PubMed:23359648
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/23359648","sourcedb":"PubMed","sourceid":"23359648","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/23359648","text":"Nedaplatin/Gemcitabine Versus Carboplatin/Gemcitabine in Treatment of Advanced Non-small Cell Lung Cancer: A Randomized Clinical Trial.\nOBJECTIVE: To evaluate the efficacy and safety of nedaplatin/gemcitabine (NG) and carboplatin/gemcitabine (CG) in the management of untreated advanced non-small cell lung cancer (NSCLC).\nMETHODS: Sixty-two patients with previously untreated advanced NSCLC were recruited between June 2006 and November 2007. Subjects were randomly assigned to the NG arm (n=30) and the CG arm (n=32). Only patients (24 and 25 in the NG and CG arms, respectively) who completed ≥2 chemotherapy cycles were included in the data analysis. The primary outcome measure was the objective response rate (ORR). The secondary outcome measures included progression-free survival (PFS), overall survival (OS) and adverse events.\nRESULTS: There were no statistically significant differences in the efficacy measures (ORR, P=0.305; median PFS, P=0.198; median OS, P=0.961) or in the major adverse events (grade 3/4 neutropenia, P=0.666; grade 3/4 anemia, P=0.263; grade 3/4 thrombocytopenia, P=0.212) between the two treatment arms. However, there was a trend towards higher ORR (37.5% vs. 24.0%), longer PFS (6.0 vs. 5.0 months), and less adverse events in the NG arm.\nCONCLUSION: NG regimen seems to be superior over CG regimen for advance NSCLS, but further investigation is needed to validate this superiority.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_23359648_2_0","span":{"begin":186,"end":208},"obj":"expanded"},{"id":"SS2_23359648_2_0","span":{"begin":210,"end":212},"obj":"abbr"},{"id":"SS1_23359648_2_1","span":{"begin":218,"end":241},"obj":"expanded"},{"id":"SS2_23359648_2_1","span":{"begin":243,"end":245},"obj":"abbr"},{"id":"SS1_23359648_2_2","span":{"begin":287,"end":313},"obj":"expanded"},{"id":"SS2_23359648_2_2","span":{"begin":315,"end":320},"obj":"abbr"},{"id":"SS1_23359648_7_0","span":{"begin":691,"end":714},"obj":"expanded"},{"id":"SS2_23359648_7_0","span":{"begin":716,"end":719},"obj":"abbr"},{"id":"SS1_23359648_8_0","span":{"begin":762,"end":787},"obj":"expanded"},{"id":"SS2_23359648_8_0","span":{"begin":789,"end":792},"obj":"abbr"},{"id":"SS1_23359648_8_1","span":{"begin":795,"end":811},"obj":"expanded"},{"id":"SS2_23359648_8_1","span":{"begin":813,"end":815},"obj":"abbr"}],"relations":[{"id":"AE1_23359648_2_0","pred":"abbreviatedTo","subj":"SS1_23359648_2_0","obj":"SS2_23359648_2_0"},{"id":"AE1_23359648_2_1","pred":"abbreviatedTo","subj":"SS1_23359648_2_1","obj":"SS2_23359648_2_1"},{"id":"AE1_23359648_2_2","pred":"abbreviatedTo","subj":"SS1_23359648_2_2","obj":"SS2_23359648_2_2"},{"id":"AE1_23359648_7_0","pred":"abbreviatedTo","subj":"SS1_23359648_7_0","obj":"SS2_23359648_7_0"},{"id":"AE1_23359648_8_0","pred":"abbreviatedTo","subj":"SS1_23359648_8_0","obj":"SS2_23359648_8_0"},{"id":"AE1_23359648_8_1","pred":"abbreviatedTo","subj":"SS1_23359648_8_1","obj":"SS2_23359648_8_1"}],"attributes":[{"subj":"SS1_23359648_2_0","pred":"source","obj":"Allie"},{"subj":"SS2_23359648_2_0","pred":"source","obj":"Allie"},{"subj":"SS1_23359648_2_1","pred":"source","obj":"Allie"},{"subj":"SS2_23359648_2_1","pred":"source","obj":"Allie"},{"subj":"SS1_23359648_2_2","pred":"source","obj":"Allie"},{"subj":"SS2_23359648_2_2","pred":"source","obj":"Allie"},{"subj":"SS1_23359648_7_0","pred":"source","obj":"Allie"},{"subj":"SS2_23359648_7_0","pred":"source","obj":"Allie"},{"subj":"SS1_23359648_8_0","pred":"source","obj":"Allie"},{"subj":"SS2_23359648_8_0","pred":"source","obj":"Allie"},{"subj":"SS1_23359648_8_1","pred":"source","obj":"Allie"},{"subj":"SS2_23359648_8_1","pred":"source","obj":"Allie"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":287,"end":313},"obj":"HP_0030358"},{"id":"T2","span":{"begin":291,"end":313},"obj":"HP_0030357"},{"id":"T3","span":{"begin":302,"end":313},"obj":"HP_0100526"},{"id":"T4","span":{"begin":307,"end":313},"obj":"HP_0002664"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#93bcec","default":true},{"id":"PubmedHPO","color":"#d6ec93"}]}]}}