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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 255-270 HP_0100280 denotes Crohn's disease

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-150 Sentence denotes Predictive value of time-intensity curves obtained with contrast-enhanced ultrasonography (CEUS) in the follow-up of 30 patients with Crohn's disease.
T2 151-271 Sentence denotes OBJECTIVES: CEUS can provide accurate quantitative estimates of intestinal wall microvascularization in Crohn's disease.
T3 272-513 Sentence denotes We hypothesized that inflammation of the intestinal wall is correlated not with the amount of wall vascularization (study of vascularization patterns, SVP) but with the degree of wall flow during a period of time (time-intensity study, TIS).
T4 514-778 Sentence denotes Our objective was to discover whether CEUS SPV and/or CEUS-TIS reflect(s) vascular inflammation of the intestinal wall and display(s) correlation with clinical activity of the disease at the time of the examination (T0) or at the 3- and 6-month follow-up (T3, T6).
T5 779-801 Sentence denotes MATERIALS AND METHODS:
T6 802-863 Sentence denotes 30 patients with Crohn's disease (12 men, 18 women, mean age:
T7 864-887 Sentence denotes 41.96 years; treatment:
T8 888-1036 Sentence denotes 5-ASA (n = 8), steroids (n = 13), anti-TNF (n = 7), azathioprine (n = 2) were studied with CEUS SPV and CEUS-TIS and followed for at least 6 months.
T9 1037-1218 Sentence denotes The sonographic examinations were performed with SonoVue (BR1, Bracco) and a dedicated scanner (TECHNOS MPX, Esaote) equipped with software for calculation of time-intensity curves.
T10 1219-1385 Sentence denotes Four vascular patterns (1: vascularization of the entire wall; 2: vascularization of >50% of the wall; 3: flow exclusively within the submucosal layer; 4: no signal).
T11 1386-1562 Sentence denotes The semiquantitative analysis consisted in measurement of the area under the curve (AUC) (cut-off between active and inactive disease, 15), mean intesnity (IMA) (cut-off = 10).
T12 1563-1624 Sentence denotes Each examination (180 s) was digitally recorded and analyzed.
T13 1625-1679 Sentence denotes RESULTS: T0: cDAI <150 in 22 pts; cDAI > 150 in 8; T3:
T14 1680-1720 Sentence denotes 22 pts. with cDAI<150, 8 with cDAI >150.
T15 1721-1842 Sentence denotes At T0 CEUS SPV and CEUS-TIS both displayed low specificity, diagnostic accuracy, and negative predictive values (p = ns).
T16 1843-1974 Sentence denotes At T0, CEUS SPV produced 8 true positives (TP), 15 true negatives (TN), 8 false positives (FP), 0 false negative (FN) (sensitivity:
T17 1975-1993 Sentence denotes 100%; specificity:
T18 1994-2021 Sentence denotes 68.2%; diagnostic accuracy:
T19 2022-2061 Sentence denotes 69.5%; Positive predictive value (PPV):
T20 2062-2099 Sentence denotes 100%; negative predictive value (NPV:
T21 2100-2184 Sentence denotes 53.3%), and CEUS-TIS produced 6 TP, 18 TN, 4 FP, 2 FN (sensitivity 75%; specificity:
T22 2185-2212 Sentence denotes 81.8%; diagnostic accuracy:
T23 2213-2222 Sentence denotes 75%; PPV:
T24 2223-2232 Sentence denotes 60%; NPV:
T25 2233-2238 Sentence denotes 90%).
T26 2239-2301 Sentence denotes At T3, CEUS SPV produced 8 TP, 12 TN, 7 FP, 3 FN (sensitivity:
T27 2302-2321 Sentence denotes 72.7%; specificity:
T28 2322-2349 Sentence denotes 63.2%; diagnostic accuracy:
T29 2350-2359 Sentence denotes 50%; PPV:
T30 2360-2371 Sentence denotes 53.3%; NPV:
T31 2372-2422 Sentence denotes 80%), and CEUS SIT produced the following results:
T32 2423-2461 Sentence denotes 10 TP, 19 TN, 0 FP, 1 FN (sensitivity:
T33 2462-2481 Sentence denotes 90,9%; specificity:
T34 2482-2508 Sentence denotes 100%; diagnostic accuracy:
T35 2509-2520 Sentence denotes 96,5%; PPV:
T36 2521-2531 Sentence denotes 100%; NPV:
T37 2532-2537 Sentence denotes 95%).
T38 2538-2749 Sentence denotes At T3 CEUS-SVP displayed low sensitivity and low diagnostic accuracy, whereas SIT was able to predict clinical activity during follow-up in all but one case (which showed reactivation after 6 months) (p = 0.001)
T39 2750-2911 Sentence denotes CONCLUSION: CEUS-TIS alone was found to reflect vascular inflammation of the intestinal wall in Crohn's disease and predicted clinical activity during follow-up.
