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PubMed:23242014 JSONTXT

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GlyCosmos15-Species

Id Subject Object Predicate Lexical cue db_id
2 31-48 Species denotes hepatitis C viral
24 246-263 Species denotes hepatitis C virus 11103
25 265-268 Species denotes HCV 11103
26 275-278 Species denotes HCV 11103
34 1095-1098 Species denotes HCV 11103
36 1150-1155 Species denotes human 9606
40 1729-1732 Species denotes HCV 11103

Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 1430-1436 https://glytoucan.org/Structures/Glycans/G00031MO denotes Core 1

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 1430-1436 Glycan_Motif denotes Core 1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO
T2 1441-1447 Glycan_Motif denotes Core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-142 Sentence denotes Mass spectrometric analysis of hepatitis C viral envelope protein E2 reveals extended microheterogeneity of mucin-type O-linked glycosylation.
TextSentencer_T2 143-270 Sentence denotes The infectious liver disease hepatitis C is caused by the small, enveloped, positive single-strand RNA hepatitis C virus (HCV).
TextSentencer_T3 271-358 Sentence denotes The HCV genome encodes for a single polyprotein precursor of ∼3010 amino acid residues.
TextSentencer_T4 359-507 Sentence denotes Host and cellular proteases co- and posttranslational process the precursor creating six nonstructural (NS) proteins and four structural components.
TextSentencer_T5 508-599 Sentence denotes Properly folded forms of the envelope proteins E1 and E2 form the associated E1-E2 complex.
TextSentencer_T6 600-732 Sentence denotes This complex represents a significant antigenic component at the viral surface that can interact with several target cell receptors.
TextSentencer_T7 733-837 Sentence denotes Extent and type of glycosylation is an important factor for virulence and escape from the immune system.
TextSentencer_T8 838-1023 Sentence denotes Detailed characterization of the glycosylated sites is helpful for the understanding of different phenotypes as well as for the development of E1/E2-related treatments of HCV infection.
TextSentencer_T9 1024-1189 Sentence denotes Here, we have investigated in detail the O-linked glycosylation of the HCV envelope protein E2 expressed in and isolated from human embryonic kidney (HEK 293) cells.
TextSentencer_T10 1190-1470 Sentence denotes Using nano-liquid chromatography and tandem mass spectrometry approaches, we clearly have identified six residues for O-linked glycosylation within isolated glycopeptides (Ser393, Thr396, Ser401, Ser404, Thr473 and Thr518), carrying mainly Core 1 and Core 2 mucin-type structures.
TextSentencer_T11 1471-1530 Sentence denotes Based on our data, Thr385 is probably glycosylated as well.
TextSentencer_T12 1531-1633 Sentence denotes In addition, we could show that Ser479 within the hyper variable region (HVR) I is not O-glycosylated.
TextSentencer_T13 1634-1717 Sentence denotes For most of these sites, different degrees of microheterogeneity could be verified.
TextSentencer_T14 1718-1840 Sentence denotes Concerning HCV E2, this is the first case of experimentally proven O-linked glycosylation in detail via mass spectrometry.
T1 0-142 Sentence denotes Mass spectrometric analysis of hepatitis C viral envelope protein E2 reveals extended microheterogeneity of mucin-type O-linked glycosylation.
T2 143-270 Sentence denotes The infectious liver disease hepatitis C is caused by the small, enveloped, positive single-strand RNA hepatitis C virus (HCV).
T3 271-358 Sentence denotes The HCV genome encodes for a single polyprotein precursor of ∼3010 amino acid residues.
T4 359-507 Sentence denotes Host and cellular proteases co- and posttranslational process the precursor creating six nonstructural (NS) proteins and four structural components.
