://www.glycoepitope.jp/epitopes/EP0004 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 67-77 | Body_part | denotes | osteoblast | FMA:66780 |
| T2 | 488-498 | Body_part | denotes | osteoblast | FMA:66780 |
| T3 | 692-703 | Body_part | denotes | osteoblasts | FMA:66780 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 176-180 | Body_part | denotes | bone | http://purl.obolibrary.org/obo/MAT_0000299 |
| T2 | 1566-1575 | Body_part | denotes | proximity | http://purl.obolibrary.org/obo/MAT_0000491 |
| T3 | 1765-1769 | Body_part | denotes | bone | http://purl.obolibrary.org/obo/MAT_0000299 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 749-754 | OrganismTaxon | denotes | wheat | 4565 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 67-77 | Body_part | denotes | osteoblast | http://purl.obolibrary.org/obo/CL_0000062 |
| T2 | 176-180 | Body_part | denotes | bone | http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481 |
| T4 | 488-498 | Body_part | denotes | osteoblast | http://purl.obolibrary.org/obo/CL_0000062 |
| T5 | 692-703 | Body_part | denotes | osteoblasts | http://purl.obolibrary.org/obo/CL_0000062 |
| T6 | 1765-1769 | Body_part | denotes | bone | http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 176-180 | Body_part | denotes | bone | http://purl.obolibrary.org/obo/MAT_0000299 |
| T2 | 1566-1575 | Body_part | denotes | proximity | http://purl.obolibrary.org/obo/MAT_0000491 |
| T3 | 1765-1769 | Body_part | denotes | bone | http://purl.obolibrary.org/obo/MAT_0000299 |
GlyCosmos15-Lectin
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 749-770 | GL_000042 | denotes | wheat germ agglutinin |
Lectin_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 749-770 | GL_000042 | denotes | wheat germ agglutinin |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 67-77 | Cell | denotes | osteoblast | http://purl.obolibrary.org/obo/CL:0000062 |
| T2 | 488-498 | Cell | denotes | osteoblast | http://purl.obolibrary.org/obo/CL:0000062 |
| T3 | 692-703 | Cell | denotes | osteoblasts | http://purl.obolibrary.org/obo/CL:0000062 |