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PubMed:23208501 JSONTXT

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c_corpus

Id Subject Object Predicate Lexical cue
T1 9-20 GO:0008610 denotes lipogenesis
T4 80-104 D002285 denotes ductal carcinoma in situ
T5 80-104 D002285 denotes ductal carcinoma in situ
T10 108-114 UBERON:0000310 denotes breast
T11 108-121 D001943 denotes breast cancer
T12 108-121 D001943 denotes breast cancer
T13 139-150 GO:0008610 denotes lipogenesis
T14 202-209 CHEBI:34922 denotes pathway
T15 228-233 D009369 denotes tumor
T16 228-233 D009369 denotes tumor
T17 228-238 CL:0001063 denotes tumor cell
T18 234-244 GO:0008219 denotes cell death
T19 248-257 GO:0097194 denotes apoptosis
T20 248-257 GO:0006915 denotes apoptosis
T21 286-297 GO:0008610 denotes lipogenesis
T22 301-306 D009369 denotes tumor
T23 301-306 D009369 denotes tumor
T26 428-452 D002285 denotes ductal carcinoma in situ
T27 428-452 D002285 denotes ductal carcinoma in situ
T33 454-458 CVCL_5552 denotes DCIS
T32 454-458 D002285 denotes DCIS
T34 454-458 D002285 denotes DCIS
T35 463-469 UBERON:0000310 denotes breast
T36 463-476 D001943 denotes breast cancer
T37 463-476 D001943 denotes breast cancer
T39 538-542 CVCL_5552 denotes DCIS
T38 538-542 D002285 denotes DCIS
T40 538-542 D002285 denotes DCIS
T41 596-600 D002285 denotes DCIS
T43 596-600 D002285 denotes DCIS
T44 596-604 CVCL_5552 denotes DCIS.com
T45 601-604 CHEBI:17905 denotes com
T46 621-633 GO:0009986 denotes cell surface
T47 650-654 PR:P15379 denotes CD44
T48 650-654 PR:P26051 denotes CD44
T49 650-654 PR:000001307 denotes CD44
T50 650-654 PR:P16070 denotes CD44
T51 657-660 Q60634 denotes ESA
T52 657-660 PR:000007559 denotes ESA
T53 657-660 Q14254 denotes ESA
T54 726-731 D009369 denotes tumor
T55 726-731 D009369 denotes tumor
T57 763-767 CVCL_5552 denotes DCIS
T56 763-767 D002285 denotes DCIS
T58 763-767 D002285 denotes DCIS
T59 958-964 UBERON:0000310 denotes breast
T60 958-971 D001943 denotes breast cancer
T61 958-971 D001943 denotes breast cancer
T62 965-976 CL:0001064 denotes cancer cell
T64 983-989 CVCL_0598 denotes MCF10A
T65 986-989 PR:000002396 denotes 10A
T68 1026-1032 O97676 denotes SREBP1
T69 1026-1032 Q60416 denotes SREBP1
T70 1026-1032 PR:P56720 denotes SREBP1
T71 1026-1032 P36956 denotes SREBP1
T72 1026-1032 P56720 denotes SREBP1
T73 1026-1032 PR:P36956 denotes SREBP1
T74 1026-1032 Q9WTN3 denotes SREBP1
T75 1026-1032 PR:000015611 denotes SREBP1
T76 1026-1032 PR:Q9WTN3 denotes SREBP1
T77 1026-1032 PR:000028989 denotes SREBP1
T79 1078-1084 CVCL_0598 denotes MCF10A
T80 1081-1084 PR:000002396 denotes 10A
T82 1108-1119 GO:0008610 denotes lipogenesis
T83 1152-1163 GO:0016049 denotes cell growth
T84 1187-1196 GO:0009058 denotes formation
T86 1208-1214 O97676 denotes SREBP1
T87 1208-1214 Q60416 denotes SREBP1
T88 1208-1214 PR:P56720 denotes SREBP1
T89 1208-1214 P36956 denotes SREBP1
T90 1208-1214 P56720 denotes SREBP1
T91 1208-1214 PR:P36956 denotes SREBP1
T92 1208-1214 Q9WTN3 denotes SREBP1
T93 1208-1214 PR:000015611 denotes SREBP1
T94 1208-1214 PR:Q9WTN3 denotes SREBP1
T95 1208-1214 PR:000028989 denotes SREBP1
T97 1292-1299 CVCL_5555 denotes MCF10AT
T99 1349-1353 CVCL_5552 denotes DCIS
T98 1349-1353 D002285 denotes DCIS
T100 1349-1353 D002285 denotes DCIS
T101 1358-1363 10090 denotes mouse
T102 1358-1363 D051379 denotes mouse
T103 1429-1440 GO:0008610 denotes lipogenesis
T106 1446-1449 SO:0002045 denotes pre
T105 1446-1449 PR:Q8LLD0 denotes pre
T107 1446-1449 UBERON:0001782 denotes pre
T104 1446-1449 GO:0003904 denotes pre
T109 1464-1468 CVCL_5552 denotes DCIS
T108 1464-1468 D002285 denotes DCIS
T110 1464-1468 D002285 denotes DCIS
T111 1469-1478 GO:0009058 denotes formation
T116 1545-1556 1000492 denotes resveratrol
T112 1545-1556 D000077185 denotes resveratrol
T113 1545-1556 CHEBI:45713 denotes resveratrol
T114 1545-1556 CHEBI:27881 denotes resveratrol
T115 1545-1556 D000077185 denotes resveratrol
T117 1595-1599 SO:0000704 denotes gene
T118 1595-1610 GO:0010467 denotes gene expression
T120 1674-1678 CVCL_5552 denotes DCIS
T119 1674-1678 D002285 denotes DCIS
T121 1674-1678 D002285 denotes DCIS
T123 1779-1783 CVCL_5552 denotes DCIS
T122 1779-1783 D002285 denotes DCIS
T124 1779-1783 D002285 denotes DCIS