T5 508-599 Sentence denotes Properly folded forms of the envelope proteins E1 and E2 form the associated E1-E2 complex.
T6 600-732 Sentence denotes This complex represents a significant antigenic component at the viral surface that can interact with several target cell receptors.
T7 733-837 Sentence denotes Extent and type of glycosylation is an important factor for virulence and escape from the immune system.
T8 838-1023 Sentence denotes Detailed characterization of the glycosylated sites is helpful for the understanding of different phenotypes as well as for the development of E1/E2-related treatments of HCV infection.
T9 1024-1189 Sentence denotes Here, we have investigated in detail the O-linked glycosylation of the HCV envelope protein E2 expressed in and isolated from human embryonic kidney (HEK 293) cells.
T10 1190-1470 Sentence denotes Using nano-liquid chromatography and tandem mass spectrometry approaches, we clearly have identified six residues for O-linked glycosylation within isolated glycopeptides (Ser393, Thr396, Ser401, Ser404, Thr473 and Thr518), carrying mainly Core 1 and Core 2 mucin-type structures.
T11 1471-1530 Sentence denotes Based on our data, Thr385 is probably glycosylated as well.
T12 1531-1633 Sentence denotes In addition, we could show that Ser479 within the hyper variable region (HVR) I is not O-glycosylated.
T13 1634-1717 Sentence denotes For most of these sites, different degrees of microheterogeneity could be verified.
T14 1718-1840 Sentence denotes Concerning HCV E2, this is the first case of experimentally proven O-linked glycosylation in detail via mass spectrometry.
T1 0-142 Sentence denotes Mass spectrometric analysis of hepatitis C viral envelope protein E2 reveals extended microheterogeneity of mucin-type O-linked glycosylation.
T2 143-270 Sentence denotes The infectious liver disease hepatitis C is caused by the small, enveloped, positive single-strand RNA hepatitis C virus (HCV).
T3 271-358 Sentence denotes The HCV genome encodes for a single polyprotein precursor of ∼3010 amino acid residues.
T4 359-507 Sentence denotes Host and cellular proteases co- and posttranslational process the precursor creating six nonstructural (NS) proteins and four structural components.
T5 508-599 Sentence denotes Properly folded forms of the envelope proteins E1 and E2 form the associated E1-E2 complex.
T6 600-732 Sentence denotes This complex represents a significant antigenic component at the viral surface that can interact with several target cell receptors.
T7 733-837 Sentence denotes Extent and type of glycosylation is an important factor for virulence and escape from the immune system.
T8 838-1023 Sentence denotes Detailed characterization of the glycosylated sites is helpful for the understanding of different phenotypes as well as for the development of E1/E2-related treatments of HCV infection.
T9 1024-1189 Sentence denotes Here, we have investigated in detail the O-linked glycosylation of the HCV envelope protein E2 expressed in and isolated from human embryonic kidney (HEK 293) cells.
T10 1190-1470 Sentence denotes Using nano-liquid chromatography and tandem mass spectrometry approaches, we clearly have identified six residues for O-linked glycosylation within isolated glycopeptides (Ser393, Thr396, Ser401, Ser404, Thr473 and Thr518), carrying mainly Core 1 and Core 2 mucin-type structures.
T11 1471-1530 Sentence denotes Based on our data, Thr385 is probably glycosylated as well.
T12 1531-1633 Sentence denotes In addition, we could show that Ser479 within the hyper variable region (HVR) I is not O-glycosylated.
T13 1634-1717 Sentence denotes For most of these sites, different degrees of microheterogeneity could be verified.
T14 1718-1840 Sentence denotes Concerning HCV E2, this is the first case of experimentally proven O-linked glycosylation in detail via mass spectrometry.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 1430-1436 https://glytoucan.org/Structures/Glycans/G00031MO denotes Core 1

