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PubMed:23355489 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-138 Sentence denotes Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells.
T2 139-338 Sentence denotes Ataxia telangiectasia mutated (ATM) is activated upon DNA double strand breaks (DSBs) and phosphorylates numerous DSB response proteins, including histone H2AX on serine 139 (Ser-139) to form γ-H2AX.
T3 339-430 Sentence denotes Through interaction with MDC1, γ-H2AX promotes DSB repair by homologous recombination (HR).
T4 431-572 Sentence denotes H2AX Ser-139 can also be phosphorylated by DNA-dependent protein kinase catalytic subunit and ataxia telangiectasia- and Rad3-related kinase.
T5 573-785 Sentence denotes Thus, we tested whether ATM functions in HR, particularly that controlled by γ-H2AX, by comparing HR occurring at the euchromatic ROSA26 locus between mouse embryonic stem cells lacking either ATM, H2AX, or both.
T6 786-935 Sentence denotes We show here that loss of ATM does not impair HR, including H2AX-dependent HR, but confers sensitivity to inhibition of poly(ADP-ribose) polymerases.
T7 936-1032 Sentence denotes Loss of ATM or H2AX has independent contributions to cellular sensitivity to ionizing radiation.
T8 1033-1139 Sentence denotes The ATM-independent HR function of H2AX requires both Ser-139 phosphorylation and γ-H2AX/MDC1 interaction.
T9 1140-1434 Sentence denotes Our data suggest that ATM is dispensable for HR, including that controlled by H2AX, in the context of euchromatin, excluding the implication of such an HR function in genomic instability, hypersensitivity to DNA damage, and poly(ADP-ribose) polymerase inhibition associated with ATM deficiency.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 127-137 http://purl.obolibrary.org/obo/MAT_0000185 denotes stem cells
T2 127-131 http://purl.obolibrary.org/obo/MAT_0000239 denotes stem
T3 740-750 http://purl.obolibrary.org/obo/MAT_0000185 denotes stem cells
T4 740-744 http://purl.obolibrary.org/obo/MAT_0000239 denotes stem

Allie

Id Subject Object Predicate Lexical cue
SS1_23355489_0_0 0-29 expanded denotes Ataxia telangiectasia mutated
SS2_23355489_0_0 31-34 abbr denotes ATM
SS1_23355489_1_0 139-168 expanded denotes Ataxia telangiectasia mutated
SS2_23355489_1_0 170-173 abbr denotes ATM
SS1_23355489_1_1 197-217 expanded denotes double strand breaks
SS2_23355489_1_1 219-223 abbr denotes DSBs
SS1_23355489_1_2 302-312 expanded denotes serine 139
SS2_23355489_1_2 314-321 abbr denotes Ser-139
SS1_23355489_2_0 400-424 expanded denotes homologous recombination
SS2_23355489_2_0 426-428 abbr denotes HR
AE1_23355489_0_0 SS1_23355489_0_0 SS2_23355489_0_0 abbreviatedTo Ataxia telangiectasia mutated,ATM
AE1_23355489_1_0 SS1_23355489_1_0 SS2_23355489_1_0 abbreviatedTo Ataxia telangiectasia mutated,ATM
AE1_23355489_1_1 SS1_23355489_1_1 SS2_23355489_1_1 abbreviatedTo double strand breaks,DSBs
AE1_23355489_1_2 SS1_23355489_1_2 SS2_23355489_1_2 abbreviatedTo serine 139,Ser-139
AE1_23355489_2_0 SS1_23355489_2_0 SS2_23355489_2_0 abbreviatedTo homologous recombination,HR

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 139-145 HP_0001251 denotes Ataxia
T2 146-160 HP_0001009 denotes telangiectasia
T3 525-531 HP_0001251 denotes ataxia
T4 532-546 HP_0001009 denotes telangiectasia

CHEMDNER-training-test

Id Subject Object Predicate Lexical cue
T1 302-308 TRIVIAL denotes serine
T2 314-317 FORMULA denotes Ser
T3 436-439 FORMULA denotes Ser
T4 906-922 SYSTEMATIC denotes poly(ADP-ribose)
T5 1087-1090 FORMULA denotes Ser
T6 1364-1380 SYSTEMATIC denotes poly(ADP-ribose)

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 127-137 Body_part denotes stem cells http://purl.obolibrary.org/obo/MAT_0000185
T2 740-750 Body_part denotes stem cells http://purl.obolibrary.org/obo/MAT_0000185

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 0-6 Phenotype denotes Ataxia HP:0001251
T2 7-21 Phenotype denotes telangiectasia HP:0001009
T3 139-145 Phenotype denotes Ataxia HP:0001251
T4 146-160 Phenotype denotes telangiectasia HP:0001009
T5 525-531 Phenotype denotes ataxia HP:0001251
T6 532-546 Phenotype denotes telangiectasia HP:0001009
T7 1328-1344 Phenotype denotes hypersensitivity HP:0041092

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 0-21 Disease denotes Ataxia telangiectasia http://purl.obolibrary.org/obo/MONDO_0008840
T2 139-160 Disease denotes Ataxia telangiectasia http://purl.obolibrary.org/obo/MONDO_0008840
T3 525-546 Disease denotes ataxia telangiectasia http://purl.obolibrary.org/obo/MONDO_0008840
T4 1328-1344 Disease denotes hypersensitivity http://purl.obolibrary.org/obo/MONDO_0000605|http://purl.obolibrary.org/obo/MONDO_0005271

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 111-116 OrganismTaxon denotes mouse 10088|10090
T3 724-729 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 127-137 Body_part denotes stem cells http://purl.obolibrary.org/obo/CL_0000034
T2 740-750 Body_part denotes stem cells http://purl.obolibrary.org/obo/CL_0000034

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 117-137 Cell denotes embryonic stem cells http://purl.obolibrary.org/obo/CL:0002322
T2 730-750 Cell denotes embryonic stem cells http://purl.obolibrary.org/obo/CL:0002322
T3 906-910 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T5 1364-1368 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775