PubMed:2333095 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/2333095","sourcedb":"PubMed","sourceid":"2333095","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/2333095","text":"Molecular genetic basis of the histo-blood group ABO system.\nThe histo-blood group ABO, the major human alloantigen system, involves three carbohydrate antigens (ABH). A, B and AB individuals express glycosyltransferase activities converting the H antigen into A or B antigens, whereas O(H) individuals lack such activity. Here we present a molecular basis for the ABO genotypes. The A and B genes differ in a few single-base substitutions, changing four amino-acid residues that may cause differences in A and B transferase specificity. A critical single-base deletion was found in the O gene, which results in an entirely different, inactive protein incapable of modifying the H antigen.","tracks":[]}