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PubMed:23322600 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-83 Sentence denotes Primary, post-primary and non-specific immunoglobulin M responses in HCV infection.
T2 84-190 Sentence denotes Delayed and variable antibody responses to HCV make it difficult to diagnose acute HCV infection reliably.
T3 191-280 Sentence denotes Immunoglobulin (Ig)M and IgG anti-HCV may be observed simultaneously as disease persists.
T4 281-410 Sentence denotes IgM plays a key role in mixed cryoglobulinemia (MC), an immune complex disease strongly associated with persistent HCV infection.
T5 411-609 Sentence denotes In MC, clonal or oligoclonal IgM rheumatoid factors facilitate the deposition of immune complexes in small blood vessels and tissue, leading to inflammation, complement activation and tissue damage.
T6 610-727 Sentence denotes Clonally expanded IgM(+)κ(+) B-cells expressing rheumatoid factor-like IgM are abundant in many HCV patients with MC.
T7 728-1000 Sentence denotes The observation that identical or similar IgM antibodies are expressed in different patients' clonally expanded B-cells supports the hypothesis that MC is driven by antigen-specific B-cell activation, rather than polyclonal B-cell activation or HCV replication in B-cells.
T8 1001-1082 Sentence denotes More study is required to identify the antigens that drive the development of MC.
T1 0-83 Sentence denotes Primary, post-primary and non-specific immunoglobulin M responses in HCV infection.
T2 84-190 Sentence denotes Delayed and variable antibody responses to HCV make it difficult to diagnose acute HCV infection reliably.
T3 191-280 Sentence denotes Immunoglobulin (Ig)M and IgG anti-HCV may be observed simultaneously as disease persists.
T4 281-410 Sentence denotes IgM plays a key role in mixed cryoglobulinemia (MC), an immune complex disease strongly associated with persistent HCV infection.
T5 411-609 Sentence denotes In MC, clonal or oligoclonal IgM rheumatoid factors facilitate the deposition of immune complexes in small blood vessels and tissue, leading to inflammation, complement activation and tissue damage.
T6 610-727 Sentence denotes Clonally expanded IgM(+)κ(+) B-cells expressing rheumatoid factor-like IgM are abundant in many HCV patients with MC.
T7 728-1000 Sentence denotes The observation that identical or similar IgM antibodies are expressed in different patients' clonally expanded B-cells supports the hypothesis that MC is driven by antigen-specific B-cell activation, rather than polyclonal B-cell activation or HCV replication in B-cells.
T8 1001-1082 Sentence denotes More study is required to identify the antigens that drive the development of MC.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 910-927 gene:29760 denotes B-cell activation
T1 877-879 disease:C0543697 denotes MC
R1 T0 T1 associated_with B-cell activation,MC

Allie

Id Subject Object Predicate Lexical cue
SS1_23322600_2_0 191-205 expanded denotes Immunoglobulin
SS2_23322600_2_0 207-209 abbr denotes Ig
SS1_23322600_3_0 305-327 expanded denotes mixed cryoglobulinemia
SS2_23322600_3_0 329-331 abbr denotes MC
AE1_23322600_2_0 SS1_23322600_2_0 SS2_23322600_2_0 abbreviatedTo Immunoglobulin,Ig
AE1_23322600_3_0 SS1_23322600_3_0 SS2_23322600_3_0 abbreviatedTo mixed cryoglobulinemia,MC

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 311-327 HP_0100778 denotes cryoglobulinemia

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23322600-6#182#199#gene29760 910-927 gene29760 denotes B-cell activation
23322600-6#149#151#diseaseC0543697 877-879 diseaseC0543697 denotes MC
182#199#gene29760149#151#diseaseC0543697 23322600-6#182#199#gene29760 23322600-6#149#151#diseaseC0543697 associated_with B-cell activation,MC