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 158-163 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T2 1166-1172 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney

ICD10

Id Subject Object Predicate Lexical cue
T1 31-48 http://purl.bioontology.org/ontology/ICD10/B18.2 denotes hepatitis C viral
T2 158-171 http://purl.bioontology.org/ontology/ICD10/K70-K77.9 denotes liver disease
T3 158-171 http://purl.bioontology.org/ontology/ICD10/K76.9 denotes liver disease

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 58-65 FMAID:67257 denotes protein
_T2 58-65 FMAID:165447 denotes protein
_T3 158-163 FMAID:7197 denotes liver
_T4 158-163 FMAID:93672 denotes liver
_T5 279-285 FMAID:198062 denotes genome
_T6 279-285 FMAID:84116 denotes genome
_T7 338-348 FMAID:196728 denotes amino acid
_T8 338-348 FMAID:82739 denotes amino acid
_T9 467-475 FMAID:67257 denotes proteins
_T10 467-475 FMAID:165447 denotes proteins
_T11 546-554 FMAID:67257 denotes proteins
_T12 546-554 FMAID:165447 denotes proteins
_T13 591-612 FMAID:162310 denotes complex. This complex
_T14 591-612 FMAID:62316 denotes complex. This complex
_T15 591-612 FMAID:165838 denotes complex. This complex
_T16 591-612 FMAID:63843 denotes complex. This complex
_T17 665-678 FMAID:198405 denotes viral surface
_T18 665-678 FMAID:84247 denotes viral surface
_T19 671-678 FMAID:146300 denotes surface
_T20 671-678 FMAID:50594 denotes surface
_T21 823-836 FMAID:97740 denotes immune system
_T22 823-836 FMAID:9825 denotes immune system
_T23 1108-1115 FMAID:67257 denotes protein
_T24 1108-1115 FMAID:165447 denotes protein
_T25 1166-1172 FMAID:7203 denotes kidney
_T26 1166-1172 FMAID:93681 denotes kidney
_T27 1183-1188 FMAID:169002 denotes cells
_T28 1183-1188 FMAID:68646 denotes cells
_T29 1201-1207 FMAID:85815 denotes liquid
_T30 1347-1360 FMAID:82784 denotes glycopeptides
_T31 1347-1360 FMAID:196778 denotes glycopeptides

uniprot-human

Id Subject Object Predicate Lexical cue
T1 377-386 http://www.uniprot.org/uniprot/P63128 denotes proteases
T2 377-386 http://www.uniprot.org/uniprot/P10265 denotes proteases
T3 377-386 http://www.uniprot.org/uniprot/P63119 denotes proteases
T4 377-386 http://www.uniprot.org/uniprot/P63120 denotes proteases
T5 377-386 http://www.uniprot.org/uniprot/P63121 denotes proteases
T6 377-386 http://www.uniprot.org/uniprot/P63122 denotes proteases
T7 377-386 http://www.uniprot.org/uniprot/P63123 denotes proteases
T8 377-386 http://www.uniprot.org/uniprot/P63124 denotes proteases
T9 377-386 http://www.uniprot.org/uniprot/P63125 denotes proteases
T10 377-386 http://www.uniprot.org/uniprot/P63127 denotes proteases
T11 377-386 http://www.uniprot.org/uniprot/P63129 denotes proteases
T12 377-386 http://www.uniprot.org/uniprot/P63131 denotes proteases
T13 377-386 http://www.uniprot.org/uniprot/Q9Y6I0 denotes proteases
T14 463-465 http://www.uniprot.org/uniprot/Q9BVP2 denotes NS
T15 1174-1177 http://www.uniprot.org/uniprot/P29320 denotes HEK
T16 1446-1453 http://www.uniprot.org/uniprot/Q02817 denotes 2 mucin

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 1446-1453 http://www.uniprot.org/uniprot/Q80Z19 denotes 2 mucin

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 246-263 http://purl.bioontology.org/ontology/NCBITAXON/248497 denotes hepatitis C virus
T2 246-263 http://purl.bioontology.org/ontology/NCBITAXON/12461 denotes hepatitis C virus
T3 246-263 http://purl.bioontology.org/ontology/NCBITAXON/10407 denotes hepatitis C virus
T4 258-263 http://purl.bioontology.org/ontology/NCBITAXON/184751 denotes virus
T5 387-389 http://purl.bioontology.org/ontology/NCBITAXON/13893 denotes co
T6 722-731 http://purl.bioontology.org/ontology/STY/T192 denotes receptors
T7 987-994 http://purl.bioontology.org/ontology/NCBITAXON/353209 denotes related
T8 1183-1188 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T9 1196-1200 http://purl.bioontology.org/ontology/NCBITAXON/490857 denotes nano

