> top > docs > PubMed:23280345 > annotations

PubMed:23280345 JSONTXT

Annnotations TAB JSON ListView MergeView

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-111 Sentence denotes Synergistic effects of interleukin-1β and interleukin-17A antibodies on collagen-induced arthritis mouse model.
T2 112-260 Sentence denotes Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that mainly causes the synovial joint inflammation and cartilage destruction.
T3 261-391 Sentence denotes Both interleukin-1β (IL-1β) and Interleukin-17 (IL-17) are important proinflammatory cytokines involved in the pathogenesis of RA.
T4 392-572 Sentence denotes We investigated whether combination therapy with IL-1β and IL-17A antibodies would generate the potential for synergistic effects on a collagen-induced arthritis (CIA) mouse model.
T5 573-689 Sentence denotes Mice with CIA were subcutaneously injected with humanized IL-1β antibody, IL-17A antibody, or combination treatment.
T6 690-877 Sentence denotes The effects of treatment were determined by arthritis severity score, histological damage and bone destruction, autoreactive humoral and cellular immune responses and cytokine production.
T7 878-1016 Sentence denotes Treatment with IL-1β antibody or IL-17A antibody alone resulted in beneficial effects on clinical and histological parameters of CIA mice.
T8 1017-1372 Sentence denotes Compared with the single antibody treatments, the combination therapy resulted in a more significant effect in alleviating the severity of arthritis by preventing bone damage and cartilage destruction, reducing humoral and cellular immune responses, and down-regulating the expression of IL-1β, IL-6, IL-17A, IFN-γ, RANKL and MMP-3 in inflammatory tissue.
T9 1373-1591 Sentence denotes In conclusion, combination treatment with humanized IL-1β and IL-17A antibodies demonstrates synergistic beneficial effects for preventing joint inflammation and cartilage destruction and bone damage in CIA mice model.
T10 1592-1734 Sentence denotes These studies also provide evidence that combination with IL-1β and IL-17A antibodies may lead to a new combinatorial therapy for RA patients.
T1 0-111 Sentence denotes Synergistic effects of interleukin-1β and interleukin-17A antibodies on collagen-induced arthritis mouse model.
T2 112-260 Sentence denotes Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that mainly causes the synovial joint inflammation and cartilage destruction.
T3 261-391 Sentence denotes Both interleukin-1β (IL-1β) and Interleukin-17 (IL-17) are important proinflammatory cytokines involved in the pathogenesis of RA.
T4 392-572 Sentence denotes We investigated whether combination therapy with IL-1β and IL-17A antibodies would generate the potential for synergistic effects on a collagen-induced arthritis (CIA) mouse model.
T5 573-689 Sentence denotes Mice with CIA were subcutaneously injected with humanized IL-1β antibody, IL-17A antibody, or combination treatment.
T6 690-877 Sentence denotes The effects of treatment were determined by arthritis severity score, histological damage and bone destruction, autoreactive humoral and cellular immune responses and cytokine production.
T7 878-1016 Sentence denotes Treatment with IL-1β antibody or IL-17A antibody alone resulted in beneficial effects on clinical and histological parameters of CIA mice.
T8 1017-1372 Sentence denotes Compared with the single antibody treatments, the combination therapy resulted in a more significant effect in alleviating the severity of arthritis by preventing bone damage and cartilage destruction, reducing humoral and cellular immune responses, and down-regulating the expression of IL-1β, IL-6, IL-17A, IFN-γ, RANKL and MMP-3 in inflammatory tissue.
T9 1373-1591 Sentence denotes In conclusion, combination treatment with humanized IL-1β and IL-17A antibodies demonstrates synergistic beneficial effects for preventing joint inflammation and cartilage destruction and bone damage in CIA mice model.
T10 1592-1734 Sentence denotes These studies also provide evidence that combination with IL-1β and IL-17A antibodies may lead to a new combinatorial therapy for RA patients.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 266-280 gene:3553 denotes interleukin-1β
T1 388-390 disease:C0003873 denotes RA
T2 441-446 gene:3553 denotes IL-1β
T3 527-553 disease:C0971858 denotes collagen-induced arthritis
T4 441-446 gene:3553 denotes IL-1β
T5 555-558 disease:C0971858 denotes CIA
T6 451-457 gene:3605 denotes IL-17A
T7 527-553 disease:C0971858 denotes collagen-induced arthritis
T8 451-457 gene:3605 denotes IL-17A
T9 555-558 disease:C0971858 denotes CIA
T10 1435-1441 gene:3605 denotes IL-17A
T11 1576-1579 disease:C0971858 denotes CIA
T12 1425-1430 gene:3553 denotes IL-1β
T13 1576-1579 disease:C0971858 denotes CIA
T14 1435-1441 gene:3605 denotes IL-17A
T15 1512-1530 disease:C0003864 denotes joint inflammation
T16 1425-1430 gene:3553 denotes IL-1β
T17 1512-1530 disease:C0003864 denotes joint inflammation
T18 1650-1655 gene:3553 denotes IL-1β
T19 1722-1724 disease:C0003873 denotes RA
T20 1660-1666 gene:3605 denotes IL-17A
T21 1722-1724 disease:C0003873 denotes RA
R1 T0 T1 associated_with interleukin-1β,RA
R2 T2 T3 associated_with IL-1β,collagen-induced arthritis
R3 T4 T5 associated_with IL-1β,CIA
R4 T6 T7 associated_with IL-17A,collagen-induced arthritis
R5 T8 T9 associated_with IL-17A,CIA
R6 T10 T11 associated_with IL-17A,CIA
R7 T12 T13 associated_with IL-1β,CIA
R8 T14 T15 associated_with IL-17A,joint inflammation
R9 T16 T17 associated_with IL-1β,joint inflammation
R10 T18 T19 associated_with IL-1β,RA
R11 T20 T21 associated_with IL-17A,RA

