> top > docs > PubMed:23389860 > annotations

PubMed:23389860 JSONTXT

Annnotations TAB JSON ListView MergeView

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 112-124 HP_0000939 denotes Osteoporosis
T2 1349-1359 HP_0011846 denotes osteoblast

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-111 Sentence denotes Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice.
T2 112-209 Sentence denotes Osteoporosis can result from intestinal inflammation, as is seen with inflammatory bowel disease.
T3 210-421 Sentence denotes Probiotics, microorganisms that provide a health benefit to the host when ingested in adequate amounts, can have anti-inflammatory properties and are currently being examined to treat inflammatory bowel disease.
T4 422-620 Sentence denotes Here, we examined if treating healthy male mice with Lactobacillus reuteri ATCC PTA 6475 (a candidate probiotic with anti-TNFα activity) could affect intestinal TNFα levels and enhance bone density.
T5 621-705 Sentence denotes Adult male mice were given L. reuteri 6475 orally by gavage for 3×/week for 4 weeks.
T6 706-887 Sentence denotes Examination of jejunal and ileal RNA profiles indicates that L. reuteri suppressed basal TNFα mRNA levels in the jejunum and ileum in male mice, but surprisingly not in female mice.
T7 888-921 Sentence denotes Next, we examined bone responses.
T8 922-1193 Sentence denotes Micro-computed tomography demonstrated that L. reuteri 6475 treatment increased male trabecular bone parameters (mineral density, bone volume fraction, trabecular number, and trabecular thickness) in the distal femur metaphyseal region as well as in the lumbar vertebrae.
T9 1194-1235 Sentence denotes Cortical bone parameters were unaffected.
T10 1236-1426 Sentence denotes Dynamic and static histomorphometry and serum remodeling parameters indicate that L. reuteri ingestion increases osteoblast serum markers and dynamic measures of bone formation in male mice.
T11 1427-1512 Sentence denotes In contrast to male mice, L. reuteri had no effect on bone parameters in female mice.
T12 1513-1693 Sentence denotes Taken together our studies indicate that femoral and vertebral bone formation increases in response to oral probiotic use, leading to increased trabecular bone volume in male mice.
T1 0-111 Sentence denotes Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice.
T2 112-209 Sentence denotes Osteoporosis can result from intestinal inflammation, as is seen with inflammatory bowel disease.
T3 210-421 Sentence denotes Probiotics, microorganisms that provide a health benefit to the host when ingested in adequate amounts, can have anti-inflammatory properties and are currently being examined to treat inflammatory bowel disease.
T4 422-620 Sentence denotes Here, we examined if treating healthy male mice with Lactobacillus reuteri ATCC PTA 6475 (a candidate probiotic with anti-TNFα activity) could affect intestinal TNFα levels and enhance bone density.
T5 621-705 Sentence denotes Adult male mice were given L. reuteri 6475 orally by gavage for 3×/week for 4 weeks.
T6 706-887 Sentence denotes Examination of jejunal and ileal RNA profiles indicates that L. reuteri suppressed basal TNFα mRNA levels in the jejunum and ileum in male mice, but surprisingly not in female mice.
T7 888-921 Sentence denotes Next, we examined bone responses.
T8 922-1193 Sentence denotes Micro-computed tomography demonstrated that L. reuteri 6475 treatment increased male trabecular bone parameters (mineral density, bone volume fraction, trabecular number, and trabecular thickness) in the distal femur metaphyseal region as well as in the lumbar vertebrae.
T9 1194-1235 Sentence denotes Cortical bone parameters were unaffected.
T10 1236-1426 Sentence denotes Dynamic and static histomorphometry and serum remodeling parameters indicate that L. reuteri ingestion increases osteoblast serum markers and dynamic measures of bone formation in male mice.
T11 1427-1512 Sentence denotes In contrast to male mice, L. reuteri had no effect on bone parameters in female mice.
T12 1513-1693 Sentence denotes Taken together our studies indicate that femoral and vertebral bone formation increases in response to oral probiotic use, leading to increased trabecular bone volume in male mice.