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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 277-283 Glycan_Motif denotes core 1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO
T2 325-331 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T3 1048-1054 Glycan_Motif denotes core 1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO

sentences

Id Subject Object Predicate Lexical cue
T1 0-108 Sentence denotes Cyclooxygenase-2 enzyme induces the expression of the α-2,3-sialyltransferase-3 (ST3Gal-I) in breast cancer.
T2 109-172 Sentence denotes Aberrant glycosylation is a common feature of malignant change.
T3 173-390 Sentence denotes Changes in mucin-type O-linked glycosylation in breast cancer can result in the expression of truncated core 1-based sialylated glycans rather than the core 2-based glycans observed in normal mammary epithelium cells.
T4 391-540 Sentence denotes This has been shown, in part, to be due to changes in the expression of glycosyltransferases, including the up-regulation of some sialyltransferases.
T5 541-869 Sentence denotes Using the breast cancer cell line T47D, we have shown that PGE2, one of the final products of the cyclooxygenase-2 (COX-2) pathway, can induce the mRNA expression of the sialyltransferase α-2,3-sialyltransferase-3 (ST3Gal-I), resulting in increased sialyltransferase activity, demonstrated by a reduction in PNA lectin staining.
T6 870-1069 Sentence denotes Induction of COX-2 in the MDA-MB-231 breast cancer cell line also results in the increased expression of ST3Gal-I, leading to increased sialylation of the substrate of ST3Gal-I, core 1 Galβ1,3GalNAc.
T7 1070-1158 Sentence denotes This effect on sialylation could be reversed by the selective COX-2 inhibitor celecoxib.
T8 1159-1312 Sentence denotes The use of siRNA to knock down COX-2 and overexpression of COX-2 in MDA-MD-231 cells confirmed the involvement of COX-2 in the up-regulation of ST3Gal-I.
T9 1313-1458 Sentence denotes Moreover, analysis of the expression of ST3Gal-I and COX-2 by 74 primary breast cancers showed a significant correlation between the two enzymes.
T10 1459-1601 Sentence denotes COX-2 expression has been associated with a number of tumors, including breast cancer, where its expression is associated with poor prognoses.
T11 1602-1812 Sentence denotes Thus, these results suggest the intriguing possibility that some of the malignant characteristics associated with COX-2 expression may be via the influence that COX-2 exerts on the glycosylation of tumor cells.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 277-283 https://glytoucan.org/Structures/Glycans/G00031MO denotes core 1
T2 1048-1054 https://glytoucan.org/Structures/Glycans/G00031MO denotes core 1

DisGeNET

Id Subject Object Predicate Lexical cue
T0 0-16 gene:5743 denotes Cyclooxygenase-2
T1 94-107 disease:C0678222 denotes breast cancer
T2 81-89 gene:6482 denotes ST3Gal-I
T3 94-107 disease:C0678222 denotes breast cancer
T4 81-89 gene:6482 denotes ST3Gal-I
T5 94-107 disease:C0006142 denotes breast cancer
T6 0-16 gene:5743 denotes Cyclooxygenase-2
T7 94-107 disease:C0006142 denotes breast cancer
T8 657-662 gene:5743 denotes COX-2
T9 551-564 disease:C0006142 denotes breast cancer
T10 657-662 gene:5743 denotes COX-2
T11 551-564 disease:C0678222 denotes breast cancer
T12 756-764 gene:6482 denotes ST3Gal-I
T13 551-564 disease:C0006142 denotes breast cancer
T14 756-764 gene:6482 denotes ST3Gal-I
T15 551-564 disease:C0678222 denotes breast cancer
T16 883-888 gene:5743 denotes COX-2
T17 907-920 disease:C0006142 denotes breast cancer
T18 975-983 gene:6482 denotes ST3Gal-I
T19 907-920 disease:C0678222 denotes breast cancer
T20 975-983 gene:6482 denotes ST3Gal-I
T21 907-920 disease:C0006142 denotes breast cancer
T22 883-888 gene:5743 denotes COX-2
T23 907-920 disease:C0678222 denotes breast cancer
T24 1353-1361 gene:6482 denotes ST3Gal-I
T25 1386-1400 disease:C0006142 denotes breast cancers
T26 1366-1371 gene:5743 denotes COX-2
T27 1386-1400 disease:C0006142 denotes breast cancers
T28 1459-1464 gene:5743 denotes COX-2
T29 1531-1544 disease:C0006142 denotes breast cancer
T30 1459-1464 gene:5743 denotes COX-2
T31 1531-1544 disease:C0678222 denotes breast cancer
T32 1459-1464 gene:4513 denotes COX-2
T33 1531-1544 disease:C0006142 denotes breast cancer
T34 1459-1464 gene:4513 denotes COX-2
T35 1531-1544 disease:C0678222 denotes breast cancer
R1 T0 T1 associated_with Cyclooxygenase-2,breast cancer
R2 T2 T3 associated_with ST3Gal-I,breast cancer
R3 T4 T5 associated_with ST3Gal-I,breast cancer
R4 T6 T7 associated_with Cyclooxygenase-2,breast cancer
R5 T8 T9 associated_with COX-2,breast cancer
R6 T10 T11 associated_with COX-2,breast cancer
R7 T12 T13 associated_with ST3Gal-I,breast cancer
R8 T14 T15 associated_with ST3Gal-I,breast cancer
R9 T16 T17 associated_with COX-2,breast cancer
R10 T18 T19 associated_with ST3Gal-I,breast cancer
R11 T20 T21 associated_with ST3Gal-I,breast cancer
R12 T22 T23 associated_with COX-2,breast cancer
R13 T24 T25 associated_with ST3Gal-I,breast cancers
R14 T26 T27 associated_with COX-2,breast cancers
R15 T28 T29 associated_with COX-2,breast cancer
R16 T30 T31 associated_with COX-2,breast cancer
R17 T32 T33 associated_with COX-2,breast cancer
R18 T34 T35 associated_with COX-2,breast cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_23275522_4_0 639-655 expanded denotes cyclooxygenase-2
SS2_23275522_4_0 657-662 abbr denotes COX-2
AE1_23275522_4_0 SS1_23275522_4_0 SS2_23275522_4_0 abbreviatedTo cyclooxygenase-2,COX-2

