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PubMed:23233592 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-83 Sentence denotes Advances in stem cell transplantation and gene therapy in the β-hemoglobinopathies.
TextSentencer_T2 84-364 Sentence denotes High-level production of β-globin, γ-globin, or therapeutic mutant globins in the RBC lineage by hematopoietic stem cell gene therapy ameliorates or cures the hemoglobinopathies sickle cell disease and beta thalassemia, which are major causes of morbidity and mortality worldwide.
TextSentencer_T3 365-501 Sentence denotes Considerable efforts have been made in the last 2 decades in devising suitable gene-transfer vectors and protocols to achieve this goal.
TextSentencer_T4 502-668 Sentence denotes Five years ago, the first β(E)/β(0)-thalassemia major (transfusion-dependent) patient was treated by globin lentiviral gene therapy without injection of backup cells.
TextSentencer_T5 669-806 Sentence denotes This patient has become completely transfusion independent for the past 4 years and has global amelioration of the thalassemic phenotype.
TextSentencer_T6 807-977 Sentence denotes Partial clonal dominance for an intragenic site (HMGA2) of chromosomal integration of the vector was observed in this patient without a loss of hematopoietic homeostasis.
TextSentencer_T7 978-1229 Sentence denotes Other patients are now receiving transplantations while researchers are carefully weighing the benefit/risk ratio and continuing the development of further modified vectors and protocols to improve outcomes further with respect to safety and efficacy.
T1 0-83 Sentence denotes Advances in stem cell transplantation and gene therapy in the β-hemoglobinopathies.
T2 84-364 Sentence denotes High-level production of β-globin, γ-globin, or therapeutic mutant globins in the RBC lineage by hematopoietic stem cell gene therapy ameliorates or cures the hemoglobinopathies sickle cell disease and beta thalassemia, which are major causes of morbidity and mortality worldwide.
T3 365-501 Sentence denotes Considerable efforts have been made in the last 2 decades in devising suitable gene-transfer vectors and protocols to achieve this goal.
T4 502-668 Sentence denotes Five years ago, the first β(E)/β(0)-thalassemia major (transfusion-dependent) patient was treated by globin lentiviral gene therapy without injection of backup cells.
T5 669-806 Sentence denotes This patient has become completely transfusion independent for the past 4 years and has global amelioration of the thalassemic phenotype.
T6 807-977 Sentence denotes Partial clonal dominance for an intragenic site (HMGA2) of chromosomal integration of the vector was observed in this patient without a loss of hematopoietic homeostasis.
T7 978-1229 Sentence denotes Other patients are now receiving transplantations while researchers are carefully weighing the benefit/risk ratio and continuing the development of further modified vectors and protocols to improve outcomes further with respect to safety and efficacy.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 119-127 gene:3047 denotes γ-globin
T1 243-261 disease:C0019045 denotes hemoglobinopathies
T2 119-127 gene:3047 denotes γ-globin
T3 286-302 disease:C0005283 denotes beta thalassemia
R1 T0 T1 associated_with γ-globin,hemoglobinopathies
R2 T2 T3 associated_with γ-globin,beta thalassemia

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23233592-1#35#43#gene3047 119-127 gene3047 denotes γ-globin
23233592-1#202#218#diseaseC0005283 286-302 diseaseC0005283 denotes beta thalassemia
23233592-1#202#218#diseaseC3841475 286-302 diseaseC3841475 denotes beta thalassemia
35#43#gene3047202#218#diseaseC0005283 23233592-1#35#43#gene3047 23233592-1#202#218#diseaseC0005283 associated_with γ-globin,beta thalassemia
35#43#gene3047202#218#diseaseC3841475 23233592-1#35#43#gene3047 23233592-1#202#218#diseaseC3841475 associated_with γ-globin,beta thalassemia

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2099 119-127 gene:3047 denotes γ-globin
T2100 286-302 disease:C0005283 denotes beta thalassemia
R1 T2099 T2100 associated_with γ-globin,beta thalassemia
R2 T2099 T2100 associated_with γ-globin,beta thalassemia

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 181-199 http://purl.obolibrary.org/obo/UBERON_0002390 denotes hematopoietic stem