DisGeNET

Id Subject Object Predicate Lexical cue
T0 657-660 gene:4072 denotes ESA
T1 763-767 disease:C0007124 denotes DCIS
T2 650-654 gene:960 denotes CD44
T3 561-567 disease:C0006826 denotes cancer
T4 650-654 gene:960 denotes CD44
T5 561-567 disease:C1306459 denotes cancer
T6 650-654 gene:960 denotes CD44
T7 596-600 disease:C0007124 denotes DCIS
T8 650-654 gene:960 denotes CD44
T9 763-767 disease:C0007124 denotes DCIS
T10 657-660 gene:2319 denotes ESA
T11 561-567 disease:C0006826 denotes cancer
T12 657-660 gene:2319 denotes ESA
T13 561-567 disease:C1306459 denotes cancer
T14 657-660 gene:5444 denotes ESA
T15 561-567 disease:C0006826 denotes cancer
T16 657-660 gene:5444 denotes ESA
T17 763-767 disease:C0007124 denotes DCIS
T18 657-660 gene:4072 denotes ESA
T19 561-567 disease:C0006826 denotes cancer
T20 657-660 gene:4072 denotes ESA
T21 561-567 disease:C1306459 denotes cancer
T22 657-660 gene:2319 denotes ESA
T23 596-600 disease:C0007124 denotes DCIS
T24 657-660 gene:5444 denotes ESA
T25 596-600 disease:C0007124 denotes DCIS
T26 657-660 gene:4072 denotes ESA
T27 596-600 disease:C0007124 denotes DCIS
T28 657-660 gene:2319 denotes ESA
T29 763-767 disease:C0007124 denotes DCIS
T30 657-660 gene:5444 denotes ESA
T31 561-567 disease:C1306459 denotes cancer
T32 1208-1214 gene:6720 denotes SREBP1
T33 1349-1353 disease:C0007124 denotes DCIS
R1 T0 T1 associated_with ESA,DCIS
R2 T2 T3 associated_with CD44,cancer
R3 T4 T5 associated_with CD44,cancer
R4 T6 T7 associated_with CD44,DCIS
R5 T8 T9 associated_with CD44,DCIS
R6 T10 T11 associated_with ESA,cancer
R7 T12 T13 associated_with ESA,cancer
R8 T14 T15 associated_with ESA,cancer
R9 T16 T17 associated_with ESA,DCIS
R10 T18 T19 associated_with ESA,cancer
R11 T20 T21 associated_with ESA,cancer
R12 T22 T23 associated_with ESA,DCIS
R13 T24 T25 associated_with ESA,DCIS
R14 T26 T27 associated_with ESA,DCIS
R15 T28 T29 associated_with ESA,DCIS
R16 T30 T31 associated_with ESA,cancer
R17 T32 T33 associated_with SREBP1,DCIS

