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PubMed:23326134 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-81 Sentence denotes Growth-inhibitory effects of MOB2 on human hepatic carcinoma cell line SMMC-7721.
TextSentencer_T2 82-86 Sentence denotes AIM:
TextSentencer_T3 87-219 Sentence denotes To investigate the growth-inhibiting and apoptosis-inducing effects of the gene MOB2 on human hepatic carcinoma cell line SMMC-7721.
TextSentencer_T4 220-228 Sentence denotes METHODS:
TextSentencer_T5 229-325 Sentence denotes The full-length cDNA of the MOB2 gene was amplified from human umbilical vein endothelial cells.
TextSentencer_T6 326-421 Sentence denotes The correct full-length MOB2 cDNA was subcloned into the eukaryotic expression vector pEGFP-C1.
TextSentencer_T7 422-555 Sentence denotes After lipofection of the MOB2 gene into cancer cells, the levels of MOB2 protein in the cancer cells were detected by immunoblotting.
TextSentencer_T8 556-825 Sentence denotes To transfect the recombined plasmid vector pEGFP-CI-MOB2 into SMMC-7721 cells, the cells were cultured in Dulbecco's Modified Eagle's Medium with 10% fetal calf serum and glutamine, and then mixed with liposomes, Lipofectamine 2000 and the plasmid vector pEGFP-CI-MOB2.
TextSentencer_T9 826-834 Sentence denotes RESULTS:
TextSentencer_T10 835-991 Sentence denotes We observed the growth and proliferation of SMMC-7721 cells containing pEGFP-CI-MOB2 and analyzed their apoptosis and growth cycle phases by flow cytometry.
TextSentencer_T11 992-1138 Sentence denotes We successfully transfected the recombined plasmid vector pEGFP-CI-MOB2 into SMMC-7721 cells and screened for a single clone cell containing MOB2.
TextSentencer_T12 1139-1333 Sentence denotes After transfection, MOB2 enhanced growth suppression, induced apoptosis, increased the ratio of G0/G1, significantly inhibited the advance of cell cycle phase, and arrested cells in G0/G1 phase.
TextSentencer_T13 1334-1497 Sentence denotes CONCLUSION: MOB2 overexpression induces apoptosis and inhibits the growth of human hepatic cancer cells, which may be useful in gene therapy for hepatic carcinoma.
T1 0-81 Sentence denotes Growth-inhibitory effects of MOB2 on human hepatic carcinoma cell line SMMC-7721.
T2 82-86 Sentence denotes AIM:
T3 87-219 Sentence denotes To investigate the growth-inhibiting and apoptosis-inducing effects of the gene MOB2 on human hepatic carcinoma cell line SMMC-7721.
T4 220-228 Sentence denotes METHODS:
T5 229-325 Sentence denotes The full-length cDNA of the MOB2 gene was amplified from human umbilical vein endothelial cells.
T6 326-421 Sentence denotes The correct full-length MOB2 cDNA was subcloned into the eukaryotic expression vector pEGFP-C1.
T7 422-555 Sentence denotes After lipofection of the MOB2 gene into cancer cells, the levels of MOB2 protein in the cancer cells were detected by immunoblotting.
T8 556-825 Sentence denotes To transfect the recombined plasmid vector pEGFP-CI-MOB2 into SMMC-7721 cells, the cells were cultured in Dulbecco's Modified Eagle's Medium with 10% fetal calf serum and glutamine, and then mixed with liposomes, Lipofectamine 2000 and the plasmid vector pEGFP-CI-MOB2.
T9 826-834 Sentence denotes RESULTS:
T10 835-991 Sentence denotes We observed the growth and proliferation of SMMC-7721 cells containing pEGFP-CI-MOB2 and analyzed their apoptosis and growth cycle phases by flow cytometry.
T11 992-1138 Sentence denotes We successfully transfected the recombined plasmid vector pEGFP-CI-MOB2 into SMMC-7721 cells and screened for a single clone cell containing MOB2.
T12 1139-1333 Sentence denotes After transfection, MOB2 enhanced growth suppression, induced apoptosis, increased the ratio of G0/G1, significantly inhibited the advance of cell cycle phase, and arrested cells in G0/G1 phase.