GO-BP

Id Subject Object Predicate Lexical cue
T1 66-68 http://purl.obolibrary.org/obo/GO_0004842 denotes E2
T2 66-68 http://purl.obolibrary.org/obo/GO_0019787 denotes E2
T3 66-68 http://purl.obolibrary.org/obo/GO_0061631 denotes E2
T4 66-68 http://purl.obolibrary.org/obo/GO_0061650 denotes E2
T5 66-68 http://purl.obolibrary.org/obo/GO_0061651 denotes E2
T6 66-68 http://purl.obolibrary.org/obo/GO_0061652 denotes E2
T7 66-68 http://purl.obolibrary.org/obo/GO_0061653 denotes E2
T8 66-68 http://purl.obolibrary.org/obo/GO_0061654 denotes E2
T9 66-68 http://purl.obolibrary.org/obo/GO_0061655 denotes E2
T10 66-68 http://purl.obolibrary.org/obo/GO_0061656 denotes E2
T11 66-68 http://purl.obolibrary.org/obo/GO_0061657 denotes E2
T12 66-68 http://purl.obolibrary.org/obo/GO_0061658 denotes E2
T13 562-564 http://purl.obolibrary.org/obo/GO_0004842 denotes E2
T14 562-564 http://purl.obolibrary.org/obo/GO_0019787 denotes E2
T15 562-564 http://purl.obolibrary.org/obo/GO_0061631 denotes E2
T16 562-564 http://purl.obolibrary.org/obo/GO_0061650 denotes E2
T17 562-564 http://purl.obolibrary.org/obo/GO_0061651 denotes E2
T18 562-564 http://purl.obolibrary.org/obo/GO_0061652 denotes E2
T19 562-564 http://purl.obolibrary.org/obo/GO_0061653 denotes E2
T20 562-564 http://purl.obolibrary.org/obo/GO_0061654 denotes E2
T21 562-564 http://purl.obolibrary.org/obo/GO_0061655 denotes E2
T22 562-564 http://purl.obolibrary.org/obo/GO_0061656 denotes E2
T23 562-564 http://purl.obolibrary.org/obo/GO_0061657 denotes E2
T24 562-564 http://purl.obolibrary.org/obo/GO_0061658 denotes E2
T25 588-590 http://purl.obolibrary.org/obo/GO_0004842 denotes E2
T26 588-590 http://purl.obolibrary.org/obo/GO_0019787 denotes E2
T27 588-590 http://purl.obolibrary.org/obo/GO_0061631 denotes E2
T28 588-590 http://purl.obolibrary.org/obo/GO_0061650 denotes E2
T29 588-590 http://purl.obolibrary.org/obo/GO_0061651 denotes E2
T30 588-590 http://purl.obolibrary.org/obo/GO_0061652 denotes E2
T31 588-590 http://purl.obolibrary.org/obo/GO_0061653 denotes E2
T32 588-590 http://purl.obolibrary.org/obo/GO_0061654 denotes E2
T33 588-590 http://purl.obolibrary.org/obo/GO_0061655 denotes E2
T34 588-590 http://purl.obolibrary.org/obo/GO_0061656 denotes E2
T35 588-590 http://purl.obolibrary.org/obo/GO_0061657 denotes E2
T36 588-590 http://purl.obolibrary.org/obo/GO_0061658 denotes E2
T37 984-986 http://purl.obolibrary.org/obo/GO_0004842 denotes E2
T38 984-986 http://purl.obolibrary.org/obo/GO_0019787 denotes E2
T39 984-986 http://purl.obolibrary.org/obo/GO_0061631 denotes E2
T40 984-986 http://purl.obolibrary.org/obo/GO_0061650 denotes E2
T41 984-986 http://purl.obolibrary.org/obo/GO_0061651 denotes E2
T42 984-986 http://purl.obolibrary.org/obo/GO_0061652 denotes E2
T43 984-986 http://purl.obolibrary.org/obo/GO_0061653 denotes E2
T44 984-986 http://purl.obolibrary.org/obo/GO_0061654 denotes E2
T45 984-986 http://purl.obolibrary.org/obo/GO_0061655 denotes E2
T46 984-986 http://purl.obolibrary.org/obo/GO_0061656 denotes E2
T47 984-986 http://purl.obolibrary.org/obo/GO_0061657 denotes E2
T48 984-986 http://purl.obolibrary.org/obo/GO_0061658 denotes E2
T49 1116-1118 http://purl.obolibrary.org/obo/GO_0004842 denotes E2
T50 1116-1118 http://purl.obolibrary.org/obo/GO_0019787 denotes E2
T51 1116-1118 http://purl.obolibrary.org/obo/GO_0061631 denotes E2
T52 1116-1118 http://purl.obolibrary.org/obo/GO_0061650 denotes E2
T53 1116-1118 http://purl.obolibrary.org/obo/GO_0061651 denotes E2
T54 1116-1118 http://purl.obolibrary.org/obo/GO_0061652 denotes E2
T55 1116-1118 http://purl.obolibrary.org/obo/GO_0061653 denotes E2
T56 1116-1118 http://purl.obolibrary.org/obo/GO_0061654 denotes E2
T57 1116-1118 http://purl.obolibrary.org/obo/GO_0061655 denotes E2
T58 1116-1118 http://purl.obolibrary.org/obo/GO_0061656 denotes E2
T59 1116-1118 http://purl.obolibrary.org/obo/GO_0061657 denotes E2
T60 1116-1118 http://purl.obolibrary.org/obo/GO_0061658 denotes E2
T61 1733-1735 http://purl.obolibrary.org/obo/GO_0004842 denotes E2
T62 1733-1735 http://purl.obolibrary.org/obo/GO_0019787 denotes E2
T63 1733-1735 http://purl.obolibrary.org/obo/GO_0061631 denotes E2
T64 1733-1735 http://purl.obolibrary.org/obo/GO_0061650 denotes E2
T65 1733-1735 http://purl.obolibrary.org/obo/GO_0061651 denotes E2
T66 1733-1735 http://purl.obolibrary.org/obo/GO_0061652 denotes E2
T67 1733-1735 http://purl.obolibrary.org/obo/GO_0061653 denotes E2
T68 1733-1735 http://purl.obolibrary.org/obo/GO_0061654 denotes E2
T69 1733-1735 http://purl.obolibrary.org/obo/GO_0061655 denotes E2
T70 1733-1735 http://purl.obolibrary.org/obo/GO_0061656 denotes E2
T71 1733-1735 http://purl.obolibrary.org/obo/GO_0061657 denotes E2
T72 1733-1735 http://purl.obolibrary.org/obo/GO_0061658 denotes E2
T73 128-141 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T74 752-765 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T75 1074-1087 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T76 1317-1330 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T77 871-883 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylated
T78 1509-1521 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylated
T79 1620-1632 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylated
T80 368-376 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T81 555-557 http://purl.obolibrary.org/obo/GO_0004839 denotes E1
T82 585-587 http://purl.obolibrary.org/obo/GO_0004839 denotes E1
T83 981-983 http://purl.obolibrary.org/obo/GO_0004839 denotes E1
T84 793-802 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T85 793-802 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T86 966-977 http://purl.obolibrary.org/obo/GO_0032502 denotes development

