PubMed:23246576 / 1088-1835 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/23246576","sourcedb":"PubMed","sourceid":"23246576","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/23246576","text":"Among the tested flavonoid compounds, pretreatment of the cells with xanthohumol significantly sensitized MCF-7/ADR cells to the radiation treatment by inducing apoptosis. In MCF-7/ADR cells, treatment with xanthohumol alone or with gamma-rays significantly decreased levels of anti-apoptotic proteins. Multi-drug resistance 1 (MDR1), epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3) expression levels in MCF-7/ADR cells were suppressed by xanthohumol treatment. In addition, xanthohumol treatment increased death receptor (DR)-4 and DR5 expression. The xanthohumol-induced changes of these resistance-related molecules in MCF-7/ADR cells were synergistically increased by gamma-ray treatment.","tracks":[{"project":"PubMed_Structured_Abstracts","denotations":[{"id":"T3","span":{"begin":0,"end":747},"obj":"RESULTS"}],"attributes":[{"subj":"T3","pred":"source","obj":"PubMed_Structured_Abstracts"}]},{"project":"sentences","denotations":[{"id":"TextSentencer_T11","span":{"begin":0,"end":171},"obj":"Sentence"},{"id":"TextSentencer_T12","span":{"begin":172,"end":302},"obj":"Sentence"},{"id":"TextSentencer_T13","span":{"begin":303,"end":516},"obj":"Sentence"},{"id":"TextSentencer_T14","span":{"begin":517,"end":603},"obj":"Sentence"},{"id":"TextSentencer_T15","span":{"begin":604,"end":747},"obj":"Sentence"},{"id":"T11","span":{"begin":0,"end":171},"obj":"Sentence"},{"id":"T12","span":{"begin":172,"end":302},"obj":"Sentence"},{"id":"T13","span":{"begin":303,"end":516},"obj":"Sentence"},{"id":"T14","span":{"begin":517,"end":603},"obj":"Sentence"},{"id":"T15","span":{"begin":604,"end":747},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T11","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T12","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T13","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T14","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T15","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T12","pred":"source","obj":"sentences"},{"subj":"T13","pred":"source","obj":"sentences"},{"subj":"T14","pred":"source","obj":"sentences"},{"subj":"T15","pred":"source","obj":"sentences"}]},{"project":"Allie","denotations":[{"id":"SS1_23246576_12_0","span":{"begin":303,"end":326},"obj":"expanded"},{"id":"SS2_23246576_12_0","span":{"begin":328,"end":332},"obj":"abbr"},{"id":"SS1_23246576_12_1","span":{"begin":335,"end":367},"obj":"expanded"},{"id":"SS2_23246576_12_1","span":{"begin":369,"end":373},"obj":"abbr"},{"id":"SS1_23246576_12_2","span":{"begin":379,"end":429},"obj":"expanded"},{"id":"SS2_23246576_12_2","span":{"begin":431,"end":436},"obj":"abbr"},{"id":"SS1_23246576_13_0","span":{"begin":562,"end":576},"obj":"expanded"},{"id":"SS2_23246576_13_0","span":{"begin":578,"end":580},"obj":"abbr"}],"relations":[{"id":"AE1_23246576_12_0","pred":"abbreviatedTo","subj":"SS1_23246576_12_0","obj":"SS2_23246576_12_0"},{"id":"AE1_23246576_12_1","pred":"abbreviatedTo","subj":"SS1_23246576_12_1","obj":"SS2_23246576_12_1"},{"id":"AE1_23246576_12_2","pred":"abbreviatedTo","subj":"SS1_23246576_12_2","obj":"SS2_23246576_12_2"},{"id":"AE1_23246576_13_0","pred":"abbreviatedTo","subj":"SS1_23246576_13_0","obj":"SS2_23246576_13_0"}],"attributes":[{"subj":"SS1_23246576_12_0","pred":"source","obj":"Allie"},{"subj":"SS2_23246576_12_0","pred":"source","obj":"Allie"},{"subj":"SS1_23246576_12_1","pred":"source","obj":"Allie"},{"subj":"SS2_23246576_12_1","pred":"source","obj":"Allie"},{"subj":"SS1_23246576_12_2","pred":"source","obj":"Allie"},{"subj":"SS2_23246576_12_2","pred":"source","obj":"Allie"},{"subj":"SS1_23246576_13_0","pred":"source","obj":"Allie"},{"subj":"SS2_23246576_13_0","pred":"source","obj":"Allie"}]},{"project":"GlyCosmos15-HP","denotations":[{"id":"T7","span":{"begin":309,"end":324},"obj":"Phenotype"}],"attributes":[{"id":"A7","pred":"hp_id","subj":"T7","obj":"HP:0020174"},{"subj":"T7","pred":"source","obj":"GlyCosmos15-HP"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T3","span":{"begin":335,"end":351},"obj":"Body_part"}],"attributes":[{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0000021"},{"subj":"T3","pred":"source","obj":"Anatomy-UBERON"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubMed_Structured_Abstracts","color":"#d993ec","default":true},{"id":"sentences","color":"#93ecbe"},{"id":"Allie","color":"#eca493"},{"id":"GlyCosmos15-HP","color":"#939bec"},{"id":"Anatomy-UBERON","color":"#b5ec93"}]}]}}