T13 1334-1497 Sentence denotes CONCLUSION: MOB2 overexpression induces apoptosis and inhibits the growth of human hepatic cancer cells, which may be useful in gene therapy for hepatic carcinoma.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 29-33 gene:81532 denotes MOB2
T1 43-60 disease:C2239176 denotes hepatic carcinoma
T2 167-171 gene:81532 denotes MOB2
T3 181-198 disease:C2239176 denotes hepatic carcinoma
T4 447-451 gene:81532 denotes MOB2
T5 462-468 disease:C0006826 denotes cancer
T6 490-494 gene:81532 denotes MOB2
T7 510-516 disease:C1306459 denotes cancer
T8 490-494 gene:81532 denotes MOB2
T9 510-516 disease:C0006826 denotes cancer
T10 447-451 gene:81532 denotes MOB2
T11 462-468 disease:C1306459 denotes cancer
T12 1346-1350 gene:81532 denotes MOB2
T13 1417-1431 disease:C0279000 denotes hepatic cancer
T14 1346-1350 gene:81532 denotes MOB2
T15 1417-1431 disease:C0345904 denotes hepatic cancer
T16 1346-1350 gene:81532 denotes MOB2
T17 1479-1496 disease:C2239176 denotes hepatic carcinoma
R1 T0 T1 associated_with MOB2,hepatic carcinoma
R2 T2 T3 associated_with MOB2,hepatic carcinoma
R3 T4 T5 associated_with MOB2,cancer
R4 T6 T7 associated_with MOB2,cancer
R5 T8 T9 associated_with MOB2,cancer
R6 T10 T11 associated_with MOB2,cancer
R7 T12 T13 associated_with MOB2,hepatic cancer
R8 T14 T15 associated_with MOB2,hepatic cancer
R9 T16 T17 associated_with MOB2,hepatic carcinoma

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23326134-0#29#33#gene81532 29-33 gene81532 denotes MOB2
23326134-0#43#60#diseaseC2239176 43-60 diseaseC2239176 denotes hepatic carcinoma
23326134-9#0#4#gene81532 1346-1350 gene81532 denotes MOB2
23326134-9#71#85#diseaseC0279000 1417-1431 diseaseC0279000 denotes hepatic cancer
23326134-9#71#85#diseaseC0345904 1417-1431 diseaseC0345904 denotes hepatic cancer
29#33#gene8153243#60#diseaseC2239176 23326134-0#29#33#gene81532 23326134-0#43#60#diseaseC2239176 associated_with MOB2,hepatic carcinoma
0#4#gene8153271#85#diseaseC0279000 23326134-9#0#4#gene81532 23326134-9#71#85#diseaseC0279000 associated_with MOB2,hepatic cancer
0#4#gene8153271#85#diseaseC0345904 23326134-9#0#4#gene81532 23326134-9#71#85#diseaseC0345904 associated_with MOB2,hepatic cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2853 1346-1350 gene:81532 denotes MOB2
T2854 1417-1431 disease:C0279000 denotes hepatic cancer
R1 T2853 T2854 associated_with MOB2,hepatic cancer
R2 T2853 T2854 associated_with MOB2,hepatic cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 292-306 http://purl.obolibrary.org/obo/UBERON_0002066 denotes umbilical vein
PD-UBERON-AE-B_T2 292-318 http://purl.obolibrary.org/obo/UBERON_0007777 denotes umbilical vein endothelial
PD-UBERON-AE-B_T3 302-306 http://purl.obolibrary.org/obo/UBERON_0001638 denotes vein
PD-UBERON-AE-B_T4 717-722 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 717-722 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T2 302-306 http://purl.obolibrary.org/obo/UBERON_0001638 denotes vein
PD-UBERON-AE-B_T3 292-306 http://purl.obolibrary.org/obo/UBERON_0002066 denotes umbilical vein
PD-UBERON-AE-B_T4 292-318 http://purl.obolibrary.org/obo/UBERON_0007777 denotes umbilical vein endothelial