Allie

Id Subject Object Predicate Lexical cue
SS1_23208501_3_0 428-452 expanded denotes ductal carcinoma in situ
SS2_23208501_3_0 454-458 abbr denotes DCIS
SS1_23208501_4_0 561-583 expanded denotes cancer stem-like cells
SS2_23208501_4_0 585-589 abbr denotes CSCs
AE1_23208501_3_0 SS1_23208501_3_0 SS2_23208501_3_0 abbreviatedTo ductal carcinoma in situ,DCIS
AE1_23208501_4_0 SS1_23208501_4_0 SS2_23208501_4_0 abbreviatedTo cancer stem-like cells,CSCs

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 123-258 DRI_Background denotes Upregulation of lipogenesis is a hallmark of cancer and blocking the lipogenic pathway is known to cause tumor cell death by apoptosis.
T2 259-346 DRI_Background denotes However, the exact role of lipogenesis in tumor initiation is as yet poorly understood.
T3 347-543 DRI_Outcome denotes We examined the expression profile of key lipogenic genes in clinical samples of ductal carcinoma in situ (DCIS) of breast cancer and found that these genes were significantly upregulated in DCIS.
T4 544-811 DRI_Approach denotes We also isolated cancer stem-like cells (CSCs) from DCIS.com cell line using cell surface markers (CS24(-)CD44(+)ESA(+)) and found that this cell population has significantly higher tumor-initiating ability to generate DCIS compared with the non-stem-like population.
T5 812-990 DRI_Outcome denotes Furthermore, the CSCs showed significantly higher level of expression of all lipogenic genes than the counterpart population from non-tumorigenic breast cancer cell line, MCF10A.
T6 991-1197 DRI_Outcome denotes Importantly, ectopic expression of SREBP1, the master regulator of lipogenic genes, in MCF10A significantly enhanced lipogenesis in stem-like cells and promoted cell growth as well as mammosphere formation.
T7 1198-1384 DRI_Outcome denotes Moreover, SREBP1 expression significantly increased the ability of cell survival of CSCs from MCF10AT, another cell line that is capable of generating DCIS, in mouse and in cell culture.
T8 1385-1520 DRI_Background denotes These results indicate that upregulation of lipogenesis is a pre-requisite for DCIS formation by endowing the ability of cell survival.
T9 1521-1784 DRI_Outcome denotes We have also shown that resveratrol was capable of blocking the lipogenic gene expression in CSCs and significantly suppressed their ability to generate DCIS in animals, which provides us with a strong rationale to use this agent for chemoprevention against DCIS.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 168-174 HP_0002664 denotes cancer
T2 228-233 HP_0002664 denotes tumor
T3 301-306 HP_0002664 denotes tumor
T4 463-476 HP_0003002 denotes breast cancer
T5 463-476 HP_0100013 denotes breast cancer
T6 470-476 HP_0002664 denotes cancer
T7 561-567 HP_0002664 denotes cancer
T8 726-731 HP_0002664 denotes tumor
T9 958-971 HP_0003002 denotes breast cancer
T10 958-971 HP_0100013 denotes breast cancer
T11 965-971 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23208501-4#113#116#gene4072 657-660 gene4072 denotes ESA
23208501-4#113#116#gene2319 657-660 gene2319 denotes ESA
23208501-4#113#116#gene5444 657-660 gene5444 denotes ESA
23208501-4#113#116#gene4072 657-660 gene4072 denotes ESA
23208501-4#113#116#gene2319 657-660 gene2319 denotes ESA
23208501-4#113#116#gene5444 657-660 gene5444 denotes ESA
23208501-4#106#110#gene960 650-654 gene960 denotes CD44
23208501-4#52#56#diseaseC0007124 596-600 diseaseC0007124 denotes DCIS
23208501-4#219#223#diseaseC0007124 763-767 diseaseC0007124 denotes DCIS
23208501-4#52#56#diseaseC0007124 596-600 diseaseC0007124 denotes DCIS
23208501-4#219#223#diseaseC0007124 763-767 diseaseC0007124 denotes DCIS
23208501-7#10#16#gene6720 1208-1214 gene6720 denotes SREBP1