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 221-234 HP_0003002 denotes breast cancer
T2 221-234 HP_0100013 denotes breast cancer
T3 228-234 HP_0002664 denotes cancer
T4 551-564 HP_0003002 denotes breast cancer
T5 551-564 HP_0100013 denotes breast cancer
T6 558-564 HP_0002664 denotes cancer
T7 907-920 HP_0003002 denotes breast cancer
T8 907-920 HP_0100013 denotes breast cancer
T9 914-920 HP_0002664 denotes cancer
T10 1386-1400 HP_0003002 denotes breast cancers
T11 1386-1400 HP_0100013 denotes breast cancers
T12 1393-1400 HP_0002664 denotes cancers
T13 1513-1519 HP_0002664 denotes tumors
T14 1531-1544 HP_0003002 denotes breast cancer
T15 1531-1544 HP_0100013 denotes breast cancer
T16 1538-1544 HP_0002664 denotes cancer
T17 1800-1805 HP_0002664 denotes tumor

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23275522-0#0#16#gene5743 0-16 gene5743 denotes Cyclooxygenase-2
23275522-0#81#89#gene6482 81-89 gene6482 denotes ST3Gal-I
23275522-0#94#107#diseaseC0006142 94-107 diseaseC0006142 denotes breast cancer
23275522-0#94#107#diseaseC0678222 94-107 diseaseC0678222 denotes breast cancer
23275522-0#94#107#diseaseC0006142 94-107 diseaseC0006142 denotes breast cancer
23275522-0#94#107#diseaseC0678222 94-107 diseaseC0678222 denotes breast cancer
23275522-9#0#5#gene4513 1459-1464 gene4513 denotes COX-2
23275522-9#72#85#diseaseC0006142 1531-1544 diseaseC0006142 denotes breast cancer
23275522-9#72#85#diseaseC0678222 1531-1544 diseaseC0678222 denotes breast cancer
0#16#gene574394#107#diseaseC0006142 23275522-0#0#16#gene5743 23275522-0#94#107#diseaseC0006142 associated_with Cyclooxygenase-2,breast cancer
0#16#gene574394#107#diseaseC0678222 23275522-0#0#16#gene5743 23275522-0#94#107#diseaseC0678222 associated_with Cyclooxygenase-2,breast cancer
0#16#gene574394#107#diseaseC0006142 23275522-0#0#16#gene5743 23275522-0#94#107#diseaseC0006142 associated_with Cyclooxygenase-2,breast cancer
0#16#gene574394#107#diseaseC0678222 23275522-0#0#16#gene5743 23275522-0#94#107#diseaseC0678222 associated_with Cyclooxygenase-2,breast cancer
81#89#gene648294#107#diseaseC0006142 23275522-0#81#89#gene6482 23275522-0#94#107#diseaseC0006142 associated_with ST3Gal-I,breast cancer
81#89#gene648294#107#diseaseC0678222 23275522-0#81#89#gene6482 23275522-0#94#107#diseaseC0678222 associated_with ST3Gal-I,breast cancer
81#89#gene648294#107#diseaseC0006142 23275522-0#81#89#gene6482 23275522-0#94#107#diseaseC0006142 associated_with ST3Gal-I,breast cancer
81#89#gene648294#107#diseaseC0678222 23275522-0#81#89#gene6482 23275522-0#94#107#diseaseC0678222 associated_with ST3Gal-I,breast cancer
0#5#gene451372#85#diseaseC0006142 23275522-9#0#5#gene4513 23275522-9#72#85#diseaseC0006142 associated_with COX-2,breast cancer
0#5#gene451372#85#diseaseC0678222 23275522-9#0#5#gene4513 23275522-9#72#85#diseaseC0678222 associated_with COX-2,breast cancer

