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PubMed:23241745 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
23241745_0 589-595 ProteinMutation denotes R1441G rs33939927
23241745_1 599-605 ProteinMutation denotes G2019S rs34637584

c_corpus

Id Subject Object Predicate Lexical cue
T7 0-3 SO:0001444 denotes Ser
T5 0-3 Q62230 denotes Ser
T6 0-3 PR:000001931 denotes Ser
T9 0-3 PR:P18168 denotes Ser
T1 0-3 CHEBI:32838 denotes Ser
T2 0-3 CHEBI:32839 denotes Ser
T4 0-3 CHEBI:29999 denotes Ser
T8 0-3 CHEBI:17115 denotes Ser
T3 0-3 GO:0005790 denotes Ser
T10 34-43 CHEBI:47867 denotes indicator
T11 47-52 PR:Q5S006 denotes LRRK2
T12 47-52 PR:000003033 denotes LRRK2
T13 47-52 PR:Q5S007 denotes LRRK2
T14 53-68 GO:0016301 denotes kinase activity
T16 143-150 6308 denotes leucine
T17 143-150 SO:0001437 denotes leucine
T15 143-150 CHEBI:15603 denotes leucine
T18 143-150 D007930 denotes leucine
T19 143-150 CHEBI:25017 denotes leucine
T20 143-150 D007930 denotes leucine
T21 156-162 SO:0001068 denotes repeat
T22 173-178 PR:Q5S006 denotes LRRK2
T23 173-178 PR:000003033 denotes LRRK2
T24 173-178 PR:Q5S007 denotes LRRK2
T25 180-184 SO:0000704 denotes gene
T30 223-242 D010300 denotes Parkinson's disease
T31 223-242 D010300 denotes Parkinson's disease
T34 331-346 GO:0016301 denotes kinase activity
T35 359-364 PR:Q5S006 denotes LRRK2
T36 359-364 PR:000003033 denotes LRRK2
T37 359-364 PR:Q5S007 denotes LRRK2
T38 417-422 PR:Q5S006 denotes LRRK2
T39 417-422 PR:000003033 denotes LRRK2
T40 417-422 PR:Q5S007 denotes LRRK2
T41 423-438 GO:0016301 denotes kinase activity
T42 468-473 PR:Q5S006 denotes LRRK2
T43 468-473 PR:000003033 denotes LRRK2
T44 468-473 PR:Q5S007 denotes LRRK2
T45 494-500 CVCL_U693 denotes on Ser
T50 497-500 Q62230 denotes Ser
T51 497-500 PR:000001931 denotes Ser
T54 497-500 PR:P18168 denotes Ser
T48 497-500 GO:0005790 denotes Ser
T46 497-500 CHEBI:32838 denotes Ser
T47 497-500 CHEBI:32839 denotes Ser
T49 497-500 CHEBI:29999 denotes Ser
T53 497-500 CHEBI:17115 denotes Ser
T52 497-500 SO:0001444 denotes Ser
T55 594-600 CHEBI:86642 denotes G/C, G
T60 673-676 Q62230 denotes Ser
T61 673-676 PR:000001931 denotes Ser
T64 673-676 PR:P18168 denotes Ser
T58 673-676 GO:0005790 denotes Ser
T62 673-676 SO:0001444 denotes Ser
T56 673-676 CHEBI:32838 denotes Ser
T57 673-676 CHEBI:32839 denotes Ser
T59 673-676 CHEBI:29999 denotes Ser
T63 673-676 CHEBI:17115 denotes Ser
T65 704-712 SO:0000109 denotes Mutation
T72 716-719 SO:0001444 denotes Ser
T70 716-719 Q62230 denotes Ser
T71 716-719 PR:000001931 denotes Ser