GO-CC

Id Subject Object Predicate Lexical cue
T1 43-57 http://purl.obolibrary.org/obo/GO_0019031 denotes viral envelope
T2 49-57 http://purl.obolibrary.org/obo/GO_0009274 denotes envelope
T3 537-545 http://purl.obolibrary.org/obo/GO_0009274 denotes envelope
T4 208-217 http://purl.obolibrary.org/obo/GO_0009274 denotes enveloped
T5 359-363 http://purl.obolibrary.org/obo/GO_0018995 denotes Host
T6 588-598 http://purl.obolibrary.org/obo/GO_0031371 denotes E2 complex
T7 717-721 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T8 1183-1188 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9 1430-1434 http://purl.obolibrary.org/obo/GO_0019013 denotes Core
T10 1441-1445 http://purl.obolibrary.org/obo/GO_0019013 denotes Core

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 158-163 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T2 823-836 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T3 1166-1172 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney

Allie

Id Subject Object Predicate Lexical cue
SS1_23242014_1_0 246-263 expanded denotes hepatitis C virus
SS2_23242014_1_0 265-268 abbr denotes HCV
SS1_23242014_3_0 448-461 expanded denotes nonstructural
SS2_23242014_3_0 463-465 abbr denotes NS
SS1_23242014_11_0 1581-1602 expanded denotes hyper variable region
SS2_23242014_11_0 1604-1607 abbr denotes HVR
AE1_23242014_1_0 SS1_23242014_1_0 SS2_23242014_1_0 abbreviatedTo hepatitis C virus,HCV
AE1_23242014_3_0 SS1_23242014_3_0 SS2_23242014_3_0 abbreviatedTo nonstructural,NS
AE1_23242014_11_0 SS1_23242014_11_0 SS2_23242014_11_0 abbreviatedTo hyper variable region,HVR

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 158-163 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T2 1166-1172 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1166-1172 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
PD-UBERON-AE-B_T2 158-163 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T3 823-836 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 1430-1436 Glycan denotes Core 1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO
T2 1441-1447 Glycan denotes Core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 31-42 Disease denotes hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231
T2 147-157 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T3 158-171 Disease denotes liver disease http://purl.obolibrary.org/obo/MONDO_0005154
T4 172-183 Disease denotes hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231
T5 246-257 Disease denotes hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231
T6 1013-1022 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T7 1604-1607 Disease denotes HVR http://purl.obolibrary.org/obo/MONDO_0008641

