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PubMed:23267857 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-81 Sentence denotes CYP2C19*17 gain-of-function polymorphism is associated with peptic ulcer disease.
T2 82-331 Sentence denotes Single-nucleotide polymorphisms (SNPs) in the CYP2C gene cluster have been extensively investigated as predisposing factors for nonsteroidal anti-inflammatory drug (NSAID)-induced peptic ulcer disease (PUD) or upper gastrointestinal bleeding (UGIB).
T3 332-460 Sentence denotes However, results have been inconclusive owing to different study designs, limited genotyping strategies, and small sample sizes.
T4 461-695 Sentence denotes We investigated whether eight functional SNPs in the CYP2C family of genes--CYP2C8*3 (rs11572080 and rs10509681), CYP2C8*4, CYP2C9*2, CYP2C9*3, CYP2C19*2, CYP2C19*3, and CYP2C19*17--are associated with PUD in 1,239 Caucasian patients.
T5 696-804 Sentence denotes Logistic regression analysis showed that only CYP2C19*17 was associated with PUD (odds ratio additive model:
T6 805-949 Sentence denotes 1.47 (95% confidence interval (CI) 1.12 to 1.92); P = 0.005; R(2) 16%), but not UGIB, independent of NSAID use or Helicobacter pylori infection.
T7 950-1085 Sentence denotes PUD distribution varied (P = 0.024) according to CYP2C19*17 genotype: *1/*1, 490 (64.3%); *1/*17, 304 (71.7%); and *17/*17, 31 (73.8%).
T8 1086-1179 Sentence denotes CYP2C19*17, a gain-of-function polymorphism, is associated with PUD irrespective of etiology.
T1 0-81 Sentence denotes CYP2C19*17 gain-of-function polymorphism is associated with peptic ulcer disease.
T2 82-331 Sentence denotes Single-nucleotide polymorphisms (SNPs) in the CYP2C gene cluster have been extensively investigated as predisposing factors for nonsteroidal anti-inflammatory drug (NSAID)-induced peptic ulcer disease (PUD) or upper gastrointestinal bleeding (UGIB).
T3 332-460 Sentence denotes However, results have been inconclusive owing to different study designs, limited genotyping strategies, and small sample sizes.
T4 461-695 Sentence denotes We investigated whether eight functional SNPs in the CYP2C family of genes--CYP2C8*3 (rs11572080 and rs10509681), CYP2C8*4, CYP2C9*2, CYP2C9*3, CYP2C19*2, CYP2C19*3, and CYP2C19*17--are associated with PUD in 1,239 Caucasian patients.
T5 696-804 Sentence denotes Logistic regression analysis showed that only CYP2C19*17 was associated with PUD (odds ratio additive model:
T6 805-949 Sentence denotes 1.47 (95% confidence interval (CI) 1.12 to 1.92); P = 0.005; R(2) 16%), but not UGIB, independent of NSAID use or Helicobacter pylori infection.
T7 950-1085 Sentence denotes PUD distribution varied (P = 0.024) according to CYP2C19*17 genotype: *1/*1, 490 (64.3%); *1/*17, 304 (71.7%); and *17/*17, 31 (73.8%).
T8 1086-1179 Sentence denotes CYP2C19*17, a gain-of-function polymorphism, is associated with PUD irrespective of etiology.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 0-7 gene:1557 denotes CYP2C19
T1 60-80 disease:C0030920 denotes peptic ulcer disease
T2 128-133 gene:1559 denotes CYP2C
T3 284-287 disease:C0030920 denotes PUD
T4 128-133 gene:1557 denotes CYP2C
T5 262-282 disease:C0030920 denotes peptic ulcer disease
T6 128-133 gene:1562 denotes CYP2C
T7 262-282 disease:C0030920 denotes peptic ulcer disease
T8 128-133 gene:1562 denotes CYP2C
T9 284-287 disease:C0030920 denotes PUD
T10 128-133 gene:1559 denotes CYP2C
T11 262-282 disease:C0030920 denotes peptic ulcer disease
T12 128-133 gene:1557 denotes CYP2C
T13 284-287 disease:C0030920 denotes PUD
T14 742-749 gene:1557 denotes CYP2C19
T15 773-776 disease:C0030920 denotes PUD
T16 742-749 gene:1557 denotes CYP2C19
T17 919-948 disease:C0850666 denotes Helicobacter pylori infection
T18 1086-1093 gene:1557 denotes CYP2C19
T19 1150-1153 disease:C0030920 denotes PUD
R1 T0 T1 associated_with CYP2C19,peptic ulcer disease
R2 T2 T3 associated_with CYP2C,PUD
R3 T4 T5 associated_with CYP2C,peptic ulcer disease
R4 T6 T7 associated_with CYP2C,peptic ulcer disease
R5 T8 T9 associated_with CYP2C,PUD
R6 T10 T11 associated_with CYP2C,peptic ulcer disease
R7 T12 T13 associated_with CYP2C,PUD
R8 T14 T15 associated_with CYP2C19,PUD
R9 T16 T17 associated_with CYP2C19,Helicobacter pylori infection
R10 T18 T19 associated_with CYP2C19,PUD