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 94-107 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T2 221-234 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T3 551-564 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T4 907-920 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T5 1378-1400 Disease denotes primary breast cancers http://purl.obolibrary.org/obo/MONDO_0007254
T6 1513-1519 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T7 1531-1544 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T8 1800-1805 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 94-107 Phenotype denotes breast cancer HP:0003002
T2 221-234 Phenotype denotes breast cancer HP:0003002
T3 551-564 Phenotype denotes breast cancer HP:0003002
T4 907-920 Phenotype denotes breast cancer HP:0003002
T5 1386-1400 Phenotype denotes breast cancers HP:0003002
T6 1531-1544 Phenotype denotes breast cancer HP:0003002
T7 1800-1805 Phenotype denotes tumor HP:0002664

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 277-283 Glycan denotes core 1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO
T2 325-331 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T3 1048-1054 Glycan denotes core 1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO
T4 1062-1068 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 94-107 Phenotype denotes breast cancer HP:0003002
T2 221-234 Phenotype denotes breast cancer HP:0003002
T3 551-564 Phenotype denotes breast cancer HP:0003002
T4 907-920 Phenotype denotes breast cancer HP:0003002
T5 1386-1400 Phenotype denotes breast cancers HP:0003002
T6 1531-1544 Phenotype denotes breast cancer HP:0003002
T7 1800-1805 Phenotype denotes tumor HP:0002664

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 94-107 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T2 221-234 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T3 551-564 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T4 907-920 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T5 1378-1400 Disease denotes primary breast cancers http://purl.obolibrary.org/obo/MONDO_0007254
T6 1513-1519 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T7 1531-1544 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T8 1800-1805 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 558-569 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064
T2 914-925 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064
T3 1800-1811 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 94-100 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T2 221-227 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T3 365-383 Body_part denotes mammary epithelium http://purl.obolibrary.org/obo/UBERON_0003244
T4 551-557 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T5 907-913 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T6 1386-1392 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T7 1531-1537 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310

sentences

Id Subject Object Predicate Lexical cue
T1 0-108 Sentence denotes Cyclooxygenase-2 enzyme induces the expression of the α-2,3-sialyltransferase-3 (ST3Gal-I) in breast cancer.
T2 109-172 Sentence denotes Aberrant glycosylation is a common feature of malignant change.
T3 173-390 Sentence denotes Changes in mucin-type O-linked glycosylation in breast cancer can result in the expression of truncated core 1-based sialylated glycans rather than the core 2-based glycans observed in normal mammary epithelium cells.
T4 391-540 Sentence denotes This has been shown, in part, to be due to changes in the expression of glycosyltransferases, including the up-regulation of some sialyltransferases.
T5 541-869 Sentence denotes Using the breast cancer cell line T47D, we have shown that PGE2, one of the final products of the cyclooxygenase-2 (COX-2) pathway, can induce the mRNA expression of the sialyltransferase α-2,3-sialyltransferase-3 (ST3Gal-I), resulting in increased sialyltransferase activity, demonstrated by a reduction in PNA lectin staining.
T6 870-1069 Sentence denotes Induction of COX-2 in the MDA-MB-231 breast cancer cell line also results in the increased expression of ST3Gal-I, leading to increased sialylation of the substrate of ST3Gal-I, core 1 Galβ1,3GalNAc.
T7 1070-1158 Sentence denotes This effect on sialylation could be reversed by the selective COX-2 inhibitor celecoxib.
T8 1159-1312 Sentence denotes The use of siRNA to knock down COX-2 and overexpression of COX-2 in MDA-MD-231 cells confirmed the involvement of COX-2 in the up-regulation of ST3Gal-I.
T9 1313-1458 Sentence denotes Moreover, analysis of the expression of ST3Gal-I and COX-2 by 74 primary breast cancers showed a significant correlation between the two enzymes.
T10 1459-1601 Sentence denotes COX-2 expression has been associated with a number of tumors, including breast cancer, where its expression is associated with poor prognoses.
T11 1602-1812 Sentence denotes Thus, these results suggest the intriguing possibility that some of the malignant characteristics associated with COX-2 expression may be via the influence that COX-2 exerts on the glycosylation of tumor cells.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-108 Sentence denotes Cyclooxygenase-2 enzyme induces the expression of the α-2,3-sialyltransferase-3 (ST3Gal-I) in breast cancer.
T2 109-172 Sentence denotes Aberrant glycosylation is a common feature of malignant change.
T3 173-390 Sentence denotes Changes in mucin-type O-linked glycosylation in breast cancer can result in the expression of truncated core 1-based sialylated glycans rather than the core 2-based glycans observed in normal mammary epithelium cells.
T4 391-540 Sentence denotes This has been shown, in part, to be due to changes in the expression of glycosyltransferases, including the up-regulation of some sialyltransferases.
T5 541-869 Sentence denotes Using the breast cancer cell line T47D, we have shown that PGE2, one of the final products of the cyclooxygenase-2 (COX-2) pathway, can induce the mRNA expression of the sialyltransferase α-2,3-sialyltransferase-3 (ST3Gal-I), resulting in increased sialyltransferase activity, demonstrated by a reduction in PNA lectin staining.
T6 870-1069 Sentence denotes Induction of COX-2 in the MDA-MB-231 breast cancer cell line also results in the increased expression of ST3Gal-I, leading to increased sialylation of the substrate of ST3Gal-I, core 1 Galβ1,3GalNAc.
T7 1070-1158 Sentence denotes This effect on sialylation could be reversed by the selective COX-2 inhibitor celecoxib.
T8 1159-1458 Sentence denotes The use of siRNA to knock down COX-2 and overexpression of COX-2 in MDA-MD-231 cells confirmed the involvement of COX-2 in the up-regulation of ST3Gal-I. Moreover, analysis of the expression of ST3Gal-I and COX-2 by 74 primary breast cancers showed a significant correlation between the two enzymes.
T9 1459-1601 Sentence denotes COX-2 expression has been associated with a number of tumors, including breast cancer, where its expression is associated with poor prognoses.
T10 1602-1812 Sentence denotes Thus, these results suggest the intriguing possibility that some of the malignant characteristics associated with COX-2 expression may be via the influence that COX-2 exerts on the glycosylation of tumor cells.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 277-283 Glycan denotes core 1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO
T2 325-331 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T3 1048-1054 Glycan denotes core 1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO
T4 1062-1068 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL

