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PubMed:23396536 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
23396536_0 55-61 ProteinMutation denotes G2019S rs34637584
23396536_1 1445-1451 ProteinMutation denotes G2019S rs34637584
23396536_2 1195-1201 ProteinMutation denotes G2019S rs34637584
23396536_3 1020-1026 ProteinMutation denotes G2019S rs34637584
23396536_4 566-572 ProteinMutation denotes G2019S rs34637584

c_corpus

Id Subject Object Predicate Lexical cue
T1 44-48 SO:0000704 denotes gene
T2 49-54 PR:Q5S006 denotes LRRK2
T3 49-54 PR:000003033 denotes LRRK2
T4 49-54 PR:Q5S007 denotes LRRK2
T5 176-183 D004194 denotes disease
T6 176-183 D004194 denotes disease
T7 229-239 GO:0023052 denotes signalling
T8 281-287 GO:0007601 denotes vision
T9 390-395 PR:Q5S006 denotes LRRK2
T10 390-395 PR:000003033 denotes LRRK2
T11 390-395 PR:Q5S007 denotes LRRK2
T12 449-459 2294143 denotes Drosophila
T13 449-459 504603 denotes Drosophila
T14 449-459 2294139 denotes Drosophila
T15 449-459 2294145 denotes Drosophila
T16 449-459 2294141 denotes Drosophila
T17 449-459 2294142 denotes Drosophila
T18 449-459 2294144 denotes Drosophila
T19 449-459 2294140 denotes Drosophila
T20 449-459 D004330 denotes Drosophila
T21 449-459 2080301 denotes Drosophila
T22 543-548 D004175 denotes flies
T23 560-565 PR:Q5S006 denotes LRRK2
T24 560-565 PR:000003033 denotes LRRK2
T25 560-565 PR:Q5S007 denotes LRRK2
T26 633-642 GO:0016236 denotes autophagy
T27 633-642 GO:0006914 denotes autophagy
T28 644-653 GO:0097194 denotes apoptosis
T29 644-653 GO:0006915 denotes apoptosis
T30 756-769 UBERON:0002104 denotes visual system
T31 919-925 GO:0007601 denotes vision
T32 995-1005 2294143 denotes Drosophila
T33 995-1005 504603 denotes Drosophila
T34 995-1005 2294139 denotes Drosophila
T35 995-1005 2294145 denotes Drosophila
T36 995-1005 2294141 denotes Drosophila
T37 995-1005 2294142 denotes Drosophila
T38 995-1005 2294144 denotes Drosophila
T39 995-1005 2294140 denotes Drosophila
T40 995-1005 D004330 denotes Drosophila
T41 995-1005 2080301 denotes Drosophila
T42 1042-1046 SO:0001742 denotes gain
T43 1072-1089 SO:0002052 denotes dominant negative
T44 1090-1098 SO:0000109 denotes mutation
T45 1127-1140 UBERON:0002104 denotes visual system
T46 1227-1233 GO:0007601 denotes vision
T47 1243-1256 UBERON:0002104 denotes visual system
T48 1439-1444 PR:Q5S006 denotes LRRK2
T49 1439-1444 PR:000003033 denotes LRRK2
T50 1439-1444 PR:Q5S007 denotes LRRK2

Allie

Id Subject Object Predicate Lexical cue
SS1_23396536_1_0 164-183 expanded denotes Parkinson's disease
SS2_23396536_1_0 185-187 abbr denotes PD
SS1_23396536_2_0 460-478 expanded denotes electroretinograms
SS2_23396536_2_0 480-484 abbr denotes ERGs
AE1_23396536_1_0 SS1_23396536_1_0 SS2_23396536_1_0 abbreviatedTo Parkinson's disease,PD
AE1_23396536_2_0 SS1_23396536_2_0 SS2_23396536_2_0 abbreviatedTo electroretinograms,ERGs