T74 716-719 PR:P18168 denotes Ser
T66 716-719 CHEBI:32838 denotes Ser
T67 716-719 CHEBI:32839 denotes Ser
T69 716-719 CHEBI:29999 denotes Ser
T73 716-719 CHEBI:17115 denotes Ser
T68 716-719 GO:0005790 denotes Ser
T79 729-736 426 denotes alanine
T80 729-736 SO:0001435 denotes alanine
T75 729-736 D000409 denotes alanine
T76 729-736 D000409 denotes alanine
T77 729-736 CHEBI:16977 denotes alanine
T78 729-736 CHEBI:46217 denotes alanine
T81 729-736 CHEBI:16449 denotes alanine
T82 773-778 PR:Q5S006 denotes LRRK2
T83 773-778 PR:000003033 denotes LRRK2
T84 773-778 PR:Q5S007 denotes LRRK2
T85 795-802 GO:0043005 denotes neurite
T86 795-812 GO:0031175 denotes neurite outgrowth
T87 825-828 10116 denotes rat
T91 825-828 D051381 denotes rat
T88 825-828 PR:P63003-1 denotes rat
T89 825-828 PR:Q2G0B1 denotes rat
T90 825-828 PR:Q8VHJ4 denotes rat
T92 829-838 P02301 denotes embryonic
T93 829-838 PR:000029532 denotes embryonic
T100 920-923 SO:0001444 denotes Ser
T98 920-923 Q62230 denotes Ser
T99 920-923 PR:000001931 denotes Ser
T102 920-923 PR:P18168 denotes Ser
T94 920-923 CHEBI:32838 denotes Ser
T95 920-923 CHEBI:32839 denotes Ser
T97 920-923 CHEBI:29999 denotes Ser
T101 920-923 CHEBI:17115 denotes Ser
T96 920-923 GO:0005790 denotes Ser
T103 961-966 UBERON:6110636 denotes brain
T104 961-966 UBERON:0000955 denotes brain
T105 979-984 PR:Q5S006 denotes LRRK2
T106 979-984 PR:000003033 denotes LRRK2
T107 979-984 PR:Q5S007 denotes LRRK2
T108 985-1001 GO:0033673 denotes kinase inhibitor
T109 992-1001 CHEBI:35222 denotes inhibitor
T116 1014-1017 SO:0001444 denotes Ser
T114 1014-1017 Q62230 denotes Ser
T115 1014-1017 PR:000001931 denotes Ser
T118 1014-1017 PR:P18168 denotes Ser
T110 1014-1017 CHEBI:32838 denotes Ser
T111 1014-1017 CHEBI:32839 denotes Ser
T113 1014-1017 CHEBI:29999 denotes Ser
T117 1014-1017 CHEBI:17115 denotes Ser
T112 1014-1017 GO:0005790 denotes Ser
T119 1096-1101 PR:Q5S006 denotes LRRK2
T120 1096-1101 PR:000003033 denotes LRRK2
T121 1096-1101 PR:Q5S007 denotes LRRK2
T126 1149-1152 Q62230 denotes Ser
T127 1149-1152 PR:000001931 denotes Ser
T130 1149-1152 PR:P18168 denotes Ser
T124 1149-1152 GO:0005790 denotes Ser
T128 1149-1152 SO:0001444 denotes Ser
T122 1149-1152 CHEBI:32838 denotes Ser
T123 1149-1152 CHEBI:32839 denotes Ser
T125 1149-1152 CHEBI:29999 denotes Ser
T129 1149-1152 CHEBI:17115 denotes Ser
T131 1195-1204 CHEBI:47867 denotes indicator
T132 1208-1213 PR:Q5S006 denotes LRRK2
T133 1208-1213 PR:000003033 denotes LRRK2
T134 1208-1213 PR:Q5S007 denotes LRRK2
T135 1214-1229 GO:0016301 denotes kinase activity

