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PubMed:23231918 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
23231918_0 640-646 ProteinMutation denotes G2019S rs34637584
23231918_1 650-656 ProteinMutation denotes R1441C rs33939927

c_corpus

Id Subject Object Predicate Lexical cue
T1 7-12 PR:Q5S006 denotes LRRK2
T2 7-12 PR:000003033 denotes LRRK2
T3 7-12 PR:Q5S007 denotes LRRK2
T4 21-28 1895 denotes calcium
T5 21-28 CHEBI:29320 denotes calcium
T6 21-28 CHEBI:22984 denotes calcium
T7 66-78 GO:0005739 denotes mitochondria
T9 108-115 6308 denotes leucine
T10 108-115 SO:0001437 denotes leucine
T8 108-115 CHEBI:15603 denotes leucine
T11 108-115 D007930 denotes leucine
T12 108-115 CHEBI:25017 denotes leucine
T13 108-115 D007930 denotes leucine
T14 121-127 SO:0001068 denotes repeat
T15 138-143 PR:Q5S006 denotes LRRK2
T16 138-143 PR:000003033 denotes LRRK2
T17 138-143 PR:Q5S007 denotes LRRK2
T20 202-219 D010300 denotes Parkinson disease
T21 202-219 D010300 denotes Parkinson disease
T24 228-233 PR:Q5S006 denotes LRRK2
T25 228-233 PR:000003033 denotes LRRK2
T26 228-233 PR:Q5S007 denotes LRRK2
T27 262-269 GO:0043005 denotes neurite
T28 302-311 GO:0016236 denotes autophagy
T29 302-311 GO:0006914 denotes autophagy
T30 345-355 SO:0000781 denotes transgenic
T31 345-360 10090 denotes transgenic mice
T32 345-360 D008822 denotes transgenic mice
T33 356-360 PR:000005054 denotes mice
T35 356-360 O89094 denotes mice
T37 479-492 GO:0009653 denotes morphogenesis
T38 541-546 PR:Q5S006 denotes LRRK2
T39 541-546 PR:000003033 denotes LRRK2
T40 541-546 PR:Q5S007 denotes LRRK2
T41 569-580 GO:0042592 denotes homeostasis
T42 593-598 10090 denotes Mouse
T43 593-598 D051379 denotes Mouse
T44 634-639 PR:Q5S006 denotes LRRK2
T45 634-639 PR:000003033 denotes LRRK2
T46 634-639 PR:Q5S007 denotes LRRK2
T47 688-699 GO:0009056 denotes degradation
T48 703-715 GO:0005739 denotes mitochondria
T49 720-728 GO:0030425 denotes dendrite
T50 761-766 PR:Q5S006 denotes LRRK2
T51 761-766 PR:000003033 denotes LRRK2
T52 761-766 PR:Q5S007 denotes LRRK2
T53 805-811 CHEBI:35225 denotes buffer
T54 812-825 GO:0005622 denotes intracellular
T56 826-833 CHEBI:29320 denotes calcium
T57 826-833 CHEBI:22984 denotes calcium
T55 826-833 1895 denotes calcium
T58 849-856 1895 denotes calcium
T61 849-866 D065096 denotes calcium chelators
T62 849-866 D065096 denotes calcium chelators
T66 870-880 CHEBI:35222 denotes inhibitors
T67 898-921 D020746 denotes L-type calcium channels
T68 905-912 1895 denotes calcium
T72 946-957 GO:0009056 denotes degradation
T73 962-970 GO:0030425 denotes dendrite
T74 1014-1019 PR:Q5S006 denotes LRRK2
T75 1014-1019 PR:000003033 denotes LRRK2
T76 1014-1019 PR:Q5S007 denotes LRRK2
T77 1040-1047 1895 denotes calcium
T78 1040-1047 CHEBI:29320 denotes calcium
T79 1040-1047 CHEBI:22984 denotes calcium
T80 1048-1059 GO:0042592 denotes homeostasis
T81 1081-1090 GO:0000423 denotes mitophagy
T82 1081-1090 GO:0000422 denotes mitophagy
T83 1095-1103 GO:0030425 denotes dendrite

Allie

Id Subject Object Predicate Lexical cue
SS1_23231918_1_0 108-136 expanded denotes leucine-rich repeat kinase 2
SS2_23231918_1_0 138-143 abbr denotes LRRK2
AE1_23231918_1_0 SS1_23231918_1_0 SS2_23231918_1_0 abbreviatedTo leucine-rich repeat kinase 2,LRRK2

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-90 DRI_Background denotes Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons.
T2 91-220 DRI_Approach denotes Mutations in the leucine-rich repeat kinase 2 (LRRK2) have been associated with familial and sporadic cases of Parkinson disease.
T3 221-412 DRI_Background denotes Mutant LRRK2 causes in vitro and in vivo neurite shortening, mediated in part by autophagy, and a parkinsonian phenotype in transgenic mice; however, the underlying mechanisms remain unclear.
T4 413-592 DRI_Background denotes Because mitochondrial content/function is essential for dendritic morphogenesis and maintenance, we investigated whether mutant LRRK2 affects mitochondrial homeostasis in neurons.
T5 593-633 DRI_Background denotes Mouse cortical neurons expressing either
T6 634-646 Token_Label.OUTSIDE denotes LRRK2 G2019S
T7 647-740 DRI_Background denotes or R1441C mutations exhibited autophagic degradation of mitochondria and dendrite shortening.
T8 741-841 DRI_Background denotes In addition, mutant LRRK2 altered the ability of the neurons to buffer intracellular calcium levels.
T9 842-982 DRI_Background denotes Either calcium chelators or inhibitors of voltage-gated L-type calcium channels prevented mitochondrial degradation and dendrite shortening.
T10 983-1115 DRI_Background denotes These data suggest that mutant LRRK2 causes a deficit in calcium homeostasis, leading to enhanced mitophagy and dendrite shortening.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 91-220 DRI_Approach denotes Mutations in the leucine-rich repeat kinase 2 (LRRK2) have been associated with familial and sporadic cases of Parkinson disease.
T2 221-412 DRI_Background denotes Mutant LRRK2 causes in vitro and in vivo neurite shortening, mediated in part by autophagy, and a parkinsonian phenotype in transgenic mice; however, the underlying mechanisms remain unclear.
T3 413-592 DRI_Background denotes Because mitochondrial content/function is essential for dendritic morphogenesis and maintenance, we investigated whether mutant LRRK2 affects mitochondrial homeostasis in neurons.
T4 593-633 DRI_Background denotes Mouse cortical neurons expressing either
T5 647-740 DRI_Background denotes or R1441C mutations exhibited autophagic degradation of mitochondria and dendrite shortening.
T6 741-841 DRI_Background denotes In addition, mutant LRRK2 altered the ability of the neurons to buffer intracellular calcium levels.
T7 842-982 DRI_Background denotes Either calcium chelators or inhibitors of voltage-gated L-type calcium channels prevented mitochondrial degradation and dendrite shortening.
T8 983-1115 DRI_Background denotes These data suggest that mutant LRRK2 causes a deficit in calcium homeostasis, leading to enhanced mitophagy and dendrite shortening.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 202-211 HP_0001300 denotes Parkinson
T2 421-434 HP_0001427 denotes mitochondrial
T3 555-568 HP_0001427 denotes mitochondrial
T4 932-945 HP_0001427 denotes mitochondrial