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-163 DRI_Background denotes Dopaminergic expression of the Parkinsonian gene LRRK2-G2019S leads to non-autonomous visual neurodegeneration, accelerated by increased neural demands for energy.
T2 164-288 DRI_Challenge denotes Parkinson's disease (PD) is associated with loss of dopaminergic signalling, and affects not just movement, but also vision.
T3 289-486 DRI_Approach denotes As both mammalian and fly visual systems contain dopaminergic neurons, we investigated the effect of LRRK2 mutations (the most common cause of inherited PD) on Drosophila electroretinograms (ERGs).
T4 487-597 DRI_Outcome denotes We reveal progressive loss of photoreceptor function in flies expressing LRRK2-G2019S in dopaminergic neurons.
T5 598-688 DRI_Background denotes The photoreceptors showed elevated autophagy, apoptosis and mitochondrial disorganization.
T6 689-837 DRI_Background denotes Head sections confirmed extensive neurodegeneration throughout the visual system, including regions not directly innervated by dopaminergic neurons.
T7 838-964 DRI_Outcome denotes Other PD-related mutations did not affect photoreceptor function, and no loss of vision was seen with kinase-dead transgenics.
T8 965-1099 DRI_Background denotes Manipulations of the level of Drosophila dLRRK suggest G2019S is acting as a gain-of-function, rather than dominant negative mutation.
T9 1100-1234 DRI_Background denotes Increasing activity of the visual system, or of just the dopaminergic neurons, accelerated the G2019S-induced deterioration of vision.
T10 1235-1477 DRI_Outcome denotes The fly visual system provides an excellent, tractable model of a non-autonomous deficit reminiscent of that seen in PD, and suggests that increased energy demand may contribute to the mechanism by which LRRK2-G2019S causes neurodegeneration.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 164-288 DRI_Challenge denotes Parkinson's disease (PD) is associated with loss of dopaminergic signalling, and affects not just movement, but also vision.
T2 289-486 DRI_Approach denotes As both mammalian and fly visual systems contain dopaminergic neurons, we investigated the effect of LRRK2 mutations (the most common cause of inherited PD) on Drosophila electroretinograms (ERGs).
T3 487-597 DRI_Outcome denotes We reveal progressive loss of photoreceptor function in flies expressing LRRK2-G2019S in dopaminergic neurons.
T4 598-688 DRI_Background denotes The photoreceptors showed elevated autophagy, apoptosis and mitochondrial disorganization.
T5 689-837 DRI_Background denotes Head sections confirmed extensive neurodegeneration throughout the visual system, including regions not directly innervated by dopaminergic neurons.
T6 838-964 DRI_Outcome denotes Other PD-related mutations did not affect photoreceptor function, and no loss of vision was seen with kinase-dead transgenics.
T7 965-1099 DRI_Background denotes Manipulations of the level of Drosophila dLRRK suggest G2019S is acting as a gain-of-function, rather than dominant negative mutation.
T8 1100-1234 DRI_Background denotes Increasing activity of the visual system, or of just the dopaminergic neurons, accelerated the G2019S-induced deterioration of vision.
T9 1235-1477 DRI_Outcome denotes The fly visual system provides an excellent, tractable model of a non-autonomous deficit reminiscent of that seen in PD, and suggests that increased energy demand may contribute to the mechanism by which LRRK2-G2019S causes neurodegeneration.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 164-173 HP_0001300 denotes Parkinson
T2 658-671 HP_0001427 denotes mitochondrial
T3 723-740 HP_0002180 denotes neurodegeneration
T4 911-925 HP_0000572 denotes loss of vision
T5 947-951 HP_0000365 denotes dead
T6 1459-1476 HP_0002180 denotes neurodegeneration

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
23396536-9#210#216#geners34637584 1445-1451 geners34637584 denotes G2019S
23396536-9#117#119#diseaseC0030567 1352-1354 diseaseC0030567 denotes PD
210#216#geners34637584117#119#diseaseC0030567 23396536-9#210#216#geners34637584 23396536-9#117#119#diseaseC0030567 associated_with G2019S,PD

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23396536-2#101#106#gene120892 390-395 gene120892 denotes LRRK2
23396536-2#153#155#diseaseC0030567 442-444 diseaseC0030567 denotes PD
101#106#gene120892153#155#diseaseC0030567 23396536-2#101#106#gene120892 23396536-2#153#155#diseaseC0030567 associated_with LRRK2,PD