Allie

Id Subject Object Predicate Lexical cue
SS1_23280345_1_0 112-132 expanded denotes Rheumatoid arthritis
SS2_23280345_1_0 134-136 abbr denotes RA
SS1_23280345_2_0 266-280 expanded denotes interleukin-1β
SS2_23280345_2_0 282-287 abbr denotes IL-1β
SS1_23280345_2_1 293-307 expanded denotes Interleukin-17
SS2_23280345_2_1 309-314 abbr denotes IL-17
SS1_23280345_3_0 527-553 expanded denotes collagen-induced arthritis
SS2_23280345_3_0 555-558 abbr denotes CIA
AE1_23280345_1_0 SS1_23280345_1_0 SS2_23280345_1_0 abbreviatedTo Rheumatoid arthritis,RA
AE1_23280345_2_0 SS1_23280345_2_0 SS2_23280345_2_0 abbreviatedTo interleukin-1β,IL-1β
AE1_23280345_2_1 SS1_23280345_2_1 SS2_23280345_2_1 abbreviatedTo Interleukin-17,IL-17
AE1_23280345_3_0 SS1_23280345_3_0 SS2_23280345_3_0 abbreviatedTo collagen-induced arthritis,CIA

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 112-132 HP_0001370 denotes Rheumatoid arthritis
T2 123-132 HP_0001369 denotes arthritis
T3 151-161 HP_0002960 denotes autoimmune
T4 238-259 HP_0100773 denotes cartilage destruction
T5 544-553 HP_0001369 denotes arthritis
T6 734-743 HP_0001369 denotes arthritis
T7 1156-1165 HP_0001369 denotes arthritis
T8 1196-1217 HP_0100773 denotes cartilage destruction
T9 1535-1556 HP_0100773 denotes cartilage destruction

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23280345-0#23#37#gene3553 23-37 gene3553 denotes interleukin-1β
23280345-0#42#57#gene3605 42-57 gene3605 denotes interleukin-17A
23280345-0#89#98#diseaseC0003864 89-98 diseaseC0003864 denotes arthritis
23280345-2#5#19#gene3553 266-280 gene3553 denotes interleukin-1β
23280345-2#21#26#gene3553 282-287 gene3553 denotes IL-1β
23280345-2#127#129#diseaseC0003873 388-390 diseaseC0003873 denotes RA
23280345-7#326#331#gene4314 1343-1348 gene4314 denotes MMP-3
23280345-7#139#148#diseaseC0003864 1156-1165 diseaseC0003864 denotes arthritis
23280345-9#68#74#gene3605 1660-1666 gene3605 denotes IL-17A
23280345-9#130#132#diseaseC0003873 1722-1724 diseaseC0003873 denotes RA
23#37#gene355389#98#diseaseC0003864 23280345-0#23#37#gene3553 23280345-0#89#98#diseaseC0003864 associated_with interleukin-1β,arthritis
42#57#gene360589#98#diseaseC0003864 23280345-0#42#57#gene3605 23280345-0#89#98#diseaseC0003864 associated_with interleukin-17A,arthritis
5#19#gene3553127#129#diseaseC0003873 23280345-2#5#19#gene3553 23280345-2#127#129#diseaseC0003873 associated_with interleukin-1β,RA
21#26#gene3553127#129#diseaseC0003873 23280345-2#21#26#gene3553 23280345-2#127#129#diseaseC0003873 associated_with IL-1β,RA
326#331#gene4314139#148#diseaseC0003864 23280345-7#326#331#gene4314 23280345-7#139#148#diseaseC0003864 associated_with MMP-3,arthritis
68#74#gene3605130#132#diseaseC0003873 23280345-9#68#74#gene3605 23280345-9#130#132#diseaseC0003873 associated_with IL-17A,RA