Allie

Id Subject Object Predicate Lexical cue
SS1_23241745_1_0 143-171 expanded denotes leucine-rich repeat kinase 2
SS2_23241745_1_0 173-178 abbr denotes LRRK2
SS1_23241745_1_1 223-242 expanded denotes Parkinson's disease
SS2_23241745_1_1 244-246 abbr denotes PD
SS1_23241745_5_0 716-736 expanded denotes Ser(1292) to alanine
SS2_23241745_5_0 738-744 abbr denotes S1292A
AE1_23241745_1_0 SS1_23241745_1_0 SS2_23241745_1_0 abbreviatedTo leucine-rich repeat kinase 2,LRRK2
AE1_23241745_1_1 SS1_23241745_1_1 SS2_23241745_1_1 abbreviatedTo Parkinson's disease,PD
AE1_23241745_5_0 SS1_23241745_5_0 SS2_23241745_5_0 abbreviatedTo Ser(1292) to alanine,S1292A

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-125 DRI_Background denotes Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.
T2 126-248 DRI_Approach denotes Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of familial Parkinson's disease (PD).
T3 249-447 DRI_Background denotes Although biochemical studies have shown that certain PD mutations confer elevated kinase activity in vitro on LRRK2, there are no methods available to directly monitor LRRK2 kinase activity in vivo.
T4 448-618 DRI_Outcome denotes We demonstrate that LRRK2 autophosphorylation on Ser(1292) occurs in vivo and is enhanced by several familial PD mutations including N1437H, R1441G/C, G2019S, and I2020T.
T5 619-703 DRI_Approach denotes Combining two PD mutations together further increases Ser(1292) autophosphorylation.
T6 704-855 DRI_Background denotes Mutation of Ser(1292) to alanine (S1292A) ameliorates the effects of LRRK2 PD mutations on neurite outgrowth in cultured rat embryonic primary neurons.
T7 856-960 DRI_Outcome denotes Using cell-based and pharmacodynamic assays with phosphorylated Ser(1292) as the readout, we developed a
T8 961-984 Token_Label.OUTSIDE denotes brain-penetrating LRRK2
T9 985-1124 DRI_Outcome denotes kinase inhibitor that blocks Ser(1292) autophosphorylation in vivo and attenuates the cellular consequences of LRRK2 PD mutations in vitro.
T10 1125-1305 DRI_Outcome denotes These data suggest that Ser(1292) autophosphorylation may be a useful indicator of LRRK2 kinase activity in vivo and may contribute to the cellular effects of certain PD mutations.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 126-248 DRI_Approach denotes Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of familial Parkinson's disease (PD).
T2 249-447 DRI_Background denotes Although biochemical studies have shown that certain PD mutations confer elevated kinase activity in vitro on LRRK2, there are no methods available to directly monitor LRRK2 kinase activity in vivo.
T3 448-618 DRI_Outcome denotes We demonstrate that LRRK2 autophosphorylation on Ser(1292) occurs in vivo and is enhanced by several familial PD mutations including N1437H, R1441G/C, G2019S, and I2020T.
T4 619-703 DRI_Approach denotes Combining two PD mutations together further increases Ser(1292) autophosphorylation.
T5 704-855 DRI_Background denotes Mutation of Ser(1292) to alanine (S1292A) ameliorates the effects of LRRK2 PD mutations on neurite outgrowth in cultured rat embryonic primary neurons.
T6 856-960 DRI_Outcome denotes Using cell-based and pharmacodynamic assays with phosphorylated Ser(1292) as the readout, we developed a
T7 985-1124 DRI_Outcome denotes kinase inhibitor that blocks Ser(1292) autophosphorylation in vivo and attenuates the cellular consequences of LRRK2 PD mutations in vitro.
T8 1125-1305 DRI_Outcome denotes These data suggest that Ser(1292) autophosphorylation may be a useful indicator of LRRK2 kinase activity in vivo and may contribute to the cellular effects of certain PD mutations.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 223-232 HP_0001300 denotes Parkinson

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23241745-7#83#88#gene120892 1208-1213 gene120892 denotes LRRK2
23241745-7#167#169#diseaseC0030567 1292-1294 diseaseC0030567 denotes PD
83#88#gene120892167#169#diseaseC0030567 23241745-7#83#88#gene120892 23241745-7#167#169#diseaseC0030567 associated_with LRRK2,PD