PubMed:23324246
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/23324246","sourcedb":"PubMed","sourceid":"23324246","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/23324246","text":"Immunohistochemical expression of HBME-1, E-cadherin, and CD56 in the differential diagnosis of thyroid nodules.\nBACKGROUND AND OBJECTIVE: Distinction between benign and malignant thyroid tumors is essential for proper clinical management. The aim of this study was to evaluate the diagnostic potential of a set of 3 molecular markers in the differential diagnosis of thyroid tumors.\nMATERIAL AND METHODS: Immunohistochemistry for HBME-1, E-cadherin (E-CAD), and CD56 was carried out in 36 follicular adenomas, 77 colloid goiters, 36 papillary thyroid carcinomas, and 14 follicular carcinomas. Sixty-eight thyroid fine needle aspiration (FNA) cases confirmed by subsequent surgical resection specimens were selected. Immunocytochemistry for HBME-1, E-CAD, and CD56 was performed in these cases, including 25 papillary thyroid carcinomas, 1 follicular carcinoma, 22 follicular adenomas, and 20 colloid goiters.\nRESULTS: PTC was characterized by a decreased expression of E-CAD and CD56 contrary to the surrounding benign thyroid tissues. There was no HBME-1 expression in benign thyroid tissues, but it was high in papillary thyroid carcinomas and weak in follicular adenomas. The expression of E-CAD and CD56 was significantly higher in follicular adenomas than in the surrounding thyroid tissues. Analyzing the FNA material, HBME-1 expression was documented in 96% of papillary thyroid carcinomas, but there was no expression in the benign lesions. E-CAD and CD56 expression was significantly weakened in papillary thyroid carcinomas, but enhanced in follicular adenomas.\nCONCLUSIONS: HBME-1 was found only in malignant lesions and can be considered the most sensitive, specific single marker in papillary thyroid carcinomas. CD56 and E-CAD can assist in the decision-making on the benign and malignant nature of the nodule. Immunocytochemistry is of value as an ancillary test to enhance the diagnostic accuracy of thyroid FNA samples.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_23324246_5_0","span":{"begin":439,"end":449},"obj":"expanded"},{"id":"SS2_23324246_5_0","span":{"begin":451,"end":456},"obj":"abbr"},{"id":"SS1_23324246_6_0","span":{"begin":614,"end":636},"obj":"expanded"},{"id":"SS2_23324246_6_0","span":{"begin":638,"end":641},"obj":"abbr"}],"relations":[{"id":"AE1_23324246_5_0","pred":"abbreviatedTo","subj":"SS1_23324246_5_0","obj":"SS2_23324246_5_0"},{"id":"AE1_23324246_6_0","pred":"abbreviatedTo","subj":"SS1_23324246_6_0","obj":"SS2_23324246_6_0"}],"attributes":[{"subj":"SS1_23324246_5_0","pred":"source","obj":"Allie"},{"subj":"SS2_23324246_5_0","pred":"source","obj":"Allie"},{"subj":"SS1_23324246_6_0","pred":"source","obj":"Allie"},{"subj":"SS2_23324246_6_0","pred":"source","obj":"Allie"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":188,"end":194},"obj":"HP_0002664"},{"id":"T2","span":{"begin":376,"end":382},"obj":"HP_0002664"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"}]},{"project":"MyTest","denotations":[{"id":"T1","span":{"begin":851,"end":860},"obj":"something"},{"id":"T2","span":{"begin":876,"end":884},"obj":"something"}],"relations":[{"id":"R1","pred":"something","subj":"T1","obj":"T2"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"T1","pred":"source","obj":"MyTest"},{"subj":"T2","pred":"source","obj":"MyTest"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#ec93bc","default":true},{"id":"PubmedHPO","color":"#93d6ec"},{"id":"MyTest","color":"#ece893"}]}]}}