23208501-7#151#155#diseaseC0007124 1349-1353 diseaseC0007124 denotes DCIS
113#116#gene407252#56#diseaseC0007124 23208501-4#113#116#gene4072 23208501-4#52#56#diseaseC0007124 associated_with ESA,DCIS
113#116#gene4072219#223#diseaseC0007124 23208501-4#113#116#gene4072 23208501-4#219#223#diseaseC0007124 associated_with ESA,DCIS
113#116#gene407252#56#diseaseC0007124 23208501-4#113#116#gene4072 23208501-4#52#56#diseaseC0007124 associated_with ESA,DCIS
113#116#gene4072219#223#diseaseC0007124 23208501-4#113#116#gene4072 23208501-4#219#223#diseaseC0007124 associated_with ESA,DCIS
113#116#gene231952#56#diseaseC0007124 23208501-4#113#116#gene2319 23208501-4#52#56#diseaseC0007124 associated_with ESA,DCIS
113#116#gene2319219#223#diseaseC0007124 23208501-4#113#116#gene2319 23208501-4#219#223#diseaseC0007124 associated_with ESA,DCIS
113#116#gene231952#56#diseaseC0007124 23208501-4#113#116#gene2319 23208501-4#52#56#diseaseC0007124 associated_with ESA,DCIS
113#116#gene2319219#223#diseaseC0007124 23208501-4#113#116#gene2319 23208501-4#219#223#diseaseC0007124 associated_with ESA,DCIS
113#116#gene544452#56#diseaseC0007124 23208501-4#113#116#gene5444 23208501-4#52#56#diseaseC0007124 associated_with ESA,DCIS
113#116#gene5444219#223#diseaseC0007124 23208501-4#113#116#gene5444 23208501-4#219#223#diseaseC0007124 associated_with ESA,DCIS
113#116#gene544452#56#diseaseC0007124 23208501-4#113#116#gene5444 23208501-4#52#56#diseaseC0007124 associated_with ESA,DCIS
113#116#gene5444219#223#diseaseC0007124 23208501-4#113#116#gene5444 23208501-4#219#223#diseaseC0007124 associated_with ESA,DCIS
113#116#gene407252#56#diseaseC0007124 23208501-4#113#116#gene4072 23208501-4#52#56#diseaseC0007124 associated_with ESA,DCIS
113#116#gene4072219#223#diseaseC0007124 23208501-4#113#116#gene4072 23208501-4#219#223#diseaseC0007124 associated_with ESA,DCIS
113#116#gene407252#56#diseaseC0007124 23208501-4#113#116#gene4072 23208501-4#52#56#diseaseC0007124 associated_with ESA,DCIS
113#116#gene4072219#223#diseaseC0007124 23208501-4#113#116#gene4072 23208501-4#219#223#diseaseC0007124 associated_with ESA,DCIS
113#116#gene231952#56#diseaseC0007124 23208501-4#113#116#gene2319 23208501-4#52#56#diseaseC0007124 associated_with ESA,DCIS
113#116#gene2319219#223#diseaseC0007124 23208501-4#113#116#gene2319 23208501-4#219#223#diseaseC0007124 associated_with ESA,DCIS
113#116#gene231952#56#diseaseC0007124 23208501-4#113#116#gene2319 23208501-4#52#56#diseaseC0007124 associated_with ESA,DCIS
113#116#gene2319219#223#diseaseC0007124 23208501-4#113#116#gene2319 23208501-4#219#223#diseaseC0007124 associated_with ESA,DCIS
113#116#gene544452#56#diseaseC0007124 23208501-4#113#116#gene5444 23208501-4#52#56#diseaseC0007124 associated_with ESA,DCIS
113#116#gene5444219#223#diseaseC0007124 23208501-4#113#116#gene5444 23208501-4#219#223#diseaseC0007124 associated_with ESA,DCIS
113#116#gene544452#56#diseaseC0007124 23208501-4#113#116#gene5444 23208501-4#52#56#diseaseC0007124 associated_with ESA,DCIS
113#116#gene5444219#223#diseaseC0007124 23208501-4#113#116#gene5444 23208501-4#219#223#diseaseC0007124 associated_with ESA,DCIS
106#110#gene96052#56#diseaseC0007124 23208501-4#106#110#gene960 23208501-4#52#56#diseaseC0007124 associated_with CD44,DCIS
106#110#gene960219#223#diseaseC0007124 23208501-4#106#110#gene960 23208501-4#219#223#diseaseC0007124 associated_with CD44,DCIS
106#110#gene96052#56#diseaseC0007124 23208501-4#106#110#gene960 23208501-4#52#56#diseaseC0007124 associated_with CD44,DCIS
106#110#gene960219#223#diseaseC0007124 23208501-4#106#110#gene960 23208501-4#219#223#diseaseC0007124 associated_with CD44,DCIS
10#16#gene6720151#155#diseaseC0007124 23208501-7#10#16#gene6720 23208501-7#151#155#diseaseC0007124 associated_with SREBP1,DCIS