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 158-163 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T2 1166-1172 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 31-40 Phenotype denotes hepatitis HP:0012115
T2 158-171 Phenotype denotes liver disease HP:0001392
T3 172-181 Phenotype denotes hepatitis HP:0012115
T4 246-255 Phenotype denotes hepatitis HP:0012115
T5 710-721 Phenotype denotes target cell HP:0034280

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 31-40 Phenotype denotes hepatitis HP:0012115
T2 158-171 Phenotype denotes liver disease HP:0001392
T3 172-181 Phenotype denotes hepatitis HP:0012115
T4 246-255 Phenotype denotes hepatitis HP:0012115

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-142 Sentence denotes Mass spectrometric analysis of hepatitis C viral envelope protein E2 reveals extended microheterogeneity of mucin-type O-linked glycosylation.
T2 143-270 Sentence denotes The infectious liver disease hepatitis C is caused by the small, enveloped, positive single-strand RNA hepatitis C virus (HCV).
T3 271-358 Sentence denotes The HCV genome encodes for a single polyprotein precursor of ∼3010 amino acid residues.
T4 359-507 Sentence denotes Host and cellular proteases co- and posttranslational process the precursor creating six nonstructural (NS) proteins and four structural components.
T5 508-599 Sentence denotes Properly folded forms of the envelope proteins E1 and E2 form the associated E1-E2 complex.
T6 600-732 Sentence denotes This complex represents a significant antigenic component at the viral surface that can interact with several target cell receptors.
T7 733-837 Sentence denotes Extent and type of glycosylation is an important factor for virulence and escape from the immune system.
T8 838-1023 Sentence denotes Detailed characterization of the glycosylated sites is helpful for the understanding of different phenotypes as well as for the development of E1/E2-related treatments of HCV infection.
T9 1024-1189 Sentence denotes Here, we have investigated in detail the O-linked glycosylation of the HCV envelope protein E2 expressed in and isolated from human embryonic kidney (HEK 293) cells.
T10 1190-1470 Sentence denotes Using nano-liquid chromatography and tandem mass spectrometry approaches, we clearly have identified six residues for O-linked glycosylation within isolated glycopeptides (Ser393, Thr396, Ser401, Ser404, Thr473 and Thr518), carrying mainly Core 1 and Core 2 mucin-type structures.
T11 1471-1530 Sentence denotes Based on our data, Thr385 is probably glycosylated as well.
T12 1531-1633 Sentence denotes In addition, we could show that Ser479 within the hyper variable region (HVR) I is not O-glycosylated.
T13 1634-1717 Sentence denotes For most of these sites, different degrees of microheterogeneity could be verified.
T14 1718-1840 Sentence denotes Concerning HCV E2, this is the first case of experimentally proven O-linked glycosylation in detail via mass spectrometry.

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 31-40 Disease denotes hepatitis MONDO:0002251
T2 147-157 Disease denotes infectious MONDO:0005550
T3 158-171 Disease denotes liver disease MONDO:0005154
T4 172-181 Disease denotes hepatitis MONDO:0002251
T5 246-255 Disease denotes hepatitis MONDO:0002251
T6 1013-1022 Disease denotes infection MONDO:0005550

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 246-263 OrganismTaxon denotes hepatitis C virus 11103
T2 265-268 OrganismTaxon denotes HCV 11103
T3 275-278 OrganismTaxon denotes HCV 11103
T4 1009-1012 OrganismTaxon denotes HCV 11103
T5 1095-1098 OrganismTaxon denotes HCV 11103
T6 1150-1155 OrganismTaxon denotes human 9606
T7 1729-1732 OrganismTaxon denotes HCV 11103

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 49-57 Body_part denotes envelope http://purl.obolibrary.org/obo/GO_0031975
T2 158-163 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T3 208-217 Body_part denotes enveloped http://purl.obolibrary.org/obo/GO_0031975
T4 537-545 Body_part denotes envelope http://purl.obolibrary.org/obo/GO_0031975
T5 823-836 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T6 1099-1107 Body_part denotes envelope http://purl.obolibrary.org/obo/GO_0031975
T7 1156-1172 Body_part denotes embryonic kidney http://purl.obolibrary.org/obo/UBERON_0002120