Allie

Id Subject Object Predicate Lexical cue
SS1_23267857_1_0 82-113 expanded denotes Single-nucleotide polymorphisms
SS2_23267857_1_0 115-119 abbr denotes SNPs
SS1_23267857_1_1 210-245 expanded denotes nonsteroidal anti-inflammatory drug
SS2_23267857_1_1 247-252 abbr denotes NSAID
SS1_23267857_1_2 262-282 expanded denotes peptic ulcer disease
SS2_23267857_1_2 284-287 abbr denotes PUD
SS1_23267857_1_3 292-323 expanded denotes upper gastrointestinal bleeding
SS2_23267857_1_3 325-329 abbr denotes UGIB
SS1_23267857_4_0 815-834 expanded denotes confidence interval
SS2_23267857_4_0 836-838 abbr denotes CI
AE1_23267857_1_0 SS1_23267857_1_0 SS2_23267857_1_0 abbreviatedTo Single-nucleotide polymorphisms,SNPs
AE1_23267857_1_1 SS1_23267857_1_1 SS2_23267857_1_1 abbreviatedTo nonsteroidal anti-inflammatory drug,NSAID
AE1_23267857_1_2 SS1_23267857_1_2 SS2_23267857_1_2 abbreviatedTo peptic ulcer disease,PUD
AE1_23267857_1_3 SS1_23267857_1_3 SS2_23267857_1_3 abbreviatedTo upper gastrointestinal bleeding,UGIB
AE1_23267857_4_0 SS1_23267857_4_0 SS2_23267857_4_0 abbreviatedTo confidence interval,CI

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 262-274 HP_0004398 denotes peptic ulcer
T2 298-323 HP_0002239 denotes gastrointestinal bleeding
T3 919-948 HP_0005202 denotes Helicobacter pylori infection

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
23267857-3#86#96#geners11572080 547-557 geners11572080 denotes rs11572080
23267857-3#101#111#geners10509681 562-572 geners10509681 denotes rs10509681
23267857-3#202#205#diseaseC0030920 663-666 diseaseC0030920 denotes PUD
86#96#geners11572080202#205#diseaseC0030920 23267857-3#86#96#geners11572080 23267857-3#202#205#diseaseC0030920 associated_with rs11572080,PUD
101#111#geners10509681202#205#diseaseC0030920 23267857-3#101#111#geners10509681 23267857-3#202#205#diseaseC0030920 associated_with rs10509681,PUD

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23267857-0#0#7#gene1557 0-7 gene1557 denotes CYP2C19
23267857-0#60#80#diseaseC0030920 60-80 diseaseC0030920 denotes peptic ulcer disease
23267857-3#53#58#gene1559 514-519 gene1559 denotes CYP2C
23267857-3#53#58#gene1562 514-519 gene1562 denotes CYP2C
23267857-3#76#82#gene1558 537-543 gene1558 denotes CYP2C8
23267857-3#114#120#gene1558 575-581 gene1558 denotes CYP2C8
23267857-3#202#205#diseaseC0030920 663-666 diseaseC0030920 denotes PUD
23267857-3#202#205#diseaseC0030920 663-666 diseaseC0030920 denotes PUD
23267857-4#46#53#gene1557 742-749 gene1557 denotes CYP2C19
23267857-4#223#252#diseaseC0850666 919-948 diseaseC0850666 denotes Helicobacter pylori infection
0#7#gene155760#80#diseaseC0030920 23267857-0#0#7#gene1557 23267857-0#60#80#diseaseC0030920 associated_with CYP2C19,peptic ulcer disease
53#58#gene1559202#205#diseaseC0030920 23267857-3#53#58#gene1559 23267857-3#202#205#diseaseC0030920 associated_with CYP2C,PUD
53#58#gene1559202#205#diseaseC0030920 23267857-3#53#58#gene1559 23267857-3#202#205#diseaseC0030920 associated_with CYP2C,PUD
53#58#gene1562202#205#diseaseC0030920 23267857-3#53#58#gene1562 23267857-3#202#205#diseaseC0030920 associated_with CYP2C,PUD
53#58#gene1562202#205#diseaseC0030920 23267857-3#53#58#gene1562 23267857-3#202#205#diseaseC0030920 associated_with CYP2C,PUD
76#82#gene1558202#205#diseaseC0030920 23267857-3#76#82#gene1558 23267857-3#202#205#diseaseC0030920 associated_with CYP2C8,PUD
76#82#gene1558202#205#diseaseC0030920 23267857-3#76#82#gene1558 23267857-3#202#205#diseaseC0030920 associated_with CYP2C8,PUD
114#120#gene1558202#205#diseaseC0030920 23267857-3#114#120#gene1558 23267857-3#202#205#diseaseC0030920 associated_with CYP2C8,PUD
114#120#gene1558202#205#diseaseC0030920 23267857-3#114#120#gene1558 23267857-3#202#205#diseaseC0030920 associated_with CYP2C8,PUD
46#53#gene1557223#252#diseaseC0850666 23267857-4#46#53#gene1557 23267857-4#223#252#diseaseC0850666 associated_with CYP2C19,Helicobacter pylori infection

PubTator4TogoVar

Id Subject Object Predicate Lexical cue resolved_to
36 547-557 SNP denotes rs11572080 tmVar:rs11572080;VariantGroup:0;CorrespondingGene:1558;RS#:11572080;CorrespondingSpecies:9606
37 562-572 SNP denotes rs10509681 tmVar:rs10509681;VariantGroup:1;CorrespondingGene:1558;RS#:10509681;CorrespondingSpecies:9606

PubTatorOnTogoVar

Id Subject Object Predicate Lexical cue resolved_to
36 547-557 SNP denotes rs11572080 tmVar:rs11572080;VariantGroup:0;CorrespondingGene:1558;RS#:11572080;CorrespondingSpecies:9606
37 562-572 SNP denotes rs10509681 tmVar:rs10509681;VariantGroup:1;CorrespondingGene:1558;RS#:10509681;CorrespondingSpecies:9606
T1 547-557 SNP denotes rs11572080 tmVar:rs11572080;VariantGroup:0;CorrespondingGene:1558;RS#:11572080;CorrespondingSpecies:9606
T2 562-572 SNP denotes rs10509681 tmVar:rs10509681;VariantGroup:1;CorrespondingGene:1558;RS#:10509681;CorrespondingSpecies:9606