PubMed:23395820
Annnotations
ngly1-sample4
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 488-494 | chem:24139 | denotes | GlcNAc |
| T2 | 754-760 | chem:24139 | denotes | GlcNAc |
| T3 | 1144-1152 | chem:24139 | denotes | GlcNAcα1 |
| T4 | 1319-1325 | chem:24139 | denotes | GlcNAc |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 504-525 | Glycan_Motif | denotes | N-acetylgalactosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G27025MB |
| T2 | 1547-1558 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T1 | 337-352 | GlycoEpitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T2 | 1528-1543 | GlycoEpitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T3 | 1547-1558 | GlycoEpitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-132 | Sentence | denotes | EXTL2, a member of the EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner. |
| T2 | 133-353 | Sentence | denotes | Mutant alleles of EXT1 or EXT2, two members of the EXT gene family, are causative agents in hereditary multiple exostoses, and their gene products function together as a polymerase in the biosynthesis of heparan sulfate. |
| T3 | 354-600 | Sentence | denotes | EXTL2, one of three EXT-like genes in the human genome that are homologous to EXT1 and EXT2, encodes a transferase that adds not only GlcNAc but also N-acetylgalactosamine to the glycosaminoglycan (GAG)-protein linkage region via an α1,4-linkage. |
| T4 | 601-717 | Sentence | denotes | However, both the role of EXTL2 in the biosynthesis of GAGs and the biological significance of EXTL2 remain unclear. |
| T5 | 718-900 | Sentence | denotes | Here we show that EXTL2 transfers a GlcNAc residue to the tetrasaccharide linkage region that is phosphorylated by a xylose kinase 1 (FAM20B) and thereby terminates chain elongation. |
| T6 | 901-1001 | Sentence | denotes | We isolated an oligosaccharide from the mouse liver, which was not detected in EXTL2 knock-out mice. |
| T7 | 1002-1277 | Sentence | denotes | Based on structural analysis by a combination of glycosidase digestion and 500-MHz (1)H NMR spectroscopy, the oligosaccharide was found to be GlcNAcα1-4GlcUAβ1-3Galβ1-3Galβ1-4Xyl(2-O-phosphate), which was considered to be a biosynthetic intermediate of an immature GAG chain. |
| T8 | 1278-1421 | Sentence | denotes | Indeed, EXTL2 specifically transferred a GlcNAc residue to a phosphorylated linkage tetrasaccharide, GlcUAβ1-3Galβ1-3Galβ1-4Xyl(2-O-phosphate). |
| T9 | 1422-1579 | Sentence | denotes | Remarkably, the phosphorylated linkage pentasaccharide generated by EXTL2 was not used as an acceptor for heparan sulfate or chondroitin sulfate polymerases. |
| T10 | 1580-1681 | Sentence | denotes | Moreover, production of GAGs was significantly higher in EXTL2 knock-out mice than in wild-type mice. |
| T11 | 1682-1916 | Sentence | denotes | These results indicate that EXTL2 functions to suppress GAG biosynthesis that is enhanced by a xylose kinase and that the EXTL2-dependent mechanism that regulates GAG biosynthesis might be a "quality control system" for proteoglycans. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 504-525 | https://glytoucan.org/Structures/Glycans/G27025MB | denotes | N-acetylgalactosamine |
| T2 | 1547-1558 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 947-952 | http://purl.obolibrary.org/obo/MAT_0000097 | denotes | liver |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_23395820_2_0 | 533-550 | expanded | denotes | glycosaminoglycan |
| SS2_23395820_2_0 | 552-555 | abbr | denotes | GAG |
| AE1_23395820_2_0 | SS1_23395820_2_0 | SS2_23395820_2_0 | abbreviatedTo | glycosaminoglycan,GAG |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 236-254 | HP_0002762 | denotes | multiple exostoses |
| T2 | 245-254 | HP_0100777 | denotes | exostoses |
NGLY1-deficiency
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-NGLY1-deficiency-B_T1 | 488-494 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T2 | 754-760 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T3 | 1319-1325 | chem:24139 | denotes | GlcNAc |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1547-1558 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T2 | 337-352 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T3 | 1528-1543 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 37-42 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T2 | 225-254 | Disease | denotes | hereditary multiple exostoses | http://purl.obolibrary.org/obo/MONDO_0005508 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 947-952 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 37-42 | Phenotype | denotes | tumor | HP:0002664 |
