PubMed:23327035 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/23327035","sourcedb":"PubMed","sourceid":"23327035","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/23327035","text":"The effect of dexmedetomidine on bispectral index monitoring in children.\nThe primary aim of this study was to test whether dexmedetomidine administration based on the bispectral index (BIS) monitoring caused a reduction in consumption of sevoflurane. Following Institutional Ethic Committee approval and written informed consent from all parents, fifty-four children undergoing sevoflurane anaesthesia randomly allocated to receive either dexmedetomidine (Group D) or saline (Group S). The anaesthesia was induced with 8% sevoflurane in nitrous oxide/oxygen in all children. Following anaesthesia induction, Group D (n=27) children received a loading dose of dexmedetomidine 1 microgkg(-1) IV over ten minutes, followed by a continuous infusion at a rate of 0.5 microgkg(-1) hr(-1) throughout the surgery. Group S (n = 27) children received same volume of saline infusion due to obtained blindness. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), body temperature and peripheral oxygen saturation (SpO2), end-tidal concentrations of oxygen, carbon dioxide (ETCO2), and sevoflurane (ETsevo) were monitorized. Bispectral index numbers and ETsevo concentrations were recorded at 2 min before incision, 2 min after incision, at the end of surgery and before the termination of anaesthesia, and finally immediately after wake-up from anaesthesia (Final BIS number). BIS number was found significantly lower in group D at before incision, after incision and at the end of surgery than in group S (p = 0.000, 0.001, 0.007). End tidal sevoflurane concentrations were significantly higher in group S at before incision, after incision and at the end of surgery than in group D (p \u003c 0.000 to p \u003c 0.001). Final BIS number and sevoflurane concentrations were similar and there were no significant difference between the groups. It was concluded that intravenous (IV) dexmedetomidine infusion at a rate of 0.5 microgkg(-1) hr(-1) during sevoflurane anaesthesia significantly reduces end-tidal sevoflurane concentration and BIS number in children undergoing minor surgical interventions.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_23327035_1_0","span":{"begin":168,"end":184},"obj":"expanded"},{"id":"SS2_23327035_1_0","span":{"begin":186,"end":189},"obj":"abbr"},{"id":"SS1_23327035_6_0","span":{"begin":900,"end":923},"obj":"expanded"},{"id":"SS2_23327035_6_0","span":{"begin":925,"end":928},"obj":"abbr"},{"id":"SS1_23327035_6_1","span":{"begin":931,"end":955},"obj":"expanded"},{"id":"SS2_23327035_6_1","span":{"begin":957,"end":960},"obj":"abbr"},{"id":"SS1_23327035_6_2","span":{"begin":963,"end":973},"obj":"expanded"},{"id":"SS2_23327035_6_2","span":{"begin":975,"end":977},"obj":"abbr"}],"relations":[{"id":"AE1_23327035_1_0","pred":"abbreviatedTo","subj":"SS1_23327035_1_0","obj":"SS2_23327035_1_0"},{"id":"AE1_23327035_6_0","pred":"abbreviatedTo","subj":"SS1_23327035_6_0","obj":"SS2_23327035_6_0"},{"id":"AE1_23327035_6_1","pred":"abbreviatedTo","subj":"SS1_23327035_6_1","obj":"SS2_23327035_6_1"},{"id":"AE1_23327035_6_2","pred":"abbreviatedTo","subj":"SS1_23327035_6_2","obj":"SS2_23327035_6_2"}],"attributes":[{"subj":"SS1_23327035_1_0","pred":"source","obj":"Allie"},{"subj":"SS2_23327035_1_0","pred":"source","obj":"Allie"},{"subj":"SS1_23327035_6_0","pred":"source","obj":"Allie"},{"subj":"SS2_23327035_6_0","pred":"source","obj":"Allie"},{"subj":"SS1_23327035_6_1","pred":"source","obj":"Allie"},{"subj":"SS2_23327035_6_1","pred":"source","obj":"Allie"},{"subj":"SS1_23327035_6_2","pred":"source","obj":"Allie"},{"subj":"SS2_23327035_6_2","pred":"source","obj":"Allie"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":889,"end":898},"obj":"HP_0000618"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#cd93ec","default":true},{"id":"PubmedHPO","color":"#93ecb3"}]}]}}