PubMed:23304686 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/23304686","sourcedb":"PubMed","sourceid":"23304686","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/23304686","text":"The effectiveness of adjunctive light-activated disinfection (LAD) in the treatment of peri-implantitis: 4-month results from a multicentre pragmatic randomised controlled trial.\nOBJECTIVES: To evaluate possible benefits of the adjunctive use of light-activated disinfection (LAD) in the treatment of peri-implantitis.\nMATERIALS AND METHODS: Eighty patients with at least one implant affected by peri-implantitis defined as at least 3 mm of bone loss from the baseline radiographs in the presence of signs of infection (pus exudation and/or soft tissue swelling and/or soft tissue redness) were nonsurgically or surgically treated. A total of 50% were randomly allocated to receive an additional treatment of LAD (FotoSan) according to a parallel group design at four different centres. Only one implant per patient was considered. Outcome measures recorded up to 4 months after treatment were implant failures, complications, probing pocket depth (PPD) changes and number of re-treatment sessions recorded by blinded assessors. Patients were followed for 4 months after treatment.\nRESULTS: Five treated patients did not fit the original inclusion criteria, 4 because they were not affected by peri-implantitis (as defined in the present study) and one because the patient was treated with antibiotics, however they were included according to an intention-to-treat analysis concept. Nine patients of the LAD group were treated surgically versus 10 control patients. After 4 months, 1 patient dropped out from the LAD group and no implant failed. Fifteen implants had to be re-treated in the LAD group versus 16 implants in the control group, the difference was not significant. Three minor complications occurred: 2 in the LAD group and 1 in the control group. PPD significantly decreased in both groups, and at 4 months there was no significant differences between groups (difference -0.12 mm, 95% CI of difference -0.94 to 0.69, P = 0.77). There were significant differences between centres for number of re-treatments needed, PPD changes, plaque and marginal bleeding 4 months after treatment. The results did not change when removing the 5 patients who did not match the present inclusion criteria.\nCONCLUSIONS: The use of adjunctive LAD therapy with mechanical cleaning of implants affected by peri-implantitis did not improve any clinical outcomes up to 4 months after treatment, however longer follow-ups are needed to evaluate the possible effect of repeated LAD therapy over time.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_23304686_0_0","span":{"begin":32,"end":60},"obj":"expanded"},{"id":"SS2_23304686_0_0","span":{"begin":62,"end":65},"obj":"abbr"},{"id":"SS1_23304686_2_0","span":{"begin":246,"end":274},"obj":"expanded"},{"id":"SS2_23304686_2_0","span":{"begin":276,"end":279},"obj":"abbr"},{"id":"SS1_23304686_7_0","span":{"begin":927,"end":947},"obj":"expanded"},{"id":"SS2_23304686_7_0","span":{"begin":949,"end":952},"obj":"abbr"}],"relations":[{"id":"AE1_23304686_0_0","pred":"abbreviatedTo","subj":"SS1_23304686_0_0","obj":"SS2_23304686_0_0"},{"id":"AE1_23304686_2_0","pred":"abbreviatedTo","subj":"SS1_23304686_2_0","obj":"SS2_23304686_2_0"},{"id":"AE1_23304686_7_0","pred":"abbreviatedTo","subj":"SS1_23304686_7_0","obj":"SS2_23304686_7_0"}],"attributes":[{"subj":"SS1_23304686_0_0","pred":"source","obj":"Allie"},{"subj":"SS2_23304686_0_0","pred":"source","obj":"Allie"},{"subj":"SS1_23304686_2_0","pred":"source","obj":"Allie"},{"subj":"SS2_23304686_2_0","pred":"source","obj":"Allie"},{"subj":"SS1_23304686_7_0","pred":"source","obj":"Allie"},{"subj":"SS2_23304686_7_0","pred":"source","obj":"Allie"}]},{"project":"PCI_RCT","denotations":[{"id":"T1","span":{"begin":87,"end":103},"obj":"DP"},{"id":"T2","span":{"begin":396,"end":412},"obj":"DP"},{"id":"T3","span":{"begin":1194,"end":1210},"obj":"DP"},{"id":"T4","span":{"begin":301,"end":317},"obj":"DP"},{"id":"T5","span":{"begin":2299,"end":2315},"obj":"DP"}],"attributes":[{"subj":"T1","pred":"source","obj":"PCI_RCT"},{"subj":"T2","pred":"source","obj":"PCI_RCT"},{"subj":"T3","pred":"source","obj":"PCI_RCT"},{"subj":"T4","pred":"source","obj":"PCI_RCT"},{"subj":"T5","pred":"source","obj":"PCI_RCT"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#ccec93","default":true},{"id":"PCI_RCT","color":"#ec93e6"}]}]}}