PubMed:23223110 / 1372-2315 JSONTXT

{"project":"PubMed_Structured_Abstracts","denotations":[{"id":"T3","span":{"begin":0,"end":943},"obj":"RESULTS"}],"text":"Wild-type nematodes demonstrated striking deficits in chemotaxis indices after exposure to isoflurane (ISO) or sevoflurane (SEVO) in the first larval stage (chemotaxis index: untreated, 85 ± 2; ISO, 52 ± 2; SEVO, 47 ± 2; P \u003c 0.05 for both exposures). The mitochondrial mutant gas-1 had a heightened effect from the anesthetic exposure (chemotaxis index: untreated, 71 ± 2; ISO, 29 ± 12; SEVO, 24 ± 13; P \u003c 0.05 for both exposures). In contrast, animals unable to undergo apoptosis because of a mutation in the pathway that mediates programmed cell death (ced-3) retained their ability to sense and move toward an attractant (chemotaxis index: untreated, 76 ± 10; ISO, 73 ± 9; SEVO, 76 ± 10). Furthermore, we discovered that the window of greatest susceptibility to anesthetic neurotoxicity in nematodes occurs in the first larval stage after hatching (L1). This coincides with a period of neurogenesis in this model. All values are means ± SD."}

{"project":"Allie","denotations":[{"id":"SS1_23223110_13_0","span":{"begin":91,"end":101},"obj":"expanded"},{"id":"SS2_23223110_13_0","span":{"begin":103,"end":106},"obj":"abbr"},{"id":"SS1_23223110_13_1","span":{"begin":111,"end":122},"obj":"expanded"},{"id":"SS2_23223110_13_1","span":{"begin":124,"end":128},"obj":"abbr"}],"relations":[{"id":"AE1_23223110_13_0","pred":"abbreviatedTo","subj":"SS1_23223110_13_0","obj":"SS2_23223110_13_0"},{"id":"AE1_23223110_13_1","pred":"abbreviatedTo","subj":"SS1_23223110_13_1","obj":"SS2_23223110_13_1"}],"text":"Wild-type nematodes demonstrated striking deficits in chemotaxis indices after exposure to isoflurane (ISO) or sevoflurane (SEVO) in the first larval stage (chemotaxis index: untreated, 85 ± 2; ISO, 52 ± 2; SEVO, 47 ± 2; P \u003c 0.05 for both exposures). The mitochondrial mutant gas-1 had a heightened effect from the anesthetic exposure (chemotaxis index: untreated, 71 ± 2; ISO, 29 ± 12; SEVO, 24 ± 13; P \u003c 0.05 for both exposures). In contrast, animals unable to undergo apoptosis because of a mutation in the pathway that mediates programmed cell death (ced-3) retained their ability to sense and move toward an attractant (chemotaxis index: untreated, 76 ± 10; ISO, 73 ± 9; SEVO, 76 ± 10). Furthermore, we discovered that the window of greatest susceptibility to anesthetic neurotoxicity in nematodes occurs in the first larval stage after hatching (L1). This coincides with a period of neurogenesis in this model. All values are means ± SD."}