PubMed:23321165
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/23321165","sourcedb":"PubMed","sourceid":"23321165","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/23321165","text":"Identification of serum microRNA-21 as a biomarker for chemosensitivity and prognosis in human osteosarcoma.\nOBJECTIVE: The aim of this study was to investigate the serum level of microRNA (miR)-21 in patients with osteosarcoma and its correlation with chemosensitivity and prognosis.\nMETHODS: miR-21 levels in sera from 65 patients with osteosarcoma and 30 healthy controls were measured by real-time reverse transcription-polymerase chain reaction. Correlations between serum miR-21 and clinicopathological features in patients with osteosarcoma were determined. The prognostic significance of serum miR-21 was assessed using a Cox proportional hazards model.\nRESULTS: The serum level of miR-21 was significantly higher in patients with osteosarcoma than in control subjects. High serum miR-21 was significantly correlated with advanced Enneking stage and chemotherapeutic resistance. Univariate and multivariate analyses for overall survival showed that upregulation of serum miR-21 was an independent, unfavourable prognostic factor for patients with osteosarcoma (hazard ratio, 2.325).\nCONCLUSIONS: miR-21 might be a good candidate for a therapeutic target, and a potential biomarker for the prediction of chemotherapeutic sensitivity and prognosis in patients with osteosarcoma.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_23321165_2_0","span":{"begin":180,"end":188},"obj":"expanded"},{"id":"SS2_23321165_2_0","span":{"begin":190,"end":193},"obj":"abbr"}],"relations":[{"id":"AE1_23321165_2_0","pred":"abbreviatedTo","subj":"SS1_23321165_2_0","obj":"SS2_23321165_2_0"}],"attributes":[{"subj":"SS1_23321165_2_0","pred":"source","obj":"Allie"},{"subj":"SS2_23321165_2_0","pred":"source","obj":"Allie"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":215,"end":227},"obj":"HP_0002669"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":478,"end":484},"obj":"gene:406991"},{"id":"T1","span":{"begin":535,"end":547},"obj":"disease:C0029463"},{"id":"T2","span":{"begin":478,"end":484},"obj":"gene:406991"},{"id":"T3","span":{"begin":535,"end":547},"obj":"disease:C0585442"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#ec93b8","default":true},{"id":"PubmedHPO","color":"#93d2ec"},{"id":"DisGeNET","color":"#ecec93"}]}]}}