T1 0-150 Sentence denotes Predictive value of time-intensity curves obtained with contrast-enhanced ultrasonography (CEUS) in the follow-up of 30 patients with Crohn's disease.
T2 151-271 Sentence denotes OBJECTIVES: CEUS can provide accurate quantitative estimates of intestinal wall microvascularization in Crohn's disease.
T3 272-513 Sentence denotes We hypothesized that inflammation of the intestinal wall is correlated not with the amount of wall vascularization (study of vascularization patterns, SVP) but with the degree of wall flow during a period of time (time-intensity study, TIS).
T4 514-778 Sentence denotes Our objective was to discover whether CEUS SPV and/or CEUS-TIS reflect(s) vascular inflammation of the intestinal wall and display(s) correlation with clinical activity of the disease at the time of the examination (T0) or at the 3- and 6-month follow-up (T3, T6).
T5 779-801 Sentence denotes MATERIALS AND METHODS:
T6 802-863 Sentence denotes 30 patients with Crohn's disease (12 men, 18 women, mean age:
T7 864-887 Sentence denotes 41.96 years; treatment:
T8 888-1036 Sentence denotes 5-ASA (n = 8), steroids (n = 13), anti-TNF (n = 7), azathioprine (n = 2) were studied with CEUS SPV and CEUS-TIS and followed for at least 6 months.
T9 1037-1218 Sentence denotes The sonographic examinations were performed with SonoVue (BR1, Bracco) and a dedicated scanner (TECHNOS MPX, Esaote) equipped with software for calculation of time-intensity curves.
T10 1219-1385 Sentence denotes Four vascular patterns (1: vascularization of the entire wall; 2: vascularization of >50% of the wall; 3: flow exclusively within the submucosal layer; 4: no signal).
T11 1386-1562 Sentence denotes The semiquantitative analysis consisted in measurement of the area under the curve (AUC) (cut-off between active and inactive disease, 15), mean intesnity (IMA) (cut-off = 10).
T12 1563-1624 Sentence denotes Each examination (180 s) was digitally recorded and analyzed.
T13 1625-1679 Sentence denotes RESULTS: T0: cDAI <150 in 22 pts; cDAI > 150 in 8; T3:
T14 1680-1720 Sentence denotes 22 pts. with cDAI<150, 8 with cDAI >150.
T15 1721-1842 Sentence denotes At T0 CEUS SPV and CEUS-TIS both displayed low specificity, diagnostic accuracy, and negative predictive values (p = ns).
T16 1843-1974 Sentence denotes At T0, CEUS SPV produced 8 true positives (TP), 15 true negatives (TN), 8 false positives (FP), 0 false negative (FN) (sensitivity:
T17 1975-1993 Sentence denotes 100%; specificity:
T18 1994-2021 Sentence denotes 68.2%; diagnostic accuracy:
T19 2022-2061 Sentence denotes 69.5%; Positive predictive value (PPV):
T20 2062-2099 Sentence denotes 100%; negative predictive value (NPV:
T21 2100-2184 Sentence denotes 53.3%), and CEUS-TIS produced 6 TP, 18 TN, 4 FP, 2 FN (sensitivity 75%; specificity:
T22 2185-2212 Sentence denotes 81.8%; diagnostic accuracy:
T23 2213-2222 Sentence denotes 75%; PPV:
T24 2223-2232 Sentence denotes 60%; NPV:
T25 2233-2238 Sentence denotes 90%).
T26 2239-2301 Sentence denotes At T3, CEUS SPV produced 8 TP, 12 TN, 7 FP, 3 FN (sensitivity:
T27 2302-2321 Sentence denotes 72.7%; specificity:
T28 2322-2349 Sentence denotes 63.2%; diagnostic accuracy:
T29 2350-2359 Sentence denotes 50%; PPV:
T30 2360-2371 Sentence denotes 53.3%; NPV:
T31 2372-2422 Sentence denotes 80%), and CEUS SIT produced the following results:
T32 2423-2461 Sentence denotes 10 TP, 19 TN, 0 FP, 1 FN (sensitivity:
T33 2462-2481 Sentence denotes 90,9%; specificity:
T34 2482-2508 Sentence denotes 100%; diagnostic accuracy:
T35 2509-2520 Sentence denotes 96,5%; PPV:
T36 2521-2531 Sentence denotes 100%; NPV:
T37 2532-2537 Sentence denotes 95%).
T38 2538-2749 Sentence denotes At T3 CEUS-SVP displayed low sensitivity and low diagnostic accuracy, whereas SIT was able to predict clinical activity during follow-up in all but one case (which showed reactivation after 6 months) (p = 0.001)
T39 2750-2911 Sentence denotes CONCLUSION: CEUS-TIS alone was found to reflect vascular inflammation of the intestinal wall in Crohn's disease and predicted clinical activity during follow-up.