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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-119 Sentence denotes The role of High Mobility Group Box 1 chromosomal protein in the pathogenesis of chronic sinusitis and nasal polyposis.
T2 120-463 Sentence denotes Chronic rhinosinusitis with nasal polyposis is considered to be a multifactorial disease where different stimuli (mechanical, viral, bacterial, fungal infection, immunological disorders or dysreactivity, environmental pollution), acting on the mucosa of nasal cavities and paranasal sinuses, lead to epithelial damage and mucosal inflammation.
T3 464-795 Sentence denotes Inflammatory cell infiltration (predominantly eosinophils, but also neutrophils, mast cells, macrophages and lymphocytes), cytokine release and sub-epithelial oedema are the histological pictures that are associated, from the clinical point of view, with nasal congestion, secretion and/or post-nasal drip and facial pain/headache.
T4 796-919 Sentence denotes Recently, the importance of the HMG B-1 protein in the pathogenesis of several inflammatory diseases has been demonstrated.
T5 920-1157 Sentence denotes This protein is released from necrotic/damaged cells or immune-activated cells, and by acting on specific membrane receptors causes the release of pro-inflammatory mediators, endothelial activation and the survival of inflammatory cells.
T6 1158-1544 Sentence denotes The objective of the present study was: i) to determine whether HMG B1 is augmented in chronic rhinosinusitis with nasal polyps; ii) if its expression is associated with eosinophils, TNF-α, IL 5 and IL 8 cytokines typically present in chronic inflammation of the nose and paranasal sinuses; iii) to investigate a hypothetical role of this protein in the pathogenesis of nasal polyposis.
T7 1545-1830 Sentence denotes Nasal polyps tissue from 21 patients affected by CRSwNP and nasal mucosa from 8 controls was collected at the ENT Department of the Chinese PLA General Hospital and underwent immunohistological staining for detection of HMG B1 protein and IL -5, IL -8 and TNF-α inflammatory cytokines.
T8 1831-1932 Sentence denotes The degree of HMG B1 protein expression was evaluated by dividing the stained sections in 4 portions:
T9 1933-2058 Sentence denotes 1) nucleus of epithelial cells, 2) cytoplasm of epithelial cells, 3) focal extracellular infiltration, 4) inflammatory cells.
T10 2059-2155 Sentence denotes HMG B1 was more expressed in the nucleus of epithelial cells of patients compared with controls.
T11 2156-2240 Sentence denotes In contrast, epithelial cytoplasm HMG B1 staining was significant lower in patients.
T12 2241-2454 Sentence denotes Sub-epithelial focal infiltration of HMG B1 protein expression was lower in controls, whereas the expression of HMG B1 in the inflammatory cells in patients was significantly increased in comparison with controls.
T13 2455-2774 Sentence denotes These data, together with the correlation we found between HMG B1 protein expression in different portions and the number of eosinophils infiltrating cells, or IL -5, IL -8 and TNF-α positive cells in patients, suggest that HMG B1 may play a crucial role in the pathogenesis of chronic rhinosinusitis with nasal polyps.
T1 0-119 Sentence denotes The role of High Mobility Group Box 1 chromosomal protein in the pathogenesis of chronic sinusitis and nasal polyposis.
T2 120-463 Sentence denotes Chronic rhinosinusitis with nasal polyposis is considered to be a multifactorial disease where different stimuli (mechanical, viral, bacterial, fungal infection, immunological disorders or dysreactivity, environmental pollution), acting on the mucosa of nasal cavities and paranasal sinuses, lead to epithelial damage and mucosal inflammation.
T3 464-795 Sentence denotes Inflammatory cell infiltration (predominantly eosinophils, but also neutrophils, mast cells, macrophages and lymphocytes), cytokine release and sub-epithelial oedema are the histological pictures that are associated, from the clinical point of view, with nasal congestion, secretion and/or post-nasal drip and facial pain/headache.
T4 796-919 Sentence denotes Recently, the importance of the HMG B-1 protein in the pathogenesis of several inflammatory diseases has been demonstrated.
T5 920-1157 Sentence denotes This protein is released from necrotic/damaged cells or immune-activated cells, and by acting on specific membrane receptors causes the release of pro-inflammatory mediators, endothelial activation and the survival of inflammatory cells.
T6 1158-1544 Sentence denotes The objective of the present study was: i) to determine whether HMG B1 is augmented in chronic rhinosinusitis with nasal polyps; ii) if its expression is associated with eosinophils, TNF-α, IL 5 and IL 8 cytokines typically present in chronic inflammation of the nose and paranasal sinuses; iii) to investigate a hypothetical role of this protein in the pathogenesis of nasal polyposis.
T7 1545-1830 Sentence denotes Nasal polyps tissue from 21 patients affected by CRSwNP and nasal mucosa from 8 controls was collected at the ENT Department of the Chinese PLA General Hospital and underwent immunohistological staining for detection of HMG B1 protein and IL -5, IL -8 and TNF-α inflammatory cytokines.
T8 1831-1932 Sentence denotes The degree of HMG B1 protein expression was evaluated by dividing the stained sections in 4 portions:
T9 1933-2058 Sentence denotes 1) nucleus of epithelial cells, 2) cytoplasm of epithelial cells, 3) focal extracellular infiltration, 4) inflammatory cells.
T10 2059-2155 Sentence denotes HMG B1 was more expressed in the nucleus of epithelial cells of patients compared with controls.
T11 2156-2240 Sentence denotes In contrast, epithelial cytoplasm HMG B1 staining was significant lower in patients.
T12 2241-2454 Sentence denotes Sub-epithelial focal infiltration of HMG B1 protein expression was lower in controls, whereas the expression of HMG B1 in the inflammatory cells in patients was significantly increased in comparison with controls.
T13 2455-2774 Sentence denotes These data, together with the correlation we found between HMG B1 protein expression in different portions and the number of eosinophils infiltrating cells, or IL -5, IL -8 and TNF-α positive cells in patients, suggest that HMG B1 may play a crucial role in the pathogenesis of chronic rhinosinusitis with nasal polyps.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 148-163 HP_0100582 denotes nasal polyposis
T2 282-305 HP_0002715 denotes immunological disorders
T3 623-629 HP_0000969 denotes oedema
T4 781-785 HP_0012531 denotes pain
T5 786-794 HP_0002315 denotes headache
T6 1273-1285 HP_0100582 denotes nasal polyps
T7 1528-1543 HP_0100582 denotes nasal polyposis
T8 1545-1557 HP_0100582 denotes Nasal polyps
T9 2761-2773 HP_0100582 denotes nasal polyps