GlyCosmos15-Lectin-Jamboree

Id Subject Object Predicate Lexical cue glycosmos_id
T1 849-852 Lectin denotes PNA GL_003655

Lectin-Jamboree-small

Id Subject Object Predicate Lexical cue glycosmos_id
T1 849-852 Lectin denotes PNA GL_003655

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-108 Sentence denotes Cyclooxygenase-2 enzyme induces the expression of the α-2,3-sialyltransferase-3 (ST3Gal-I) in breast cancer.
T2 109-172 Sentence denotes Aberrant glycosylation is a common feature of malignant change.
T3 173-390 Sentence denotes Changes in mucin-type O-linked glycosylation in breast cancer can result in the expression of truncated core 1-based sialylated glycans rather than the core 2-based glycans observed in normal mammary epithelium cells.
T4 391-540 Sentence denotes This has been shown, in part, to be due to changes in the expression of glycosyltransferases, including the up-regulation of some sialyltransferases.
T5 541-869 Sentence denotes Using the breast cancer cell line T47D, we have shown that PGE2, one of the final products of the cyclooxygenase-2 (COX-2) pathway, can induce the mRNA expression of the sialyltransferase α-2,3-sialyltransferase-3 (ST3Gal-I), resulting in increased sialyltransferase activity, demonstrated by a reduction in PNA lectin staining.
T6 870-1069 Sentence denotes Induction of COX-2 in the MDA-MB-231 breast cancer cell line also results in the increased expression of ST3Gal-I, leading to increased sialylation of the substrate of ST3Gal-I, core 1 Galβ1,3GalNAc.
T7 1070-1158 Sentence denotes This effect on sialylation could be reversed by the selective COX-2 inhibitor celecoxib.
T8 1159-1458 Sentence denotes The use of siRNA to knock down COX-2 and overexpression of COX-2 in MDA-MD-231 cells confirmed the involvement of COX-2 in the up-regulation of ST3Gal-I. Moreover, analysis of the expression of ST3Gal-I and COX-2 by 74 primary breast cancers showed a significant correlation between the two enzymes.
T9 1459-1601 Sentence denotes COX-2 expression has been associated with a number of tumors, including breast cancer, where its expression is associated with poor prognoses.
T10 1602-1812 Sentence denotes Thus, these results suggest the intriguing possibility that some of the malignant characteristics associated with COX-2 expression may be via the influence that COX-2 exerts on the glycosylation of tumor cells.

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 94-100 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T2 221-227 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T3 365-383 Body_part denotes mammary epithelium http://purl.obolibrary.org/obo/UBERON_0003244
T4 551-557 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T5 907-913 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T6 1386-1392 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T7 1531-1537 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 558-569 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064
T2 914-925 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064
T3 1800-1811 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063