| T2 | 236-254 | Phenotype | denotes | multiple exostoses | HP:0002762 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1547-1558 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T4 | 337-352 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T2 | 1528-1543 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 337-352 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T2 | 1528-1543 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T3 | 1547-1558 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 37-42 | Phenotype | denotes | tumor | HP:0002664 |
| T2 | 236-254 | Phenotype | denotes | multiple exostoses | HP:0002762 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 947-952 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 37-42 | Disease | denotes | tumor | MONDO:0005070 |
| T2 | 225-254 | Disease | denotes | hereditary multiple exostoses | MONDO:0005508 |
GlyCosmos15-Taxon
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 396-401 | Organism | denotes | human | 9606 |
| T2 | 941-946 | Organism | denotes | mouse | 10088|10090 |
| T4 | 996-1000 | Organism | denotes | mice | 10088 |
| T5 | 1653-1657 | Organism | denotes | mice | 10088 |
| T6 | 1676-1680 | Organism | denotes | mice | 10088 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-132 | Sentence | denotes | EXTL2, a member of the EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner. |
| T2 | 133-353 | Sentence | denotes | Mutant alleles of EXT1 or EXT2, two members of the EXT gene family, are causative agents in hereditary multiple exostoses, and their gene products function together as a polymerase in the biosynthesis of heparan sulfate. |
| T3 | 354-600 | Sentence | denotes | EXTL2, one of three EXT-like genes in the human genome that are homologous to EXT1 and EXT2, encodes a transferase that adds not only GlcNAc but also N-acetylgalactosamine to the glycosaminoglycan (GAG)-protein linkage region via an α1,4-linkage. |
| T4 | 601-717 | Sentence | denotes | However, both the role of EXTL2 in the biosynthesis of GAGs and the biological significance of EXTL2 remain unclear. |
| T5 | 718-900 | Sentence | denotes | Here we show that EXTL2 transfers a GlcNAc residue to the tetrasaccharide linkage region that is phosphorylated by a xylose kinase 1 (FAM20B) and thereby terminates chain elongation. |
| T6 | 901-1001 | Sentence | denotes | We isolated an oligosaccharide from the mouse liver, which was not detected in EXTL2 knock-out mice. |
| T7 | 1002-1277 | Sentence | denotes | Based on structural analysis by a combination of glycosidase digestion and 500-MHz (1)H NMR spectroscopy, the oligosaccharide was found to be GlcNAcα1-4GlcUAβ1-3Galβ1-3Galβ1-4Xyl(2-O-phosphate), which was considered to be a biosynthetic intermediate of an immature GAG chain. |
| T8 | 1278-1421 | Sentence | denotes | Indeed, EXTL2 specifically transferred a GlcNAc residue to a phosphorylated linkage tetrasaccharide, GlcUAβ1-3Galβ1-3Galβ1-4Xyl(2-O-phosphate). |
| T9 | 1422-1579 | Sentence | denotes | Remarkably, the phosphorylated linkage pentasaccharide generated by EXTL2 was not used as an acceptor for heparan sulfate or chondroitin sulfate polymerases. |
| T10 | 1580-1681 | Sentence | denotes | Moreover, production of GAGs was significantly higher in EXTL2 knock-out mice than in wild-type mice. |
| T11 | 1682-1916 | Sentence | denotes | These results indicate that EXTL2 functions to suppress GAG biosynthesis that is enhanced by a xylose kinase and that the EXTL2-dependent mechanism that regulates GAG biosynthesis might be a "quality control system" for proteoglycans. |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 337-352 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T2 | 1528-1543 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T3 | 1547-1558 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 402-408 | Body_part | denotes | genome | FMA:84116 |
| T2 | 947-952 | Body_part | denotes | liver | FMA:7197 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 947-952 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 396-401 | OrganismTaxon | denotes | human | 9606 |
| T2 | 941-946 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T4 | 996-1000 | OrganismTaxon | denotes | mice | 10088 |
| T5 | 1653-1657 | OrganismTaxon | denotes | mice | 10088 |
| T6 | 1676-1680 | OrganismTaxon | denotes | mice | 10088 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 947-952 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |