PubMed:23328113 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/23328113","sourcedb":"PubMed","sourceid":"23328113","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/23328113","text":"Low-n-6 and low-n-6 plus high-n-3 diets for use in clinical research.\nFew trials have evaluated the metabolic effects and health outcomes of lowering dietary n-6 PUFA. The objectives of the present paper were (1) to report the methods employed to lower dietary n-6 PUFA, while either increasing or maintaining n-3 PUFA intake and (2) to validate our methods with 24 h recalls and erythrocyte fatty acid analyses. A total of sixty-seven subjects were randomised to either (1) an average-n-3 PUFA, low-n-6 PUFA (L6) intervention designed to lower linoleic acid (LA; #2·5% of energy (en%)) and arachidonic acid (#60 mg/d), while maintaining an average US intake of n-3 PUFA or (2) a high-n-3 PUFA, low-n-6 PUFA (H3-L6) intervention designed to lower n-6 LA, while increasing the n-3 PUFA a-linolenic acid (ALA; $1·5 en%) and EPA þ DHA ($1000 mg/d). Pre- and intraintervention nutrient intakes were estimated with six 24 h dietary recalls per subject. Both groups achieved the targeted reductions in dietary LA to #2·5 en% (median LA 2·45 (2·1, 3·1); P,0·001). Intakes of n-3 PUFA did not change for the L6 group. Target increases in n-3 ALA (median 1·6 en%, (1·3, 2·0), P,0·001) and EPA þ DHA (1482 mg, (374, 2558), P,0·001) were achieved in the H3-L6 group. Dietary changes were validated by corresponding changes in erythrocyte n-6 and n-3 fatty acid composition. Dietary LA can be lowered to #2·5 en%, with or without concurrent increases in dietary n-3 PUFA, in an outpatient clinical trial setting using this integrated diet method.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_23328113_3_0","span":{"begin":496,"end":508},"obj":"expanded"},{"id":"SS2_23328113_3_0","span":{"begin":510,"end":512},"obj":"abbr"},{"id":"SS1_23328113_3_1","span":{"begin":680,"end":707},"obj":"expanded"},{"id":"SS2_23328113_3_1","span":{"begin":709,"end":714},"obj":"abbr"},{"id":"SS1_23328113_3_2","span":{"begin":545,"end":558},"obj":"expanded"},{"id":"SS2_23328113_3_2","span":{"begin":560,"end":562},"obj":"abbr"},{"id":"SS1_23328113_3_3","span":{"begin":785,"end":801},"obj":"expanded"},{"id":"SS2_23328113_3_3","span":{"begin":803,"end":806},"obj":"abbr"}],"relations":[{"id":"AE1_23328113_3_0","pred":"abbreviatedTo","subj":"SS1_23328113_3_0","obj":"SS2_23328113_3_0"},{"id":"AE1_23328113_3_1","pred":"abbreviatedTo","subj":"SS1_23328113_3_1","obj":"SS2_23328113_3_1"},{"id":"AE1_23328113_3_2","pred":"abbreviatedTo","subj":"SS1_23328113_3_2","obj":"SS2_23328113_3_2"},{"id":"AE1_23328113_3_3","pred":"abbreviatedTo","subj":"SS1_23328113_3_3","obj":"SS2_23328113_3_3"}],"attributes":[{"subj":"SS1_23328113_3_0","pred":"source","obj":"Allie"},{"subj":"SS2_23328113_3_0","pred":"source","obj":"Allie"},{"subj":"SS1_23328113_3_1","pred":"source","obj":"Allie"},{"subj":"SS2_23328113_3_1","pred":"source","obj":"Allie"},{"subj":"SS1_23328113_3_2","pred":"source","obj":"Allie"},{"subj":"SS2_23328113_3_2","pred":"source","obj":"Allie"},{"subj":"SS1_23328113_3_3","pred":"source","obj":"Allie"},{"subj":"SS2_23328113_3_3","pred":"source","obj":"Allie"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":380,"end":391},"obj":"HP_0001901"},{"id":"T2","span":{"begin":1315,"end":1326},"obj":"HP_0001901"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#93bbec","default":true},{"id":"PubmedHPO","color":"#d5ec93"}]}]}}